Genomes and Genes
Experts and Doctors on cell nucleus in Anguilla
Topic: cell nucleus
- Umar S, Sellin J, Morris A. Increased nuclear translocation of catalytically active PKC-zeta during mouse colonocyte hyperproliferation. Am J Physiol Gastrointest Liver Physiol. 2000;279:G223-37 pubmed..These results suggest separate cellular and nuclear roles, respectively, for PKC-zeta in quiescent and mitotically active colonocytes. PKM-zeta may specifically act as a modulator of proliferation during TMCH. ..
- Dickinson D, Iles K, Zhang H, Blank V, Forman H. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. FASEB J. 2003;17:473-5 pubmed..Thus, the beneficial effects elicited by curcumin appear to be due to changes in the pool of transcription factors that compose EpRE and AP-1 complexes, affecting gene expression of GCL and other phase II enzymes. ..
- Al Abed Y, Dubrovsky L, Ruzsicska B, Seepersaud M, Bukrinsky M. Inhibition of HIV-1 nuclear import via schiff base formation with arylene bis(methylketone) compounds. Bioorg Med Chem Lett. 2002;12:3117-9 pubmed..Arylene bis(methylketone) compounds specifically block nuclear translocation of the HIV-1 pre-integration complex by forming Schiff-base adducts with contiguous lysines within nuclear localization signal. ..
- Jansa S, Forsman J, Voss R. Different patterns of selection on the nuclear genes IRBP and DMP-1 affect the efficiency but not the outcome of phylogeny estimation for didelphid marsupials. Mol Phylogenet Evol. 2006;38:363-80 pubmed..Thus, for these two genes, relaxed functional constraints and positive selection appear to improve the efficiency of phylogenetic estimation without compromising its accuracy...
- Wang I, Chen Y, Hughes D, Petrovic V, Major M, Park H, et al. Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol Cell Biol. 2005;25:10875-94 pubmed..Taken together, these results demonstrate that FoxM1 regulates transcription of cell cycle genes critical for progression into S-phase and mitosis. ..
- Nehyba J, Hrdlickova R, Bose H. Differences in kappaB DNA-binding properties of v-Rel and c-Rel are the result of oncogenic mutations in three distinct functional regions of the Rel protein. Oncogene. 1997;14:2881-97 pubmed
- George A, Rajoria S, Suriano R, Mittleman A, Tiwari R. Hypoxia and estrogen are functionally equivalent in breast cancer-endothelial cell interdependence. Mol Cancer. 2012;11:80 pubmed publisher..Further, hypoxia and estrogen are interchangeable as both similarly modulate epithelial-endothelial cell interaction. ..
- Azmi A. Unveiling the role of nuclear transport in epithelial-to-mesenchymal transition. Curr Cancer Drug Targets. 2013;13:906-14 pubmed
- Xu J, Teran Garcia M, Park J, Nakamura M, Clarke S. Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay. J Biol Chem. 2001;276:9800-7 pubmed
- Lesort M, Chun W, Johnson G, Ferrante R. Tissue transglutaminase is increased in Huntington's disease brain. J Neurochem. 1999;73:2018-27 pubmed..These data clearly indicate that tissue transglutaminase is elevated in HD brain and may play a role in the disease process. ..
- Wiellette E, Harding K, Mace K, Ronshaugen M, Wang F, McGinnis W. spen encodes an RNP motif protein that interacts with Hox pathways to repress the development of head-like sclerites in the Drosophila trunk. Development. 1999;126:5373-85 pubmed..This raises the intriguing possibility that the Spen RNP protein might integrate signals from both the Raf and Hox pathways. ..
- Oh S, Lee S, Yu S, Choi D. Expression of a novel NAC domain-containing transcription factor (CaNAC1) is preferentially associated with incompatible interactions between chili pepper and pathogens. Planta. 2005;222:876-87 pubmed publisher..Our results collectively suggest that the plant-specific NAC domain protein, CaNAC1, may play a role in the regulation of defense responses in plants...
- Pan X, Roberts P, Chen Y, Kvam E, Shulga N, Huang K, et al. Nucleus-vacuole junctions in Saccharomyces cerevisiae are formed through the direct interaction of Vac8p with Nvj1p. Mol Biol Cell. 2000;11:2445-57 pubmed..Overexpression of Nvj1p caused the profound proliferation of NV junctions. We conclude that Vac8p and Nvj1p are necessary components of a novel interorganelle junction apparatus. ..
- Doughty M, Seabert W, Bergmanson J, Blocker Y. A descriptive and quantitative study of the keratocytes of the corneal stroma of albino rabbits using transmission electron microscopy. Tissue Cell. 2001;33:408-22 pubmed..The cell nucleus, while a dominant feature in transverse section, has a normal size in relation to the cell cytoplasm when viewed in coronal section. ..
- Jo Y, Cho W, Rim Y, Moon J, Chen X, Chu H, et al. Plasmodesmal receptor-like kinases identified through analysis of rice cell wall extracted proteins. Protoplasma. 2011;248:191-203 pubmed publisher..These findings suggest potential PD functions in apoplasmic signaling in response to environmental stimuli and developmental inputs. ..
- Ding B, Yuan Y. Testing the utility of fluorescent proteins in Mimulus lewisii by an Agrobacterium-mediated transient assay. Plant Cell Rep. 2016;35:771-7 pubmed publisher..Both the transient assay and the fluorescent proteins are valuable additions to the M. lewisii toolbox, making this emerging genetic and developmental model system even more powerful. ..
- Roggero V, Zhang J, Parente L, Doshi Y, Dziedzic R, McGregor E, et al. Nuclear import of the thyroid hormone receptor Î±1 is mediated by importin 7, importin Î²1, and adaptor importin Î±1. Mol Cell Endocrinol. 2016;419:185-97 pubmed publisher..Coimmunoprecipitation assays confirmed that TRÎ±1 interacts with importin 7, as well as importin Î²1 and the adapter importin Î±1, suggesting that TRÎ±1 trafficking into the nucleus is mediated by two distinct pathways. ..
- Perales R, Bentley D. "Cotranscriptionality": the transcription elongation complex as a nexus for nuclear transactions. Mol Cell. 2009;36:178-91 pubmed publisher..From this perspective, TECs can be viewed as potent "community organizers" within the nucleus. ..
- Han M, Jung K, Yi G, An G. Rice Importin ?1 gene affects pollen tube elongation. Mol Cells. 2011;31:523-30 pubmed publisher..However, in vitro assays showed that tube elongation was hampered in the mutant grains. These results indicate that OsImp?1 is specifically required for pollen tube elongation. ..
- Phee B, Kim J, Shin D, Yoo J, Park K, Han Y, et al. A novel protein phosphatase indirectly regulates phytochrome-interacting factor 3 via phytochrome. Biochem J. 2008;415:247-55 pubmed publisher..Taken together, we suggest that PAPP2C functions as a regulator of PIF3 by dephosphorylating phytochromes in the nucleus. ..
- Kim C, Lee S, Nguyen T, Lee K, Um S, Kim J, et al. Long isoform of ErbB3 binding protein, p48, mediates protein kinase B/Akt-dependent HDM2 stabilization and nuclear localization. Exp Cell Res. 2012;318:136-43 pubmed publisher..Hence, higher expression of p48 in cancer cells reduces p53 levels through modulation of HDM2 nuclear localization and protein stability via regulation of its Akt-mediated phosphorylation. ..
- Zong X, Li D, Gu L, Li D, Liu L, Hu X. Abscisic acid and hydrogen peroxide induce a novel maize group C MAP kinase gene, ZmMPK7, which is responsible for the removal of reactive oxygen species. Planta. 2009;229:485-95 pubmed publisher..Finally, we have shown that the ZmMPK7 protein localizes in the nucleus. These results broaden our knowledge regarding plant group C MAPK activity in response to stress signals...
- Zhou H, Spicuglia S, Hsieh J, Mitsiou D, Høiby T, Veenstra G, et al. Uncleaved TFIIA is a substrate for taspase 1 and active in transcription. Mol Cell Biol. 2006;26:2728-35 pubmed..We propose that cleavage fine tunes the transcription regulation of a subset of genes during differentiation and development. ..
- Lafreniere J, Mills P, Bouchentouf M, Tremblay J. Interleukin-4 improves the migration of human myogenic precursor cells in vitro and in vivo. Exp Cell Res. 2006;312:1127-41 pubmed..Therefore, IL-4 co-injection with transplanted myoblasts might be an approach to enhance the migration of transplanted cells for the treatment of a damaged myocardium or of a Duchenne Muscular Dystrophy patient. ..
- Guo R, Yu F, Gao Z, An H, Cao X, Guo X. GhWRKY3, a novel cotton (Gossypium hirsutum L.) WRKY gene, is involved in diverse stress responses. Mol Biol Rep. 2011;38:49-58 pubmed publisher..These data suggested that GhWRKY3 might play an important role in plant defense responses and fulfill a pivotal role in plant development. ..
- Bondar T, Kalinina A, Khair L, Kopanja D, Nag A, Bagchi S, et al. Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome. Mol Cell Biol. 2006;26:2531-9 pubmed..Moreover, we provide evidence for a physical association between Cul4A, DDB1, and Skp2. We speculate that the F-box protein Skp2, in addition to utilizing Cul1-Skp1, utilizes Cul4A-DDB1 to induce proteolysis of p27Kip1. ..
- Bai Y, Pontoglio M, Hiesberger T, Sinclair A, Igarashi P. Regulation of kidney-specific Ksp-cadherin gene promoter by hepatocyte nuclear factor-1beta. Am J Physiol Renal Physiol. 2002;283:F839-51 pubmed..Mutations of HNF-1beta, as occur in humans with inherited renal cysts and diabetes, may cause dysregulated Ksp-cadherin promoter activity. ..
- Chinoy M, Nielsen H, Volpe M. Mesenchymal nuclear transcription factors in nitrofen-induced hypoplastic lung. J Surg Res. 2002;108:203-11 pubmed..We speculate that nitrofen induces PH via RAR-dependent but RXR-independent interactions, which may be downstream of the Hoxb-5 gene or may involve other more anteriorly expressed Hox genes. ..
- Mosammaparast N, Jackson K, Guo Y, Brame C, Shabanowitz J, Hunt D, et al. Nuclear import of histone H2A and H2B is mediated by a network of karyopherins. J Cell Biol. 2001;153:251-62 pubmed..These data suggest that the import of H2A and H2B is mediated by a network of Kaps, in which Kap114p may play the major role. ..
- Kusano A, Staber C, Ganetzky B. Nuclear mislocalization of enzymatically active RanGAP causes segregation distortion in Drosophila. Dev Cell. 2001;1:351-61 pubmed..Nuclear transport of a GFP reporter in salivary glands is impaired by SD, suggesting that a defect in nuclear transport may underlie sperm dysfunction. ..
- Ho J, Kallstrom G, Johnson A. Nascent 60S ribosomal subunits enter the free pool bound by Nmd3p. RNA. 2000;6:1625-34 pubmed..These results suggest that Nmd3p recruits nascent 60S subunits into the pool of free 60S subunits and exchanges on 60S subunits as they recycle during translation. ..
- Kumar R, Thompson E. The structure of the nuclear hormone receptors. Steroids. 1999;64:310-9 pubmed..In this review, we summarize and discuss the current information on structures of the steroid-thyroid-retinoid receptors. ..
- Rasmussen E, Lis J. Short transcripts of the ternary complex provide insight into RNA polymerase II elongational pausing. J Mol Biol. 1995;252:522-35 pubmed..In both of the small heat shock genes, we found evidence of previously unknown sites of transcriptional termination, residing immediately upstream of the regions of polymerase pausing. ..
- Batra J, Tripathi S, Kumar A, Katz J, Cox N, Lal R, et al. Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins. Sci Rep. 2016;6:19063 pubmed publisher..These studies demonstrate an important role for cellular chaperone Hsp40/DnaJB1 in influenza A virus life cycle by assisting nuclear trafficking of viral ribonucleoproteins. ..
- Qin F, Zhang Y, Liu J, Li H. SLC45A3-ELK4 functions as a long non-coding chimeric RNA. Cancer Lett. 2017;404:53-61 pubmed publisher..In addition, similar to many long non-coding RNAs, the fusion RNA is enriched in the nuclear fraction. Altogether, these results indicate that SLC45A3-ELK4 regulates cancer cell proliferation by its transcript, not translated protein. ..
- Park N, Song J, Jeong S, Thi Tran T, Ko H, Kim E. Vaccinia-related kinase 3 (VRK3) sets the circadian period and amplitude by affecting the subcellular localization of clock proteins in mammalian cells. Biochem Biophys Res Commun. 2017;487:320-326 pubmed publisher..Taken together, these data suggest that VRK3 plays a role in setting the amplitude and period length of circadian rhythms in mammalian cells. ..
- Sanchez A, Zhao J, You Y, Declèves A, Diamond Stanic M, Sharma K. Role of the USF1 transcription factor in diabetic kidney disease. Am J Physiol Renal Physiol. 2011;301:F271-9 pubmed publisher..AMPK activity may play a key role in high glucose-induced regulation of USF1. ..
- Fisher Reid M, Wiens J. What are the consequences of combining nuclear and mitochondrial data for phylogenetic analysis? Lessons from Plethodon salamanders and 13 other vertebrate clades. BMC Evol Biol. 2011;11:300 pubmed publisher..However, given cases like Plethodon, there is also the need for routine checking of incongruence between mtDNA and nucDNA data and its impacts on combined-data analyses. ..
- McGoldrick J, Yeh Y, Solomon M, Essigmann J, Lu A. Characterization of a mammalian homolog of the Escherichia coli MutY mismatch repair protein. Mol Cell Biol. 1995;15:989-96 pubmed..The eukaryotic MYH may be involved in the major repair of both replication errors and oxidative damage to DNA, the same functions as those of the E. coli MutY protein. ..
- Chen Y, Riley D, Chen P, Lee W. HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis. Mol Cell Biol. 1997;17:6049-56 pubmed..These results suggest that the HEC protein may play an important role in chromosome segregation during M phase. ..
- Furukawa K. LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction. J Cell Sci. 1999;112 ( Pt 15):2485-92 pubmed..Further, the L2BP1 binding domain of LAP2 overlaps its chromosome-binding region. These findings suggest that L2BP1 is a candidate mediator of LAP2-chromosome interaction at the end of mitosis. ..
- Sarkar S, Azad A, Hopper A. Nuclear tRNA aminoacylation and its role in nuclear export of endogenous tRNAs in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1999;96:14366-71 pubmed..Saturation of tRNA export pathway is a possible explanation of this phenomenon. ..
- Heidkamp M, Russell B. Calcium not strain regulates localization of alpha-myosin heavy chain mRNA in oriented cardiac myocytes. Cell Tissue Res. 2001;305:121-7 pubmed..These data suggest that calcium is essential for alpha-MyHC mRNA distribution throughout the cell whereas stretch and alignment affect myocyte shape but have little effect on mRNA localization. ..
- Brown K, Rüber L, Bills R, Day J. Mastacembelid eels support Lake Tanganyika as an evolutionary hotspot of diversification. BMC Evol Biol. 2010;10:188 pubmed publisher..Mastacembelid eels (Teleostei: Mastacembelidae) are a predominately riverine family of freshwater fish, occurring across Africa and Asia, but which also form a small species flock in LT...
- Johnson A. Rat1p and Xrn1p are functionally interchangeable exoribonucleases that are restricted to and required in the nucleus and cytoplasm, respectively. Mol Cell Biol. 1997;17:6122-30 pubmed..It is likely that the higher eukaryotic homologs of these proteins will function similarly in the cytoplasm and nucleus. ..
- Stade K, Ford C, Guthrie C, Weis K. Exportin 1 (Crm1p) is an essential nuclear export factor. Cell. 1997;90:1041-50 pubmed..cerevisiae. The presented data are consistent with the conclusion that Crm1p is a carrier for the NES-mediated protein export pathway. We propose CRM1 be renamed exportin 1 (XPO1). ..
- Kaffman A, Rank N, O Neill E, Huang L, O Shea E. The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus. Nature. 1998;396:482-6 pubmed..Our results reveal a simple mechanism by which phosphorylation can control the nuclear export of a protein. ..
- Chacko B, Reily C, Srivastava A, Johnson M, Ye Y, Ulasova E, et al. Prevention of diabetic nephropathy in Ins2(+/)?(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. Biochem J. 2010;432:9-19 pubmed publisher..They also highlight a relatively unexplored aspect of mitochondrial ROS signalling in the control of fibrosis. ..
- McKinsey T, Zhang C, Lu J, Olson E. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature. 2000;408:106-11 pubmed
- Tan J, Kuang W, Jin Z, Jin F, Xu L, Yu Q, et al. Inhibition of NFkappaB by activated c-Jun NH2 terminal kinase 1 acts as a switch for C2C12 cell death under excessive stretch. Apoptosis. 2009;14:764-70 pubmed publisher..Taken together, our study suggests that excessive ROS induced by undue stretch favor the activation of JNK1, which in turn inhibit the activity of NFkappaB, resulting in significant apoptosis. ..
- Takahashi N, van Kilsdonk J, Ostendorf B, Smeets R, Bruggeman S, Alonso A, et al. Tumor marker nucleoporin 88 kDa regulates nucleocytoplasmic transport of NF-kappaB. Biochem Biophys Res Commun. 2008;374:424-30 pubmed publisher..We conclude that Nup88 regulates the activity of NF-kappaB at the level of nucleocytoplasmic transport. Overexpression of Nup88 in tumor cells may, thus be involved in the constitutive NF-kappaB activation. ..
- Nguyen A, Ikner A, Shiozaki M, Warren S, Shiozaki K. Cytoplasmic localization of Wis1 MAPKK by nuclear export signal is important for nuclear targeting of Spc1/Sty1 MAPK in fission yeast. Mol Biol Cell. 2002;13:2651-63 pubmed..Moreover, we have observed that a fraction of Wis1 translocates into the nucleus in response to stress. These results suggest that cytoplasmic localization of Wis1 MAPKK by its NES is important for stress signaling to the nucleus. ..
- Dominski Z, Yang X, Raska C, Santiago C, Borchers C, Duronio R, et al. 3' end processing of Drosophila melanogaster histone pre-mRNAs: requirement for phosphorylated Drosophila stem-loop binding protein and coevolution of the histone pre-mRNA processing system. Mol Cell Biol. 2002;22:6648-60 pubmed..20 nucleotides downstream from the stem, and an Sm-reactive factor, most likely the Drosophila counterpart of vertebrate U7 snRNP. ..
- Yao J, Roy Chowdhury S, Allison L. AtSig5 is an essential nucleus-encoded Arabidopsis sigma-like factor. Plant Physiol. 2003;132:739-47 pubmed..Therefore, SIG5 encodes an essential member of the Arabidopsis sigma-factor family that plays a role in plant reproduction in addition to its previously proposed role in leaf chloroplast gene expression. ..
- Rousseau J, Tetu B, Caron D, Malenfant P, Cattaruzzi P, Audette M, et al. RCAS1 is associated with ductal breast cancer progression. Biochem Biophys Res Commun. 2002;293:1544-9 pubmed..In addition, RCAS1 was identified in MCF7 culture supernatants. Those observations suggest that RCAS1 is a new marker for breast cancer progression and a possible mechanism for breast cancer immune escape. ..
- Glenn L, Searles L. Distinct domains mediate the early and late functions of the Drosophila ovarian tumor proteins. Mech Dev. 2001;102:181-91 pubmed..This study substantially clarifies the relationship between Otu structure and function and reveals new clues about interacting components. ..
- Dawson S, Pham J, House S, Slawson E, Cronembold D, Cande W. Stable transformation of an episomal protein-tagging shuttle vector in the piscine diplomonad Spironucleus vortens. BMC Microbiol. 2008;8:71 pubmed publisher..This construct also contains selectable antibiotic resistance markers for both S. vortens and E. coli...
- Jackson J, Kreisberg J, Koterba A, Yee D, Brattain M. Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells. Oncogene. 2000;19:4574-81 pubmed..Thus, these results demonstrate the phosphorylation and nuclear exclusion of FKHR after EGF treatment by a PI3 kinase dependent mechanism, and represent the first report of growth factor regulation of endogenous FKHR localization. ..
- Forrest S, Barringhaus K, Perlegas D, Hammarskjold M, McNamara C. Intron retention generates a novel Id3 isoform that inhibits vascular lesion formation. J Biol Chem. 2004;279:32897-903 pubmed
- Monga S, Micsenyi A, Germinaro M, Apte U, Bell A. beta-Catenin regulation during matrigel-induced rat hepatocyte differentiation. Cell Tissue Res. 2006;323:71-9 pubmed..Thus, beta-catenin undergoes multifactorial regulation during matrigel-induced hepatocyte differentiation and maturation; this induces its stabilization and membrane translocation, possibly contributing to hepatocyte differentiation. ..
- Weaver B, Kumar K, Reich N. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1. Mol Cell Biol. 1998;18:1359-68 pubmed..The cellular response that leads to DRAF1 activation and specific gene expression may serve to increase host survival during viral infection. ..
- Kwok S, Staub J, Deng X. Characterization of two subunits of Arabidopsis 19S proteasome regulatory complex and its possible interaction with the COP9 complex. J Mol Biol. 1999;285:85-95 pubmed..This notion is consistent with the parallel tissue-specific expression patterns and the similar, predominantly nuclear localization of both the COP9 complex and the AtS9 protein. ..
- Molkentin J, Lu J, Antos C, Markham B, Richardson J, Robbins J, et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell. 1998;93:215-28 pubmed..Pharmacologic inhibition of calcineurin activity blocks hypertrophy in vivo and in vitro. These results define a novel hypertrophic signaling pathway and suggest pharmacologic approaches to prevent cardiac hypertrophy and heart failure. ..
- Kannouche P, Fernández de Henestrosa A, Coull B, Vidal A, Gray C, Zicha D, et al. Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. EMBO J. 2002;21:6246-56 pubmed..Our results provide strong evidence that poleta targets poliota to the replication machinery, where it may play a general role in maintaining genome integrity as well as participating in translesion DNA synthesis. ..
- Gatalica Z. Immunohistochemical analysis of apocrine breast lesions. Consistent over-expression of androgen receptor accompanied by the loss of estrogen and progesterone receptors in apocrine metaplasia and apocrine carcinoma in situ. Pathol Res Pract. 1997;193:753-8 pubmed..An identical pattern of immuno-reactivity is seen in in situ apocrine carcinomas, but it is observed with less frequency in invasive apocrine carcinomas, which only infrequently express AR as the only steroid hormone receptor...
- Ordway J, Tallaksen Greene S, Gutekunst C, Bernstein E, Cearley J, Wiener H, et al. Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse. Cell. 1997;91:753-63 pubmed..Neuronal intranuclear inclusions are present in affected mice. Our results show that CAG repeats do not need to be located within one of the classic repeat disorder genes to have a neurotoxic effect. ..
- Stoltz R, Abraham N, Laniado Schwartzman M. The role of NF-kappaB in the angiogenic response of coronary microvessel endothelial cells. Proc Natl Acad Sci U S A. 1996;93:2832-7 pubmed..It is suggested that 12(R)-HETrE's angiogenic activity involves the activation of NF-kappaB, possibly via protein kinase C stimulation and the generation of reactive oxygen intermediates for downstream signaling. ..
- Lu X, Guruju M, Oswald J, Ferreira P. Limited proteolysis differentially modulates the stability and subcellular localization of domains of RPGRIP1 that are distinctly affected by mutations in Leber's congenital amaurosis. Hum Mol Genet. 2005;14:1327-40 pubmed..A novel RPGRIP1-mediated nucleocytoplasmic crosstalk and transport pathway regulated by RID, and hence by RPGR, emerges with implications in the molecular pathogenesis of retinopathies, and a model to other diseases. ..
- Young E, Pak C, Kahl B, Yang D, Callander N, Miyamoto S, et al. Microscale functional cytomics for studying hematologic cancers. Blood. 2012;119:e76-85 pubmed publisher..Our platform can be applied to myriad biological questions, enabling high-content functional cytomics of primary hematologic malignancies. ..
- Jeon T, Osborne T. SREBPs: metabolic integrators in physiology and metabolism. Trends Endocrinol Metab. 2012;23:65-72 pubmed publisher..This review focuses on recent advances and new roles for mammalian SREBPs in physiology and metabolism. ..
- Wang X, Krupczak Hollis K, Tan Y, Dennewitz M, Adami G, Costa R. Increased hepatic Forkhead Box M1B (FoxM1B) levels in old-aged mice stimulated liver regeneration through diminished p27Kip1 protein levels and increased Cdc25B expression. J Biol Chem. 2002;277:44310-6 pubmed
- Xu K, Luduena R. Characterization of nuclear betaII-tubulin in tumor cells: a possible novel target for taxol. Cell Motil Cytoskeleton. 2002;53:39-52 pubmed
- Dirscherl S, Krebs J. Functional diversity of ISWI complexes. Biochem Cell Biol. 2004;82:482-9 pubmed..This review will focus on just one subfamily, the Imitation Switch (ISWI) family, which is proving to be one of the most diverse groups of chromatin remodelers in both form and function. ..
- Yao Q, Jin W, Wang Y, Ju G. Regulated shuttling of Slit-Robo-GTPase activating proteins between nucleus and cytoplasm during brain development. Cell Mol Neurobiol. 2008;28:205-21 pubmed..4) These results suggest that srGAPs are not only involved in the regulation of the Slit-Robo signal transduction, but also in neuronal development and that the translocation of srGAPs is important for their functions. ..
- Ridanpaa M, Fodde R, Kielman M. Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures. Mech Dev. 2001;109:173-81 pubmed..These results further elucidate the role of the Wnt signal transduction pathway during hair follicle related development and tumorigenesis and illustrate the dynamic role of beta-catenin in signal transduction and cell-adhesion. ..
- Hardt W, Chen L, Schuebel K, Bustelo X, Gal n J. S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells. Cell. 1998;93:815-26 pubmed..These findings establish a paradigm for microbial stimulation of cellular responses in which the pathogen induces signaling events by directly engaging the signaling machinery within the host cell...
- Zhou Y, Zhang D, Pan J, Kong X, Liu Y, Sun L, et al. Overexpression of a multiple stress-responsive gene, ZmMPK4, enhances tolerance to low temperature in transgenic tobacco. Plant Physiol Biochem. 2012;58:174-81 pubmed publisher..Taken together, these results strongly suggest that ZmMPK4 positively regulates low temperature stress tolerance in plants...
- Ah Hot P, Rivet J, Saliou C, Bailly C, Bruneval P. [Atypical cellular blue nevus. Apropos of 1 case]. Ann Pathol. 2000;20:228-31 pubmed..The differential diagnosis such as malignant blue nevus and melanoma are discussed in search of a better definition of these rare lesions...
- Chandler J, McArdle B, Callis J. AtUBP3 and AtUBP4 are two closely related Arabidopsis thaliana ubiquitin-specific proteases present in the nucleus. Mol Gen Genet. 1997;255:302-10 pubmed..Subcellular localization studies show that AtUBP3 and/or AtUBP4 are present in nuclear extracts. Possible physiological roles for these UBPs are discussed. ..