Experts and Doctors on animal disease models in New South Wales, Australia

Summary

Locale: New South Wales, Australia
Topic: animal disease models

Top Publications

  1. Robinson M, Bye P. Mucociliary clearance in cystic fibrosis. Pediatr Pulmonol. 2002;33:293-306 pubmed
    ..A summary of the results of interventional studies utilizing the measurement of MCC as an outcome measure is presented. ..
  2. Gillen C, Courtney H, Schulze K, Rohde M, Wilson M, Timmer A, et al. Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete. J Biol Chem. 2008;283:6359-66 pubmed publisher
    ..We demonstrate that while the N terminus of SOF does not directly mediate intracellular uptake by epithelial cells, this domain enhances epithelial cell uptake mediated by full-length SOF, in comparison to the FnBD alone. ..
  3. Mitchell V, Greenwood R, Jayamanne A, Vaughan C. Actions of the endocannabinoid transport inhibitor AM404 in neuropathic and inflammatory pain models. Clin Exp Pharmacol Physiol. 2007;34:1186-90 pubmed
  4. Kee A, Schevzov G, Nair Shalliker V, Robinson C, Vrhovski B, Ghoddusi M, et al. Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy. J Cell Biol. 2004;166:685-96 pubmed
    ..Our findings raise the possibility that mutations in these tropomyosin and these structures may underpin these types of myopathies. ..
  5. Young A, Smith M, Smith S, Cake M, Ghosh P, Read R, et al. Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis. Arthritis Res Ther. 2005;7:R852-61 pubmed
    ..This study highlights the focal nature of the degenerative changes that occur in OA cartilage and suggests that altered synthesis and proteolysis of SLRPs may play an important role in cartilage destruction in arthritis. ..
  6. Little C, Ghosh P, Bellenger C. Topographic variation in biglycan and decorin synthesis by articular cartilage in the early stages of osteoarthritis: an experimental study in sheep. J Orthop Res. 1996;14:433-44 pubmed
    ..These data suggest that an altered chondrocyte phenotypic expression of proteoglycans in response to abnormal mechanical loading is an early event in osteoarthritis. ..
  7. van Eersel J, Ke Y, Liu X, Delerue F, Kril J, Götz J, et al. Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A. 2010;107:13888-93 pubmed publisher
    ..Taken together, sodium selenate mitigates tau pathology in several AD models, making it a promising lead compound for tau-targeted treatments of AD and related dementias. ..
  8. Himmelreich U, Dzendrowskyj T, Allen C, Dowd S, Malik R, Shehan B, et al. Cryptococcomas distinguished from gliomas with MR spectroscopy: an experimental rat and cell culture study. Radiology. 2001;220:122-8 pubmed
    ..Application of these results to the noninvasive diagnosis of cerebral cryptococcomas would help reduce the risk and expense of unnecessary surgery or biopsy and expedite patient treatment. ..
  9. Preston J, Beagley K, Gibson P, Hansbro P. Genetic background affects susceptibility in nonfatal pneumococcal bronchopneumonia. Eur Respir J. 2004;23:224-31 pubmed
    ..These different susceptibilities result from a greater inflammatory response in BALB/c compared with C57BL/6 mice. ..

More Information

Publications24

  1. Miu J, Mitchell A, Müller M, Carter S, Manders P, McQuillan J, et al. Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency. J Immunol. 2008;180:1217-30 pubmed
    ..These data suggest a role for CXCR3 in the pathogenesis of FMCM through the recruitment and activation of pathogenic CD8+ T cells...
  2. Eamens G. Pathogenicity of field isolates of Erysipelothrix rhusiopathiae in mice, rats and pigs. Aust Vet J. 1988;65:280-4 pubmed
    ..Clinical lameness, joint swelling and urticariae were of limited use as indicators of joint changes. The more virulent strains caused lameness as early as 2 days, whereas strains of low virulence took up to 8 weeks...
  3. Cao Q, Wang Y, Zheng D, Sun Y, Wang Y, Lee V, et al. IL-10/TGF-beta-modified macrophages induce regulatory T cells and protect against adriamycin nephrosis. J Am Soc Nephrol. 2010;21:933-42 pubmed publisher
    ..Taken together, these data demonstrate that IL-10/TGF-beta-modified macrophages effectively protect against renal injury in AN and may become part of a therapeutic strategy for chronic inflammatory disease...
  4. Smith M, Sakurai G, Smith S, Young A, Melrose J, Stewart C, et al. Modulation of aggrecan and ADAMTS expression in ovine tendinopathy induced by altered strain. Arthritis Rheum. 2008;58:1055-66 pubmed publisher
    ..Tendon abnormalities induced by increased strain are accompanied by increased aggrecan, decreased ADAMTS, and low PG expression, which may negatively impact the structural integrity of the tissue and predispose to rupture. ..
  5. Vlahovich N, Schevzov G, Nair Shaliker V, Ilkovski B, Artap S, Joya J, et al. Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle. Cell Motil Cytoskeleton. 2008;65:73-85 pubmed
    ..This Tm4-defined cytoskeleton is a marker of growth and repair/regeneration in response to injury, disease state and stress in skeletal muscle. ..
  6. Corbett M, Robinson C, Dunglison G, Yang N, Joya J, Stewart A, et al. A mutation in alpha-tropomyosin(slow) affects muscle strength, maturation and hypertrophy in a mouse model for nemaline myopathy. Hum Mol Genet. 2001;10:317-28 pubmed
    ..We suggest that the clinical phenotype is precipitated by a failure of the hypertrophy to persist and therefore compensate for muscle weakness...
  7. Spicer S, Tran G, Killingsworth M, Carter N, Power D, Paizis K, et al. Induction of passive Heymann nephritis in complement component 6-deficient PVG rats. J Immunol. 2007;179:172-8 pubmed
    ..These studies showed proteinuria in PHN occurs without MAC and that other mechanisms, such as immune complex size, early complement components, CD4+ and CD8+ T cells, disrupt glomerular integrity and lead to proteinuria. ..
  8. Shum B, Mackay C, Gorgun C, Frost M, Kumar R, Hotamisligil G, et al. The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation. J Clin Invest. 2006;116:2183-2192 pubmed
    ..Thus, aP2 regulates allergic airway inflammation and may provide a link between fatty acid metabolism and asthma. ..
  9. Saunders B, Cooper A. Restraining mycobacteria: role of granulomas in mycobacterial infections. Immunol Cell Biol. 2000;78:334-41 pubmed
    ..In the present review, the principal components of the protective response are outlined and the role of granuloma formation and maintenance in mediating prolonged containment of mycobacteria within the lung is addressed...
  10. Su Y, Rolph M, Hansbro N, Mackay C, Sewell W. Granulocyte-macrophage colony-stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammation. J Immunol. 2008;180:2600-7 pubmed
    ..These findings demonstrate distinctive abnormalities to a model of allergic asthma in the absence of GM-CSF. ..
  11. Walters K, Allan C, Jimenez M, Lim P, Davey R, Zajac J, et al. Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility. Endocrinology. 2007;148:3674-84 pubmed
  12. Ellis J, Miller C, Quinn H, Ryce C, Reichel M. Evaluation of recombinant proteins of Neospora caninum as vaccine candidates (in a mouse model). Vaccine. 2008;26:5989-96 pubmed publisher
    ..The field of vaccines against Neospora-associated abortion in cattle is discussed...
  13. Jackson M, Smith M, Smith S, Jackson C, Xue M, Little C. Activation of cartilage matrix metalloproteinases by activated protein C. Arthritis Rheum. 2009;60:780-91 pubmed publisher
    ..APC could not directly activate proMMP-13, but it was associated with increased MMP-2 and MMP-9 activity. APC may be a relevant activator of MMPs in cartilage and may play a role in progressive cartilage degradation in arthritis...
  14. Hosking B, Stein P. Effect of fasting sheep for a short period on the efficacy and safety of monepantel. Vet Rec. 2009;165:50-2 pubmed
    ..Worm burdens were determined 15 days after the treatments. Fasting or feeding had no statistically significant effects on the efficacy of the monepantel solution against the nematodes, and the period of fasting had no adverse effects...
  15. Corbett M, Akkari P, Domazetovska A, Cooper S, North K, Laing N, et al. An alphaTropomyosin mutation alters dimer preference in nemaline myopathy. Ann Neurol. 2005;57:42-9 pubmed
    ..We suggest this perturbation of tropomyosin isoform levels and dimer preference alters sarcomeric thin filament dynamics and contributes to muscle weakness in nemaline myopathy...