Experts and Doctors on mitochondrial proteins in Western Australia, Australia


Locale: Western Australia, Australia
Topic: mitochondrial proteins

Top Publications

  1. Huang S, Taylor N, Whelan J, Millar A. Refining the definition of plant mitochondrial presequences through analysis of sorting signals, N-terminal modifications, and cleavage motifs. Plant Physiol. 2009;150:1272-85 pubmed publisher
    ..Our data also suggest a novel cleavage motif of (F/Y) downward arrow(S/A) in plant class III sequences. ..
  2. Goggin D, Lipscombe R, Fedorova E, Millar A, Mann A, Atkins C, et al. Dual intracellular localization and targeting of aminoimidazole ribonucleotide synthetase in cowpea. Plant Physiol. 2003;131:1033-41 pubmed
  3. Hickey J, Ruhayel R, Barnard P, Baker M, Berners Price S, Filipovska A. Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols. J Am Chem Soc. 2008;130:12570-1 pubmed publisher
  4. Ito J, Taylor N, Castleden I, Weckwerth W, Millar A, Heazlewood J. A survey of the Arabidopsis thaliana mitochondrial phosphoproteome. Proteomics. 2009;9:4229-40 pubmed publisher
    ..Information gained from this study provides a better understanding of protein phosphorylation at both the subcellular and the cellular level in Arabidopsis. ..
  5. Steer J, Mann T, Lo S, Inglis J, Yap H, Henry P, et al. Early induction of uncoupling protein-2 in pulmonary macrophages in hyperoxia-associated lung injury. Inhal Toxicol. 2013;25:544-52 pubmed publisher
    ..That, in turn, may limit inappropriate pro-inflammatory activation in HALI. ..
  6. Considine M, Daley D, Whelan J. The expression of alternative oxidase and uncoupling protein during fruit ripening in mango. Plant Physiol. 2001;126:1619-29 pubmed
    ..Because both message and protein for the Aox and Ucp increased in a similar pattern, it suggests that their expression is not controlled in a reciprocal manner but may be active simultaneously. ..
  7. Ng S, Giraud E, Duncan O, Law S, Wang Y, Xu L, et al. Cyclin-dependent kinase E1 (CDKE1) provides a cellular switch in plants between growth and stress responses. J Biol Chem. 2013;288:3449-59 pubmed publisher
    ..Together, these results place CDKE1 as a central kinase integrating diverse cellular signals and shed light on a mechanism by which plants can effectively switch between growth and stress responses. ..
  8. Giraud E, Ho L, Clifton R, Carroll A, Estavillo G, Tan Y, et al. The absence of ALTERNATIVE OXIDASE1a in Arabidopsis results in acute sensitivity to combined light and drought stress. Plant Physiol. 2008;147:595-610 pubmed publisher
  9. Richman T, Davies S, Shearwood A, Ermer J, Scott L, Hibbs M, et al. A bifunctional protein regulates mitochondrial protein synthesis. Nucleic Acids Res. 2014;42:5483-94 pubmed publisher
    ..Because of its role in leucine metabolism, we investigated the importance of the catalytic activity of AUH and found that it affects the regulation of mitochondrial translation and biogenesis in response to leucine. ..

More Information


  1. Van Aken O, Zhang B, Law S, Narsai R, Whelan J. AtWRKY40 and AtWRKY63 modulate the expression of stress-responsive nuclear genes encoding mitochondrial and chloroplast proteins. Plant Physiol. 2013;162:254-71 pubmed publisher
    ..In conclusion, this study establishes the role of WRKY transcription factors in the coordination of stress-responsive genes encoding mitochondrial and chloroplast proteins. ..
  2. Duncan O, Taylor N, Carrie C, Eubel H, Kubiszewski Jakubiak S, Zhang B, et al. Multiple lines of evidence localize signaling, morphology, and lipid biosynthesis machinery to the mitochondrial outer membrane of Arabidopsis. Plant Physiol. 2011;157:1093-113 pubmed publisher
  3. Tomaz T, Bagard M, Pracharoenwattana I, Lindén P, Lee C, Carroll A, et al. Mitochondrial malate dehydrogenase lowers leaf respiration and alters photorespiration and plant growth in Arabidopsis. Plant Physiol. 2010;154:1143-57 pubmed publisher
  4. Carrie C, Giraud E, Duncan O, Xu L, Wang Y, Huang S, et al. Conserved and novel functions for Arabidopsis thaliana MIA40 in assembly of proteins in mitochondria and peroxisomes. J Biol Chem. 2010;285:36138-48 pubmed publisher
    ..Thus, the mechanistic operation of the mitochondrial disulfide relay system is different in A. thaliana compared with other systems, and Mia40 has taken on new roles in peroxisomes and mitochondria. ..
  5. Chai T, Simmonds D, Day D, Colmer T, Finnegan P. Photosynthetic performance and fertility are repressed in GmAOX2b antisense soybean. Plant Physiol. 2010;152:1638-49 pubmed publisher
    ..Taken together, the results presented here indicate that AOX expression has an important role in determining normal gametophyte development and function...
  6. Giraud E, Van Aken O, Ho L, Whelan J. The transcription factor ABI4 is a regulator of mitochondrial retrograde expression of ALTERNATIVE OXIDASE1a. Plant Physiol. 2009;150:1286-96 pubmed publisher
    ..Furthermore, they provide a molecular link between mitochondrial and chloroplast retrograde signaling, as ABI4 has been previously shown to act downstream of at least two chloroplast retrograde signaling pathways. ..
  7. Huang S, Taylor N, Narsai R, Eubel H, Whelan J, Millar A. Experimental analysis of the rice mitochondrial proteome, its biogenesis, and heterogeneity. Plant Physiol. 2009;149:719-34 pubmed publisher
  8. Ho L, Giraud E, Uggalla V, Lister R, Clifton R, Glen A, et al. Identification of regulatory pathways controlling gene expression of stress-responsive mitochondrial proteins in Arabidopsis. Plant Physiol. 2008;147:1858-73 pubmed publisher
    ..Furthermore, posttranscriptional regulation accounts for changes in transcript abundance by SA treatment for some genes. ..
  9. Lister R, Carrie C, Duncan O, Ho L, Howell K, Murcha M, et al. Functional definition of outer membrane proteins involved in preprotein import into mitochondria. Plant Cell. 2007;19:3739-59 pubmed publisher
    ..Thus, it is proposed that all three components directly interact with precursor proteins to participate in early stages of mitochondrial protein import...
  10. Court N, Ingley E, Klinken S, Bogoyevitch M. Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3. Biochim Biophys Acta. 2005;1744:68-75 pubmed
    ..This is a new mechanism for the regulation of SAPK3 and suggests that its intracellular activity should not be solely assessed by its phosphorylation status. ..
  11. Lister R, Chew O, Lee M, Heazlewood J, Clifton R, Parker K, et al. A transcriptomic and proteomic characterization of the Arabidopsis mitochondrial protein import apparatus and its response to mitochondrial dysfunction. Plant Physiol. 2004;134:777-89 pubmed
    ..These findings suggest that transcription of import component genes is induced when mitochondrial function is limited and that minor gene isoforms display a greater response than the predominant isoforms. ..
  12. Considine M, Holtzapffel R, Day D, Whelan J, Millar A. Molecular distinction between alternative oxidase from monocots and dicots. Plant Physiol. 2002;129:949-53 pubmed