Experts and Doctors on secondary protein structure in Canberra, Australian Capital Territory, Australia


Locale: Canberra, Australian Capital Territory, Australia
Topic: secondary protein structure

Top Publications

  1. Stevenson B, Liu J, Ollis D. Directed evolution of yeast pyruvate decarboxylase 1 for attenuated regulation and increased stability. Biochemistry. 2008;47:3013-25 pubmed publisher
    ..This allowed rapid preparation of libraries for analysis of activity in crude lysates and can be applied to other directed evolution projects. ..
  2. Thorn J, Barton J, Dixon N, Ollis D, Edwards K. Crystal structure of Escherichia coli QOR quinone oxidoreductase complexed with NADPH. J Mol Biol. 1995;249:785-99 pubmed
    ..The overall structure of quinone oxidoreductase shows strong structural homology to that of horse liver alcohol dehydrogenase. ..
  3. Sutherland T, Weisman S, Trueman H, Sriskantha A, Trueman J, Haritos V. Conservation of essential design features in coiled coil silks. Mol Biol Evol. 2007;24:2424-32 pubmed publisher
    ..Despite a high background level of sequence diversity, we have identified conserved design elements that we propose are essential to the assembly and function of coiled coil silks...
  4. Kim H, Liu J, Carr P, Ollis D. Following directed evolution with crystallography: structural changes observed in changing the substrate specificity of dienelactone hydrolase. Acta Crystallogr D Biol Crystallogr. 2005;61:920-31 pubmed
    ..This rotation of the inhibitor caused the displacement of a large section of a loop on one side of the active site. Residues that could stabilize the transition state for the reaction were identified. ..
  5. Fan J, Rangasamy D, Luger K, Tremethick D. H2A.Z alters the nucleosome surface to promote HP1alpha-mediated chromatin fiber folding. Mol Cell. 2004;16:655-61 pubmed
    ..Z (the acidic patch). This shows that the surface of the nucleosome can regulate the formation of distinct higher order chromatin structures mediated by an architectural chromatin binding protein. ..
  6. Martin R, Kirk K. The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily. Mol Biol Evol. 2004;21:1938-49 pubmed
  7. Hamdan S, Carr P, Brown S, Ollis D, Dixon N. Structural basis for proofreading during replication of the Escherichia coli chromosome. Structure. 2002;10:535-46 pubmed
    ..These data are used to develop a mechanism for epsilon and to produce a plausible model of the complex of epsilon186 with DNA. ..
  8. Gustiananda M, Haris P, Milburn P, Gready J. Copper-induced conformational change in a marsupial prion protein repeat peptide probed using FTIR spectroscopy. FEBS Lett. 2002;512:38-42 pubmed
    ..The copper-induced conformational change is pH dependent, and occurs at pH >7...
  9. Keniry M, Berthon H, Yang J, Miles C, Dixon N. NMR solution structure of the theta subunit of DNA polymerase III from Escherichia coli. Protein Sci. 2000;9:721-33 pubmed
    ..Preliminary chemical shift mapping experiments with a domain of the epsilon subunit have identified a loop region (Ala20-Glu29) in theta as the site of association with epsilon. ..

More Information


  1. Board P, Coggan M, Chelvanayagam G, Easteal S, Jermiin L, Schulte G, et al. Identification, characterization, and crystal structure of the Omega class glutathione transferases. J Biol Chem. 2000;275:24798-806 pubmed
    ..Unlike other mammalian GSTs, GSTO 1-1 appears to have an active site cysteine that can form a disulfide bond with glutathione. ..
  2. Maleszka R, Lupas A, Hanes S, Miklos G. The dodo gene family encodes a novel protein involved in signal transduction and protein folding. Gene. 1997;203:89-93 pubmed
    ..The genetic, molecular, biochemical and structural data are reviewed in the context of the potential biological properties of this new protein family. ..
  3. Edwards K, Ollis D, Dixon N. Crystal structure of cytoplasmic Escherichia coli peptidyl-prolyl isomerase: evidence for decreased mobility of loops upon complexation. J Mol Biol. 1997;271:258-65 pubmed
    ..There is evidence to suggest that two surface loops have significantly reduced mobility in the complexed structure. ..
  4. Webb D, Rosenberg H, Cox G. Mutational analysis of the Escherichia coli phosphate-specific transport system, a member of the traffic ATPase (or ABC) family of membrane transporters. A role for proline residues in transmembrane helices. J Biol Chem. 1992;267:24661-8 pubmed
    ..The double mutation in the PstA protein resulted in a permanently "closed" system, whereas the double mutation in the PstC protein resulted in a permanently "open" transport system...
  5. Zuegg J, Gready J. Molecular dynamics simulations of human prion protein: importance of correct treatment of electrostatic interactions. Biochemistry. 1999;38:13862-76 pubmed
    ..2 for ShPrP and 4.5 for mouse PrP). ..
  6. Hayden C, Mackenzie A, Skotnicki M, Gibbs A. Turnip yellow mosaic virus isolates with experimentally produced recombinant virion proteins. J Gen Virol. 1998;79 ( Pt 2):395-403 pubmed
    ..The recently published structure of the TYMV VP determined by X-ray crystallography confirms the accuracy of the predicted secondary structure of the VP, and hence the utility of the methods used. ..
  7. Delhaize E, Gruber B, Ryan P. The roles of organic anion permeases in aluminium resistance and mineral nutrition. FEBS Lett. 2007;581:2255-62 pubmed
    ..We review the roles of these proteins in Al(3+) resistance as well as their roles in other aspects of mineral nutrition...
  8. Hewawasam R, Liu D, Casarotto M, Dulhunty A, Board P. The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor. Biochem Pharmacol. 2010;80:381-8 pubmed publisher