Experts and Doctors on protein binding in Sydney, New South Wales, Australia

Summary

Locale: Sydney, New South Wales, Australia
Topic: protein binding

Top Publications

  1. Cameron D, Thompson J, March P, Dahlberg A. Initiation factor IF2, thiostrepton and micrococcin prevent the binding of elongation factor G to the Escherichia coli ribosome. J Mol Biol. 2002;319:27-35 pubmed
    ..Micrococcin stimulates GTP hydrolysis by both factors. We show directly that these drugs act by destabilizing the interaction of EF-G with the ribosome, and provide evidence that they have similar effects on IF2. ..
  2. Bernhard O, Lai J, Wilkinson J, Sheil M, Cunningham A. Proteomic analysis of DC-SIGN on dendritic cells detects tetramers required for ligand binding but no association with CD4. J Biol Chem. 2004;279:51828-35 pubmed
  3. Shi T, Giannakopoulos B, Iverson G, Cockerill K, Linnik M, Krilis S. Domain V of beta2-glycoprotein I binds factor XI/XIa and is cleaved at Lys317-Thr318. J Biol Chem. 2005;280:907-12 pubmed
    ..We also demonstrate that FXIa proteolytically cleaves beta2GPI at Lys317-Thr318 in DV. Thus, FXIa cleavage of beta2GPI in vivo during thrombus formation may accelerate FXI activation by decreasing the inhibitory effect of beta2GPI. ..
  4. Liew C, Simpson R, Kwan A, Crofts L, Loughlin F, Matthews J, et al. Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction. Proc Natl Acad Sci U S A. 2005;102:583-8 pubmed
    ..Details of the architecture of the contact domains and their physical properties provide a molecular explanation for how the GATA-1 mutations contribute to distinct but related genetic diseases. ..
  5. Chen J, Liu M, Parish C, Chong B, Khachigian L. Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine. Int J Biochem Cell Biol. 2011;43:905-12 pubmed publisher
  6. Erce M, Low J, Hart Smith G, Wilkins M. A conditional two-hybrid (C2H) system for the detection of protein-protein interactions that are mediated by post-translational modification. Proteomics. 2013;13:1059-64 pubmed publisher
    ..We demonstrate the use of the C2H system to study the dimerization of the yeast protein Npl3, which is increased when methylated by the methyltransferase Hmt1. ..
  7. Lynch D, Winata S, Lyons R, Hughes W, Lehrbach G, Wasinger V, et al. A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. J Biol Chem. 2003;278:21805-13 pubmed
    ..Therefore, by binding both CD2AP and the Arp2/3 complex, cortactin links receptor endocytosis to actin polymerization, which may facilitate the trafficking of internalized growth factor receptors. ..
  8. Zavitsanou K, Katsifis A, Yu Y, Huang X. M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders. Brain Res Bull. 2005;65:397-403 pubmed
  9. Kwok J, Perdomo J, Chong B. Identification of a monopartite sequence in PU.1 essential for nuclear import, DNA-binding and transcription of myeloid-specific genes. J Cell Biochem. 2007;101:1456-74 pubmed
    ..By identifying and characterizing the mechanisms of PU.1 nuclear import and the specific amino acids involved, this report may provide insights into the molecular basis of diseases. ..

More Information

Publications114 found, 100 shown here

  1. Giaquinto L, Curmi P, Siddiqui K, Poljak A, DeLong E, Dassarma S, et al. Structure and function of cold shock proteins in archaea. J Bacteriol. 2007;189:5738-48 pubmed
    ..The initial biochemical analysis of M. frigidum Csp has developed a platform for further characterization and demonstrates the potential for expanding molecular studies of proteins from this important archaeal stenopsychrophile. ..
  2. Xu X, Sutak R, Richardson D. Iron chelation by clinically relevant anthracyclines: alteration in expression of iron-regulated genes and atypical changes in intracellular iron distribution and trafficking. Mol Pharmacol. 2008;73:833-44 pubmed
    ..Despite increased TfR1 and Ndrg1 mRNA after DOX treatment, this agent decreased TfR1 and Ndrg1 protein expression. Hence, the effects of DOX on iron metabolism were complex because of its multiple effector mechanisms. ..
  3. Goodchild S, Howell M, Littler D, Mandyam R, Sale K, Mazzanti M, et al. Metamorphic response of the CLIC1 chloride intracellular ion channel protein upon membrane interaction. Biochemistry. 2010;49:5278-89 pubmed publisher
    ..Consistent with previous findings, the N-terminal domain of CLIC1 is likely to insert into the lipid bilayer, while the C-domain remains in solution on the extravesicular side of the membrane. ..
  4. Bourdier T, Pham T, Henderson D, Jackson T, Lam P, Izard M, et al. Automated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the Tracerlab FXFN and Tracerlab MXFDG module for imaging the peripheral benzodiazepine receptor with PET. Appl Radiat Isot. 2012;70:176-83 pubmed publisher
    ..For all tracers, radiochemical purity was >99% and specific activity was >150GBq/?mol after less than 60min of preparation time. ..
  5. Li A, Ponten F, dos Remedios C. The interactome of LIM domain proteins: the contributions of LIM domain proteins to heart failure and heart development. Proteomics. 2012;12:203-25 pubmed publisher
    ..We believe that the complexity of LIM interactions is properly described by the term LIM interactome. ..
  6. Qi Y, Xia P. Cellular inhibitor of apoptosis protein-1 (cIAP1) plays a critical role in ?-cell survival under endoplasmic reticulum stress: promoting ubiquitination and degradation of C/EBP homologous protein (CHOP). J Biol Chem. 2012;287:32236-45 pubmed publisher
    ..These findings define a novel mechanism for ?-cell survival under ER stress and help to identify targets for therapeutic intervention against lipotoxicity in ?-cells. ..
  7. Kristiana I, Luu W, Stevenson J, Cartland S, Jessup W, Belani J, et al. Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses. J Biol Chem. 2012;287:33897-904 pubmed
    ..Together, these findings provide compelling evidence that cholesterol maintains its own homeostasis not only via direct protein interactions, but also by altering membrane properties. ..
  8. van Vliet J, Crofts L, Quinlan K, Czolij R, Perkins A, Crossley M. Human KLF17 is a new member of the Sp/KLF family of transcription factors. Genomics. 2006;87:474-82 pubmed
    ..This is the first report of the DNA-binding characteristics and transactivation activity of human KLF17, which, together with the homology it displays to other KLF proteins, put it in the Sp/KLF family. ..
  9. Wong J, Gao S, Lees J, Best M, Wang R, Tuch B. Definitive endoderm derived from human embryonic stem cells highly express the integrin receptors alphaV and beta5. Cell Adh Migr. 2010;4:39-45 pubmed
    ..This suggested a potential role of vitronectin binding integrins in the development of definitive endoderm. ..
  10. Dalton V, Zavitsanou K. Cannabinoid effects on CB1 receptor density in the adolescent brain: an autoradiographic study using the synthetic cannabinoid HU210. Synapse. 2010;64:845-54 pubmed publisher
    ..This reduced compensatory response may contribute to some acute behavioral effects, the pharmacological cross-tolerance and the long-lasting, adverse psychological consequences of cannabinoid exposure during adolescence. ..
  11. Du X, Kumar J, Ferguson C, Schulz T, Ong Y, Hong W, et al. A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking. J Cell Biol. 2011;192:121-35 pubmed publisher
    ..Our results establish the first link between NPC1 and a cytoplasmic sterol carrier, and suggest that ORP5 may cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. ..
  12. Clancy R, Markham A, Reed J, Blumenberg M, Halushka M, Buyon J. Targeting downstream transcription factors and epigenetic modifications following Toll-like receptor 7/8 ligation to forestall tissue injury in anti-Ro60 associated heart block. J Autoimmun. 2016;67:36-45 pubmed publisher
    ..The beneficial scope of antimalarials in the prevention of organ damage, inclusive of heart block in an anti-Ro offspring or more broadly SLE, may include in part, a mechanism targeting TLR-dependent epigenetic modification. ..
  13. Grewal T, Enrich C. Molecular mechanisms involved in Ras inactivation: the annexin A6-p120GAP complex. Bioessays. 2006;28:1211-20 pubmed
    ..This review discusses how annexin A6 modulates the involvement of negative regulators of the Ras-Raf-MAPK pathway contributing to Ras inactivation. ..
  14. Smith J, Evans K, Wright A, Willows R, Jamie J, Griffith R. Novel indoleamine 2,3-dioxygenase-1 inhibitors from a multistep in silico screen. Bioorg Med Chem. 2012;20:1354-63 pubmed publisher
    ..Eighteen compounds were tested in vitro, yielding four novel inhibitors with low micromolar IC(50) values, comparable with current inhibitors. ..
  15. Hicks C, Jorgensen W, Brown C, Fardell J, Koehbach J, Gruber C, et al. The nonpeptide oxytocin receptor agonist WAY 267,464: receptor-binding profile, prosocial effects and distribution of c-Fos expression in adolescent rats. J Neuroendocrinol. 2012;24:1012-29 pubmed publisher
    ..Antagonism of the V(1a) R by WAY 267,464 could underlie some of the prosocial effects of this drug either through a direct action or through disinhibition of oxytocin circuitry that is subject to vasopressin inhibitory influences. ..
  16. Piper M, Hong S, Ball G, Dawes I. Regulation of the balance of one-carbon metabolism in Saccharomyces cerevisiae. J Biol Chem. 2000;275:30987-95 pubmed
    ..When glycine is in excess, 5, 10-CH(2)-H(4)folate is decreased, and the regulation loop shifts the balance of generation of one-carbon units into the mitochondrion. ..
  17. Hawkins C, Brown B, Davies M. Hypochlorite- and hypobromite-mediated radical formation and its role in cell lysis. Arch Biochem Biophys. 2001;395:137-45 pubmed
    ..Overall these experiments demonstrate that HOCl and HOBr react with different selectivity with cellular targets, and that this can result in radical formation. This radical generation can precede, and may play a role in, cell lysis. ..
  18. Muiznieks L, Jensen S, Weiss A. Structural changes and facilitated association of tropoelastin. Arch Biochem Biophys. 2003;410:317-23 pubmed
  19. Naidoo N, Harrop S, Sobti M, Haynes P, Szymczyna B, Williamson J, et al. Crystal structure of Lsm3 octamer from Saccharomyces cerevisiae: implications for Lsm ring organisation and recruitment. J Mol Biol. 2008;377:1357-71 pubmed publisher
    ..Our coordinates also provide updated homology models for the active Lsm[1-7] and Lsm[2-8] heptameric rings. ..
  20. Mohammed Abdul M, Jiang X, Williams K, Day R, Roufogalis B, Liauw W, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol. 2008;154:1691-700 pubmed publisher
    ..Cranberry alters the pharmacodynamics of warfarin with the potential to increase its effects significantly. Co-administration of warfarin and cranberry requires careful monitoring. ..
  21. Yoo P, Ho Y, Zhou B, Zomaya A. SiteSeek: post-translational modification analysis using adaptive locality-effective kernel methods and new profiles. BMC Bioinformatics. 2008;9:272 pubmed publisher
    ..Our newly proposed methods used in SiteSeek were shown to be useful for the identification of protein phosphorylation sites as it performed much better than widely known predictors on the newly built PS-Benchmark_1 dataset. ..
  22. du Bois T, Deng C, Han M, Newell K, Huang X. Excitatory and inhibitory neurotransmission is chronically altered following perinatal NMDA receptor blockade. Eur Neuropsychopharmacol. 2009;19:256-65 pubmed publisher
    ..Glutamatergic and GABAergic transmission is therefore chronically altered by this treatment, which has relevance to disease processes that may be involved in schizophrenia. ..
  23. Catts V, Farnsworth M, Haber M, Norris M, Lutze Mann L, Lock R. High level resistance to glucocorticoids, associated with a dysfunctional glucocorticoid receptor, in childhood acute lymphoblastic leukemia cells selected for methotrexate resistance. Leukemia. 2001;15:929-35 pubmed
  24. Westman B, Perdomo J, Matthews J, Crossley M, Mackay J. Structural studies on a protein-binding zinc-finger domain of Eos reveal both similarities and differences to classical zinc fingers. Biochemistry. 2004;43:13318-27 pubmed
    ..These studies provide the first structural insights into how EosC mediates protein-protein interactions and contributes to our understanding of why it does not exhibit high-affinity DNA binding. ..
  25. Nosworthy N, Ho J, Kondyurin A, McKenzie D, Bilek M. The attachment of catalase and poly-l-lysine to plasma immersion ion implantation-treated polyethylene. Acta Biomater. 2007;3:695-704 pubmed
    ..The results show that PIII treatment of polymers increases their usefulness for protein microarrays. ..
  26. Brummer T, Larance M, Herrera Abreu M, Lyons R, Timpson P, Emmerich C, et al. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. EMBO J. 2008;27:2305-16 pubmed
    ..This represents a novel regulatory mechanism with implications for diverse tyrosine kinase signalling systems. ..
  27. Qi W, Holian J, Tan C, Kelly D, Chen X, Pollock C. The roles of Kruppel-like factor 6 and peroxisome proliferator-activated receptor-? in the regulation of macrophage inflammatory protein-3? at early onset of diabetes. Int J Biochem Cell Biol. 2011;43:383-92 pubmed publisher
    ..Targeting pro-inflammatory chemokine MIP-3? and its signaling pathways will provide novel strategy to treat diabetic kidney disease. ..
  28. Ma Q, Sowa Y, Baker M, Bai F. Bacterial Flagellar Motor Switch in Response to CheY-P Regulation and Motor Structural Alterations. Biophys J. 2016;110:1411-20 pubmed publisher
  29. Holmes M, Turner J, Fox A, Chisholm O, Crossley M, Chong B. hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation. J Biol Chem. 1999;274:23491-8 pubmed
    ..Finally, we have identified a repression domain in hFOG-2 and show that repression is dependent upon the integrity of the mCtBP2 interaction motif Pro-Ile-Asp-Leu-Ser. ..
  30. Yeh M, Craig S, Lum M, Foong F. Effects of the PT region of EngD and HLD of CbpA on solubility, catalytic activity and purification characteristics of EngD-CBD(CbpA) fusions from Clostridium cellulovorans. J Biotechnol. 2005;116:233-44 pubmed
    ..The reasons for these are discussed. These fusion proteins may be important in applications, such as immobilization to solid cellulose substrate for purification of proteins and enrichment/aggregation of protein complexes...
  31. Walton J. Evidence for participation of aluminum in neurofibrillary tangle formation and growth in Alzheimer's disease. J Alzheimers Dis. 2010;22:65-72 pubmed publisher
    ..The photographic evidence presented combines with existing evidence to support a role for aluminum in the formation and growth of NFTs in neurons of humans with Alzheimer's disease. ..
  32. Passam F, Rahgozar S, Qi M, Raftery M, Wong J, Tanaka K, et al. Redox control of ?2-glycoprotein I-von Willebrand factor interaction by thioredoxin-1. J Thromb Haemost. 2010;8:1754-62 pubmed publisher
    ..Given the importance of thiol oxidoreductases in thrombus formation, we provide preliminary evidence that the thiol-dependent interaction of ?(2) GPI with VWF may contribute to the redox regulation of platelet adhesion. ..
  33. Khalid M, Fouassier G, Apell H, Cornelius F, Clarke R. Interaction of ATP with the phosphoenzyme of the Na+,K+-ATPase. Biochemistry. 2010;49:1248-58 pubmed publisher
    ..ATP binding to E2P could also fix ATP within the enzyme ready to phosphorylate it in the subsequent turnover...
  34. Sumer Bayraktar Z, Kolarich D, Campbell M, Ali S, Packer N, Thaysen Andersen M. N-glycans modulate the function of human corticosteroid-binding globulin. Mol Cell Proteomics. 2011;10:M111.009100 pubmed publisher
    ..This confirms that N-glycans are involved in the CBG:receptor interaction and indicates that the modulation is performed by steric and/or electrostatic means through the terminal NeuAc residues. ..
  35. Yamamoto I, Carland J, Locock K, Gavande N, Absalom N, Hanrahan J, et al. Structurally diverse GABA antagonists interact differently with open and closed conformational states of the ?1 receptor. ACS Chem Neurosci. 2012;3:293-301 pubmed publisher
    ..This study contributes to our understanding of the mechanism of inverse agonism. This is important, as such agents are emerging as potential therapeutics. ..
  36. Yu M, Yu Q, Rutledge P, Todd M. A fluorescent "allosteric scorpionand" complex visualizes a biological recognition event. Chembiochem. 2013;14:224-9 pubmed publisher
    ..The observed change might arise from a specific quenching effect in the biotin binding pocket or from a binding-induced change in the coordination geometry of the complex. ..
  37. Toonkool P, Jensen S, Maxwell A, Weiss A. Hydrophobic domains of human tropoelastin interact in a context-dependent manner. J Biol Chem. 2001;276:44575-80 pubmed
    ..Thus, the capability for coacervation is determined by contributions from individual hydrophobic domains for which function should be considered in the context of their positions in the intact tropoelastin molecule. ..
  38. Thach O, Mielczarek M, Ma C, Kutty S, Yang X, Black D, et al. From indole to pyrrole, furan, thiophene and pyridine: Search for novel small molecule inhibitors of bacterial transcription initiation complex formation. Bioorg Med Chem. 2016;24:1171-82 pubmed publisher
    ..The structural features of the synthesized transcription initiation inhibitors needed for antibacterial activity were identified employing molecular modelling and structure-activity relationship (SAR) studies. ..
  39. Musgrove E, Hunter L, Lee C, Swarbrick A, Hui R, Sutherland R. Cyclin D1 overexpression induces progestin resistance in T-47D breast cancer cells despite p27(Kip1) association with cyclin E-Cdk2. J Biol Chem. 2001;276:47675-83 pubmed
    ..These data indicate that regulation of cyclin D1 is a critical element of progestin inhibition in breast cancer cells and suggest that breast cancers overexpressing cyclin D1 may respond poorly to progestin therapy. ..
  40. Gamsjaeger R, Swanton M, Kobus F, Lehtomaki E, Lowry J, Kwan A, et al. Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1. J Biol Chem. 2008;283:5158-67 pubmed
    ..Our data indicate that MyT1 ZnFs recognize the major groove of DNA in a way that appears to differ from other known zinc binding domains. ..
  41. Peters K, Brooks B, Schumacher M, Skurray R, Brennan R, Brown M. A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity. PLoS ONE. 2011;6:e15974 pubmed publisher
  42. Gao J, Nguyen K, Hunter N. Characterization of a hemophore-like protein from Porphyromonas gingivalis. J Biol Chem. 2010;285:40028-38 pubmed publisher
    ..It is predicted that HusA efficiently sequesters heme from gingipains and fulfills the function of a high affinity hemophore-like protein to meet the heme requirement for growth of P. gingivalis during establishment of infection. ..
  43. Connerty P, Ahadi A, Hutvagner G. RNA Binding Proteins in the miRNA Pathway. Int J Mol Sci. 2015;17: pubmed publisher
    ..Moreover, we hypothesise that the interaction between miRNA regulation and RBPs is potentially more widespread based on the analysis of available high-throughput datasets. ..
  44. Midgley V, Khachigian L. Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1. J Biol Chem. 2004;279:40289-95 pubmed
    ..These findings thus demonstrate that PDGF-C transcription, activated by FGF-2, is mediated by Egr-1 and its upstream kinase ERK. ..
  45. Sobti M, Cubeddu L, Haynes P, Mabbutt B. Engineered rings of mixed yeast Lsm proteins show differential interactions with translation factors and U-rich RNA. Biochemistry. 2010;49:2335-45 pubmed publisher
    ..Our findings suggest Lsm1 and/or Lsm4 can interact with translationally active mRNA. ..
  46. Ozsarac N, Bhattacharyya M, Dawes I, Clancy M. The SPR3 gene encodes a sporulation-specific homologue of the yeast CDC3/10/11/12 family of bud neck microfilaments and is regulated by ABFI. Gene. 1995;164:157-62 pubmed
  47. Wang Y, Slade M, Gooley A, Atwell B, Williams K. Cellulose-binding modules from extracellular matrix proteins of Dictyostelium discoideum stalk and sheath. Eur J Biochem. 2001;268:4334-45 pubmed
    ..The biological functions and potential role of St15 and ShD in building extracellular matrices during D. discoideum development are discussed. ..
  48. Gaus K, Kritharides L, Schmitz G, Boettcher A, Drobnik W, Langmann T, et al. Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages. FASEB J. 2004;18:574-6 pubmed
    ..We propose that cholesterol exported to apoA-1 from this major slow efflux pool derives from nonraft regions of the plasma membrane but that the interaction of apoA-1 with lipid rafts is necessary to stimulate this efflux...
  49. Schmidt B, Ho L, Hogg P. Allosteric disulfide bonds. Biochemistry. 2006;45:7429-33 pubmed
    ..We suggest that the -RHStaple configuration is a hallmark of allosteric disulfides. About 1 in 15 of all structurally determined disulfides is a potential allosteric bond. ..
  50. Quinlan K, Nardini M, Verger A, Francescato P, Yaswen P, Corda D, et al. Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins. Mol Cell Biol. 2006;26:8159-72 pubmed
    ..These results identify a new CtBP interaction motif and establish ZNF217 as a transcriptional repressor protein that functions, at least in part, by associating with CtBP. ..
  51. Philips A, Kwok J, Chong B. Analysis of the signals and mechanisms mediating nuclear trafficking of GATA-4. Loss of DNA binding is associated with localization in intranuclear speckles. J Biol Chem. 2007;282:24915-27 pubmed
    ..The current study provides detailed information on the nuclear shuttling pathways of GATA-4 that represents an additional mechanism of gene regulation. ..
  52. Korlimbinis A, Aquilina J, Truscott R. Protein-bound and free UV filters in cataract lenses. The concentration of UV filters is much lower than in normal lenses. Exp Eye Res. 2007;85:219-25 pubmed
  53. Tee A, Marshall G, Liu P, Xu N, Haber M, Norris M, et al. Opposing effects of two tissue transglutaminase protein isoforms in neuroblastoma cell differentiation. J Biol Chem. 2010;285:3561-7 pubmed publisher
  54. Font J, Mackay J. Beyond DNA: zinc finger domains as RNA-binding modules. Methods Mol Biol. 2010;649:479-91 pubmed publisher
  55. Perdomo J, Fock E, Kaur G, Yan F, Khachigian L, Jans D, et al. A monopartite sequence is essential for p45 NF-E2 nuclear translocation, transcriptional activity and platelet production. J Thromb Haemost. 2010;8:2542-53 pubmed publisher
    ..The NLS is critical for p45 NF-E2 function, with the present study being the first to demonstrate the importance of NLS-dependent nuclear import of p45 NF-E2 for platelet development. ..
  56. Perdomo J, Jiang X, Carter D, Khachigian L, Chong B. SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4. PLoS ONE. 2012;7:e50637 pubmed publisher
    ..These data suggest a new dynamics in which GATA-4 may alter the activity of FOG-2 by influencing its SUMOylation status. ..
  57. Das T, Kutty S, Kumar N, Manefield M. Pyocyanin facilitates extracellular DNA binding to Pseudomonas aeruginosa influencing cell surface properties and aggregation. PLoS ONE. 2013;8:e58299 pubmed publisher
    ..Based on these findings we propose that pyocyanin intercalation with eDNA promotes cell-to-cell interactions in P. aeruginosa cells by influencing their cell surface properties and physico-chemical interactions...
  58. Otara C, Jones C, Younan N, Viles J, Elphick M. Structural analysis of the starfish SALMFamide neuropeptides S1 and S2: the N-terminal region of S2 facilitates self-association. Biochim Biophys Acta. 2014;1844:358-65 pubmed publisher
    ..Collectively, the data obtained indicate that the N-terminal region of S2 facilitates peptide self-association at high concentrations, which may have relevance to the biosynthesis and/or bioactivity of S2 in vivo. ..
  59. Sweeney K, Sarcevic B, Sutherland R, Musgrove E. Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells. Oncogene. 1997;14:1329-40 pubmed
    ..This is the first evidence of cyclin D2 activating Cdk2 in mammalian cells thus providing further evidence that D-type cyclins are not necessarily redundant. ..
  60. Wu W, Vrhovski B, Weiss A. Glycosaminoglycans mediate the coacervation of human tropoelastin through dominant charge interactions involving lysine side chains. J Biol Chem. 1999;274:21719-24 pubmed
    ..Following lysyl oxidase modification of tropoelastin lysine residues, they are released from glycosaminoglycan interactions, thereby permitting those residues to contribute to elastin cross-links. ..
  61. Eisbacher M, Holmes M, Newton A, Hogg P, Khachigian L, Crossley M, et al. Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding. Mol Cell Biol. 2003;23:3427-41 pubmed
    ..This work suggests that Fli-1 and GATA-1 work together to activate the expression of genes associated with the terminal differentiation of megakaryocytes. ..
  62. Zhang C, Kavurma M, Lai A, Khachigian L. Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21WAF1/Cip1: ETS-1 regulates basal and and inducible p21WAF1/Cip: ETS-1 regulates basal and inducible p21WAF1/Cip1 transcription via distinct cis-acting elements in . J Biol Chem. 2003;278:27903-9 pubmed
    ..The phenotypic importance of Ets-1 regulation of p21WAF1/Cip1 was demonstrated by the capacity of antisense p21WAF1/Cip1 strategies to block Ets-1-inhibition of apoptosis and inhibit Ets-1-induction of proliferation. ..
  63. Widberg C, Bryant N, Girotti M, Rea S, James D. Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. J Biol Chem. 2003;278:35093-101 pubmed
    ..These data suggest that Tomosyn and Munc18c operate at a similar stage of the Syntaxin4 SNARE assembly cycle, which likely primes Syntaxin4 for entry into the ternary SNARE complex. ..
  64. Beilharz T, Preiss T. Widespread use of poly(A) tail length control to accentuate expression of the yeast transcriptome. RNA. 2007;13:982-97 pubmed
    ..They further provide a molecular explanation for deadenylase function in the cell cycle and suggest additional cellular processes that depend on control of mRNA polyadenylation. ..
  65. Chuang C, Lord M, Melrose J, Rees M, Knox S, Freeman C, et al. Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan. Biochemistry. 2010;49:5524-32 pubmed publisher
    ..The presence and activity of mammalian heparanase may be important in the turnover of HS and subsequent signaling required for the establishment and maintenance of functional osteo-chondral junctions in long bone growth. ..
  66. Chapman G, Sparrow D, Kremmer E, Dunwoodie S. Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis. Hum Mol Genet. 2011;20:905-16 pubmed publisher
  67. Rowland A, Larance M, Hughes W, James D. Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin. Mol Cell Biol. 2011;31:4789-800 pubmed publisher
  68. Lei N, Franken L, Ruzehaji N, Offenhäuser C, Cowin A, Murray R. Flightless, secreted through a late endosome/lysosome pathway, binds LPS and dampens cytokine secretion. J Cell Sci. 2012;125:4288-96 pubmed publisher
    ..These results show secreted Flii binds to LPS and in doing so alters macrophage activation and cytokine secretion, suggesting that like the intracellular pool of Flii, secreted Flii also has the ability to alter inflammation. ..
  69. Kim Y, Wong A, Power J, Tadros S, Klugmann M, Moorhouse A, et al. Alternative splicing of the TRPC3 ion channel calmodulin/IP3 receptor-binding domain in the hindbrain enhances cation flux. J Neurosci. 2012;32:11414-23 pubmed publisher
    ..This novel TRPC3c ion channel therefore has enhanced efficacy as a neuronal GPCR-Ca(2+) signaling effector, and is associated with sensorimotor coordination, neuronal development, and brain injury. ..
  70. Oates E, Rossor A, Hafezparast M, Gonzalez M, Speziani F, MacArthur D, et al. Mutations in BICD2 cause dominant congenital spinal muscular atrophy and hereditary spastic paraplegia. Am J Hum Genet. 2013;92:965-73 pubmed publisher
  71. Chaston J, Stewart A, Christie M. Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha. PLoS ONE. 2017;12:e0183587 pubmed publisher
    ..Our results highlight the ability of monopartite cNLS sequences to maximise contacts at the importin-? major binding site, as well as regions outside the main binding cavities. ..
  72. Sharer J, Koosha H, Church W, March P. The function of conserved amino acid residues adjacent to the effector domain in elongation factor G. Proteins. 1999;37:293-302 pubmed
    ..This model indicates that the effector domain contains a negative potential field that may be important for ribosome binding. ..
  73. Rafty L, Khachigian L. Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical protein kinase C-zeta. Nucleic Acids Res. 2001;29:1027-33 pubmed
    ..Nogalamycin stimulated the phosphorylation of PKC-zeta (on residue Thr(410)). These findings demonstrate for the first time that PKC-zeta and Sp1 phosphorylation mediate the inducible expression of this growth factor. ..
  74. Rodgers U, Weiss A. Integrin alpha v beta 3 binds a unique non-RGD site near the C-terminus of human tropoelastin. Biochimie. 2004;86:173-8 pubmed
    ..This is the first identification of a specific, single binding site on tropoelastin and the first observation of direct binding of an integrin to a tropoelastin domain. ..
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    ..These findings demonstrate negative regulation of PDGF-A expression by GCF2. This is the first report of the induction of an endogenous transcriptional repressor in the rat vessel wall. ..
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    ..These data reveal that SM proteins cycle on and off membranes in a stage-specific manner during the vesicle transport reaction, and suggest that protein phosphorylation plays a key role in the regulation of this cycle. ..
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    ..These findings, using complementary approaches, demonstrate the inverse relationship between Sp1 and p21WAF1/Cip1 in SMCs and the capacity of Sp1 to regulate SMC proliferation and apoptosis via its repression of p21WAF1/Cip1. ..
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    ..C110S revealed that the NMR spectral perturbations correlate more closely to protein structural changes upon complex formation rather than to interactions at the protein-DNA interface. ..
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    ..These results demonstrate that the PXDLS binding cleft is functionally important but suggest that it is primarily required for localization of the CtBP complex to promoter-bound transcription factors. ..
  87. Santiago F, Ishii H, Shafi S, Khurana R, Kanellakis P, Bhindi R, et al. Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-cyclin D1 assembly. Circ Res. 2007;101:146-55 pubmed
    ..These findings define a new role for YY1 as both an inducer of p53 instability in smooth muscle cells, and an indirect repressor of p21(WAF1/Cip1) transcription, p21(WAF1/Cip1)-cdk4-cyclin D1 assembly and intimal thickening. ..
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    ..Conversely, moving the arginine residue from HP1 to TM8 in Glt(Ph) results in a transporter that has reduced affinity for aspartate. ..
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  92. Pangon L, Van Kralingen C, Abas M, Daly R, Musgrove E, Kohonen Corish M. The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells. Biochim Biophys Acta. 2012;1823:1058-67 pubmed publisher
    ..Importantly, we propose that the function of this complex is under the regulation of a newly described phosphorylation of the PDZ-binding motif at position -1. ..