Genomes and Genes
Experts and Doctors on cell line in Brisbane, Queensland, Australia
Locale: Brisbane, Queensland, Australia
Topic: cell line
Publications181 found, 100 shown here
- Sim E, Smith A, Szilagi E, Rae F, Ioannou P, Lindsay M, et al. Wnt-4 regulation by the Wilms' tumour suppressor gene, WT1. Oncogene. 2002;21:2948-60 pubmed..We propose that Wnt-4 regulation by WT1 occurs at a more distant promoter or enhancer site, or is indirect. ..
- Beaumont K, Newton R, Smit D, Leonard J, Stow J, Sturm R. Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk. Hum Mol Genet. 2005;14:2145-54 pubmed
- Varnavski A, Young P, Khromykh A. Stable high-level expression of heterologous genes in vitro and in vivo by noncytopathic DNA-based Kunjin virus replicon vectors. J Virol. 2000;74:4394-403 pubmed..The noncytopathic nature of DNA-based KUN replicon vectors combined with high-level and stability of HG expression in a broad range of host cells should prove them to be useful in a variety of applications in vitro and in vivo. ..
- Pagan J, Wylie F, Joseph S, Widberg C, Bryant N, James D, et al. The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion. Curr Biol. 2003;13:156-60 pubmed..This represents a novel regulatory role for SNAREs in regulated secretion and in macrophage-mediated host defense. ..
- Cassady A, Luchin A, Ostrowski M, Hume D. Regulation of the murine TRACP gene promoter. J Bone Miner Res. 2003;18:1901-4 pubmed..This directly links two controlling factors of osteoclast differentiation to the expression of an effector of cell function. ..
- Roy S, Plowman S, Rotblat B, Prior I, Muncke C, Grainger S, et al. Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling. Mol Cell Biol. 2005;25:6722-33 pubmed..Finally we show that the plasma membrane affinity of monopalmitoylated anchors is absolutely dependent on cholesterol, identifying a new role for cholesterol in promoting interactions with the raft and nonraft plasma membrane. ..
- Suen J, Barry G, Lohman R, Halili M, Cotterell A, Le G, et al. Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110). Br J Pharmacol. 2012;165:1413-23 pubmed publisher..The novel PAR2 agonist and antagonist modulate intracellular Ca(2+) and rat paw oedema, providing novel molecular tools for examining PAR2-mediated diseases. ..
- Bolderson E, Petermann E, Croft L, Suraweera A, Pandita R, Pandita T, et al. Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks. Nucleic Acids Res. 2014;42:6326-36 pubmed publisher..Overall, our findings demonstrate the importance of hSSB1 in maintaining and repairing DNA replication forks and for overall genomic stability. ..
- Fernandez L, Sykes M, Andrews K, Avery V. Antiparasitic activity of alkaloids from plant species of Papua New Guinea and Australia. Int J Antimicrob Agents. 2010;36:275-9 pubmed publisher..These findings suggest a potential for indole alkaloids from Flindersia spp. as new antiparasitic agents...
- Rehli M, Lichanska A, Cassady A, Ostrowski M, Hume D. TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors. J Immunol. 1999;162:1559-65 pubmed
- Beck L, Markovich D. The mouse Na(+)-sulfate cotransporter gene Nas1. Cloning, tissue distribution, gene structure, chromosomal assignment, and transcriptional regulation by vitamin D. J Biol Chem. 2000;275:11880-90 pubmed..It also provides the basis for a detailed analysis of Nas1 gene regulation and the tools required for assessing Nas1 role in sulfate homeostasis using targeted gene manipulation in mice. ..
- Rae F, Martinez G, Gillinder K, Smith A, Shooter G, Forrest A, et al. Anlaysis of complementary expression profiles following WT1 induction versus repression reveals the cholesterol/fatty acid synthetic pathways as a possible major target of WT1. Oncogene. 2004;23:3067-79 pubmed..Therefore, the tumour suppressor activities of WT1 may be achieved by repressing the mevalonate pathway, thereby controlling cellular proliferation and promoting terminal differentiation. ..
- Greenwood K, Daly N, Brown D, Stow J, Craik D. The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis. Int J Biochem Cell Biol. 2007;39:2252-64 pubmed..The ready uptake, coupled with low cytotoxicity, indicates that MCoTI-II has the potential to transport grafted bioactivities to intracellular targets, making it a potentially valuable framework in drug design applications. ..
- Scott S, Bendix R, Chen P, Clark R, Dork T, Lavin M. Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer. Proc Natl Acad Sci U S A. 2002;99:925-30 pubmed..This approach represents a means of identifying genuine ATM mutations and addressing the significance of missense changes in the ATM gene in a variety of cancers including breast cancer. ..
- Hollier B, Harkin D, Leavesley D, Upton Z. Responses of keratinocytes to substrate-bound vitronectin: growth factor complexes. Exp Cell Res. 2005;305:221-32 pubmed..Indeed, similar responses are observed in primary cultures of human skin keratinocytes, highlighting the potential use of these novel complexes for a wide range of tissue repair applications. ..
- Yang Z, Ney A, Cromer B, Ng H, Parker M, Lynch J. Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition. J Neurochem. 2007;100:758-69 pubmed..To our knowledge, tropisetron is the most exquisitely sensitive modulator yet identified for a cys-loop receptor. ..
- Hyde J, Gillespie L, Mackenzie J. Mouse norovirus 1 utilizes the cytoskeleton network to establish localization of the replication complex proximal to the microtubule organizing center. J Virol. 2012;86:4110-22 pubmed publisher..This study highlights the role of the cytoskeleton in early virus replication events and demonstrates the importance of this interaction in establishing the intracellular location of MNV-1 replication complexes. ..
- Khromykh A, Westaway E. Subgenomic replicons of the flavivirus Kunjin: construction and applications. J Virol. 1997;71:1497-505 pubmed..The constructed KUN replicons should provide valuable tools to study flavivirus RNA replication as well as providing possible vectors for a long-lasting and noncytopathic RNA virus expression system. ..
- Hall R, Scherret J, Sedlak P, Poidinger M, Mackenzie J. Isolation of homologous arbovirus cultures from heterologous mixtures using limit dilution and virus-specific enzyme immunoassays. J Virol Methods. 1999;83:189-92 pubmed..This procedure is particularly useful for isolating virus populations from heterogeneous mixtures that fail to develop discrete plaques in infected cell monolayers. ..
- Zhao Z, Sugerman P, Walsh L, Savage N. Expression of RANTES and CCR1 in oral lichen planus and association with mast cell migration. J Oral Pathol Med. 2002;31:158-62 pubmed..The present study shows, for the first time, the distribution of RANTES and CCR1 in OLP. It is hypothesized that RANTES and CCR1 may play important roles in mast cell trafficking and related events in OLP. ..
- Hryciw D, Ekberg J, Lee A, Lensink I, Kumar S, Guggino W, et al. Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells. J Biol Chem. 2004;279:54996-5007 pubmed..These data demonstrate that normal constitutive uptake of albumin by the proximal tubule requires Nedd4-2, which may act via ubiquitination to shunt ClC-5 into the endocytic pathway. ..
- Rosengren K, Lin F, Bathgate R, Tregear G, Daly N, Wade J, et al. Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3. J Biol Chem. 2006;281:5845-51 pubmed..This structural feature is likely important for the activation of its endogenous receptor, GPCR135. ..
- Hempel N, Negishi M, McManus M. Human SULT1A genes: cloning and activity assays of the SULT1A promoters. Methods Enzymol. 2005;400:147-65 pubmed..They will also help reveal how different cellular environments and polymorphisms affect the activity of SULT1A gene promoters. ..
- Plowman S, Ariotti N, Goodall A, Parton R, Hancock J. Electrostatic interactions positively regulate K-Ras nanocluster formation and function. Mol Cell Biol. 2008;28:4377-85 pubmed publisher..Together, these data illustrate that Ras nanocluster composition regulates effector recruitment and highlight the importance of lipid/protein nanoscale environments to the activation of signaling cascades. ..
- Xu M, Andrews K, Birrell G, Tran T, Camp D, Davis R, et al. Psammaplysin H, a new antimalarial bromotyrosine alkaloid from a marine sponge of the genus Pseudoceratina. Bioorg Med Chem Lett. 2011;21:846-8 pubmed publisher..All compounds were tested in vitro against the 3D7 line of Plasmodium falciparum and mammalian cell lines (HEK293 and HepG2), with 1 having the most potent (IC(50) 0.41?M) and selective (>97-fold) antimalarial activity...
- Preston F, Straub C, Ramirez R, Mahalingam S, Spann K. siRNA against the G gene of human metapneumovirus. Virol J. 2012;9:105 pubmed publisher..Expression of G by recombinant adenovirus did not affect type I IFN expression. G has been previously described as a type I interferon antagonist, although our findings suggest it may not be a significant antagonist...
- Wyse B, Prior I, Qian H, Morrow I, Nixon S, Muncke C, et al. Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. J Biol Chem. 2003;278:23738-46 pubmed..Caveolin therefore acts as a molecular chaperone rather than a plasma membrane scaffold for AT1-R. ..
- Vajjhala P, Macmillan E, Gonda T, Little M. The Wilms' tumour suppressor protein, WT1, undergoes CRM1-independent nucleocytoplasmic shuttling. FEBS Lett. 2003;554:143-8 pubmed..We have also mapped the region responsible for nuclear export to residues 182-324. Our data add further complexity to the role of WT1 in transcriptional and post-transcriptional regulation. ..
- Murray R, Kay J, Sangermani D, Stow J. A role for the phagosome in cytokine secretion. Science. 2005;310:1492-5 pubmed..Fusion of the RE at the cup simultaneously allows rapid release of TNFalpha and expands the membrane for phagocytosis. ..
- Darnell G, Schroder W, Antalis T, Lambley E, Major L, Gardner J, et al. Human papillomavirus E7 requires the protease calpain to degrade the retinoblastoma protein. J Biol Chem. 2007;282:37492-500 pubmed publisher..Calpain, thus, emerges as a central player in E7-mediated degradation of Rb and represents a potential new drug target for the treatment of HPV-associated lesions...
- Jeanes A, Smutny M, Leerberg J, Yap A. Phosphatidylinositol 3'-kinase signalling supports cell height in established epithelial monolayers. J Mol Histol. 2009;40:395-405 pubmed publisher..This is independent of potential effects on adhesion or polarity, but may occur through PI3-kinase-stimulated Rac signaling...
- Matigian N, Abrahamsen G, Sutharsan R, Cook A, Vitale A, Nouwens A, et al. Disease-specific, neurosphere-derived cells as models for brain disorders. Dis Model Mech. 2010;3:785-98 pubmed publisher..They do not require genetic reprogramming and they can be obtained from adults with complex genetic diseases. They will be useful for understanding disease aetiology, for diagnostics and for drug discovery. ..
- Frentiu F, Robinson J, Young P, McGraw E, O Neill S. Wolbachia-mediated resistance to dengue virus infection and death at the cellular level. PLoS ONE. 2010;5:e13398 pubmed publisher..Our results parallel findings in mosquitoes and flies, indicating that cell line models will provide useful and experimentally tractable models to study the mechanisms underlying Wolbachia-mediated protection from viruses. ..
- Offenh user C, Lei N, Roy S, Collins B, Stow J, Murray R. Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages. Traffic. 2011;12:762-73 pubmed publisher..Our results suggest that by regulating the availability of Vti1b, Stx11 regulates trafficking steps between late endosomes, lysosomes and the cell surface in macrophages...
- Heads J, Hawthorne R, Lynagh T, Lynch J. Structure-activity analysis of ginkgolide binding in the glycine receptor pore. J Neurochem. 2008;105:1418-27 pubmed publisher..This property may be exploited to create improved pharmacological probes for discriminating among anionic Cys-loop receptor isoforms with 6' structural variations. ..
- Faddy H, Smart C, Xu R, Lee G, Kenny P, Feng M, et al. Localization of plasma membrane and secretory calcium pumps in the mammary gland. Biochem Biophys Res Commun. 2008;369:977-81 pubmed publisher..Our studies highlight the likely specific roles of PMCA2 and SPCA2 in lactation and indicate that calcium transport into milk is a complex interplay between apical and secretory pathways. ..
- Deshpande C, Xin V, Lu Y, Savage T, Anderson G, Jormakka M. Large scale expression and purification of secreted mouse hephaestin. PLoS ONE. 2017;12:e0184366 pubmed publisher..Here, we present an expression and purification protocol of soluble mouse hephaestin, yielding milligram amounts of enzymatically active, purified protein using the baculovirus/insect cell system. ..
- Westaway E, MacKenzie J, Kenney M, Jones M, Khromykh A. Ultrastructure of Kunjin virus-infected cells: colocalization of NS1 and NS3 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures. J Virol. 1997;71:6650-61 pubmed..The collection of induced membranes may represent virus factories in which translation, RNA synthesis, and virus assembly occur. ..
- Khromykh A, Sedlak P, Westaway E. trans-Complementation analysis of the flavivirus Kunjin ns5 gene reveals an essential role for translation of its N-terminal half in RNA replication. J Virol. 1999;73:9247-55 pubmed
- Popa C, Dicker A, Dahler A, Saunders N. Cytochrome P450, CYP26AI, is expressed at low levels in human epidermal keratinocytes and is not retinoic acid-inducible. Br J Dermatol. 1999;141:460-8 pubmed..These studies also indicate that as yet unknown isoforms of cytochrome P450 may be involved in RA metabolism in keratinocytes. ..
- Hogg N, Browning J, Howard T, Winterford C, Fitzpatrick D, Gobe G. Apoptosis in vascular endothelial cells caused by serum deprivation, oxidative stress and transforming growth factor-beta. Endothelium. 1999;7:35-49 pubmed..Future therapies against inappropriate vessel deletion in disease states may use the known gene-driven nature of apoptosis to modify this sort of cell death in endothelial cells. ..
- Khromykh A, Meka H, Guyatt K, Westaway E. Essential role of cyclization sequences in flavivirus RNA replication. J Virol. 2001;75:6719-28 pubmed
- Shan Q, Haddrill J, Lynch J. Comparative surface accessibility of a pore-lining threonine residue (T6') in the glycine and GABA(A) receptors. J Biol Chem. 2002;277:44845-53 pubmed..The results also indicate that the GABA(A)R pore structure at the 6' level may vary between different expression systems. ..
- Underwood C, Reid K, May L, Bartlett P, Coulson E. Palmitoylation of the C-terminal fragment of p75(NTR) regulates death signaling and is required for subsequent cleavage by gamma-secretase. Mol Cell Neurosci. 2008;37:346-58 pubmed
- Cook A, Vitale A, Ravishankar S, Matigian N, Sutherland G, Shan J, et al. NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease. PLoS ONE. 2011;6:e21907 pubmed publisher..However, our results also demonstrated that the response of PD patient-derived cells was not co-ordinated in the same way as in Control cells. This may be an important factor when developing new therapeutics. ..
- Schuessler A, Funk A, Lazear H, Cooper D, Torres S, Daffis S, et al. West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response. J Virol. 2012;86:5708-18 pubmed publisher..The results define a novel function of sfRNA in flavivirus pathogenesis via its contribution to viral evasion of the type I interferon response. ..
- Domingo Fernández R, Coll R, Kearney J, Breit S, O Neill L. The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1? transcription and activate the NLRP3 inflammasome. J Biol Chem. 2017;292:12077-12087 pubmed publisher..Collectively, our results demonstrate that CLIC1 and CLIC4 participate both in the priming signal for IL-1? and in NLRP3 activation. ..
- Metharom P, Takyar S, Xia H, Ellem K, Wilcox G, Wei M. Development of disabled, replication-defective gene transfer vectors from the Jembrana disease virus, a new infectious agent of cattle. Vet Microbiol. 2001;80:9-22 pubmed..To our knowledge, this is the first such vector system developed from a cattle virus...
- Xu Z, Walker T, Liu K, Cooper H, Lu G, Bartlett P. Layered double hydroxide nanoparticles as cellular delivery vectors of supercoiled plasmid DNA. Int J Nanomedicine. 2007;2:163-74 pubmed..The lower delivery efficiency could be attributed to the aggregation of LDH nanoparticles caused by the long-chain plasmid DNA...
- Bolderson E, Tomimatsu N, Richard D, Boucher D, Kumar R, Pandita T, et al. Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Res. 2010;38:1821-31 pubmed publisher..These data establish a role for Exo1 in resection of DSBs in human cells, highlighting the critical requirement of Exo1 for DSB repair via HR and thus the maintenance of genomic stability. ..
- Cassady A, Stacey K, Nimmo K, Murphy K, von der Ahe D, Pearson D, et al. Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig. Nucleic Acids Res. 1991;19:6839-47 pubmed..The conserved, transcribed 5' non-coding sequences were also required for maximal gene expression. Hence, the uPA promoter contains multiple weak cis-acting elements distributed over 7.0 kb 5' to the translation start site. ..
- Khromykh A, Harvey T, Abedinia M, Westaway E. Expression and purification of the seven nonstructural proteins of the flavivirus Kunjin in the E. coli and the baculovirus expression systems. J Virol Methods. 1996;61:47-58 pubmed
- Khromykh A, Sedlak P, Guyatt K, Hall R, Westaway E. Efficient trans-complementation of the flavivirus kunjin NS5 protein but not of the NS1 protein requires its coexpression with other components of the viral replicase. J Virol. 1999;73:10272-80 pubmed..The results are interpreted and discussed in relation to our proposed model of formation of the flavivirus RC largely based on previous ultrastructural and biochemical analyses of KUN replication. ..
- Gatei M, Young D, Cerosaletti K, Desai Mehta A, Spring K, Kozlov S, et al. ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet. 2000;25:115-9 pubmed..ATM phosphorylation of nibrin does not affect nibrin-MRE11-RAD50 association as revealed by radiation-induced foci formation. Our data provide a biochemical explanation for the similarity in phenotype between A-T and NBS. ..
- Liu W, Sedlak P, Kondratieva N, Khromykh A. Complementation analysis of the flavivirus Kunjin NS3 and NS5 proteins defines the minimal regions essential for formation of a replication complex and shows a requirement of NS3 in cis for virus assembly. J Virol. 2002;76:10766-75 pubmed..The results define minimal regions in the NS3 and NS5 genes essential for the formation of complementable replication complex and show a requirement of NS3 in cis for virus assembly...
- Nevin S, Cromer B, Haddrill J, Morton C, Parker M, Lynch J. Insights into the structural basis for zinc inhibition of the glycine receptor. J Biol Chem. 2003;278:28985-92 pubmed..The binding of zinc at the interface between adjacent alpha1 subunits could restrict intersubunit movements, providing a feasible mechanism for the inhibition of channel activation by zinc. ..
- Sturm R, Duffy D, Box N, Newton R, Shepherd A, Chen W, et al. Genetic association and cellular function of MC1R variant alleles in human pigmentation. Ann N Y Acad Sci. 2003;994:348-58 pubmed..With this objective, we have established more than 300 melanocyte cell strains of defined MC1R genotype. ..
- Wang X, Rothnagel J. 5'-untranslated regions with multiple upstream AUG codons can support low-level translation via leaky scanning and reinitiation. Nucleic Acids Res. 2004;32:1382-91 pubmed..This study shows that for mRNAs containing multiple uORFs/uAUGs, ribosome reinitiation and leaky scanning are efficient mechanisms for initiation at their main AUGs. ..
- Murray R, Wylie F, Khromykh T, Hume D, Stow J. Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha. J Biol Chem. 2005;280:10478-83 pubmed publisher..This study shows how macrophages have uniquely adapted a novel Golgi-associated SNARE complex to accommodate their requirement for increased cytokine secretion...
- Hryciw D, Ekberg J, Ferguson C, Lee A, Wang D, Parton R, et al. Regulation of albumin endocytosis by PSD95/Dlg/ZO-1 (PDZ) scaffolds. Interaction of Na+-H+ exchange regulatory factor-2 with ClC-5. J Biol Chem. 2006;281:16068-77 pubmed..Thus NHERF1 and NHERF2 differentially regulate albumin uptake by mechanisms that ultimately alter the cell-surface levels of ClC-5. ..
- Maddugoda M, Crampton M, Shewan A, Yap A. Myosin VI and vinculin cooperate during the morphogenesis of cadherin cell cell contacts in mammalian epithelial cells. J Cell Biol. 2007;178:529-40 pubmed..We propose that myosin VI and vinculin form a molecular apparatus that generates cohesive cell-cell contacts in cultured mammalian epithelia. ..
- Young L, Melian E, Khromykh A. NS1' colocalizes with NS1 and can substitute for NS1 in West Nile virus replication. J Virol. 2013;87:9384-90 pubmed publisher..Using complementation analysis with NS1-deleted WNV cDNA, we demonstrated that NS1' is able to substitute for the crucial function of NS1 in virus replication. ..
- Amini Khoei H, Hosseini M, Momeny M, Rahimi Balaei M, Amiri S, Haj Mirzaian A, et al. Morphine Attenuated the Cytotoxicity Induced by Arsenic Trioxide in H9c2 Cardiomyocytes. Biol Trace Elem Res. 2016;173:132-9 pubmed publisher..Results of this study suggest that morphine may have protective properties in management of cardiac toxicity in patients who receive ATO as an anti-cancer treatment. ..
- Dickinson J, Bates E, Ferrante A, Antalis T. Plasminogen activator inhibitor type 2 inhibits tumor necrosis factor alpha-induced apoptosis. Evidence for an alternate biological function. J Biol Chem. 1995;270:27894-904 pubmed..The results suggest that intracellular PAI-2 might be an important factor in regulating cell death in TNF-mediated inflammatory processes through inhibition of a proteinase involved in TNF-induced apoptosis. ..
- Miranda K, Khromykh T, Christy P, Le T, Gottardi C, Yap A, et al. A dileucine motif targets E-cadherin to the basolateral cell surface in Madin-Darby canine kidney and LLC-PK1 epithelial cells. J Biol Chem. 2001;276:22565-72 pubmed..These results provide the first direct insights into how E-cadherin is targeted to the basolateral membrane. ..
- Hume D, Underhill D, Sweet M, Ozinsky A, Liew F, Aderem A. Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state. BMC Immunol. 2001;2:11 pubmed..Upon exposure to a TLR agonist, macrophages enter a state of sustained activation in which they continuously sense the presence of a microbial challenge. ..
- Himes S, Tagoh H, Goonetilleke N, Sasmono T, Oceandy D, Clark R, et al. A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression. J Leukoc Biol. 2001;70:812-20 pubmed..Removal of FIRE abolished reporter gene expression, revealing a suppressive activity in the remaining intronic sequences. Hence, FIRE is shown to be a key regulatory element in the fms gene. ..
- Bodetti T, Viggers K, Warren K, Swan R, Conaghty S, Sims C, et al. Wide range of Chlamydiales types detected in native Australian mammals. Vet Microbiol. 2003;96:177-87 pubmed..These findings provide further evidence that novel Chlamydiales infections occur in a wide range of hosts and that, in some of these, the chlamydial infections may contribute to clinical disease. ..
- Helwani F, Kovacs E, Paterson A, Verma S, Ali R, Fanning A, et al. Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization. J Cell Biol. 2004;164:899-910 pubmed..Together, our findings identify a necessary role for cortactin in the cadherin-actin cooperation that supports productive contact formation. ..
- Stewart T, Drane D, Malliaros J, Elmer H, Malcolm K, Cox J, et al. ISCOMATRIX adjuvant: an adjuvant suitable for use in anticancer vaccines. Vaccine. 2004;22:3738-43 pubmed..These findings demonstrate the potential of ISCOMATRIX adjuvant to stimulate both cellular and humoral immune responses to endogenously processed target antigens, and hence is the preferred adjuvant when CTL responses are desirable. ..
- Gueven N, Chen P, Nakamura J, Becherel O, Kijas A, Grattan Smith P, et al. A subgroup of spinocerebellar ataxias defective in DNA damage responses. Neuroscience. 2007;145:1418-25 pubmed..These data provide further evidence that different forms of AOA have in common a reduced capacity to cope with damage to DNA, which may account for the neurodegeneration observed in these syndromes. ..
- Vetter I, Wyse B, Roberts Thomson S, Monteith G, Cabot P. Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol. Eur J Pain. 2008;12:441-54 pubmed..The results presented here suggest that morphine may be of limited use in inhibiting nociceptive TRPV1 responses that have been sensitised by exposure to ethanol. ..
- Ovchinnikov D, van Zuylen W, DeBats C, Alexander K, Kellie S, Hume D. Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice. J Leukoc Biol. 2008;83:430-3 pubmed..The new mouse line provides a useful tool for overexpression of transgenes in cells of the myeloid lineage, while simultaneously labeling them by ECFP expression. ..
- Hill M, Bastiani M, Luetterforst R, Kirkham M, Kirkham A, Nixon S, et al. PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell. 2008;132:113-24 pubmed publisher..We conclude that PTRF-Cavin is required for caveola formation and sequestration of mobile caveolin into immobile caveolae. ..
- Neumann B, Zhao L, Murphy K, Gonda T. Subcellular localization of the Schlafen protein family. Biochem Biophys Res Commun. 2008;370:62-6 pubmed publisher..Thus, we propose the different subgroups of Schlafen proteins are likely to have functionally distinct roles, reflecting their differing localizations within the cell. ..
- Harris J, Jakob B, Taucher Scholz G, Dianov G, Becherel O, Lavin M. Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage. Hum Mol Genet. 2009;18:4102-17 pubmed publisher..These data support both direct and indirect modulating functions for aprataxin on base excision repair. ..
- Achard M, Hamilton A, Dankowski T, Heras B, Schembri M, Edwards J, et al. A periplasmic thioredoxin-like protein plays a role in defense against oxidative stress in Neisseria gonorrhoeae. Infect Immun. 2009;77:4934-9 pubmed publisher..The tlpA mutant also exhibited reduced intracellular survival in human primary cervical epithelial cells. ..
- Richards A, Colgrave M, Zhang J, Webster J, Simpson F, Preston E, et al. Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation. Mol Endocrinol. 2010;24:229-39 pubmed publisher..These data suggest an important role for sialic acid content in the regulation of circulating adiponectin levels and highlight the importance of understanding mechanisms regulating adiponectin sialylation/desialylation. ..
- Nguyen Q, Qi Y, Wu Y, Chan L, Nielsen L, Reid S. In vitro production of Helicoverpa baculovirus biopesticides--automated selection of insect cell clones for manufacturing and systems biology studies. J Virol Methods. 2011;175:197-205 pubmed publisher..Hence, this method can create a high contrast system (OB/cell yield basis), for comparative studies using a systems biology approach, which should inform a more targeted approach to engineer genetically a production cell line. ..
- Gomez G, McLachlan R, Yap A. Productive tension: force-sensing and homeostasis of cell-cell junctions. Trends Cell Biol. 2011;21:499-505 pubmed publisher..In this review, we examine these advances and discuss their implications...
- Rist M, Cooper L, Elkington R, Walker S, Fazou C, Tellam J, et al. Ex vivo expansion of human cytomegalovirus-specific cytotoxic T cells by recombinant polyepitope: implications for HCMV immunotherapy. Eur J Immunol. 2005;35:996-1007 pubmed..These studies show the effectiveness of a polyepitope antigen presentation system for reproducible expansion of antigen-specific T cells from immunocompetent and immunocompromised settings. ..
- Regeer R, Lee A, Markovich D. Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1). DNA Cell Biol. 2003;22:107-17 pubmed..This study represents the first functional characterization of the human SAT1 gene and protein encoded by the anion transporter hsat-1. ..
- Lock J, Stow J. Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin. Mol Biol Cell. 2005;16:1744-55 pubmed..The recycling endosome is identified as an intermediate compartment for the post-Golgi trafficking and exocytosis of E-cadherin, with a potentially important role in establishing and maintaining cadherin-based adhesion. ..
- Tian T, Harding A, Inder K, Plowman S, Parton R, Hancock J. Plasma membrane nanoswitches generate high-fidelity Ras signal transduction. Nat Cell Biol. 2007;9:905-14 pubmed..A requirement for high-fidelity signalling may explain the non-random distribution of other plasma membrane signalling complexes. ..
- Bradford S, Wilhelm D, Koopman P. Comparative analysis of anti-mouse SRY antibodies. Sex Dev. 2007;1:305-10 pubmed publisher..Our findings underline the need to distinguish between useful and spurious reagents for biochemical and immunolocalization studies involving mouse SRY protein...
- den Elzen N, Buttery C, Maddugoda M, Ren G, Yap A. Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia. Mol Biol Cell. 2009;20:3740-50 pubmed publisher..Together, these findings establish a novel morphogenetic function for cadherin adhesion receptors to guide spindle orientation during symmetric cell division. ..
- Collet T, Macnaughton T, Walsh T, Debattista J, Timms P. Identification of novel markers for uncomplicated lower genital tract infections and upper genital tract pathology due to Chlamydia trachomatis. Int J Infect Dis. 2011;15:e257-66 pubmed publisher..The use of these assays could potentially facilitate earlier diagnoses in women suffering UGT pathology due to C. trachomatis. ..
- Yau M, Liu L, Lim J, Lohman R, Cotterell A, Suen J, et al. Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity. Bioorg Med Chem Lett. 2016;26:986-991 pubmed publisher..These findings show that new benzylamide antagonists of PAR2 have anti-inflammatory activity. ..
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