Genomes and Genes
Experts and Doctors on amino acid sequence in Queensland, Australia
Locale: Queensland, Australia
Topic: amino acid sequence
- Pearson M, Pickering D, Tribolet L, Cooper L, Mulvenna J, Oliveira L, et al. Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis. J Infect Dis. 2010;201:1561-9 pubmed publisher..americanus Na-GST-1; antibodies against both chimeras neutralized the enzymatic activity of Na-APR-1. These findings support the incorporation of Na-APR-1 into a multivalent vaccine against hookworm and/or schistosomiasis. ..
- Liu W, Harrison D, Chalupska D, Gornicki P, O donnell C, Adkins S, et al. Single-site mutations in the carboxyltransferase domain of plastid acetyl-CoA carboxylase confer resistance to grass-specific herbicides. Proc Natl Acad Sci U S A. 2007;104:3627-32 pubmed..These mutations are very likely to confer resistance to any grass weed species under selection imposed by the extensive agricultural use of the herbicides. ..
- Mitchell C, Hutton S, Myers G, Brunham R, Timms P. Chlamydia pneumoniae is genetically diverse in animals and appears to have crossed the host barrier to humans on (at least) two occasions. PLoS Pathog. 2010;6:e1000903 pubmed publisher..We identified a separate human lineage present in two Australian Indigenous isolates (independent geographical locations). This lineage is distinct and is present in Australian amphibians as well as a range of Australian marsupials. ..
- Jaumot M, Yan J, Clyde Smith J, Sluimer J, Hancock J. The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase. J Biol Chem. 2002;277:272-8 pubmed..Mutations in the linker domain also suppress the dominant negative phenotype of Ha-RasS17N, indicating that HVR sequences are essential for efficient interaction of Ha-Ras with exchange factors in intact cells. ..
- Deuis J, Dekan Z, Inserra M, Lee T, Aguilar M, Craik D, et al. Development of a ?O-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8. J Biol Chem. 2016;291:11829-42 pubmed publisher..This analogue had increased potency at NaV1.8 and was analgesic in the mouse formalin assay. ..
- Ghai R, Mobli M, Norwood S, Bugarcic A, Teasdale R, King G, et al. Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases. Proc Natl Acad Sci U S A. 2011;108:7763-8 pubmed publisher..In summary, this work defines a novel family of proteins that participate in a network of interactions that will impact on both endosomal protein trafficking and compartment specific Ras signaling cascades. ..
- Sharpe I, Thomas L, Loughnan M, Motin L, Palant E, Croker D, et al. Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA. J Biol Chem. 2003;278:34451-7 pubmed
- Jin A, Dutertre S, Kaas Q, Lavergne V, Kubala P, Lewis R, et al. Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Mol Cell Proteomics. 2013;12:3824-33 pubmed publisher..Together with the variable peptide processing identified previously, background genetic and phenotypic levels of biological messiness in venoms contribute to the hypervariability of venom peptides and their ability to evolve rapidly. ..
- Kuballa A, Merritt D, Elizur A. Gene expression profiling of cuticular proteins across the moult cycle of the crab Portunus pelagicus. BMC Biol. 2007;5:45 pubmed..This study provides a molecular entry path into the investigation of the gene networks associated with cuticle formation. ..
- Rae A, Casu R, Perroux J, Jackson M, Grof C. A soluble acid invertase is directed to the vacuole by a signal anchor mechanism. J Plant Physiol. 2011;168:983-9 pubmed publisher..The results suggest that soluble acid invertase is sorted to the vacuole in a membrane-bound form. ..
- Skwarczynski M, Dougall A, Khoshnejad M, Chandrudu S, Pearson M, Loukas A, et al. Peptide-based subunit vaccine against hookworm infection. PLoS ONE. 2012;7:e46870 pubmed publisher..This approach offers promise for the development of vaccines against helminth parasites of humans and their livestock and companion animals. ..
- Kollipara A, Polkinghorne A, Beagley K, Timms P. Vaccination of koalas with a recombinant Chlamydia pecorum major outer membrane protein induces antibodies of different specificity compared to those following a natural live infection. PLoS ONE. 2013;8:e74808 pubmed publisher..This work paves the way for further refinement of a MOMP-based Chlamydia vaccine that will offer wide cross-protection against the variety of chlamydial infections circulating in wild koala populations. ..
- Jennings M, Anderson J, Beacham I. Cloning and molecular analysis of the Salmonella enterica ansP gene, encoding an L-asparagine permease. Microbiology. 1995;141 ( Pt 1):141-6 pubmed..Strains containing the cloned ansP gene demonstrated a many-fold increase in L-asparagine uptake in comparison with control strains. ..
- Case R, Sharp E, Benned Jensen T, Rosenkilde M, Davis Poynter N, Farrell H. Functional analysis of the murine cytomegalovirus chemokine receptor homologue M33: ablation of constitutive signaling is associated with an attenuated phenotype in vivo. J Virol. 2008;82:1884-98 pubmed..In addition, HCMV UL33 was found to partially compensate for the lack of M33 in vivo, suggesting conserved biological roles of the UL33 gene family...
- Dave K, Whelan F, Bindloss C, Furness S, Chapman Smith A, Whitelaw M, et al. Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications. Mol Cell Proteomics. 2009;8:706-19 pubmed publisher..Furthermore this is only the second report of serine sulfonation of eukaryotic proteins. Mutagenesis studies are underway to assess the functional consequences of these modifications. ..
- Gagen E, Denman S, Padmanabha J, Zadbuke S, Al Jassim R, Morrison M, et al. Functional gene analysis suggests different acetogen populations in the bovine rumen and tammar wallaby forestomach. Appl Environ Microbiol. 2010;76:7785-95 pubmed publisher..The community structures of the acsB and fhs libraries from the rumen and the tammar wallaby forestomach were different (LIBSHUFF, P < 0.001), and these differences may have significance for overall hydrogenotrophy in both ecosystems...
- Simons C, Wolf N, McNeil N, Caldovic L, Devaney J, Takanohashi A, et al. A de novo mutation in the ?-tubulin gene TUBB4A results in the leukoencephalopathy hypomyelination with atrophy of the basal ganglia and cerebellum. Am J Hum Genet. 2013;92:767-73 pubmed publisher..Together, these data demonstrate that a single de novo mutation in TUBB4A results in H-ABC. ..
- Nocillado J, Biran J, Lee Y, Levavi Sivan B, Mechaly A, Zohar Y, et al. The Kiss2 receptor (Kiss2r) gene in Southern Bluefin Tuna, Thunnus maccoyii and in Yellowtail Kingfish, Seriola lalandi - functional analysis and isolation of transcript variants. Mol Cell Endocrinol. 2012;362:211-20 pubmed publisher..This is the first time that transcript variants of the Kiss2r gene that contain deletions and show responsiveness to treatments with kisspeptin have been reported in any teleost...
- Papp L, Lu J, Striebel F, Kennedy D, Holmgren A, Khanna K. The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function. Mol Cell Biol. 2006;26:4895-910 pubmed
- Weil D, Power M, Smith S, Li C. Predominant expression of murine Bmx tyrosine kinase in the granulo-monocytic lineage. Blood. 1997;90:4332-40 pubmed..Our results indicate that Bmx is another member of the Btk/Itk/Tec PTK family, which is predominantly expressed in the granulo-monocytic lineage within the hematopoietic system. ..
- Brown R, Adams J, Pelekanos R, Wan Y, McKinstry W, Palethorpe K, et al. Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat Struct Mol Biol. 2005;12:814-21 pubmed..We propose an activation mechanism involving a relative rotation of subunits within a dimeric receptor as a result of asymmetric placement of the receptor-binding sites on the ligand. ..
- Brown A, Kay G. Bex1, a gene with increased expression in parthenogenetic embryos, is a member of a novel gene family on the mouse X chromosome. Hum Mol Genet. 1999;8:611-9 pubmed
- Short A, Paczkowski N, Vogen S, Sanderson S, Taylor S. Response-selective C5a agonists: differential effects on neutropenia and hypotension in the rat. Br J Pharmacol. 1999;128:511-4 pubmed..These results demonstrate selectivity of a new C5a agonist in vitro, which is paralleled in vivo. The results suggest the possibility of developing selective agonists of C5a for in vivo use in humans. ..
- Geijskes R, Braithwaite K, Dale J, Harding R, Smith G. Sequence analysis of an Australian isolate of sugarcane bacilliform badnavirus. Arch Virol. 2002;147:2393-404 pubmed
- Walker P, Wang Y, Cowley J, McWilliam S, Prehaud C. Structural and antigenic analysis of the nucleoprotein of bovine ephemeral fever rhabdovirus. J Gen Virol. 1994;75 ( Pt 8):1889-99 pubmed publisher..Polyclonal mouse ascitic fluids derived from BEFV, rabies virus and several other related viruses were also shown to cross-react in immunoblots with purified preparations of rabies virus and BEFV N proteins...
- Brooks A, Dai W, O Mara M, Abankwa D, Chhabra Y, Pelekanos R, et al. Mechanism of activation of protein kinase JAK2 by the growth hormone receptor. Science. 2014;344:1249783 pubmed publisher..This model may well generalize to other class I cytokine receptors. ..
- Wade N, Bryant N, Connolly L, Simpson R, Luzio J, Piper R, et al. Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells. J Biol Chem. 2001;276:19820-7 pubmed
- Brooks A, Johansson M, John A, Xu Y, Jans D, Vasudevan S. The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin beta 1 and importin alpha/beta-recognized nuclear localization signals. J Biol Chem. 2002;277:36399-407 pubmed publisher..Intriguingly, the bNLS is highly conserved among Dengue and related flaviviruses, implying a general role for the region and importin beta in the infectious cycle...
- Mudge S, Rae A, Diatloff E, Smith F. Expression analysis suggests novel roles for members of the Pht1 family of phosphate transporters in Arabidopsis. Plant J. 2002;31:341-53 pubmed..These results suggest that this gene family plays a wider role in phosphate uptake and remobilisation throughout the plant than was previously believed. ..
- Hooker C, Scott J, Apolloni A, Parry E, Harrich D. Human immunodeficiency virus type 1 reverse transcription is stimulated by tat from other lentiviruses. Virology. 2002;300:226-35 pubmed..These data highlight the finding that the role of Tat in reverse transcription is not related to trans-activation and demonstrate that other tat genes conserve this function. ..
- Gharahkhani P, O Leary C, Kyaw Tanner M, Sturm R, Duffy D. A non-synonymous mutation in the canine Pkd1 gene is associated with autosomal dominant polycystic kidney disease in Bull Terriers. PLoS ONE. 2011;6:e22455 pubmed publisher..Thus, BTPKD is associated with a missense mutation in Pkd1, and the application of this mutation specific assay could reduce disease transmission by allowing diagnosis of disease in young animals prior to breeding...
- Kann R, Kyaw Tanner M, Seddon J, Lehrbach P, Zwijnenberg R, Meers J. Molecular subtyping of feline immunodeficiency virus from domestic cats in Australia. Aust Vet J. 2006;84:112-6 pubmed..To determine the prevalent subtypes of feline immunodeficiency virus (FIV) present in the domestic cat population of Australia...
- Kerr M, Bennetts J, Simpson F, Thomas E, Flegg C, Gleeson P, et al. A novel mammalian retromer component, Vps26B. Traffic. 2005;6:991-1001 pubmed..Based on these observations, we propose that the mammalian retromer complex is located at both endosomes and the plasma membrane in some cell types. ..
- Day B, To C, Himanen J, Smith F, Nikolov D, Boyd A, et al. Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3. J Biol Chem. 2005;280:26526-32 pubmed
- Norwood S, Shaw D, Cowieson N, Owen D, Teasdale R, Collins B. Assembly and solution structure of the core retromer protein complex. Traffic. 2011;12:56-71 pubmed publisher..Solution studies of the retromer core using small-angle X-ray scattering allow us to propose a model whereby VPS35 forms an extended platform with VPS29 and VPS26 bound at distal ends, with the potential for forming dimeric assemblies. ..
- Kappler U, Bailey S. Molecular basis of intramolecular electron transfer in sulfite-oxidizing enzymes is revealed by high resolution structure of a heterodimeric complex of the catalytic molybdopterin subunit and a c-type cytochrome subunit. J Biol Chem. 2005;280:24999-5007 pubmed..A potential site of electron transfer to an external acceptor cytochrome c was also identified on the SorB subunit on the opposite side to the interaction with the catalytic SorA subunit. ..
- Binks M, Sriprakash K. Characterization of a complement-binding protein, DRS, from strains of Streptococcus pyogenes containing the emm12 and emm55 genes. Infect Immun. 2004;72:3981-6 pubmed..Despite this, the recombinant DRS preparation showed no significant effect on complement function, as determined by lysis of sensitized sheep erythrocytes. Furthermore, the presence of DRS is not inhibitory to SIC activity. ..
- Casu R, Dimmock C, Chapman S, Grof C, McIntyre C, Bonnett G, et al. Identification of differentially expressed transcripts from maturing stem of sugarcane by in silico analysis of stem expressed sequence tags and gene expression profiling. Plant Mol Biol. 2004;54:503-17 pubmed
- Ravipati A, Poth A, Troeira Henriques S, Bhandari M, Huang Y, Niño J, et al. Understanding the Diversity and Distribution of Cyclotides from Plants of Varied Genetic Origin. J Nat Prod. 2017;80:1522-1530 pubmed publisher..This result is consistent with studies suggesting that peptides can undergo deamidation after being subjected to external factors, including pH, temperature, and enzymatic digestion...
- Riddles P, Richards L, Bowles M, Pond S. Cloning and analysis of a cDNA encoding a human liver carboxylesterase. Gene. 1991;108:289-92 pubmed..DNA obtained from a number of human livers and probed with the CE cDNA gave identical hybridization patterns. These patterns were moderately complex by comparison with published data. ..
- Jones R, Jermiin L, Easteal S, Patel B, Beacham I. Amylase and 16S rRNA genes from a hyperthermophilic archaebacterium. J Appl Microbiol. 1999;86:93-107 pubmed..e. an (AMY superfamily) alpha-amylase from Natronococcus...
- Dobson A, Schmidt D, Hughes J. Sequence variation in the melanocortin-1 receptor (MC1R) does not explain continent-wide plumage color differences in the Australian Magpie (Cracticus tibicen). J Hered. 2012;103:769-80 pubmed publisher..Our results suggest that genes or regulatory elements other than MC1R may determine back-color variation in C. tibicen. ..
- Tnimov Z, Guo Z, Gambin Y, Nguyen U, Wu Y, Abankwa D, et al. Quantitative analysis of prenylated RhoA interaction with its chaperone, RhoGDI. J Biol Chem. 2012;287:26549-62 pubmed publisher..We demonstrate that membrane extraction of Rho GTPase by RhoGDI is a thermodynamically favored passive process that operates through a series of progressively tighter intermediates, much like the one that is mediated by RabGDI. ..
- Lee A, Anderson A, Stevens M, Pow D. Exon 4-skipping GLT-1: a new form of an abundantly expressed glutamate transporter. Neurosci Lett. 2011;504:228-31 pubmed publisher..We conclude that exon-4 skipping GLT 1 is abundantly expressed in the brain and may represent either a functional glutamate transporter or a modulator of glutamate transporter function. ..
- Watterson D, Kobe B, Young P. Residues in domain III of the dengue virus envelope glycoprotein involved in cell-surface glycosaminoglycan binding. J Gen Virol. 2012;93:72-82 pubmed publisher..These studies have also demonstrated differential binding between mosquito and human cells...
- Williamson A, Brindley P, Abbenante G, Datu B, Prociv P, Berry C, et al. Hookworm aspartic protease, Na-APR-2, cleaves human hemoglobin and serum proteins in a host-specific fashion. J Infect Dis. 2003;187:484-94 pubmed..americanus cathepsin D, Na-APR-1. Antiserum against Na-APR-2 inhibited migration of 50% of third-stage N. americanus larvae through skin, which suggests that aspartic proteases might be effective vaccines against human hookworm disease...
- Gobius K, Higgs G, Desmarchelier P. Presence of activatable Shiga toxin genotype (stx(2d)) in Shiga toxigenic Escherichia coli from livestock sources. J Clin Microbiol. 2003;41:3777-83 pubmed..Surveillance for STEC strains expressing activatable Stx2d Shiga toxin among clinical cases may indicate the significance of this toxin subtype to human health...
- Barry D, Daly N, Bokesch H, Gustafson K, Craik D. Solution structure of the cyclotide palicourein: implications for the development of a pharmaceutical framework. Structure. 2004;12:85-94 pubmed..The cyclotide core fold, thus, can in principle be used as a framework for the development of useful pharmaceutical and agricultural bioactivities. ..
- Fry B, Scheib H, de L M Junqueira de Azevedo I, Silva D, Casewell N. Novel transcripts in the maxillary venom glands of advanced snakes. Toxicon. 2012;59:696-708 pubmed publisher..The additional complexity of snake venoms has important implications not only for understanding their molecular evolution, but also reinforces the tremendous importance of venoms as a diverse bio-resource...
- Seim I, Collet C, Herington A, Chopin L. Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts. BMC Genomics. 2007;8:298 pubmed..This study reveals several novel aspects of the ghrelin gene and suggests that the ghrelin locus is far more complex than previously recognised. ..
- Dutertre S, Nicke A, Lewis R. Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor. J Biol Chem. 2005;280:30460-8 pubmed
- Southerton S, Marshall H, Mouradov A, Teasdale R. Eucalypt MADS-box genes expressed in developing flowers. Plant Physiol. 1998;118:365-72 pubmed..The possible role of these three genes in eucalypt floral development is discussed...
- Mould J, Yasuda T, Schroeder C, Beedle A, Doering C, Zamponi G, et al. The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels. J Biol Chem. 2004;279:34705-14 pubmed..These results may have implications for the antinociceptive properties of omega-conotoxins, given that the alpha(2)delta subunit is up-regulated in certain pain states. ..