Experts and Doctors on mice in Anguilla


Locale: Anguilla
Topic: mice

Top Publications

  1. Lin Q, Taniuchi I, Kitamura D, Wang J, Kearney J, Watanabe T, et al. T and B cell development in BP-1/6C3/aminopeptidase A-deficient mice. J Immunol. 1998;160:4681-7 pubmed
    ..These findings indicate that BP-1 ectoenzyme activity is not essential for normal B and T cell development. ..
  2. Xie W, Chow L, Paterson A, Chin E, Kudlow J. Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFalpha expression in transgenic mice. Oncogene. 1999;18:3593-607 pubmed
  3. Lundberg A, Granger N, Russell J, Callicutt S, Gaber L, Kotb M, et al. Temporal correlation of tumor necrosis factor-alpha release, upregulation of pulmonary ICAM-1 and VCAM-1, neutrophil sequestration, and lung injury in diet-induced pancreatitis. J Gastrointest Surg. 2000;4:248-57 pubmed
    ..The adhesion molecule axis may be a potential target for practical intervention to ameliorate lung injury and morbidity in acute pancreatitis. ..
  4. Hu J, Zhang C, Sun X, Yang Y, Cao X, Ryu O, et al. Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors. Gene. 2000;251:1-8 pubmed
    ..This pattern supports a role for the PRSS17 protein in the degradation of enamel proteins. ..
  5. Bain G, Cravatt C, Loomans C, Alberola Ila J, Hedrick S, Murre C. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade. Nat Immunol. 2001;2:165-71 pubmed
    ..Activation of Id3 transcription is regulated in a dose-dependent manner by the extracellular signal-regulated kinase (ERK) MAPK module. These observations directly connect the ERK MAPK cascade and HLH proteins in a linear pathway. ..
  6. Castiglioni P, MartIn Fontecha A, Milan G, Tomajer V, Magni F, Michaelsson J, et al. Apoptosis-dependent subversion of the T-lymphocyte epitope hierarchy in lymphoma cells. Cancer Res. 2002;62:1116-22 pubmed
    ..Therefore, subversion of the epitope hierarchy in apoptotic tumor cells might be relevant in the induction of tumor-specific T-lymphocyte responses. ..
  7. Ochsenbauer Jambor C, Delos S, Accavitti M, White J, Hunter E. Novel monoclonal antibody directed at the receptor binding site on the avian sarcoma and leukosis virus Env complex. J Virol. 2002;76:7518-27 pubmed
    ..Thus, anti-ASLV-SU-A mc8C5-4 proves to be a unique new immunoreagent that targets the receptor-binding site on a prototypical retroviral envelope...
  8. Casanovas O, Hager J, Chun M, Hanahan D. Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis. Oncogene. 2005;24:6597-604 pubmed
  9. Awasthi S, Singhal S, Yadav S, Singhal J, Drake K, Nadkar A, et al. RLIP76 is a major determinant of radiation sensitivity. Cancer Res. 2005;65:6022-8 pubmed

More Information

Publications364 found, 100 shown here

  1. Szczesna Skorupa E, Kemper B. BAP31 is involved in the retention of cytochrome P450 2C2 in the endoplasmic reticulum. J Biol Chem. 2006;281:4142-8 pubmed
  2. Janzen C, van Deursen F, Shi H, Cross G, Matthews K, Ullu E. Expression site silencing and life-cycle progression appear normal in Argonaute1-deficient Trypanosoma brucei. Mol Biochem Parasitol. 2006;149:102-107 pubmed publisher
  3. Semerad C, Mercer E, Inlay M, Weissman I, Murre C. E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors. Proc Natl Acad Sci U S A. 2009;106:1930-5 pubmed publisher
    ..Last, the data mechanistically link E2A, cell cycle regulators, and the maintenance of the HSC pool in a common pathway. ..
  4. Lee H, Choi S, Ku S. Regional distribution and relative frequency of gastrointestinal endocrine cells in the ddN mice: an immunohistochemical study. Anat Histol Embryol. 2010;39:521-8 pubmed publisher
    ..However, some strain and/or species-dependent unique distributions and frequencies of endocrine cells were also observed in the present study. ..
  5. Cao M, Prima V, Nelson D, SVETLOV S. Composite fatty acid ether amides suppress growth of liver cancer cells in vitro and in an in vivo allograft mouse model. Cell Oncol (Dordr). 2013;36:247-57 pubmed publisher
    ..They show a low toxicity towards normal hepatocytes. The addition of AIPs may represent a new avenue towards the management of chronic liver injury and, ultimately, the prevention and treatment of HCC. ..
  6. Kolandaivelu S, Ramamurthy V. AIPL1 protein and its indispensable role in cone photoreceptor function and survival. Adv Exp Med Biol. 2014;801:43-8 pubmed publisher
    ..However, the need for AIPL1 in cone cell survival and function is not clearly understood. In this chapter, using results obtained from multiple lines of animal models, we discuss the role for AIPL1 in photoreceptors. ..
  7. Miller B. TRPC2. Handb Exp Pharmacol. 2014;222:53-65 pubmed publisher
    ..TRPC2-depleted red cells were resistant to oxidative stress-induced hemolysis. ..
  8. Propst C, Nwabueze A, Kanev I, Pepin R, Gutting B, Morozov V, et al. Nanoaerosols reduce required effective dose of liposomal levofloxacin against pulmonary murine Francisella tularensis subsp. novicida infection. J Nanobiotechnology. 2016;14:29 pubmed publisher
    ..This could represent a significant advance for the use of expensive therapeutics and lung directed therapies. ..
  9. Rasley A, Bost K, Marriott I. Murine gammaherpesvirus-68 elicits robust levels of interleukin-12 p40, but not interleukin-12 p70 production, by murine microglia and astrocytes. J Neurovirol. 2004;10:171-80 pubmed
    ..Indeed, the production of IL-12p40 may point to an anti-inflammatory role for these cells during herpesvirus infections of the CNS. ..
  10. Reddypalli S, Roll K, Lee H, Lundell M, Barea Rodriguez E, Wheeler E. p75NTR-mediated signaling promotes the survival of myoblasts and influences muscle strength. J Cell Physiol. 2005;204:819-29 pubmed
    ..Taken together, the data indicate that the p75(NTR) mediates survival of myoblasts prior to differentiation and that the activity of this receptor during myogenesis is important for developing muscle. ..
  11. Ness J, Harvey C, Strasser A, Bouillet P, Klocke B, Roth K. Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia. Brain Res. 2006;1099:150-9 pubmed
    ..These results indicate that Bad and Bim are selectively involved in neuron death following neonatal HI and may be targets for therapeutic intervention. ..
  12. Zhang Y, Wu H, Zhang M, Jiang Y, Zhuo W, Zhang Y, et al. Nicotinamide induces apoptosis of F9 mouse teratocarcinoma stem cells by downregulation of SATB1 expression. Tumour Biol. 2015;36:4339-48 pubmed publisher
    ..The results showed that NA could inhibit the proliferation and induce apoptosis of MF9 cells. These findings might be used as an efficient candidate for teratocarcinoma therapy. ..
  13. Jeon Y, Ahn Y, Chung W, Choi H, Suh Y. Synergistic effect between celecoxib and luteolin is dependent on estrogen receptor in human breast cancer cells. Tumour Biol. 2015;36:6349-59 pubmed publisher
  14. Ulyanchenko S, O Neill K, Medley T, Farley A, Vaidya H, Cook A, et al. Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus. Cell Rep. 2016;14:2819-32 pubmed publisher
    ..Our data provide a phenotypically defined adult thymic epithelial progenitor/stem cell that is able to generate both cTECs and mTECs, opening avenues for improving thymus function in patients. ..
  15. Ordway J, Tallaksen Greene S, Gutekunst C, Bernstein E, Cearley J, Wiener H, et al. Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse. Cell. 1997;91:753-63 pubmed
    ..Neuronal intranuclear inclusions are present in affected mice. Our results show that CAG repeats do not need to be located within one of the classic repeat disorder genes to have a neurotoxic effect. ..
  16. Alley T, Cooper M, Chen M, Kubagawa H. Genomic structure of PIR-B, the inhibitory member of the paired immunoglobulin-like receptor genes in mice. Tissue Antigens. 1998;51:224-31 pubmed
    ..A microsatellite composed of the trinucleotide repeat AAG in the intron between exons 9 and 10 provides a useful marker for studying population genetics. ..
  17. Zhu Z, Zhang S, Wagner C, Kurtz A, Maeda N, Coffman T, et al. Angiotensin AT1B receptor mediates calcium signaling in vascular smooth muscle cells of AT1A receptor-deficient mice. Hypertension. 1998;31:1171-7 pubmed
    ..Our results demonstrate that Ang II causes calcium signaling in AT1A-deficient VSMCs that is mediated by an endogenous losartan-sensitive AT1B receptor. ..
  18. Kornblum H, Hussain R, Wiesen J, Miettinen P, Zurcher S, Chow K, et al. Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor. J Neurosci Res. 1998;53:697-717 pubmed
    ..These data demonstrate that EGF-R expression is critical for the maintenance of large portions of the postnatal mouse forebrain as well as the normal development of astrocytes. ..
  19. Voncken J, Baram T, Gonzales Gomez I, van Schaick H, Shih J, Chen K, et al. Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product. Int J Mol Med. 1998;2:577-83 pubmed
    ..Combined biochemical and behavioral data indicate that bcr is involved in mediating the cellular effects of glucocorticoids, specifically down-regulation of the stress-activated hippocampal hypothalamic-pituitary-adrenal axis. ..
  20. McLean P, Kawamata H, Hyman B. Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons. Neuroscience. 2001;104:901-12 pubmed
    ..Our finding that manipulations of the carboxy-terminus of alpha-synuclein lead to inclusion formation may provide a model for studies of the pathogenic mechanisms of alpha-synuclein aggregation in Lewy bodies. ..
  21. Lee C, Raz R, Gimeno R, Gertner R, Wistinghausen B, Takeshita K, et al. STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity. 2002;17:63-72 pubmed
  22. Xie C, Zhou X, Liu X, Mohan C. Enhanced susceptibility to end-organ disease in the lupus-facilitating NZW mouse strain. Arthritis Rheum. 2003;48:1080-92 pubmed
    ..The availability of B6-based congenic strains bearing individual NZW-derived lupus susceptibility loci will permit future genetic dissection of end-organ susceptibility in murine lupus. ..
  23. LaVail J, Tauscher A, Aghaian E, Harrabi O, Sidhu S. Axonal transport and sorting of herpes simplex virus components in a mature mouse visual system. J Virol. 2003;77:6117-26 pubmed
    ..These finding confirm the subassembly model of viral transport in neurons and suggest that there is a 4- to 5-day window for initiation of effective antiviral treatment with valacyclovir. ..
  24. Mentor Marcel R, Lamartiniere C, Eltoum I, Greenberg N, Elgavish A. Dietary genistein improves survival and reduces expression of osteopontin in the prostate of transgenic mice with prostatic adenocarcinoma (TRAMP). J Nutr. 2005;135:989-95 pubmed
    ..05). Studies are consistent with the possibility that dietary genistein may delay the progression from benign to malignant tumors by inhibiting OPN expression. ..
  25. Kang H, Kim J, Kwon H, Nam K, Youn H, Sok D, et al. Basic fibroblast growth factor activates ERK and induces c-fos in human embryonic stem cell line MizhES1. Stem Cells Dev. 2005;14:395-401 pubmed
    ..mRNA and protein levels of the c-fos gene were increased by bFGF. Induction of c-Fos was dependent on MEKl. Therefore, it is likely that bFGF contributes to maintenance of human ES cells, at least in part, through the MEK1/ERK pathway. ..
  26. Schlenker E, Shi Y, Johnson C, Wipf J. Acetazolamide affects breathing differently in ICR and C57 mice. Respir Physiol Neurobiol. 2006;152:119-27 pubmed
    ..ACZ decreased hypercapnic ventilatory responsiveness in both strains. Differential effects of ACZ breathing in these two strains suggest that genetic factors modulate its effect on breathing. ..
  27. Rahman M, Bhattacharya A, Fernandes G. Conjugated linoleic acid inhibits osteoclast differentiation of RAW264.7 cells by modulating RANKL signaling. J Lipid Res. 2006;47:1739-48 pubmed
    ..Thus, CLA may have important therapeutic implications for the treatment of bone diseases associated with enhanced bone resorption by excessive osteoclastogenesis. ..
  28. Yi X, Maeda N. alpha-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet. Diabetes. 2006;55:2238-44 pubmed
    ..Our results suggest that dietary alpha-lipoic acid is a promising protective agent for reducing cardiovascular complications of diabetes. ..
  29. Ray H, Cong Y, Murthy A, Selby D, Klose K, Barker J, et al. Oral live vaccine strain-induced protective immunity against pulmonary Francisella tularensis challenge is mediated by CD4+ T cells and antibodies, including immunoglobulin A. Clin Vaccine Immunol. 2009;16:444-52 pubmed publisher
    ..These results suggest that oral vaccination with LVS induces protective immunity against i.n. challenge with F. tularensis SCHU S4 by a process mediated cooperatively by CD4(+) T cells and antibodies, including IgA. ..
  30. Ginsberg G, Neafsey P, Hattis D, Guyton K, Johns D, Sonawane B. Genetic polymorphism in paraoxonase 1 (PON1): Population distribution of PON1 activity. J Toxicol Environ Health B Crit Rev. 2009;12:473-507 pubmed publisher
  31. Cheng H, Kimura K, Peter A, Cui L, Ouyang K, Shen T, et al. Loss of enigma homolog protein results in dilated cardiomyopathy. Circ Res. 2010;107:348-56 pubmed publisher
    ..We have identified an ENH-CypherS-Calsarcin protein complex at the Z-line. Ablation of ENH leads to destabilization of this protein complex and dilated cardiomyopathy. ..
  32. Jude J, Solway J, Panettieri R, Walseth T, Kannan M. Differential induction of CD38 expression by TNF-{alpha} in asthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2010;299:L879-90 pubmed publisher
    ..The findings suggest a potential role for CD38 in the pathophysiology of asthma. ..
  33. Shang H, Cao S, Wang J, Zheng H, Putheti R. Glabridin from Chinese herb licorice inhibits fatigue in mice. Afr J Tradit Complement Altern Med. 2009;7:17-23 pubmed
    ..Results showed that glabridin significantly inhibited fatigue, which extended the exhaustive exercise time of mice, effectively delayed the elevation of blood lactic acid and increase in the storage of liver and muscle glycogen. ..
  34. Durgan D, Tsai J, Grenett M, Pat B, Ratcliffe W, Villegas Montoya C, et al. Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice. Chronobiol Int. 2011;28:187-203 pubmed publisher
    ..This diurnal variation was absent in CCM mice. Collectively, these data suggest that the cardiomyocyte circadian clock likely influences responsiveness of the heart to hypertrophic stimuli. ..
  35. Martinerie L, Viengchareun S, Meduri G, Kim H, Luther J, Lombes M. Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption. Endocrinology. 2011;152:2483-91 pubmed publisher
    ..Understanding of MR-regulatory mechanisms could therefore lead to new therapeutic strategies for the management of sodium loss in preterms and neonates. ..
  36. Pyle L, Ehrhardt A, Mitchell L, Fan L, Ren A, Naren A, et al. Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators. Am J Physiol Lung Cell Mol Physiol. 2011;301:L587-97 pubmed publisher
    ..g., activators and potentiators), and demonstrates that a number of different mechanisms can be successfully employed to activate mutant CFTR. ..
  37. Tigges U, Boroujerdi A, Welser Alves J, Milner R. TNF-? promotes cerebral pericyte remodeling in vitro, via a switch from ?1 to ?2 integrins. J Neuroinflammation. 2013;10:33 pubmed publisher
    ..These results thus define a fundamental molecular mechanism in which TNF-? stimulates pericyte remodeling in an ?2 integrin-dependent manner. ..
  38. Sankaran J, Li B, Donahue L, Judex S. Modulation of unloading-induced bone loss in mice with altered ERK signaling. Mamm Genome. 2016;27:47-61 pubmed publisher
    ..Together, we narrowed a previous list of QTL-derived candidate genes from over 300 to 30, and showed that CD44, NOD2, and Fas have distinct functions in regulating changes in trabecular and cortical bone indices during unloading. ..
  39. Muotri A. L1 Retrotransposition in Neural Progenitor Cells. Methods Mol Biol. 2016;1400:157-63 pubmed publisher
    ..These de novo L1 insertions can impact neuronal transcriptional expression, creating unique transcriptomes of individual neurons, possibly contributing to the uniqueness of the individual cognition and mental disorders in humans. ..
  40. Rui J, Deng S, Lebastchi J, Clark P, Usmani Brown S, Herold K. Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice. Diabetologia. 2016;59:1021-9 pubmed publisher
    ..Epigenetic modification of DNA by methylation in response to immunological stressors may be a mechanism that affects insulin gene expression during the progression of type 1 diabetes. ..
  41. Karunakaran D, Kanadia R. In Vivo and Explant Electroporation of Morpholinos in the Developing Mouse Retina. Methods Mol Biol. 2017;1565:215-227 pubmed publisher
    ..Here, we describe a rapid and efficient delivery of morpholinos to add another tool to perturb gene expression during mouse retinal development. ..
  42. Ebersole T, Chen Q, Justice M, Artzt K. The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins. Nat Genet. 1996;12:260-5 pubmed
    ..The size and conservation of the quaking gene family implies that the pathway defined by this mutation may have broad relevance for rapid conveyance of extracellular information directly to primary gene transcripts. ..
  43. Cheng L, Chan F, Cado D, Winoto A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 1997;16:1865-75 pubmed
    ..Constitutive expression of Nur77 in gld/gld mice rescues the lymphoproliferative phenotype of the FasL mutant mice. Thus, Nor-1 and Nur77 demonstrate functional redundancy in an apparently Fas-independent apoptosis. ..
  44. MacDougall M. Refined mapping of the human dentin sialophosphoprotein (DSPP) gene within the critical dentinogenesis imperfecta type II and dentin dysplasia type II loci. Eur J Oral Sci. 1998;106 Suppl 1:227-33 pubmed
    ..Both DSPP and DMP-1 have been placed on the physical map of human chromosome 4 within the interval defined by markers D4S564 and D4S1292. DSPP is thereby strengthened as a candidate gene for both DGI-II and DD-II. ..
  45. Yan R, Wang S. neuroD induces photoreceptor cell overproduction in vivo and de novo generation in vitro. J Neurobiol. 1998;36:485-96 pubmed
    ..We propose that neuroD is important for photoreceptor cell production in the vertebrate retina. ..
  46. Vulpe C, Kuo Y, Murphy T, Cowley L, Askwith C, Libina N, et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet. 1999;21:195-9 pubmed
    ..We suggest that the hephaestin protein is a multicopper ferroxidase necessary for iron egress from intestinal enterocytes into the circulation and that it is an important link between copper and iron metabolism in mammals. ..
  47. Ichiyama T, Sakai T, Catania A, Barsh G, Furukawa S, Lipton J. Inhibition of peripheral NF-kappaB activation by central action of alpha-melanocyte-stimulating hormone. J Neuroimmunol. 1999;99:211-7 pubmed
    ..The pathway involves beta2-adrenergic receptors, but does not require activation of MC1R within the brain...
  48. Fenster S, Chung W, Zhai R, Cases Langhoff C, Voss B, Garner A, et al. Piccolo, a presynaptic zinc finger protein structurally related to bassoon. Neuron. 2000;25:203-14 pubmed
    ..These data suggest that Piccolo plays a role in the trafficking of synaptic vesicles (SVs) at the active zone. ..
  49. Carvan M, Sonntag D, Cmar C, Cook R, Curran M, Miller G. Oxidative stress in zebrafish cells: potential utility of transgenic zebrafish as a deployable sentinel for site hazard ranking. Sci Total Environ. 2001;274:183-96 pubmed
  50. Evans M, Park Y, Pariza M, Curtis L, Kuebler B, McIntosh M. Trans-10,cis-12 conjugated linoleic acid reduces triglyceride content while differentially affecting peroxisome proliferator activated receptor gamma2 and aP2 expression in 3T3-L1 preadipocytes. Lipids. 2001;36:1223-32 pubmed
  51. Krzywinska E, Schorey J. Characterization of genetic differences between Mycobacterium avium subsp. avium strains of diverse virulence with a focus on the glycopeptidolipid biosynthesis cluster. Vet Microbiol. 2003;91:249-64 pubmed
  52. Zagon I, Jaglowski J, Verderame M, Smith J, Leure Dupree A, McLaughlin P. Combination chemotherapy with gemcitabine and biotherapy with opioid growth factor (OGF) enhances the growth inhibition of pancreatic adenocarcinoma. Cancer Chemother Pharmacol. 2005;56:510-20 pubmed
    ..This preclinical evidence shows that combined chemotherapy (e.g. gemcitabine) and biotherapy (OGF) provides an enhanced therapeutic benefit for pancreatic cancer. ..
  53. Myers M, Sosinowski T, Dragone L, White C, Band H, Gu H, et al. Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex. Nat Immunol. 2006;7:57-66 pubmed
    ..These studies indicate that SLAP links the E3 ligase activity of c-Cbl to the TCR, allowing for stage-specific regulation of TCR expression. ..
  54. Clark S. Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells. Oncology. 2006;70:13-8 pubmed
    ..We report that DFMO strongly protects cells from POH-induced apoptosis. These results show that in Bcr/Abl-transformed cells, POH activates a Myc-ODC apoptotic pathway that is not protected by the Bcr/Abl antiapoptotic mechanism. ..
  55. Hnia K, Tuffery Giraud S, Vermaelen M, Hugon G, Chazalette D, Masmoudi A, et al. Pathological pattern of Mdx mice diaphragm correlates with gradual expression of the short utrophin isoform Up71. Biochim Biophys Acta. 2006;1762:362-72 pubmed
    ..Our data provide novel functional insights into the pathological role of the Up71 isoform in dystrophinopathies. ..
  56. Mauldin J, Srinivasan S, Mulya A, Gebre A, Parks J, Daugherty A, et al. Reduction in ABCG1 in Type 2 diabetic mice increases macrophage foam cell formation. J Biol Chem. 2006;281:21216-24 pubmed
    ..These observations demonstrate that ABCG1 plays a major role in macrophage cholesterol efflux and that decreased ABCG1 function can facilitate foam cell formation in Type 2 diabetic mice...
  57. Li W, Zhang J, Liu X, Xu R, Zhang Y. Correlation of appearance of metastasis-associated protein1 (Mta1) with spermatogenesis in developing mouse testis. Cell Tissue Res. 2007;329:351-62 pubmed
    ..These results collectively demonstrate that Mta1 appears during postnatal testis development and suggest that this expression may be crucial for spermatogenesis. ..
  58. Li S, Luo X, Ye J, Xiong Y, Yu L, Zhong F, et al. [Inhibitory effect of combined bacterin on growth of sarcoma 180 in mice]. Ai Zheng. 2007;26:382-5 pubmed
    ..01). The chosen bacterins in this study can induce the mice to produce IL-12(p70) and suppress the growth of S180. The effect of the combined bacterin is much better than the single bacterins. ..
  59. Richter M, Cloutier S, Sirois P. Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice. Prostaglandins Leukot Essent Fatty Acids. 2007;76:299-308 pubmed
    ..These results suggest an important role for endothelin, PAF and thromboxane A2 in AHR in mice actively sensitized and challenged with ovalbumin. ..
  60. Joo S, Jang S, Kim S, Choi J, Hwang K, Lee D. Anti-acne activity of Selaginella involvens extract and its non-antibiotic antimicrobial potential on Propionibacterium acnes. Phytother Res. 2008;22:335-9 pubmed
    ..In conclusion, SIE may be a safe non-antibiotic anti-acne source in the therapeutic application of the treatment of acne development by reducing the chance of non-specific initiation and augmentation phase of the inflammatory response. ..
  61. Botchkina I, Rowehl R, Rivadeneira D, Karpeh M, Crawford H, Dufour A, et al. Phenotypic subpopulations of metastatic colon cancer stem cells: genomic analysis. Cancer Genomics Proteomics. 2009;6:19-29 pubmed
    ..Genomic analysis of several candidate CSC phenotypic populations may contribute to the identification of novel targets for colon cancer stem cell-targeted drug development and treatment. ..
  62. Yu W, Liu C, Liu Y, Zhang N, Xu W. Mannan-modified solid lipid nanoparticles for targeted gene delivery to alveolar macrophages. Pharm Res. 2010;27:1584-96 pubmed publisher
    ..One major problem with SLN is the lack of cell-targeting ability. In the present study, a mannan-based PE-grafted ligand was synthesized and used for the surface modification of DNA-loaded cationic SLN to prepare Man-SLN-DNA...
  63. Borthakur A, Anbazhagan A, Kumar A, Raheja G, Singh V, Ramaswamy K, et al. The probiotic Lactobacillus plantarum counteracts TNF-{alpha}-induced downregulation of SMCT1 expression and function. Am J Physiol Gastrointest Liver Physiol. 2010;299:G928-34 pubmed publisher
    ..Efficacy of LP or their secreted soluble factors to stimulate SMCT1 expression and function and to counteract the inhibitory effects of TNF-? on butyrate absorption could have potential therapeutic value. ..
  64. Held K, Steward O, Blanc C, Lane T. Impaired immune responses following spinal cord injury lead to reduced ability to control viral infection. Exp Neurol. 2010;226:242-53 pubmed publisher
    ..Collectively, these data indicate that the inability to control viral replication following SCI is not level dependent and that increased susceptibility to infection is due to suppression of both innate and adaptive immune responses...
  65. Choi J, Lim I. TIS21/BTG2 inhibits invadopodia formation by downregulating reactive oxygen species level in MDA-MB-231 cells. J Cancer Res Clin Oncol. 2013;139:1657-65 pubmed publisher
    ..This was further confirmed in the TIS21(-/-)MEF cells. This is the first report to provide insight into invasion signals regulated by tumor suppressor, TIS21(/BTG2/Pc3) gene, in the intractable breast cancer cells. ..
  66. Hamilton Williams E, Rainbow D, Cheung J, Christensen M, Lyons P, Peterson L, et al. Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity. Mamm Genome. 2013;24:358-75 pubmed publisher
    ..1 and Idd9.2 regions. These findings highlight that multiple, relatively small genetic effects combine and interact to produce significant changes in immune tolerance and diabetes onset. ..
  67. Thao L, Byeon H, Lee C, Lee S, Lee E, Choi Y, et al. Doxorubicin-Bound Albumin Nanoparticles Containing a TRAIL Protein for Targeted Treatment of Colon Cancer. Pharm Res. 2016;33:615-26 pubmed publisher
    ..Data indicate that TRAIL 1.0%/Dox HSA NPs offer advantages of co-delivery of Dox and TRAIL in tumors, with potential synergistic apoptosis-based anticancer therapy. ..
  68. Zwolak R, Bogdziewicz M, Wróbel A, Crone E. Advantages of masting in European beech: timing of granivore satiation and benefits of seed caching support the predator dispersal hypothesis. Oecologia. 2016;180:749-58 pubmed publisher
  69. Kwon Y, Kim S, Lee Y, Lee J, Cho M, Lee W, et al. Novel nuclear targeting coiled-coil protein of Helicobacter pylori showing Ca(2+)-independent, Mg(2+)-dependent DNase I activity. J Microbiol. 2016;54:387-95 pubmed publisher
    ..0-8.0 and 55°C, respectively. These results indicate that HP0059 possesses a novel DNase I activity along with a role in the genomic instability of human gastric cells, which may result in the transformation of gastric cells. ..
  70. Weiss A, Schiaffino S, Leinwand L. Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity. J Mol Biol. 1999;290:61-75 pubmed
    ..Results indicate that functional diversity among MyHCs is likely to be accomplished by having small pockets of sequence diversity in an otherwise highly conserved molecule. ..
  71. Weston B, Lin J, Muenzer J, Cameron H, Arnold R, Seydewitz H, et al. Glucose-6-phosphatase mutation G188R confers an atypical glycogen storage disease type 1b phenotype. Pediatr Res. 2000;48:329-34 pubmed
    ..The unusual association of neutrophil abnormalities in patients with homozygous G188R mutations in the G6Pase gene supports a modified translocase/catalytic unit model. ..
  72. Schwiebert E, Wallace D, Braunstein G, King S, Peti Peterdi J, Hanaoka K, et al. Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys. Am J Physiol Renal Physiol. 2002;282:F763-75 pubmed
    ..Therefore, we hypothesize that autocrine purinergic signaling may augment detrimentally cyst volume expansion in ADPKD or tubule dilation in ARPKD, accelerating disease progression. ..
  73. Yon J, Baek I, Lee S, Jin Y, Kim M, Nahm S, et al. The spatio-temporal expression pattern of cytoplasmic Cu/Zn superoxide dismutase (SOD1) mRNA during mouse embryogenesis. J Mol Histol. 2008;39:95-103 pubmed
    ..These results suggest that SOD1 may be related to organogenesis of embryos as an antioxidant enzyme. ..
  74. Granic A, Padmanabhan J, Norden M, Potter H. Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP. Mol Biol Cell. 2010;21:511-20 pubmed publisher
    ..These results indicate that Abeta-induced microtubule dysfunction leads to aneuploid neurons and may thereby contribute to the pathogenesis of AD. ..
  75. Sims B, Clarke M, Francillion L, Kindred E, Hopkins E, Sontheimer H. Hypoxic preconditioning involves system Xc- regulation in mouse neural stem cells. Stem Cell Res. 2012;8:285-91 pubmed publisher
    ..These data provide the first evidence of hypoxic regulation of the cystine glutamate exchanger system Xc-. ..
  76. Zhang H, Chen Y, Fan B, Wang W, Zhu W. Overexpression of VEGF183 promotes murine breast cancer cell proliferation in vitro and induces dilated intratumoral microvessels. Tumour Biol. 2015;36:3871-80 pubmed publisher
  77. Ettwiller L, Buswell J, Yigit E, Schildkraut I. A novel enrichment strategy reveals unprecedented number of novel transcription start sites at single base resolution in a model prokaryote and the gut microbiome. BMC Genomics. 2016;17:199 pubmed publisher
  78. Kim J, Choi I, Lee Y. Involvement of Atm and Trp53 in neural cell loss due to Terf2 inactivation during mouse brain development. Histochem Cell Biol. 2017;148:489-501 pubmed publisher
    ..These giant neural cells disappeared in Lig4 deficiency. These data demonstrate ATM and TP53 are important for the maintenance of telomere homeostasis and the surveillance of telomere dysfunction during neurogenesis. ..
  79. Li Z, Massengill J, O Dowd D, Smith M. Agrin gene expression in mouse somatosensory cortical neurons during development in vivo and in cell culture. Neuroscience. 1997;79:191-201 pubmed
    ..Changes in agrin gene expression, observed both in vivo and in vitro, are consistent with a role for agrin in synapse formation in the central nervous system. ..
  80. Firulli A, McFadden D, Lin Q, Srivastava D, Olson E. Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nat Genet. 1998;18:266-70 pubmed
    ..Heart development was also perturbed and did not progress beyond the cardiac-looping stage. Our results demonstrate important roles for Hand1 in extraembryonic mesodermal and heart development. ..
  81. Guay Woodford L, Wright C, Walz G, Churchill G. Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model. J Am Soc Nephrol. 2000;11:1253-60 pubmed
    ..It is hypothesized that the gene encoding the polycystin-binding partner RGS7 is a candidate for the Chr 1 genetic modifier. ..
  82. Marriott I, Bost K. Substance P receptor mediated macrophage responses. Adv Exp Med Biol. 2001;493:247-54 pubmed
    ..We anticipate that these ongoing investigations will further define the positive contributions that substance P/substance P receptor interactions have in the initiation of immune responses. ..
  83. Berlin A, Paller A, Chan L. Incontinentia pigmenti: a review and update on the molecular basis of pathophysiology. J Am Acad Dermatol. 2002;47:169-87; quiz 188-90 pubmed
    ..Additionally, participants will gain the most current knowledge of the genetic and molecular basis of cutaneous pathomechanism. ..
  84. Rose Hellekant T, Gilchrist K, Sandgren E. Strain background alters mammary gland lesion phenotype in transforming growth factor-alpha transgenic mice. Am J Pathol. 2002;161:1439-47 pubmed
  85. Boukhelifa M, Parast M, Bear J, Gertler F, Otey C. Palladin is a novel binding partner for Ena/VASP family members. Cell Motil Cytoskeleton. 2004;58:17-29 pubmed
    ..These results suggest that the recently described actin-associated protein palladin may play an important role in recruiting VASP to sites of actin filament growth, anchorage, and crosslinking. ..
  86. Gangi E, Kapatral V, El Azami El Idrissi M, Martinez O, Prabhakar B. Characterization of a recombinant Yersinia enterocolitica lipoprotein; implications for its role in autoimmune response against thyrotropin receptor. Autoimmunity. 2004;37:515-20 pubmed
    ..1 and B7.2 coupled with its ability to induce antibodies that can cross-react with the TSHR showed several potential mechanisms by which it can cause breakdown of self-tolerance to TSHR. ..
  87. Ji H, Yeo H, Lee N, Hwang J, Koo K, Cheong S, et al. A carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tectrachlorodibenzo-p-dioxin. Biotechnol Lett. 2005;27:253-7 pubmed
    ..These findings indicate that the AIP1 fraction suppresses TCDD-induced thymocyte apoptosis through the modulation of Fas gene expression. ..
  88. Leclerc D, Rozen R. [Molecular genetics of MTHFR: polymorphisms are not all benign]. Med Sci (Paris). 2007;23:297-302 pubmed
    ..We describe here the complex structure of the MTHFR gene, summarize the current state of knowledge on rare and common mutations in MTHFR and discuss some relevant findings in a mouse model for MTHFR deficiency...
  89. Francis H, Glaser S, Demorrow S, Gaudio E, Ueno Y, Venter J, et al. Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway. Am J Physiol Cell Physiol. 2008;295:C499-513 pubmed publisher
    ..Gene knockdown of CaMK I ablated the effects of HTMT dimaleate on small cholangiocyte proliferation and CREB activation. The IP(3)/Ca(2+)/CaMK I/CREB pathway is important in the regulation of small cholangiocyte function...
  90. Raheja G, Singh V, Ma K, Boumendjel R, Borthakur A, Gill R, et al. Lactobacillus acidophilus stimulates the expression of SLC26A3 via a transcriptional mechanism. Am J Physiol Gastrointest Liver Physiol. 2010;298:G395-401 pubmed publisher
    ..In conclusion, increase in DRA promoter activity and expression may contribute to the upregulation of intestinal electrolyte absorption and might underlie the potential antidiarrheal effects of LA. ..
  91. Yang Z, Teng Y, Wang H, Hou H. Enhancement of skin permeation of bufalin by limonene via reservoir type transdermal patch: formulation design and biopharmaceutical evaluation. Int J Pharm. 2013;447:231-40 pubmed publisher
    ..The bufalin patch was successfully applied to biopharmaceutical study in rats and demonstrated the feasibility of this transdermal formulation for future development and clinical trials. ..
  92. Paul D, Grevengoed T, Pascual F, Ellis J, Willis M, Coleman R. Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin. Biochim Biophys Acta. 2014;1841:880-7 pubmed publisher
    ..These data indicate that Acsl1-deficiency causes diastolic dysfunction and that mTOR activation is linked to the development of cardiac hypertrophy in Acsl1(H-/-) mice. ..