Genomes and Genes
Experts and Doctors on messenger rna in Queensland, Australia
Locale: Queensland, Australia
Topic: messenger rna
- Saunus J, French J, Edwards S, Beveridge D, Hatchell E, Wagner S, et al. Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR. Cancer Res. 2008;68:9469-78 pubmed publisher..These results identify the first posttranscriptional protein regulator of BRCA1 and have implications for understanding BRCA1 regulation in human breast cancer. ..
- Seim I, Carter S, Herington A, Chopin L. Complex organisation and structure of the ghrelin antisense strand gene GHRLOS, a candidate non-coding RNA gene. BMC Mol Biol. 2008;9:95 pubmed publisher..The overlapping genomic arrangement of GHRLOS with the ghrelin gene indicates that it is likely to have interesting regulatory and functional roles in the ghrelin axis. ..
- Norris B, Whan V. A gene duplication affecting expression of the ovine ASIP gene is responsible for white and black sheep. Genome Res. 2008;18:1282-93 pubmed publisher..This is the first sheep trait attributable to gene duplication and shows nonallelic homologous recombination and gene conversion events at the ovine ASIP locus could have an important role in the evolution of sheep pigmentation...
- Ramsay A, Reid J, Velasco G, Quigley J, Hooper J. The type II transmembrane serine protease matriptase-2--identification, structural features, enzymology, expression pattern and potential roles. Front Biosci. 2008;13:569-79 pubmed..Here we overview the identification of matriptase-2, summarise its structural features, biochemistry, expression pattern and disease associations and discuss its potential functions. ..
- Saunus J, Edwards S, French J, Smart C, Brown M. Regulation of BRCA1 messenger RNA stability in human epithelial cell lines and during cell cycle progression. FEBS Lett. 2007;581:3435-42 pubmed..Our data identify a new post-transcriptional regulatory axis and a novel mechanism for modulating the levels of BRCA1 protein, with possible implications for understanding the mechanisms underlying BRCA1 repression in breast cancer. ..
- Lichanska A, Browne C, Henkel G, Murphy K, Ostrowski M, McKercher S, et al. Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1. Blood. 1999;94:127-38 pubmed..The results support previous evidence that yolk sac-derived fetal phagocytes are functionally distinct from those arising in the liver and develop via a different pathway. ..
- Wallace D, Summerville L, Subramaniam V. Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload. Gastroenterology. 2007;132:301-10 pubmed
- Johnson B, Costelloe E, Fitzpatrick D, Haanen J, Schumacher T, Brown L, et al. Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice. Proc Natl Acad Sci U S A. 2003;100:2657-62 pubmed..The data suggest that some CTL mature into perforin/granzyme-expressing effector cells in MLN but reach detectable frequencies only when they accumulate in the infected lung. ..
- Shan J, Munro T, Barbarese E, Carson J, Smith R. A molecular mechanism for mRNA trafficking in neuronal dendrites. J Neurosci. 2003;23:8859-66 pubmed..A2RE-like sequences are found in a subset of dendritically localized mRNAs, which, together with these results, suggests that a molecular mechanism based on this cis-acting sequence may contribute to dendritic RNA localization. ..
- McKinnon B, Li H, Richard K, Mortimer R. Synthesis of thyroid hormone binding proteins transthyretin and albumin by human trophoblast. J Clin Endocrinol Metab. 2005;90:6714-20 pubmed..Placenta produces a series of thyroid hormone binding proteins that may modify thyroid hormone deiodination and materno-fetal thyroid hormone transport. ..
- Ramakrishnan S, Lau P, Burke L, Muscat G. Rev-erbbeta regulates the expression of genes involved in lipid absorption in skeletal muscle cells: evidence for cross-talk between orphan nuclear receptors and myokines. J Biol Chem. 2005;280:8651-9 pubmed..In conclusion, we speculate that selective modulators of Rev-erbbeta may have therapeutic utility in the treatment of dyslipidemia and regulation of muscle growth. ..
- Maxwell M, Allen T, Solly P, Svingen T, Paton B, Crane D. Novel PEX1 mutations and genotype-phenotype correlations in Australasian peroxisome biogenesis disorder patients. Hum Mutat. 2002;20:342-51 pubmed..The findings are consistent with a close correlation between cellular phenotype, disease severity, and PEX1 genotype. ..
- Lau P, Nixon S, Parton R, Muscat G. RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR. J Biol Chem. 2004;279:36828-40 pubmed..In conclusion, we speculate that ROR agonists would increase fatty acid catabolism in muscle and suggest selective activators of ROR may have therapeutic utility in the treatment of obesity and atherosclerosis. ..
- Barclay J, Anderson S, Waters M, Curlewis J. SOCS3 as a tumor suppressor in breast cancer cells, and its regulation by PRL. Int J Cancer. 2009;124:1756-66 pubmed publisher..This study demonstrates that SOCS3 acts as an anti-proliferative agent in breast cancer cells, and highlights the complexity of SOCS3 regulation and crosstalk. ..
- Wong C, Barnes L, Smith L, Popa C, Serewko Auret M, Saunders N. E2F6: a member of the E2F family that does not modulate squamous differentiation. Biochem Biophys Res Commun. 2004;324:497-503 pubmed..These results demonstrate that E2F6 does not contain the domains required for modulation of squamous differentiation and imply isoform-specific functions for individual E2F family members. ..
- Smith R. Moving molecules: mRNA trafficking in Mammalian oligodendrocytes and neurons. Neuroscientist. 2004;10:495-500 pubmed..Several other cis-acting sequences and trans-acting factors that participate in neuronal RNA localization have been discovered. ..
- Green M, Gandhi M, Camilleri E, Marlton P, Lea R, Griffiths L. High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma. Leuk Res. 2009;33:731-4 pubmed publisher..This indicates that BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation. ..
- Ripoll V, Irvine K, Ravasi T, Sweet M, Hume D. Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. J Immunol. 2007;178:6557-66 pubmed..Thus, GPNMB acts as a negative regulator of macrophage inflammatory responses. ..
- Pearen M, Myers S, Raichur S, Ryall J, Lynch G, Muscat G. The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle. Endocrinology. 2008;149:2853-65 pubmed publisher..In conclusion, NOR-1 is necessary for oxidative metabolism in skeletal muscle. ..
- Anderson S, Barclay J, Fanning K, Kusters D, Waters M, Curlewis J. Mechanisms underlying the diminished sensitivity to prolactin negative feedback during lactation: reduced STAT5 signaling and up-regulation of cytokine-inducible SH2 domain-containing protein (CIS) expression in tuberoinfundibular dopaminergic neuron. Endocrinology. 2006;147:1195-202 pubmed..05) increased in lactating rats with sucking pups. Together, these results support the hypothesis that loss of sensitivity to PRL-negative feedback during lactation is a result of increased CIS expression in TIDA neurons. ..
- Bain P, Shaw G, Patel B. Induction of p53-regulated gene expression in human cell lines exposed to the cyanobacterial toxin cylindrospermopsin. J Toxicol Environ Health A. 2007;70:1687-93 pubmed..Accumulation of p53 protein occurred after longer exposures in the HepG2-derived cell line C3A. Data suggest that cylindrospermopsin induces stress responses that result in the activation of the p53 transcription factor. ..
- Seim I, Collet C, Herington A, Chopin L. Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts. BMC Genomics. 2007;8:298 pubmed..This study reveals several novel aspects of the ghrelin gene and suggests that the ghrelin locus is far more complex than previously recognised. ..
- Barclay J, Anderson S, Waters M, Curlewis J. Regulation of suppressor of cytokine signaling 3 (SOC3) by growth hormone in pro-B cells. Mol Endocrinol. 2007;21:2503-15 pubmed..This study has implications for cytokine regulation of SOCS gene expression in lymphoid cells. ..
- Walshe J, Serewko Auret M, Teakle N, Cameron S, Minto K, Smith L, et al. Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation. Cancer Res. 2007;67:4751-8 pubmed..These studies showed that Gpx2 deficiency predisposed mice to UV-induced CSCC formation. These results suggest that inactivation of GPX2 in human skin may be an early event in UV-induced SCC formation. ..