Genomes and Genes
Experts and Doctors on protein binding in Anguilla
Topic: protein binding
Publications180 found, 100 shown here
- Chen J, Xie Z, Wu Y. Study of protein structural deformations under external mechanical perturbations by a coarse-grained simulation method. Biomech Model Mechanobiol. 2016;15:317-29 pubmed publisher..Our simulation results show that mechanical properties of adherens junctions are functionally important to cell adhesion. ..
- Kil K, Poutiainen P, Zhang Z, Zhu A, Kuruppu D, Prabhakar S, et al. Synthesis and evaluation of N-(methylthiophenyl)picolinamide derivatives as PET radioligands for metabotropic glutamate receptor subtype 4. Bioorg Med Chem Lett. 2016;26:133-9 pubmed publisher..Therefore, [(11)C]11 will be a useful radioligand to investigate mGlu4 in different biological applications. ..
- Wang H, Matsumura P. Characterization of the CheAS/CheZ complex: a specific interaction resulting in enhanced dephosphorylating activity on CheY-phosphate. Mol Microbiol. 1996;19:695-703 pubmed..Finally, the CheAS/CheZ complex formed in vitro shows a greater dephosphorylating activity on CheY-P than does free CheZ. ..
- Webb B, Cox M, Inman R. Recombinational DNA repair: the RecF and RecR proteins limit the extension of RecA filaments beyond single-strand DNA gaps. Cell. 1997;91:347-56 pubmed..These observations are incorporated into an expanded model for the functions of RecF, RecO, and RecR proteins in the early stages of postreplication DNA repair. ..
- Golstein P, Boom A, van Geffel J, Jacobs P, Masereel B, Beauwens R. P-glycoprotein inhibition by glibenclamide and related compounds. Pflugers Arch. 1999;437:652-60 pubmed
- Rousseau J, Tetu B, Caron D, Malenfant P, Cattaruzzi P, Audette M, et al. RCAS1 is associated with ductal breast cancer progression. Biochem Biophys Res Commun. 2002;293:1544-9 pubmed..In addition, RCAS1 was identified in MCF7 culture supernatants. Those observations suggest that RCAS1 is a new marker for breast cancer progression and a possible mechanism for breast cancer immune escape. ..
- Presnell S, Stafford D. The vitamin K-dependent carboxylase. Thromb Haemost. 2002;87:937-46 pubmed
- Bondar T, Kalinina A, Khair L, Kopanja D, Nag A, Bagchi S, et al. Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome. Mol Cell Biol. 2006;26:2531-9 pubmed..Moreover, we provide evidence for a physical association between Cul4A, DDB1, and Skp2. We speculate that the F-box protein Skp2, in addition to utilizing Cul1-Skp1, utilizes Cul4A-DDB1 to induce proteolysis of p27Kip1. ..
- Fang W, Goldberg M, Pohl N, Bi X, Tong C, Xiong B, et al. Functional and physical interaction between the selenium-binding protein 1 (SBP1) and the glutathione peroxidase 1 selenoprotein. Carcinogenesis. 2010;31:1360-6 pubmed publisher..The results presented establish an interaction between two distinct selenium-containing proteins that may enhance the understanding of the mechanisms by which selenium and selenoproteins affect carcinogenesis in humans. ..
- Piao J, Tsuji K, Ochi H, Iwata M, Koga D, Okawa A, et al. Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling. Sci Rep. 2013;3:3022 pubmed publisher..ChIP assay revealed the affinity of ATF4 to the Ihh promoter was markedly decreased by Sirt6 knockdown. These data indicate Sirt6 directly controls proliferation and differentiation of chondrocytes...
- Lin S, Ho C, Chuo W, Li S, Wang T, Lin C. Effective inhibition of MERS-CoV infection by resveratrol. BMC Infect Dis. 2017;17:144 pubmed publisher..In this study, we first demonstrated that resveratrol is a potent anti-MERS agent in vitro. We perceive that resveratrol can be a potential antiviral agent against MERS-CoV infection in the near future. ..
- Cornelissen C, Sparling P. Binding and surface exposure characteristics of the gonococcal transferrin receptor are dependent on both transferrin-binding proteins. J Bacteriol. 1996;178:1437-44 pubmed..These observations indicate that Tbp1 and Tbp2 function together in the wild-type strain to evoke binding conformations that are distinct from those expressed by the mutants lacking either protein. ..
- Soares R, Siqueira C, Bruno L, Oppenheim F, Offner G, Troxler R. MG2 and lactoferrin form a heterotypic complex in salivary secretions. J Dent Res. 2003;82:471-5 pubmed..This complex may enhance the properties of these salivary components in the oral environment. ..
- Schmitz U, James T, Lukavsky P, Walter P. Structure of the most conserved internal loop in SRP RNA. Nat Struct Biol. 1999;6:634-8 pubmed..The structure completely explains the phylogenetic conservation of the loop bases, underlining its importance for SRP54 binding and SRP function. ..
- Huang N, Kalyanaraman C, Irwin J, Jacobson M. Physics-based scoring of protein-ligand complexes: enrichment of known inhibitors in large-scale virtual screening. J Chem Inf Model. 2006;46:243-53 pubmed..We also present anecdotal but encouraging results assessing the ability of the rescoring method to predict specificity of inhibitors for structurally related proteins. ..
- Viriyakosol S, Tobias P, Kitchens R, Kirkland T. MD-2 binds to bacterial lipopolysaccharide. J Biol Chem. 2001;276:38044-51 pubmed..These data indicate that MD-2 is a genuine LPS-binding protein and strongly suggest that MD-2 could play a role in regulation of cellular activation by LPS depending on its local availability. ..
- Kashentseva E, Seki T, Curiel D, Dmitriev I. Adenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomain. Cancer Res. 2002;62:609-16 pubmed..The use of recombinant trimeric sCAR-scFv adapter proteins may augment Ad vector potency for targeting cancer cell types. ..
- Won M, Park S, Hoe K, Jang Y, Chung K, Kim D, et al. Rkp1/Cpc2, a fission yeast RACK1 homolog, is involved in actin cytoskeleton organization through protein kinase C, Pck2, signaling. Biochem Biophys Res Commun. 2001;282:10-5 pubmed..We propose that Rkp1/Cpc2 may function as a receptor for Pck2 in the regulation of actin cytoskeleton organization during cell wall synthesis and morphogenesis of Schizosaccharomyces pombe. ..
- Deng W, Tang S, Tseng H, Wu K. Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding. Blood. 2006;108:518-24 pubmed..These results suggest that melatonin inhibits COX-2 and iNOS transcriptional activation by inhibiting p300 HAT activity, thereby suppressing p52 acetylation, binding, and transactivation. ..
- Stinson M, McLaughlin R, Choi S, Juarez Z, Barnard J. Streptococcal histone-like protein: primary structure of hlpA and protein binding to lipoteichoic acid and epithelial cells. Infect Immun. 1998;66:259-65 pubmed..These results support a potential role for HlpA in the pathogenesis of streptococcus-induced tissue inflammation...
- Kaartinen V, Haataja L, Nagy A, Heisterkamp N, Groffen J. TGFbeta3-induced activation of RhoA/Rho-kinase pathway is necessary but not sufficient for epithelio-mesenchymal transdifferentiation: implications for palatogenesis. Int J Mol Med. 2002;9:563-70 pubmed..These changes are likely to be necessary in biological processes in which EMT has been shown to play a critical role, such as palatal fusion. ..
- Triolo T, Sternglanz R. Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing. Nature. 1996;381:251-3 pubmed..Here we report that SIR1 can bind directly to ORC1, the largest of the ORC subunits, and that targeting of SIR1 to ORC1 at a silencer is sufficient to establish a silenced state. ..
- Cho H, Oh Y, Kwon J, Kwon J, Kim K, Kim H. c-Myc stimulates cell invasion by inhibiting FBX8 function. Mol Cells. 2010;30:355-62 pubmed publisher..Together, these results suggest that FBX8 is a novel c-Myc binding protein and that c-Myc induces cell invasive activity through the inhibition of FBX8 effects on ARF6 function during cell invasion. ..
- Lehrer R, Jung G, Ruchala P, Andre S, Gabius H, Lu W. Multivalent binding of carbohydrates by the human alpha-defensin, HD5. J Immunol. 2009;183:480-90 pubmed publisher..Self-association and multivalent binding may play integral roles in the ability of HD5 to protect against infections caused by viruses and other infectious agents. ..
- McKethan B, Spiro S. Cooperative and allosterically controlled nucleotide binding regulates the DNA binding activity of NrdR. Mol Microbiol. 2013;90:278-89 pubmed publisher..We propose a model in which NrdR selectively binds (deoxy)nucleoside triphosphates, which are hydrolysed to their monophosphate counterparts in order to regulate DNA binding...
- Zhu X, Amsler C, Volz K, Matsumura P. Tyrosine 106 of CheY plays an important role in chemotaxis signal transduction in Escherichia coli. J Bacteriol. 1996;178:4208-15 pubmed..These data also suggest that the binding of phosphoryl-CheY to the flagellar motor is a necessary, but not sufficient, event for signal transduction. ..
- Schalinske K, Anderson S, Tuazon P, Chen O, Kennedy M, Eisenstein R. The iron-sulfur cluster of iron regulatory protein 1 modulates the accessibility of RNA binding and phosphorylation sites. Biochemistry. 1997;36:3950-8 pubmed..Taken together, our results indicate that significant structural changes occur in IRP1 during cluster insertion or removal that affect the accessibility to RNA binding and phosphorylation sites. ..
- Bodine S, Latres E, Baumhueter S, Lai V, Nunez L, Clarke B, et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 2001;294:1704-8 pubmed..Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx or MuRF1 were found to be resistant to atrophy. These proteins are potential drug targets for the treatment of muscle atrophy. ..
- Yegneswaran S, Nguyen P, Gale A, Griffin J. Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C. Thromb Haemost. 2009;101:55-61 pubmed..Only following FII activation and dissociation of the FII Gla domain fragments from the FII-ase complex, can APC inactivate FVa and down-regulate thrombin generation. ..
- Davies C, Chakraborty A, Cipriani F, Haigh K, Haigh J, Behrens A. Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation. Nat Cell Biol. 2010;12:963-72 pubmed publisher..Thus RACO-1 is a co-activator that links c-Jun to growth factor signalling and is essential for AP-1 function in proliferation. ..
- Das A, Acharya S, Gottipati K, McKnight J, Chandru H, Alcorn J, et al. Thyroid transcription factor-1 (TTF-1) gene: identification of ZBP-89, Sp1, and TTF-1 sites in the promoter and regulation by TNF-? in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011;301:L427-40 pubmed publisher..Because TTF-1 serves as a positive regulator for surfactant protein gene expression, TNF-? inhibition of TTF-1 expression could have important implications for the reduction of surfactant protein levels in diseases such as ARDS. ..
- Liebl D, Koo P. Serotonin-activated alpha 2-macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons. J Neurosci Res. 1993;35:170-82 pubmed..In addition, higher concentrations of such complexes can seriously damage certain CNS neurons which do not depend solely on NGF for survival. ..
- Paul S, Weiskopf D, Angelo M, Sidney J, Peters B, Sette A. HLA class I alleles are associated with peptide-binding repertoires of different size, affinity, and immunogenicity. J Immunol. 2013;191:5831-9 pubmed publisher..Finally, we investigated the genetic and structural basis of the phenomenon. Although no stringent correlate was defined, on average HLA B alleles are associated with significantly narrower repertoires than are HLA A alleles. ..
- Lin B, Makhov A, Griffith J, Broker T, Chow L. Chaperone proteins abrogate inhibition of the human papillomavirus (HPV) E1 replicative helicase by the HPV E2 protein. Mol Cell Biol. 2002;22:6592-604 pubmed..An E1 mutation in the ATP binding site caused deficient binding and unwinding of origin DNA, indicating the importance of ATP binding in efficient helicase assembly on the origin. ..
- Boukhelifa M, Parast M, Bear J, Gertler F, Otey C. Palladin is a novel binding partner for Ena/VASP family members. Cell Motil Cytoskeleton. 2004;58:17-29 pubmed..These results suggest that the recently described actin-associated protein palladin may play an important role in recruiting VASP to sites of actin filament growth, anchorage, and crosslinking. ..
- Hong S, Lee M, Cheong J. Functional interaction of transcriptional coactivator ASC-2 and C/EBPalpha in granulocyte differentiation of HL-60 promyelocytic cell. Biochem Biophys Res Commun. 2001;282:1257-62 pubmed
- Johnston L, Yoshino T. Larval Schistosoma mansoni excretory-secretory glycoproteins (ESPs) bind to hemocytes of Biomphalaria glabrata (Gastropoda) via surface carbohydrate binding receptors. J Parasitol. 2001;87:786-93 pubmed..mansoni larval ESPs likely represent a multiple receptor-ligand system. Previously reported findings of differential effects of ESPs on a variety of in vitro hemocyte functions are consistent with such a hypothesis. ..
- Kim C, Xiong W, Mei L. Regulation of MuSK expression by a novel signaling pathway. J Biol Chem. 2003;278:38522-7 pubmed..Rather, MuSK expression is increased in muscle cells stimulated with Wnt or at conditions when the Wnt signaling was activated. These results suggest a novel mechanism for the MuSK synapse-specific expression. ..
- Kim H, Kim J, Park Y, Choi H. Synergistic activation of the human orphan nuclear receptor SHP gene promoter by basic helix-loop-helix protein E2A and orphan nuclear receptor SF-1. Nucleic Acids Res. 2003;31:6860-72 pubmed..Our findings suggest that the E2A proteins differentially regulate the human and mouse SHP promoters and cooperate with orphan nuclear receptor SF-1 for transcriptional activation of the hSHP promoter. ..
- Lemoff A, Williams E. Binding energies of water to lithiated valine: formation of solution-phase structure in vacuo. J Am Soc Mass Spectrom. 2004;15:1014-24 pubmed..e., valine is zwitterionic with three water molecules. The agreement between the experimentally determined and calculated binding energies is good for all the clusters, with deviations of <== 0.12 eV. ..
- Karbstein K, Doudna J. GTP-dependent formation of a ribonucleoprotein subcomplex required for ribosome biogenesis. J Mol Biol. 2006;356:432-43 pubmed..This quantitative description of an early and essential step in pre-ribosome assembly provides a framework for elucidating the network of interactions between the Bms1 subcomplex and additional factors involved in ribosome biogenesis. ..
- Chi W, Jin X, Jung S, Oh E, Hong S. Characterization of Sgr3394 produced only by the A-factor-producin Streptomyces griseus IFO 13350, not by the A-factor deficient mutant. J Microbiol. 2011;49:155-60 pubmed publisher..8 and 1.1 times those observed in the control, respectively, suggesting that overexpression of sgr3394 can stimulate secondary metabolism, especially actinorhodin biosynthesis, in S. lividans and S. coelicolor. ..
- Leem Y, Choi H, Jung S, Kim B, Lee K, Yoon K, et al. Esco2 promotes neuronal differentiation by repressing Notch signaling. Cell Signal. 2011;23:1876-84 pubmed publisher..Taken together, our study suggests that Esco2 may play an important role in neurogenesis by attenuating Notch signaling to promote neuronal differentiation...
- Chen X, Kong X, Zhuang W, Teng B, Yu X, Hua S, et al. Dynamic changes in protein interaction between AKAP95 and Cx43 during cell cycle progression of A549 cells. Sci Rep. 2016;6:21224 pubmed publisher..dynamic interaction between AKAP95 and Cx43 varies with cell cycle progression to regulate multiple biological processes. ..
- Jezewska M, Bujalowski W. Global conformational transitions in Escherichia coli primary replicative helicase DnaB protein induced by ATP, ADP, and single-stranded DNA binding. Multiple conformational states of the helicase hexamer. J Biol Chem. 1996;271:4261-5 pubmed
- Lacombe A, Lee H, Zahed L, Choucair M, Muller J, Nelson S, et al. Disruption of POF1B binding to nonmuscle actin filaments is associated with premature ovarian failure. Am J Hum Genet. 2006;79:113-9 pubmed..Our study suggests that a homozygous point mutation in POF1B influences the pathogenesis of POF by altering POF1B binding to nonmuscle actin filaments. ..
- Herrick D, Kuo W, Huang H, Schwieters C, Ellena J, Cafiso D. Solution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridging. J Mol Biol. 2009;390:913-23 pubmed publisher..The result suggests that syt1 functions to bridge across the vesicle and plasma membrane surfaces in a Ca(2+)-dependent manner. ..
- Lee R, Gam J, Moon J, Lee S, Suh Y, Lee B, et al. A critical element of the light-induced quaternary structural changes in YtvA-LOV. Protein Sci. 2015;24:1997-2007 pubmed publisher..Our results demonstrate an alternative way of photo-induced signal propagation that leads to a bigger functional response through dimer/monomer conversions of the YtvA-LOV than the local disruption of JÎ± helix in the As-LOV domain. ..
- Mosammaparast N, Jackson K, Guo Y, Brame C, Shabanowitz J, Hunt D, et al. Nuclear import of histone H2A and H2B is mediated by a network of karyopherins. J Cell Biol. 2001;153:251-62 pubmed..These data suggest that the import of H2A and H2B is mediated by a network of Kaps, in which Kap114p may play the major role. ..
- Yu X, Ling E, Tracy M, Zhu Y. Immulectin-4 from the tobacco hornworm Manduca sexta binds to lipopolysaccharide and lipoteichoic acid. Insect Mol Biol. 2006;15:119-28 pubmed..IML-4 agglutinated bacteria and yeast, and agglutination of Escherichia coli by IML-4 was concentration- and calcium-dependent. IML-4 also enhanced haemocyte encapsulation and melanization. ..
- Shani G, Fischer W, Justice N, Kelber J, Vale W, Gray P. GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Mol Cell Biol. 2008;28:666-77 pubmed..Together, our results indicate that these proteins bind at the cell surface to enhance tumor growth via the inhibition of TGF-beta signaling. ..
- Hu G, Chen L. In silico experiments of single-chain antibody fragment against drugs of abuse. Biophys Chem. 2010;153:97-103 pubmed publisher..These experiments lead to the theoretical prediction of absolute binding energies of METH and AMP that are in agreement with the in vitro experimental results. ..
- Batra J, Tripathi S, Kumar A, Katz J, Cox N, Lal R, et al. Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins. Sci Rep. 2016;6:19063 pubmed publisher..These studies demonstrate an important role for cellular chaperone Hsp40/DnaJB1 in influenza A virus life cycle by assisting nuclear trafficking of viral ribonucleoproteins. ..
- Park J, Bae Y. Phosphorylation of ribosomal protein L5 by protein kinase CKII decreases its 5S rRNA binding activity. Biochem Biophys Res Commun. 1999;263:475-81 pubmed..Based on our present results, we suggest that the phosphorylation of L5 by CKII is one of the mechanisms that regulates nucleolar targeting of 5S rRNA and/or ribosome assembly in the cell. ..
- Sakamoto K, Kim K, Kumagai A, Mercurio F, Crews C, Deshaies R. Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation. Proc Natl Acad Sci U S A. 2001;98:8554-9 pubmed..In the future, this approach may be useful for conditional inactivation of proteins, and for targeting disease-causing proteins for destruction. ..
- Faure G, Copic A, Le Porrier S, Gubensek F, Bon C, Krizaj I. Crotoxin acceptor protein isolated from Torpedo electric organ: binding properties to crotoxin by surface plasmon resonance. Toxicon. 2003;41:509-17 pubmed..4 nM was calculated for the interaction of pure CAPT and crotoxin from the dissociation rate constant (k(off)=1.2 x 10(-2)s(-1)) and the association rate constant (k(on)=3.5 x 10(6)M(-1)s(-1))...
- Vigerust D, Vick S, Shepherd V. Characterization of functional mannose receptor in a continuous hybridoma cell line. BMC Immunol. 2012;13:51 pubmed publisher..This cell line provides an important cell model for other researchers for the study of human MR biology and host-pathogen interactions. ..
- Kang K, Guo K, Tang Q, Zhang Y, Wu J, Li W, et al. Interactive cellular proteins related to classical swine fever virus non-structure protein 2 by yeast two-hybrid analysis. Mol Biol Rep. 2012;39:10515-24 pubmed publisher..However, the CSFV NS2 interactive proteins in the SUVEC cDNA library obtained in the current study provides valuable information for gaining a better understanding of the host protein-virus interactions of the CSFV NS2 protein. ..
- Frank D, Saecker R, Bond J, Capp M, Tsodikov O, Melcher S, et al. Thermodynamics of the interactions of lac repressor with variants of the symmetric lac operator: effects of converting a consensus site to a non-specific site. J Mol Biol. 1997;267:1186-206 pubmed..We propose that this variant-specific behavior arises from a strong effect of operator sequence on the extent of induced conformational changes in the protein (and possibly also in the DNA site) which accompany binding. ..
- Yu S, Roth M. Casein kinase I regulates membrane binding by ARF GAP1. Mol Biol Cell. 2002;13:2559-70 pubmed..Thus, a CKI isoform is required for protein traffic through the early secretory pathway and can modulate the amount of ARF GAP1 that can bind to membranes. ..
- Heo T, Lee S, Bartosch B, Cosset F, Kang C. Hepatitis C virus E2 links soluble human CD81 and SR-B1 protein. Virus Res. 2006;121:58-64 pubmed..These data further elucidate our understanding of HCV entry and provide new insight into directing future studies identifying novel liver-specific fusion receptor(s). ..
- Shumway S, Li Y, Xiong Y. 14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin. J Biol Chem. 2003;278:2089-92 pubmed..We suggest that 14-3-3 proteins interact with the TSC1-TSC2 complex and negatively regulate the function of the TSC proteins. ..
- Marchal L, Ulijn R, De Gooijer C, Franke G, Tramper J. Monte Carlo simulation of the alpha-amylolysis of amylopectin potato starch. 2. alpha-amylolysis of amylopectin. Bioprocess Biosyst Eng. 2003;26:123-32 pubmed..The advantage of this type of modeling over a regular fit is the additional information about all the saccharides produced during hydrolysis, including the ones that are difficult to measure experimentally. ..
- Manders P, Tjan Heijnen V, Span P, Grebenchtchikov N, Geurts Moespot A, van Tienoven D, et al. The complex between urokinase-type plasminogen activator (uPA) and its type-1 inhibitor (PAI-I) independently predicts response to first-line endocrine therapy in advanced breast cancer. Thromb Haemost. 2004;91:514-21 pubmed..Further studies are warranted to explain this underlying resistance to endocrine therapy when uPA:PAI-I levels are high. ..
- Davies B, Wang H, Rine J. Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae: similar activation/regulatory domains but different response mechanisms. Mol Cell Biol. 2005;25:7375-85 pubmed..However, induction resulted in decreased Ecm22p levels and a corresponding decrease in the amount of Ecm22p bound to promoters. Thus, these two activators differ in their contributions to the regulation of their targets. ..
- Mendonsa R, Engebrecht J. Phosphatidylinositol-4,5-bisphosphate and phospholipase D-generated phosphatidic acid specify SNARE-mediated vesicle fusion for prospore membrane formation. Eukaryot Cell. 2009;8:1094-105 pubmed publisher..These data suggest that PLD-generated PA and PI(4,5)P(2) collaborate at multiple levels to promote SNARE-mediated fusion for PSM formation. ..
- Li C, Zhang Y, Yang Q, Ye F, Sun S, Chen E, et al. NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity. Sci Rep. 2016;6:18773 pubmed publisher..Hence, this study provides new insights into the function of NuSAP in spindle formation during mitosis. ..
- Scoles D, Huynh D, Chen M, Burke S, Gutmann D, Pulst S. The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate. Hum Mol Genet. 2000;9:1567-74 pubmed..The identification of schwannomin as a HRS interactor implicates schwannomin in HRS-mediated cell signaling. ..
- Parker M, Brouillette C, Prevelige P. Kinetic and calorimetric evidence for two distinct scaffolding protein binding populations within the bacteriophage P22 procapsid. Biochemistry. 2001;40:8962-70 pubmed..A mutant scaffolding protein that forms covalent dimers (R74C/L177I) bound only to the high-affinity sites. These data comprise the first quantitative measurements of the energetics of the coat protein/scaffolding protein interaction...
- Li J, Cheng X, Lee J. Structure and dynamics of the modular halves of Escherichia coli cyclic AMP receptor protein. Biochemistry. 2002;41:14771-8 pubmed..The acquisition of this unique property is intimately associated with the dynamics of the molecule. ..
- Hartsel S, Weiland T. Amphotericin B binds to amyloid fibrils and delays their formation: a therapeutic mechanism?. Biochemistry. 2003;42:6228-33 pubmed..In kinetic fibril formation studies, AmB was able to significantly kinetically delay the formation of Abeta 25-35 fibrils at pH 7.4 but not insulin fibrils at pH 2. ..
- Dyer C, Dahlquist F. Switched or not?: the structure of unphosphorylated CheY bound to the N terminus of FliM. J Bacteriol. 2006;188:7354-63 pubmed..Additionally, this structure provides a high-resolution view of an intermediate conformation of a response regulator protein, which had been generally assumed to be two state. ..
- Chiu H, Johnson E, Schr der I, Rees D. Crystal structures of a novel ferric reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus and its complex with NADP+. Structure. 2001;9:311-9 pubmed..This structural information helps identify roles for specific residues during the reduction of ferric iron complexes by the A. fulgidus FeR...
- Wu X, Chang A, Sudol M, Hanes S. Genetic interactions between the ESS1 prolyl-isomerase and the RSP5 ubiquitin ligase reveal opposing effects on RNA polymerase II function. Curr Genet. 2001;40:234-42 pubmed..The results suggest a model in which Essl and Rsp5 act opposingly on pol II function to control the level of pol II available for transcription. ..
- Sakamoto K, Kim K, Verma R, Ransick A, Stein B, Crews C, et al. Development of Protacs to target cancer-promoting proteins for ubiquitination and degradation. Mol Cell Proteomics. 2003;2:1350-8 pubmed..Future improvements to this technology may yield a general approach to treat a number of human diseases, including cancer. ..
- Feng P, Everly D, Read G. mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. J Virol. 2005;79:9651-64 pubmed..The data suggest a mechanism for linking the degradation of an mRNA to its translation and for targeting Vhs to mRNAs and to regions of translation initiation. ..
- Kim J, Han D, Kim J, Lee S, Kim S, Woo J, et al. PPAR gamma partial agonist, KR-62776, inhibits adipocyte differentiation via activation of ERK. Cell Mol Life Sci. 2009;66:1766-81 pubmed publisher..These results support the conclusion that the localization of PPAR gamma is one of the key factors explaining the biological responses of the ligands...
- Li G, Li W, Angelastro J, Greene L, Liu D. Identification of a novel DNA binding site and a transcriptional target for activating transcription factor 5 in c6 glioma and mcf-7 breast cancer cells. Mol Cancer Res. 2009;7:933-43 pubmed publisher..These data provide new insight on the mechanisms by which ATF5 promotes gene regulation and cancer-specific cell survival. ..
- Petukhova G, Stratton S, Sung P. Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins. Nature. 1998;393:91-4 pubmed..We conclude that Rad54 acts to overcome kinetic impediments that would limit homologous DNA pairing between recombining chromosomes in vivo. ..
- Lee Y, Liu B. Identification of a phragmoplast-associated kinesin-related protein in higher plants. Curr Biol. 2000;10:797-800 pubmed..Our results provide evidence that AtPAKRP1 is a hitherto unknown motor that may take part in the establishment and/or maintenance of the phragmoplast microtubule array. ..
- Li Y, Spangenberg O, Paarmann I, Konrad M, Lavie A. Structural basis for nucleotide-dependent regulation of membrane-associated guanylate kinase-like domains. J Biol Chem. 2002;277:4159-65 pubmed..These conformational changes may act to regulate hCASK-GK function in a nucleotide-dependent manner. ..
- de Haan E, Wauben M, Grosfeld Stulemeyer M, Kruijtzer J, Liskamp R, Moret E. Major histocompatibility complex class II binding characteristics of peptoid-peptide hybrids. Bioorg Med Chem. 2002;10:1939-45 pubmed..We conclude that the side chain position as well as the backbone nitrogen atom hydrogen bonding features of solvent-exposed residues in the peptide can be important for MHC binding affinity. ..
- Maiyar A, Leong M, Firestone G. Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain. Mol Biol Cell. 2003;14:1221-39 pubmed..Our results define a new role importin-alpha in the stimulus-dependent control of signal transduction by nuclear localized protein kinases. ..
- Zhou C, Wong O, Masters J, Williamson M. Effect of cancer-associated mutations in the PlexinB1 gene. Mol Cancer. 2012;11:11 pubmed publisher..PlexinB1 mutations block plexinB1-mediated signalling pathways that inhibit cell motility. ..
- Ďuriš A, Daïch A, Santos C, Fleury L, Ausseil F, Rodriguez F, et al. Asymmetric Synthesis and Binding Study of New Long-Chain HPA-12 Analogues as Potent Ligands of the Ceramide Transfer Protein CERT. Chemistry. 2016;22:6676-86 pubmed publisher..In silico studies were used to rationalized these trends, leading to a model of protein recognition coherent with the stronger binding of (1R,3S)-syn HPAs. ..
- Beamer L, Carroll S, Eisenberg D. The BPI/LBP family of proteins: a structural analysis of conserved regions. Protein Sci. 1998;7:906-14 pubmed..A model of human LBP derived from the BPI structure provides a rational basis for future experiments, such as site-directed mutagenesis and inhibitor design. ..
- Kim D, Sarbassov D, Ali S, Latek R, Guntur K, Erdjument Bromage H, et al. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell. 2003;11:895-904 pubmed..Thus, we propose that the opposing effects on mTOR activity of the GbetaL- and raptor-mediated interactions regulate the mTOR pathway. ..
- Jou I, Lee J, Park S, Yoon H, Joe E, Park E. Gangliosides trigger inflammatory responses via TLR4 in brain glia. Am J Pathol. 2006;168:1619-30 pubmed..Taken together, these results suggest that TLR4 may provide an explanation for the pathological ability of gangliosides to cause inflammatory conditions in the brain. ..
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