Experts and Doctors on cholinesterase inhibitors in Anguilla
Topic: cholinesterase inhibitors
Cummings J, Nadel A, Masterman D, Cyrus P. Efficacy of metrifonate in improving the psychiatric and behavioral disturbances of patients with Alzheimer's disease. J Geriatr Psychiatry Neurol. 2001;14:101-8 pubmed
..Metrifonate significantly reduced many of the psychiatric and behavioral symptoms of AD. The observations suggest that enhancement of cholinergic functions in AD has beneficial effects on behavior. ..
Overstreet D, Djuric V. A genetic rat model of cholinergic hypersensitivity: implications for chemical intolerance, chronic fatigue, and asthma. Ann N Y Acad Sci. 2001;933:92-102 pubmed
..An elucidation of these mechanisms may provide useful clues to those involved in chemical intolerance in humans. ..
Chambers J, Chambers H, Funck K, Meek E, Pringle R, Ross M. Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX. Chem Biol Interact. 2016;259:154-159 pubmed publisher
..These novel oximes have the potential to be developed into improved antidotes for nerve agent therapy. ..
Gallagher E, Minn I, Chambers J, Searson P. In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs). Fluids Barriers CNS. 2016;13:10 pubmed publisher
..This elucidates one of the reasons for the necessity of sustained intravascular (IV) infusion in response to organophosphate poisoning. ..
Easton A, Sankaranarayanan S, Tanghe A, Terwel D, Lin A, Hoque N, et al
. Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer's disease. Psychopharmacology (Berl). 2013;230:279-89 pubmed publisher
..These results suggest that the observed cognitive improvement produced by donepezil in Alzheimer's disease may be due, at least in part, to reduction of brain A?. ..
Lee S, Barron M. A mechanism-based 3D-QSAR approach for classification and prediction of acetylcholinesterase inhibitory potency of organophosphate and carbamate analogs. J Comput Aided Mol Des. 2016;30:347-63 pubmed publisher
..Our combined computation approach provided detailed understanding of the mechanism of action of OP and carbamate compounds and may be useful for screening a diversity of chemical structures for AChE inhibitory potency. ..
Mega M, Cummings J, O Connor S, Dinov I, Reback E, Felix J, et al
. Cognitive and metabolic responses to metrifonate therapy in Alzheimer disease. Neuropsychiatry Neuropsychol Behav Neurol. 2001;14:63-8 pubmed
..The clinical benefits observed in AD with cholinesterase inhibitor therapy are associated with a metabolic increase of heteromodal cognitive and medial temporal networks. ..
Gordon C, Mack C. Diurnal variation in thermoregulatory response to chlorpyrifos and carbaryl in the rat. Toxicology. 2001;169:93-105 pubmed
..Hence, cholinergic stimulation is probably not the only mechanism to explain the effects of the chronotoxicogical effects of some antiChE insecticides...
McGaugh J, McIntyre C, Power A. Amygdala modulation of memory consolidation: interaction with other brain systems. Neurobiol Learn Mem. 2002;78:539-52 pubmed
..These findings provide strong support for the hypothesis that the BLA plays a critical role in regulating the consolidation of lasting memories of significant experiences. ..