Experts and Doctors on osteoarthritis in New South Wales, Australia
Locale: New South Wales, Australia
Little C, Ghosh P, Bellenger C. Topographic variation in biglycan and decorin synthesis by articular cartilage in the early stages of osteoarthritis: an experimental study in sheep. J Orthop Res. 1996;14:433-44 pubmed
..These data suggest that an altered chondrocyte phenotypic expression of proteoglycans in response to abnormal mechanical loading is an early event in osteoarthritis. ..
Young A, Smith M, Smith S, Cake M, Ghosh P, Read R, et al
. Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis. Arthritis Res Ther. 2005;7:R852-61 pubmed
..This study highlights the focal nature of the degenerative changes that occur in OA cartilage and suggests that altered synthesis and proteolysis of SLRPs may play an important role in cartilage destruction in arthritis. ..
Jackson M, Smith M, Smith S, Jackson C, Xue M, Little C. Activation of cartilage matrix metalloproteinases by activated protein C. Arthritis Rheum. 2009;60:780-91 pubmed publisher
..APC could not directly activate proMMP-13, but it was associated with increased MMP-2 and MMP-9 activity.
APC may be a relevant activator of MMPs in cartilage and may play a role in progressive cartilage degradation in arthritis...
Little C, Barai A, Burkhardt D, Smith S, Fosang A, Werb Z, et al
. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum. 2009;60:3723-33 pubmed publisher
..To investigate the role of matrix metalloproteinase 13 (MMP-13; collagenase 3) in osteoarthritis (OA)...
Zreiqat H, Belluoccio D, Smith M, Wilson R, Rowley L, Jones K, et al
. S100A8 and S100A9 in experimental osteoarthritis. Arthritis Res Ther. 2010;12:R16 pubmed publisher
Xue M, Chan Y, Shen K, Dervish S, March L, Sambrook P, et al
. Protease-activated receptor 2, rather than protease-activated receptor 1, contributes to the aggressive properties of synovial fibroblasts in rheumatoid arthritis. Arthritis Rheum. 2012;64:88-98 pubmed publisher
..To investigate whether protease-activated receptor 1 (PAR-1) and/or PAR-2 promotes the invasiveness/proliferation of synovial fibroblasts (SFs) and to determine the signaling mechanisms of these pathways...