Genomes and Genes
Experts and Doctors on mice in Victoria, Australia
Locale: Victoria, Australia
Publications437 found, 100 shown here
- Sims N, Brennan K, Spaliviero J, Handelsman D, Seibel M. Perinatal testosterone surge is required for normal adult bone size but not for normal bone remodeling. Am J Physiol Endocrinol Metab. 2006;290:E456-62 pubmed..These data suggest a role for the perinatal T surge in determining adult bone length and confirms that adult circulating T determines adult bone density. ..
- Manes G, Masendycz P, Nguyen T, Achuthan A, Dinh H, Hamilton J, et al. A potential role for the Src-like adapter protein SLAP-2 in signaling by the colony stimulating factor-1 receptor. FEBS J. 2006;273:1791-804 pubmed..Taken together, our results suggest that SLAP-2 could potentially be involved in signaling by the CSF-1 receptor. ..
- Schertzer J, van der Poel C, Shavlakadze T, Grounds M, Lynch G. Muscle-specific overexpression of IGF-I improves E-C coupling in skeletal muscle fibers from dystrophic mdx mice. Am J Physiol Cell Physiol. 2008;294:C161-8 pubmed..The results demonstrate that IGF-I can ameliorate fundamental aspects of E-C coupling failure in dystrophic muscle fibers and that these effects are important for the improvements in cellular function induced by this growth factor. ..
- Smyth M, Teng M, Sharkey J, Westwood J, Haynes N, Yagita H, et al. Interleukin 21 enhances antibody-mediated tumor rejection. Cancer Res. 2008;68:3019-25 pubmed publisher..These data further support the use of IL-21 in adjuvant settings where strong T cell-mediated immune responses to tumors can be generated. ..
- Pang T, Du X, Zajac M, Howard M, Hannan A. Altered serotonin receptor expression is associated with depression-related behavior in the R6/1 transgenic mouse model of Huntington's disease. Hum Mol Genet. 2009;18:753-66 pubmed publisher..Our findings implicate altered serotonergic signaling as the basis for the development of depression during the preclinical stages of HD. ..
- Allison J, Zhang Y, Parker M. Tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein in transgenic mice. Mol Cell Biol. 1989;9:2254-7 pubmed
- Wu L, D Amico A, Winkel K, Suter M, Lo D, Shortman K. RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells. Immunity. 1998;9:839-47 pubmed..However, the deficiency in splenic CD8alpha- DEC-205- DC is a direct, stem cell intrinsic effect of the RelB mutation. Thus, RelB selectively regulates a myeloid-related DC lineage. ..
- Zwar T, Read S, van Driel I, Gleeson P. CD4+CD25+ regulatory T cells inhibit the antigen-dependent expansion of self-reactive T cells in vivo. J Immunol. 2006;176:1609-17 pubmed
- Fisher J, Thomas Mudge R, Elliott J, Hards D, Sims N, Slavin J, et al. Osteoprotegerin overexpression by breast cancer cells enhances orthotopic and osseous tumor growth and contrasts with that delivered therapeutically. Cancer Res. 2006;66:3620-8 pubmed
- Lefevre C, Mann J. RNA expression microarray analysis in mouse prospermatogonia: identification of candidate epigenetic modifiers. Dev Dyn. 2008;237:1082-9 pubmed publisher..These data provide a useful resource in the discovery of molecular pathways involved in epigenetic reprogramming in the mammalian germ line...
- Samuel C, Royce S, Chen B, Cao H, Gossen J, Tregear G, et al. Relaxin family peptide receptor-1 protects against airway fibrosis during homeostasis but not against fibrosis associated with chronic allergic airways disease. Endocrinology. 2009;150:1495-502 pubmed publisher..These combined findings demonstrate that RXFP1 is involved in mediating relaxin's effects on airway fibrosis during homeostasis but not during inflammation-induced fibrosis associated with chronic AAD. ..
- Desmond M, Lee D, Fraser S, Katerelos M, Gleich K, Martinello P, et al. Tubular proteinuria in mice and humans lacking the intrinsic lysosomal protein SCARB2/Limp-2. Am J Physiol Renal Physiol. 2011;300:F1437-47 pubmed publisher..Failure of proteolysis is a novel mechanism for tubular proteinuria. ..
- Darido C, Georgy S, Wilanowski T, Dworkin S, Auden A, Zhao Q, et al. Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis. Cancer Cell. 2011;20:635-48 pubmed publisher..Our data define the GRHL3-PTEN axis as a critical tumor suppressor pathway in SCC. ..
- Liu G, Peshavariya H, Higuchi M, Brewer A, Chang C, Chan E, et al. Microphthalmia-associated transcription factor modulates expression of NADPH oxidase type 4: a negative regulator of melanogenesis. Free Radic Biol Med. 2012;52:1835-43 pubmed publisher..Such sequence of actions appears to act as an internal feedback mechanism to fine-tune melanin synthesis in response to exogenous challenges such as UV radiation. ..
- Marques F, Morris B. Neurogenic hypertension: revelations from genome-wide gene expression profiling. Curr Hypertens Rep. 2012;14:485-91 pubmed publisher..Such information may lead to better therapies for neurogenic hypertension in humans. ..
- Nicola N, Robb L, Metcalf D, Cary D, Drinkwater C, Begley C. Functional inactivation in mice of the gene for the interleukin-3 (IL-3)-specific receptor beta-chain: implications for IL-3 function and the mechanism of receptor transmodulation in hematopoietic cells. Blood. 1996;87:2665-74 pubmed
- Cretney E, Street S, Smyth M. TNF contributes to the immunopathology of perforin/Fas ligand double deficiency. Immunol Cell Biol. 2002;80:436-40 pubmed..We conclude that TNF is necessary for the full manifestation of immune dysregulation caused by pfp/FasL-deficiency, in particular in the early and overwhelming tissue infiltration and destruction caused by inflammatory cells. ..
- James W, Hutchinson P, Bullard D, Hickey M. Cerebral leucocyte infiltration in lupus-prone MRL/MpJ-fas lpr mice--roles of intercellular adhesion molecule-1 and P-selectin. Clin Exp Immunol. 2006;144:299-308 pubmed..In addition, endothelial adhesion molecules ICAM-1 and P-selectin, which modulate survival of MRL/MpJ-fas(lpr) mice, do not markedly inhibit leucocyte entry into the central nervous system. ..
- Shields B, Hauser C, Bukczynska P, Court N, Tiganis T. DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression. Cancer Cell. 2008;14:166-79 pubmed publisher..Therefore, inactivating JAK, Src, and STAT3 signaling pathways in response to DNA replication stress may be essential for the suppression of S phase progression and the maintenance of genomic stability. ..
- Shen H, Crowston J, Huber F, Saubern S, McLean K, Hartley P. The influence of dipalmitoyl phosphatidylserine on phase behaviour of and cellular response to lyotropic liquid crystalline dispersions. Biomaterials. 2010;31:9473-81 pubmed publisher..We propose that the cytotoxicity of the DPPS-containing dispersions results from changes in lipid/surfactant phase behaviour and the preferential attachment and fusion of vesicles at the cell membrane. ..
- Huynh N, Yim M, Chernoff J, Shulkes A, Baldwin G, He H. p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways. Am J Physiol Gastrointest Liver Physiol. 2013;304:G561-7 pubmed publisher..These results indicate that PAK1 mediates the stimulation of colorectal proliferation by gastrins via multiple signaling pathways involving activation of ERK, AKT, and ?-catenin. ..
- Lim N, Yeap Y, Ang C, Williamson N, Bogoyevitch M, Quinn L, et al. Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation. Cell Cycle. 2016;15:413-24 pubmed publisher..Thus, our study highlights the role of AURKA signaling in the spatiotemporal control of WDR62 at spindle poles where it maintains spindle organization. ..
- Tucek C, Godfrey D, Boyd R. Five novel antigens illustrate shared phenotype between mouse thymic stromal cells, thymocytes, and peripheral lymphocytes. Int Immunol. 1992;4:1021-30 pubmed..These findings may be of importance in the delineation of intercellular communications within the thymus and emphasize the integrated nature of the microenvironment in this organ. ..
- Hilton D, Nicola N, Gough N, Metcalf D. Resolution and purification of three distinct factors produced by Krebs ascites cells which have differentiation-inducing activity on murine myeloid leukemic cell lines. J Biol Chem. 1988;263:9238-43 pubmed..LIF-A had no colony-stimulating activity and induced differentiation in and inhibited the proliferation of only M1 cells. Each factor bound to a unique cell surface receptor with no evidence of direct cross-reactivity...
- Verhagen A, Ekert P, Pakusch M, Silke J, Connolly L, Reid G, et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell. 2000;102:43-53 pubmed..As transfection of cells with DIABLO was able to counter the protection afforded by MIHA against UV irradiation, DIABLO may promote apoptosis by binding to IAPs and preventing them from inhibiting caspases. ..
- Cretney E, McQualter J, Kayagaki N, Yagita H, Bernard C, Grewal I, et al. TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice. Immunol Cell Biol. 2005;83:511-9 pubmed..These data are the first to illustrate the potential therapeutic value of recombinant TRAIL/Apo2L in suppressing T-cell-mediated autoimmune diseases. ..
- Cain J, Bertram J. Ureteric branching morphogenesis in BMP4 heterozygous mutant mice. J Anat. 2006;209:745-55 pubmed..In addition, reduced endogenous levels of BMP4 do not alter the inhibitory effects of exogenous BMP4 on ureteric branching or amplification of normal renal asymmetry. ..
- Martinez G, Wijesinghe M, Turner K, Abud H, Taketo M, Noda T, et al. Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009;50:4794-806 pubmed publisher..These data indicate that the Wnt/beta-catenin pathway plays key roles in regulating proliferation of lens stem/progenitor cells during early stages of fiber cell differentiation. ..
- Materia S, Cater M, Klomp L, Mercer J, La Fontaine S. Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B. J Biol Chem. 2012;287:2485-99 pubmed publisher..Together these data indicate that clusterin and COMMD1 represent alternative and independent systems regulating Cu-ATPase quality control, and consequently contributing to the maintenance of copper homeostasis. ..
- Li C, Johnson G. Rhodamine123 reveals heterogeneity within murine Lin-, Sca-1+ hemopoietic stem cells. J Exp Med. 1992;175:1443-7 pubmed..Both myeloid and lymphoid cells were of donor origin. By comparison, the Rh123med/hi population produced recipients with 1-2% donor cells in peripheral blood, the majority of which were lymphoid. ..
- Stacker S, Hovens C, Vitali A, Pritchard M, Baker E, Sutherland G, et al. Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases (RYK). Oncogene. 1993;8:1347-56 pubmed..RYK therefore appears to define a new subclass of receptor-type tyrosine kinases whose structure has remained highly conserved across species. ..
- Alderuccio F, Sentry J, Marshall A, Biondo M, Toh B. Animal models of human disease: experimental autoimmune gastritis--a model for autoimmune gastritis and pernicious anemia. Clin Immunol. 2002;102:48-58 pubmed..A precise understanding of the pathogenesis of autoimmune gastritis will permit the design of innovative and rational therapeutic strategies to prevent, arrest, ameliorate or reverse the disease. ..
- Belz G, Behrens G, Smith C, Miller J, Jones C, Lejon K, et al. The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J Exp Med. 2002;196:1099-104 pubmed
- Scott D, Tregear G, Bathgate R. LGR7-truncate is a splice variant of the relaxin receptor LGR7 and is a relaxin antagonist in vitro. Ann N Y Acad Sci. 2005;1041:22-6 pubmed..Expression of LGR7-Truncate with LGR7 in HEK-293T cells resulted in decreased relaxin-induced signaling of LGR7. LGR7-Truncate is potentially an endogenous regulator of LGR7 signaling. ..
- Wu Q, Yang Q, Cate H, Kemper D, Binder M, Wang H, et al. MRI identification of the rostral-caudal pattern of pathology within the corpus callosum in the cuprizone mouse model. J Magn Reson Imaging. 2008;27:446-53 pubmed
- Tucker E, O Donnell K, Fuchsberger M, Hilton A, Metcalf D, Greig K, et al. A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor". J Immunol. 2007;179:7514-22 pubmed..These findings demonstrate a key role for NF-kappaB2 in the regulation of RelA activation and suggest overlap in the function of NF-kappaB members in canonical and noncanonical pathway signaling. ..
- Jamsai D, O Connor A, Deboer K, Clark B, Smith S, Browne C, et al. Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse. PLoS ONE. 2013;8:e56955 pubmed publisher..Together, our results suggest that GGN plays a role in male meiotic DSB repair and is absolutely required for the survival of pre-implantation embryos. ..
- Harvey R. The Xenopus MyoD gene: an unlocalised maternal mRNA predates lineage-restricted expression in the early embryo. Development. 1990;108:669-80 pubmed..In addition, the initiation of MyoD transcription at the MBT and its stimulation by mesoderm-inducing factors implies that MyoD gene expression is an immediate early response to mesoderm induction. ..
- Grumont R, Gerondakis S. Structure of a mammalian c-rel protein deduced from the nucleotide sequence of murine cDNA clones. Oncogene Res. 1989;4:1-8 pubmed..This suggests that the conserved domain of the rel related family of proteins performs a common function that is modulated by the carboxyl terminal domain. ..
- Robb L, Lyons I, Li R, Hartley L, Kontgen F, Harvey R, et al. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A. 1995;92:7075-9 pubmed..Transcripts of GATA-1 and PU.1 transcription factors were absent from RNA from scl-/- yolk sacs and embryos. These results implicate scl as a crucial regulator of early hematopoiesis. ..
- Zhang J, Hilton D, Willson T, McFarlane C, Roberts B, Moritz R, et al. Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains. J Biol Chem. 1997;272:9474-80 pubmed..Finally, unlike the cloned receptor, the IL-13BP acts as a potent inhibitor of IL-13 binding to its cell surface receptor, raising the possibility that it may be used to modulate the effects of IL-13 in vivo. ..
- Starr R, Metcalf D, Elefanty A, Brysha M, Willson T, Nicola N, et al. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc Natl Acad Sci U S A. 1998;95:14395-9 pubmed..Thus, SOCS-1 is required for in vivo regulation of multiple cell types and is indispensable for normal postnatal growth and survival. ..
- Alexander W, Starr R, Metcalf D, Nicholson S, Farley A, Elefanty A, et al. Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction. J Leukoc Biol. 1999;66:588-92 pubmed..We propose that the absence of SOCS-1 in these mice prevents lymphocytes and liver cells from appropriately controlling signals from cytokines with cytotoxic side effects. ..
- Metcalf D, Di Rago L, Mifsud S, Hartley L, Alexander W. The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-gamma and lacking the SOCS-1 gene. Proc Natl Acad Sci U S A. 2000;97:9174-9 pubmed
- Samuel C, Zhao C, Yang Q, Wang H, Tian H, Tregear G, et al. The relaxin gene knockout mouse: a model of progressive scleroderma. J Invest Dermatol. 2005;125:692-9 pubmed
- Datla S, Dusting G, Mori T, Taylor C, Croft K, Jiang F. Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress. Hypertension. 2007;50:636-42 pubmed..Thus, systemic expression of HO-1 suppresses NADPH oxidase activity by mechanisms at least partly mediated by the bile pigment bilirubin, thereby reducing oxidative stress. ..
- Swann J, Vesely M, Silva A, Sharkey J, Akira S, Schreiber R, et al. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci U S A. 2008;105:652-6 pubmed publisher..Overall, these data not only confirm the key role that MyD88 plays in promoting tumor development but also demonstrate that inflammation-induced carcinogenesis and cancer immunoediting can indeed occur in the same mouse tumor model. ..
- Herbert K, Levesque J, Haylock D, Prince H, Prince M. The use of experimental murine models to assess novel agents of hematopoietic stem and progenitor cell mobilization. Biol Blood Marrow Transplant. 2008;14:603-21 pubmed publisher..Technical aspects regarding mobilization regimens and control arms, and choice of experimental animals are also discussed. ..
- Gray L, McOmish C, Scarr E, Dean B, Hannan A. Sensitivity to MK-801 in phospholipase C-?1 knockout mice reveals a specific NMDA receptor deficit. Int J Neuropsychopharmacol. 2009;12:917-28 pubmed publisher..These results also shed further light on the capacity of environmental factors to modulate subsets of these phenotypes. ..
- Smith C, Shen P, Ma S, Sutton S, Gundlach A. Verification of a relaxin-3 knockout/LacZ reporter mouse as a model of relaxin-3 deficiency. Ann N Y Acad Sci. 2009;1160:259-60 pubmed publisher..Before conducting detailed neurochemical and behavioral examinations of a recently generated relaxin-3 knockout mouse strain, the present study determined whether this mouse was a viable model of relaxin-3 deficiency. ..
- Zhang X, Milton C, Humbert P, Harvey K. Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines. Cancer Res. 2009;69:6033-41 pubmed publisher..melanogaster and optimally activate Sd. This shows that Yki/YAP WW domains have distinct regulatory roles in different cell types and implies the existence of proteins that promote tissue growth in collaboration with Yki and Sd. ..
- Li J, Qu X, Yao J, Caruana G, Ricardo S, Yamamoto Y, et al. Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy. Diabetes. 2010;59:2612-24 pubmed publisher..EndoMT is a novel pathway leading to early development of diabetic nephropathy. Blockade of EndoMT by SIS3 may provide a new strategy to retard the progression of diabetic nephropathy and other diabetes complications. ..
- Hanifa S, Scott H, Crewther P, Guipponi M, Tan J. Thyroxine treatments do not correct inner ear defects in tmprss1 mutant mice. Neuroreport. 2010;21:897-901 pubmed publisher..Both the treatments could not ameliorate hearing loss or correct deformities in the tectorial membrane of these mutant mice, suggesting that a deficiency in tmprss1 affects thyroxine responsiveness in the inner ear in vivo. ..
- Nguyen N, Maxwell M, Ooms L, Davies E, Hilton A, Collinge J, et al. An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation. Blood. 2011;117:5362-71 pubmed publisher..Our results suggest that s-SHIP synergizes with SHIP1 for suppression of macrophage activation, thus providing the first evidence for a role of s-SHIP in adult hematopoiesis. ..
- Paget C, Chow M, Duret H, Mattarollo S, Smyth M. Role of ?? T cells in ?-galactosylceramide-mediated immunity. J Immunol. 2012;188:3928-39 pubmed publisher..We conclude that ?? T cells amplify the innate and acquired response to ?-GalCer, with possibly important outcomes for the therapeutic effects of this compound. ..
- Ng W, Liong S, Tate M, Irimura T, Denda Nagai K, Brooks A, et al. The macrophage galactose-type lectin can function as an attachment and entry receptor for influenza virus. J Virol. 2014;88:1659-72 pubmed publisher..Together, these studies identify MGL1 as a cell surface glycoprotein that can act as an authentic receptor for both attachment and infectious entry of IAV. ..
- Rao R, Long J, White J, Svensson K, Lou J, Lokurkar I, et al. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 2014;157:1279-91 pubmed publisher..Thus, Metrnl links host-adaptive responses to the regulation of energy homeostasis and tissue inflammation and has therapeutic potential for metabolic and inflammatory diseases...
- Turcotte M, Allard D, Mittal D, Bareche Y, Buisseret L, JosÃ© V, et al. CD73 Promotes Resistance to HER2/ErbB2 Antibody Therapy. Cancer Res. 2017;77:5652-5663 pubmed publisher..In conclusion, our findings establish CD73 in mediating resistance to trastuzumab and provide new insights into how CD73 is regulated in breast cancer. Cancer Res; 77(20); 5652-63. Â©2017 AACR. ..
- Purton J, Boyd R, Cole T, Godfrey D. Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling. Immunity. 2000;13:179-86 pubmed..In contrast to earlier reports, these data demonstrate that GR signaling is not essential for intrathymic T cell development or selection. ..
- Hibbs M, Harder K, Armes J, Kountouri N, Quilici C, Casagranda F, et al. Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity. J Exp Med. 2002;196:1593-604 pubmed..These studies highlight the difficulty in maintaining tolerance in the face of chronic stimulation and emphasize the pivotal role of Lyn in B cell signaling. ..
- Church J, Moldrich R, Beart P, Hodgson W. Modulation of intracellular Ca2+ levels by Scorpaenidae venoms. Toxicon. 2003;41:679-89 pubmed..These data indicate that the effects of all three venoms are due in part to an increase in intracellular Ca(2+), possibly via the formation of pores in the cellular membrane which, under certain conditions, can lead to necrosis...
- Sims N, Jenkins B, Quinn J, Nakamura A, Glatt M, Gillespie M, et al. Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways. J Clin Invest. 2004;113:379-89 pubmed..Furthermore, the latter pathway can directly inhibit osteoclastogenesis in vivo. ..
- Stupka N, Schertzer J, Bassel Duby R, Olson E, Lynch G. Calcineurin-A alpha activation enhances the structure and function of regenerating muscles after myotoxic injury. Am J Physiol Regul Integr Comp Physiol. 2007;293:R686-94 pubmed..Therefore, calcineurin activation can confer structural and functional benefits to regenerating skeletal muscles, which may be mediated in part by differential expression of MRFs. ..
- Cullinane M, Gong L, Li X, Lazar Adler N, Tra T, Wolvetang E, et al. Stimulation of autophagy suppresses the intracellular survival of Burkholderia pseudomallei in mammalian cell lines. Autophagy. 2008;4:744-53 pubmed..pseudomallei, but which the bacteria can actively evade. However, when autophagy is pharmacologically induced using rapamycin, bacteria are actively sequestered in autophagosomes, ultimately decreasing their survival. ..
- Johnstone R, Frew A, Smyth M. The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nat Rev Cancer. 2008;8:782-98 pubmed publisher..Herein we review what is known about the molecular control of TRAIL-mediated apoptosis, the role of TRAIL in carcinogenesis and the potential therapeutic utility of recombinant TRAIL and agonistic antibodies against TRAILR1 and TRAILR2. ..
- Bachtiar E, Coloe P, Smooker P. Construction and immunogenicity of Salmonella vaccine vector expressing HIV-1 antigen and MCP3. Acta Microbiol Immunol Hung. 2009;56:403-15 pubmed publisher..This result confirms other studies that Salmonella was able to deliver HIV antigens to the immune system and induced specific immune responses to the HIV antigen and for the HIV p24 antigen, STM1/MCP3 induces secretion of IFNgamma. ..
- Bayne S, Li H, Jones M, Pinto A, Van Sinderen M, Drummond A, et al. Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo. Protein Cell. 2011;2:333-46 pubmed publisher..Estrogen deficiency or over-activity may cause ovarian tissue aging or tumorigenesis, respectively, through estrogen regulation of telomere remodeling. ..
- Dubsky S, Hooper S, Siu K, Fouras A. Synchrotron-based dynamic computed tomography of tissue motion for regional lung function measurement. J R Soc Interface. 2012;9:2213-24 pubmed publisher..Although proof-of-concept data were acquired on a synchrotron, the methodology developed potentially lends itself to clinical CT scanning and therefore offers translational research opportunities. ..
- Stringer J, Suzuki S, Pask A, Shaw G, Renfree M. Promoter-specific expression and imprint status of marsupial IGF2. PLoS ONE. 2012;7:e41690 pubmed publisher..The conservation of the IGF2 promoters suggests they originated before the divergence of marsupials and eutherians, and have been selectively maintained for at least 160 million years. ..
- Moujalled D, Grubman A, Acevedo K, Yang S, Ke Y, Moujalled D, et al. TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway. Hum Mol Genet. 2017;26:1732-1746 pubmed publisher..Our findings indicate that further exploration of the interplay between hnRNP K (or other hnRNPs) and Nrf2-mediated antioxidant signaling is warranted and may be an important driver for motor neuron degeneration in ALS. ..
- Fabri L, Maruta H, Muramatsu H, Muramatsu T, Simpson R, Burgess A, et al. Structural characterisation of native and recombinant forms of the neurotrophic cytokine MK. J Chromatogr. 1993;646:213-25 pubmed..The disulphide bond assignment of MK is C12-C36, C20-C45, C27-C49, C59-C91 and C69-C101, and is equivalent to that of PTN. ..
- Gehrig S, Koopman R, Naim T, Tjoakarfa C, Lynch G. Making fast-twitch dystrophic muscles bigger protects them from contraction injury and attenuates the dystrophic pathology. Am J Pathol. 2010;176:29-33 pubmed publisher..These novel results further support the contention that anabolic agents have therapeutic potential for muscle wasting conditions including DMD. ..
- Leedman P, Faulkner Jones B, Cram D, Harrison P, West J, O BRIEN E, et al. Cloning from the thyroid of a protein related to actin binding protein that is recognized by Graves disease immunoglobulins. Proc Natl Acad Sci U S A. 1993;90:5994-8 pubmed..We suggest, therefore, that signal transduction by TSH in the thyroid involves direct linkage of the TSH receptor to actin microfilaments by ABP and that TABP may interact with ABP to mediate TSH-induced actin microfilament disruption. ..
- Grigoriadis G, Zhan Y, Grumont R, Metcalf D, Handman E, Cheers C, et al. The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations. EMBO J. 1996;15:7099-107 pubmed..Collectively, these results establish that Rel is a positive or negative regulator of transcription in macrophages and that Rel has distinct roles in different macrophage populations. ..
- Zhu H, Iaria J, Sizeland A. Smad7 differentially regulates transforming growth factor beta-mediated signaling pathways. J Biol Chem. 1999;274:32258-64 pubmed..However, expression of Smad7 had little effect on TGF-beta-induced growth inhibition. ..
- Martin T, Sims N. Osteoclast-derived activity in the coupling of bone formation to resorption. Trends Mol Med. 2005;11:76-81 pubmed..We argue that osteoclasts contribute in important ways to the transiently activated osteoclast, and stimulate osteoblast lineage cells to begin replacing the resorbed bone in each BMU. ..
- Piccenna L, Shen P, Ma S, Burazin T, Gossen J, Mosselman S, et al. Localization of LGR7 gene expression in adult mouse brain using LGR7 knock-out/LacZ knock-in mice: correlation with LGR7 mRNA distribution. Ann N Y Acad Sci. 2005;1041:197-204 pubmed
- Liu J, Jones K, Sumer H, Verma P. Stable transgene expression in human embryonic stem cells after simple chemical transfection. Mol Reprod Dev. 2009;76:580-6 pubmed publisher..Following injection into immunodeficient mice, the transfected cell lines showed robust formation of teratomas with cell types representative of the three germ layers. ..
- Andrews D, Smyth M. A potential role for RAG-1 in NK cell development revealed by analysis of NK cells during ontogeny. Immunol Cell Biol. 2010;88:107-16 pubmed publisher..Liver NK cells may represent an independent pool of cells from those developing out of the bone marrow, and RAG-1 itself may have a significant role in NK cell development. ..
- Senior P, Zhang B, Chan S. Loss of cell-surface receptor EphB2 is important for the growth, migration, and invasiveness of a colon cancer cell line. Int J Colorectal Dis. 2010;25:687-94 pubmed publisher..05) compared to tumours from control cells. Even a moderate level of EphB2 expression has effects on tumour cells which results in reduced migration and invasiveness and slows the growth of colonic tumour implants in an in vivo model. ..
- Andrews D, Chow M, Ma Y, Cotterell C, Watt S, Anthony D, et al. Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin. Immunol Cell Biol. 2011;89:739-46 pubmed publisher..These results reveal novel requirements for IL-18 in innate immune cell homeostasis and activation, demonstrating that the role of IL-18 in innate immunity occurs at a level other than activation. ..
- Gentle I, Wong W, Evans J, Bankovacki A, Cook W, Khan N, et al. In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8. J Biol Chem. 2011;286:13282-91 pubmed publisher..This resulted in processing of p100 NF-?B2 to p52, a decrease in levels of cFLIP(L), and activation of caspase-8, culminating in cell death. Therefore, the pro-survival effect of RIPK1 is mediated by stabilization of TRAF2 and cIAP1. ..
- Seach N, Wong K, Hammett M, Boyd R, Chidgey A. Purified enzymes improve isolation and characterization of the adult thymic epithelium. J Immunol Methods. 2012;385:23-34 pubmed publisher..The data reveal more extensive expression of K8 than previously recognized and indicates considerable heterogeneity still exists within currently defined adult TEC subsets...
- Chow M, Sceneay J, Paget C, Wong C, Duret H, Tschopp J, et al. NLRP3 suppresses NK cell-mediated responses to carcinogen-induced tumors and metastases. Cancer Res. 2012;72:5721-32 pubmed publisher..Together, these data suggested that NLRP3 is an important suppressor of NK cell-mediated control of carcinogenesis and metastases and identify CD11b(+)Gr-1(int) myeloid cells that promote NK cell antimetastatic function. ..
- Abubaker K, Latifi A, Luwor R, Nazaretian S, Zhu H, Quinn M, et al. Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden. Mol Cancer. 2013;12:24 pubmed publisher..The novel findings in this study are important in understanding the early molecular mechanisms by which chemoresistance and subsequent relapse may be triggered after the first line of chemotherapy treatment. ..
- Smeets M, Mackenzie Kludas C, Mohtashami M, Zhang H, Zuniga Pflucker J, Izon D. Removal of myeloid cytokines from the cellular environment enhances T-cell development in vitro. Int Immunol. 2013;25:589-99 pubmed publisher..These T-cell precursors could be used for treating immunodeficient patients. ..
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