Experts and Doctors on tumor suppressor protein p53 in Victoria, Australia

Summary

Locale: Victoria, Australia
Topic: tumor suppressor protein p53

Top Publications

  1. Hughes N, Pairojkul C, Royce S, Clouston A, Bhathal P. Liver fluke-associated and sporadic cholangiocarcinoma: an immunohistochemical study of bile duct, peribiliary gland and tumour cell phenotypes. J Clin Pathol. 2006;59:1073-8 pubmed
    ..Many more fluke-associated cholangiocarcinomas than sporadic cholangiocarcinoma display an intestinal goblet cell phenotype and overexpress p53, indicating differences in the aetiopathology of the cancers in the two groups of patients. ..
  2. Quin J, Devlin J, Cameron D, Hannan K, Pearson R, Hannan R. Targeting the nucleolus for cancer intervention. Biochim Biophys Acta. 2014;1842:802-16 pubmed publisher
    ..This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease. ..
  3. Azad A, Bukczynska P, Jackson S, Haupt Y, Haput Y, Cullinane C, et al. Co-targeting deoxyribonucleic acid-dependent protein kinase and poly(adenosine diphosphate-ribose) polymerase-1 promotes accelerated senescence of irradiated cancer cells. Int J Radiat Oncol Biol Phys. 2014;88:385-94 pubmed publisher
    ..These data provide a rationale for further preclinical and clinical testing of this therapeutic combination. ..
  4. Hung J, Anderson R. p53: functions, mutations and sarcomas. Acta Orthop Scand Suppl. 1997;273:68-73 pubmed
    ..This article reviews briefly the structure, function, and dysfunction of the p53 tumor-suppressor gene with particular focus on its role in the development of bone and soft tissue sarcoma. ..
  5. Li H, Cao Y, Berndt M, Funder J, Liu J. Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro. Oncogene. 1999;18:6785-94 pubmed
  6. Johnstone R, Wei W, Greenway A, Trapani J. Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16. Oncogene. 2000;19:6033-42 pubmed
    ..These findings demonstrate a possible link between gene induction following interferon stimulation and p53-mediated cellular events. ..
  7. Frew I, Dickins R, Cuddihy A, Del Rosario M, Reinhard C, O Connell M, et al. Normal p53 function in primary cells deficient for Siah genes. Mol Cell Biol. 2002;22:8155-64 pubmed
    ..Our loss-of-function experiments do not support a general role for Siah genes in p53-mediated responses or mitosis. ..
  8. Patrikis M, Bryan E, Thomas N, Rice G, Quinn M, Baker M, et al. Mutation analysis of CDP, TP53, and KRAS in uterine leiomyomas. Mol Carcinog. 2003;37:61-4 pubmed
    ..It is possible that CDP belongs to a class of tumor suppressor in which loss of only one copy of the gene, either by genetic or epigenetic mechanisms, is sufficient to allow tumor growth. ..
  9. Lindemann R, Newbold A, Whitecross K, Cluse L, Frew A, Ellis L, et al. Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma. Proc Natl Acad Sci U S A. 2007;104:8071-6 pubmed
    ..Our studies provide important information regarding the mechanisms of action of HDACi that have broad implications regarding stratification of patients receiving HDACi therapy alone or in combination with other anticancer agents. ..

More Information

Publications16

  1. Roth D, Moseley G, Glover D, Pouton C, Jans D. A microtubule-facilitated nuclear import pathway for cancer regulatory proteins. Traffic. 2007;8:673-86 pubmed
    ..The results indicate that, additional to IMP/diffusion-dependent processes, certain cancer regulatory proteins utilize an MT-enhanced pathway for accelerated nuclear import that is presumably required for their nuclear functions. ..
  2. Bolitho P, Street S, Westwood J, Edelmann W, MacGregor D, Waring P, et al. Perforin-mediated suppression of B-cell lymphoma. Proc Natl Acad Sci U S A. 2009;106:2723-8 pubmed publisher
    ..These transgenic models have allowed us to distinguish the role of pfp in surveillance of B-cell lymphomagenesis, as opposed to its loss simply driving the onset of a spontaneous lymphoma characteristic of pfp deficiency. ..
  3. Haupt S, Di Agostino S, Mizrahi I, Alsheich Bartok O, Voorhoeve M, Damalas A, et al. Promyelocytic leukemia protein is required for gain of function by mutant p53. Cancer Res. 2009;69:4818-26 pubmed publisher
    ..Our results suggest that the tumor suppression function of PML depends on the status of p53. In the context of mutant p53, PML enhances its cancer-promoting activities. ..
  4. Wiegmans A, Alsop A, Bots M, Cluse L, Williams S, Banks K, et al. Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737. Cancer Res. 2011;71:3603-15 pubmed publisher
  5. Azad A, Jackson S, Cullinane C, Natoli A, Neilsen P, Callen D, et al. Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells. Mol Cancer Res. 2011;9:1696-707 pubmed publisher
    ..These results validate DNA-PK as an important therapeutic target in irradiated cancer cells and establish accelerated senescence as a novel mechanism of radiosensitization induced by DNA-PK blockade. ..
  6. Bywater M, Poortinga G, Sanij E, Hein N, Peck A, Cullinane C, et al. Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. Cancer Cell. 2012;22:51-65 pubmed publisher
    ..These results identify selective inhibition of rDNA transcription as a therapeutic strategy for the cancer specific activation of p53 and treatment of hematologic malignancies. ..
  7. King A, Li L, Wong D, Liu R, Bamford R, Strasser A, et al. Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms. PLoS Genet. 2017;13:e1007010 pubmed publisher
    ..These results identify ASCIZ and DYNLL1 as the core of a transcriptional circuit that differentially regulates the development of the B-1a and B-2 B lymphoid cell lineages and plays a critical role in lymphomagenesis. ..