Experts and Doctors on amino acid sequence in Anguilla


Locale: Anguilla
Topic: amino acid sequence

Top Publications

  1. Jansa S, Forsman J, Voss R. Different patterns of selection on the nuclear genes IRBP and DMP-1 affect the efficiency but not the outcome of phylogeny estimation for didelphid marsupials. Mol Phylogenet Evol. 2006;38:363-80 pubmed
    ..Thus, for these two genes, relaxed functional constraints and positive selection appear to improve the efficiency of phylogenetic estimation without compromising its accuracy...
  2. Shylo N, Christopher K, Iglesias A, Daluiski A, Weatherbee S. TMEM107 Is a Critical Regulator of Ciliary Protein Composition and Is Mutated in Orofaciodigital Syndrome. Hum Mutat. 2016;37:155-9 pubmed publisher
    ..These data indicate that TMEM107 plays a key, conserved role in regulating ciliary protein composition, and is a novel candidate for ciliopathies of unknown etiology. ..
  3. Deng J, Lazar I. Proteolytic Digestion and TiO2 Phosphopeptide Enrichment Microreactor for Fast MS Identification of Proteins. J Am Soc Mass Spectrom. 2016;27:686-98 pubmed publisher
    ..Preliminary analysis of cell extracts and recombinant proteins indicated the feasibility of integration of these microreactors in more advanced workflows amenable for handling real-world biological samples. Graphical Abstract á…Ÿ. ..
  4. Molkentin J, Li L, Olson E. Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity. J Biol Chem. 1996;271:17199-204 pubmed
    ..This phosphorylation site, which corresponds to a CKII recognition site, is conserved in all known MEF2 factors in organisms ranging from flies to humans, consistent with its importance for the functions of MEF2C. ..
  5. Huang C, Jan Y, Jan L. Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. FEBS Lett. 1997;405:291-8 pubmed
    ..These results are consistent with the idea that the N- and C-terminal domains of the cardiac G protein-gated K+ channel subunits may interact with each other to form higher affinity binding site(s) for G betagamma. ..
  6. Spier A, de Lecea L. Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res Brain Res Rev. 2000;33:228-41 pubmed
    ..recent advances in our understanding of the neurobiology of cortistatin, examines the similarities and differences between cortistatin and somatostatin, and asks the question: does cortistatin bind to a cortistatin-specific receptor? ..
  7. Zheng L, Pan H, Li S, Flesken Nikitin A, Chen P, Boyer T, et al. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. Mol Cell. 2000;6:757-68 pubmed
    ..These results thus reveal a novel corepressor function for BRCA1 and provide a mechanistic basis for the biological activity of BRCA1 through sequence-specific transcriptional regulation. ..
  8. Song C, Dubay S, Hunter E. A tyrosine motif in the cytoplasmic domain of mason-pfizer monkey virus is essential for the incorporation of glycoprotein into virions. J Virol. 2003;77:5192-200 pubmed
    ..Antibody uptake studies show that tyrosine 22 is part of an efficient internalization signal in the cytoplasmic domain of the M-PMV glycoprotein that can also be positively and negatively influenced by changes at this site...
  9. Levy M, Ellington A. Peptide-templated nucleic acid ligation. J Mol Evol. 2003;56:607-15 pubmed
    ..These results support the possibility that life could have originated with peptide replicators and transitioned to nucleic acid replicators or that peptide and nucleic acid replicators could have been interdependent. ..

More Information

Publications380 found, 100 shown here

  1. Rao X, Li S, Hu J, Jin X, Hu X, Huang J, et al. A novel carrier molecule for high-level expression of peptide antibiotics in Escherichia coli. Protein Expr Purif. 2004;36:11-8 pubmed
    ..These results show that the carrier molecule can result in high-level expression of peptide antibiotics, and expression products can be easily recovered from their fusion partner and retain their bioactivity. ..
  2. Szymczyna B, Taurog R, Young M, Snyder J, Johnson J, Williamson J. Synergy of NMR, computation, and X-ray crystallography for structural biology. Structure. 2009;17:499-507 pubmed publisher
    ..This approach takes advantage of the most accessible aspects of each structural technique and may be widely applicable for structure determination...
  3. Thulasitha W, Umasuthan N, Whang I, Nam B, Lee J. Antimicrobial response of galectin-1 from rock bream Oplegnathus fasciatus: Molecular, transcriptional, and biological characterization. Fish Shellfish Immunol. 2016;50:66-78 pubmed publisher
    ..Collectively, results from the present study indicate that OfGal-1 can recognize a wide range of microbes and is a vital pattern recognition receptor in the innate immune system of rock bream. ..
  4. Tong S, Porco A, Isturiz T, Conway T. Cloning and molecular genetic characterization of the Escherichia coli gntR, gntK, and gntU genes of GntI, the main system for gluconate metabolism. J Bacteriol. 1996;178:3260-9 pubmed
  5. Roos M, Su K, Baker J, Kudlow J. O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions. Mol Cell Biol. 1997;17:6472-80 pubmed
    ..We propose the hypothesis that the removal of O-GlcNAc from an interaction domain can be a signal for protein association. O-GlcNAc may thereby prevent untimely and ectopic interactions. ..
  6. Alfonzo J, Sahota A, Taylor M. Purification and characterization of adenine phosphoribosyltransferase from Saccharomyces cerevisiae. Biochim Biophys Acta. 1997;1341:173-82 pubmed
    ..The Km for adenine and PRPP were 6 microM and 15 microM, respectively and the Vmax was 15 micromol/min. These kinetic constants are comparable to the constants of APRT from other organisms. ..
  7. Patterson K, Krieg P. Hox11-family genes XHox11 and XHox11L2 in xenopus: XHox11L2 expression is restricted to a subset of the primary sensory neurons. Dev Dyn. 1999;214:34-43 pubmed
    ..The timing of Xhox11 and Xhox11L2 expression indicates that Hox11-family members may participate in the final stages of the differentiation process. ..
  8. Lee T, Kim S, Kang S, Lee K, Rhee S, Yu D. Molecular cloning and characterization of the mouse peroxiredoxin V gene. Biochem Biophys Res Commun. 2000;270:356-62 pubmed
    ..The inability of protein expression for the long-form cDNA in testis suggests that the uORFs might inhibit translation of the major ORF and thereby confer the tissue-specific regulation of the mouse Prx V gene. ..
  9. Dreier B, Segal D, Barbas C. Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains. J Mol Biol. 2000;303:489-502 pubmed
    ..This understanding should enable us to refine rapidly the specificity of other zinc finger domains, as well as polydactyl proteins constructed with these domains to recognize extended DNA sequences. ..
  10. Hudson B, Martinez Yamout M, Dyson H, Wright P. Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain. J Mol Biol. 2000;304:355-70 pubmed
  11. Reed W, Carson J, Moats Staats B, Lucier T, Hu P, Brighton L, et al. Characterization of an axonemal dynein heavy chain expressed early in airway epithelial ciliogenesis. Am J Respir Cell Mol Biol. 2000;23:734-41 pubmed
    ..These data suggested that the gene encodes an axonemal DHC that is expressed early during ciliogenesis, before the appearance of cilia. ..
  12. Liu P, Kaufman T. Kruppel is a gap gene in the intermediate germband insect Oncopeltus fasciatus and is required for development of both blastoderm and germband-derived segments. Development. 2004;131:4567-79 pubmed
    ..Our results show that Krüppel is required for both blastoderm-derived and germband-derived segments and indicate that Krüppel function is largely conserved in Oncopeltus and Drosophila despite their divergent embryogenesis...
  13. Verdijk P, Dijkman R, Plasmeijer E, Mulder A, Zoutman W, Mieke Mommaas A, et al. A lack of Birbeck granules in Langerhans cells is associated with a naturally occurring point mutation in the human Langerin gene. J Invest Dermatol. 2005;124:714-7 pubmed
    ..Expression of mutated Langerin in human fibroblasts induces tubular-like structures that are negative for BG-specific antibodies and do not resemble the characteristic structural features of BG. ..
  14. Chu S, Zengel J, Lindahl L. A novel protein shared by RNase MRP and RNase P. RNA. 1997;3:382-91 pubmed
    ..Immunoprecipitation studies indicate that Pop4p is associated with both RNase MRP and RNase P. The protein is also required for accumulation of RNA from each of the two ribonucleoprotein particles. ..
  15. Smith A, Roche H, Trombe M, Briles D, H kansson A. Characterization of the dihydrolipoamide dehydrogenase from Streptococcus pneumoniae and its role in pneumococcal infection. Mol Microbiol. 2002;44:431-48 pubmed
    ..The DLDH-negative bacteria produced only 50% of normal capsular polysaccharide, a phenotype that may be associated with impaired carbohydrate metabolism...
  16. Gaucher D, Chadee K. Molecular cloning and expression of gerbil granulocyte/macrophage colony-stimulating factor. Gene. 2002;294:233-8 pubmed
    ..COS-7 cells transfected with gerbil GM-CSF cDNA secreted high levels of bioactive GM-CSF, as their supernatant stimulated gerbil bone-marrow cell proliferation and colony formation in semi-solid medium. ..
  17. Cui Q, Thorgersen M, Westler W, Markley J, Downs D. Solution structure of YggX: a prokaryotic protein involved in Fe(II) trafficking. Proteins. 2006;62:578-86 pubmed
    ..The finding that iron binds only weakly to YggX, and not to a highly conserved region of the structure, suggests that the role of this protein in iron homeostasis is more complex than previously thought. ..
  18. Barile M, Giancaspero T, Brizio C, Panebianco C, Indiveri C, Galluccio M, et al. Biosynthesis of flavin cofactors in man: implications in health and disease. Curr Pharm Des. 2013;19:2649-75 pubmed
  19. Scovill W, Schreier H, Bayles K. Identification and characterization of the pckA gene from Staphylococcus aureus. J Bacteriol. 1996;178:3362-4 pubmed
    ..Both enzymatic activity and pckA promoter activity in wild-type cells grown in the absence of glucose were at least 22-fold greater than activities in cells grown in the presence of glucose...
  20. Wang Z, Harkins P, Ulevitch R, Han J, Cobb M, Goldsmith E. The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proc Natl Acad Sci U S A. 1997;94:2327-32 pubmed
    ..The results explain why MAP kinases are specific for different activating enzymes, substrates, and inhibitors. A model presented for substrate and activator interactions has implications for the evolution of protein kinase cascades. ..
  21. Kuramoto T, Nomoto T, Fujiwara A, Mizutani M, Sugimura T, Ushijima T. Insertional mutation of the Attractin gene in the black tremor hamster. Mamm Genome. 2002;13:36-40 pubmed
    ..The bt/bt hamster will provide a useful tool for further understanding of the pleiotropic functions of Attractin. ..
  22. de Haan E, Wauben M, Grosfeld Stulemeyer M, Kruijtzer J, Liskamp R, Moret E. Major histocompatibility complex class II binding characteristics of peptoid-peptide hybrids. Bioorg Med Chem. 2002;10:1939-45 pubmed
    ..We conclude that the side chain position as well as the backbone nitrogen atom hydrogen bonding features of solvent-exposed residues in the peptide can be important for MHC binding affinity. ..
  23. Kim Y, Woloshuk C, Cho E, Bae J, Song Y, Huh G. Cloning and functional expression of the gene encoding an inhibitor against Aspergillus flavus alpha-amylase, a novel seed lectin from Lablab purpureus (Dolichos lablab). Plant Cell Rep. 2007;26:395-405 pubmed
    ..These results are a valuable contribution to our knowledge of plant-pathogen interactions and will be applicable for developing protocols aimed at controlling A. flavus infection...
  24. Li A, Xie C, Zhang J, Zhang J, Li D. Cloning, expression, and characterization of serine protease from thermophilic fungus Thermoascus aurantiacus var. levisporus. J Microbiol. 2011;49:121-9 pubmed publisher
    ..The protease activity was found to be inhibited by PMSF, but not by DTT or EDTA. The enzyme has broad substrate specificity such as gelatin, casein and pure milk, and exhibiting highest activity towards casein. ..
  25. Golling G, Li L, Pepling M, Stebbins M, Gergen J. Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate the DNA-binding properties of Runt. Mol Cell Biol. 1996;16:932-42 pubmed
  26. Kim K, Farrand S. Ti plasmid-encoded genes responsible for catabolism of the crown gall opine mannopine by Agrobacterium tumefaciens are homologs of the T-region genes responsible for synthesis of this opine by the plant tumor. J Bacteriol. 1996;178:3275-84 pubmed
    ..We propose that moc genes derived from genes located elsewhere in the bacterial genome and that the tumor-expressed mas genes evolved from the bacterial moc genes. ..
  27. Johnson A. Rat1p and Xrn1p are functionally interchangeable exoribonucleases that are restricted to and required in the nucleus and cytoplasm, respectively. Mol Cell Biol. 1997;17:6122-30 pubmed
    ..It is likely that the higher eukaryotic homologs of these proteins will function similarly in the cytoplasm and nucleus. ..
  28. Pestova T, Lomakin I, Lee J, Choi S, Dever T, Hellen C. The joining of ribosomal subunits in eukaryotes requires eIF5B. Nature. 2000;403:332-5 pubmed
    ..It is a homologue of the prokaryotic initiation factor IF2 (re and, like it, mediates joining of subunits and has a ribosome-dependent GTPase activity that is essential for its function. ..
  29. Horton A, Hak K, Steffan R, Foster J, Bej A. Adaptive response to cold temperatures and characterization of cspA in Salmonella typhimurium LT2. Antonie Van Leeuwenhoek. 2000;77:13-20 pubmed
    ..typhimurium following exposure to cold temperatures suggest that adaptation and continued growth and survival at cold temperatures in this pathogen may be aided by these cold-responsive proteins. ..
  30. Lea I, Sivashanmugam P, O Rand M. Zonadhesin: characterization, localization, and zona pellucida binding. Biol Reprod. 2001;65:1691-700 pubmed
    ..We show that recombinant D4 domain can bind zona pellucida, and we propose that zonadhesin functions after the acrosome reaction has been initiated to bind the acrosomal shroud to the zona pellucida...
  31. Yun Y, Lee Y. Purification and some properties of superoxide dismutase from Deinococcus radiophilus, the UV-resistant bacterium. Extremophiles. 2004;8:237-42 pubmed
    ..The N-terminal peptide sequence of D. radiophilus Mn/FeSOD (MAFELPQLPYAYDALEPHIDA(> D) is strikingly similar to those of D. radiodurans MnSOD and Aerobacter aerogenes FeSOD. ..
  32. Wang Z, Wei H, Yu Y, Sun J, Yang Y, Xing G, et al. Characterization of Ceap-11 and Ceap-16, two novel splicing-variant-proteins, associated with centrosome, microtubule aggregation and cell proliferation. J Mol Biol. 2004;343:71-82 pubmed
    ..Taken together, our data provide the first evidence for the function of Ceap-11 and Ceap-16, the two novel human proteins, namely, association with centrosome, microtubule aggregation and cell proliferation. ..
  33. Kong B, Foster L, Foster D. Comparison of avian cell substrates for propagating subtype C avian metapneumovirus. Virus Res. 2006;116:58-68 pubmed
    ..These results suggest that AMPV propagated in homologous avian cellular substrates may produce more infectious virus with possibly more effective fusion activity, compared to Vero cell propagation. ..
  34. Mohammadi M, Dikic I, Sorokin A, Burgess W, Jaye M, Schlessinger J. Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. Mol Cell Biol. 1996;16:977-89 pubmed
    ..Binding of the Grb2/Sos complex to phosphorylated Shc and pp90 may therefore be the key link between FGFR1 and the Ras signaling pathway, mito-genesis, and neuronal differentiation. ..
  35. Oliver T, Berg J, Cheney R. Tails of unconventional myosins. Cell Mol Life Sci. 1999;56:243-57 pubmed
    ..1, Ezrin, Radixin, Moesin) domains, that are present in the tails of otherwise very different myosins as well as a plant kinesin-like protein. Recent progress in the identification of novel unconventional myosins will also be summarized. ..
  36. Murakami M, Ohtake T, Dorschner R, Schittek B, Garbe C, Gallo R. Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin. J Invest Dermatol. 2002;119:1090-5 pubmed
    ..Thus, sweat represents a unique mode of delivery for potent innate immune effector molecules in the absence of inflammation. ..
  37. Nishizawa M, Kataoka K, Vogt P. MafA has strong cell transforming ability but is a weak transactivator. Oncogene. 2003;22:7882-90 pubmed
    ..These regulatable constructs permit a kinetic characterization of target gene responses and facilitate discrimination between direct and indirect targets. ..
  38. Lee C, Yeo Y, Lee J, Kim S, Kim J, Han N, et al. Identification of a novel 4-hydroxyphenylpyruvate dioxygenase from the soil metagenome. Biochem Biophys Res Commun. 2008;370:322-6 pubmed publisher
    ..The recombinant protein expressed in E. coli generated homogentisic acid. Thus, we present the successful heterologous expression of a previously uncharacterized hppd gene from an uncultured soil bacterium. ..
  39. McGoldrick J, Yeh Y, Solomon M, Essigmann J, Lu A. Characterization of a mammalian homolog of the Escherichia coli MutY mismatch repair protein. Mol Cell Biol. 1995;15:989-96 pubmed
    ..The eukaryotic MYH may be involved in the major repair of both replication errors and oxidative damage to DNA, the same functions as those of the E. coli MutY protein. ..
  40. Torok T, Harvie P, Buratovich M, Bryant P. The product of proliferation disrupter is concentrated at centromeres and required for mitotic chromosome condensation and cell proliferation in Drosophila. Genes Dev. 1997;11:213-25 pubmed
    ..We propose that Prod is a nonhistone protein essential for chromosome condensation and that the chromosomal and developmental defects are caused by incomplete centromere condensation in prod mutants. ..
  41. Li P, Nijhawan D, Budihardjo I, Srinivasula S, Ahmad M, Alnemri E, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997;91:479-89 pubmed
  42. Roggy J, Bangs J. Molecular cloning and biochemical characterization of a VCP homolog in African trypanosomes. Mol Biochem Parasitol. 1999;98:1-15 pubmed
    ..Also like other VCP homologs, TbVCP contains an NEM-inhibitable ATPase activity. This is the first characterization of an AAA (ATPases Associated with a variety of cellular Activities) family member in African trypanosomes. ..
  43. Graves L, Guy H, Kozlowski P, Huang M, Lazarowski E, Pope R, et al. Regulation of carbamoyl phosphate synthetase by MAP kinase. Nature. 2000;403:328-32 pubmed
    ..Hence these studies may indicate a direct link between activation of the MAP kinase cascade and de novo biosynthesis of pyrimidine nucleotides. ..
  44. Lim S, Longley R, Couchman J, Woods A. Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase C alpha (PKC alpha) increases focal adhesion localization of PKC alpha. J Biol Chem. 2003;278:13795-802 pubmed
    ..The data support a mechanism where syndecan-4 binds PKC alpha and localizes it to focal adhesions, whose assembly may be regulated by the kinase. ..
  45. Aneja P, Charles T. Characterization of bdhA, encoding the enzyme D-3-hydroxybutyrate dehydrogenase, from Sinorhizobium sp. strain NGR234. FEMS Microbiol Lett. 2005;242:87-94 pubmed
    ..meliloti acsA2 gene. The glpK-bdhA-xdhA gene organization and the bdhA-xdhA operon arrangement observed in S. meliloti are also conserved in NGR234. ..
  46. Dean D, Millman K. Molecular and mutation trends analyses of omp1 alleles for serovar E of Chlamydia trachomatis. Implications for the immunopathogenesis of disease. J Clin Invest. 1997;99:475-83 pubmed publisher
    ..Understanding the mutation trends, phylogeny, and molecular epidemiology of E variants is essential for designing public health control interventions and a vaccine...
  47. Dosé A, Burnside B. Cloning and chromosomal localization of a human class III myosin. Genomics. 2000;67:333-42 pubmed
    ..1 on the human cytogenetic map. Since mutations in NINAC have been shown to alter the photoresponse and compromise photoreceptor survival, the human homologue MYO3A may also play a role in photoreceptor function and/or maintenance. ..
  48. Migliaccio C, Van De Water J, Ansari A, Kaplan M, Coppel R, Lam K, et al. Heterogeneous response of antimitochondrial autoantibodies and bile duct apical staining monoclonal antibodies to pyruvate dehydrogenase complex E2: the molecule versus the mimic. Hepatology. 2001;33:792-801 pubmed
    ..These findings further highlight the heterogeneous response of patient autoantibodies to the inner lipoyl domain of PDC-E2. ..
  49. Hart P, Deep S, Taylor A, Shu Z, Hinck C, Hinck A. Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex. Nat Struct Biol. 2002;9:203-8 pubmed
  50. Misenheimer T, Hannah B, Annis D, Mosher D. Interactions among the three structural motifs of the C-terminal region of human thrombospondin-2. Biochemistry. 2003;42:5125-32 pubmed
    ..Both transitions were stabilized in constructs containing E3. These results indicate that E3, Ca, and G function as a complex structural unit, and that the structures of both Ca and G are influenced by the presence or absence of Ca(2+). ..
  51. Kim D, Lee K, Kim J, Kim S, Song J, Seo Y, et al. Identification of Kunitz trypsin inhibitor mutations using SNAP markers in soybean mutant lines. Theor Appl Genet. 2010;121:751-60 pubmed publisher
    ..These results indicate that the designed SNAP marker was capable of identifying the KTi type and that Tia activity was higher than Tib activity in soybean. ..
  52. Fang Y, Tyler B. Efficient disruption and replacement of an effector gene in the oomycete Phytophthora sojae using CRISPR/Cas9. Mol Plant Pathol. 2016;17:127-39 pubmed publisher
    ..Our results establish a powerful tool for the study of functional genomics in Phytophthora, which provides new avenues for better control of this pathogen. ..
  53. Khakinejad M, Kondalaji S, Donohoe G, Valentine S. Ion Mobility Spectrometry-Hydrogen Deuterium Exchange Mass Spectrometry of Anions: Part 3. Estimating Surface Area Exposure by Deuterium Uptake. J Am Soc Mass Spectrom. 2016;27:462-73 pubmed publisher
    ..Using ions of similar conformational type, this comparison highlights the complementary nature of HDX data obtained from positive- and negative-ion analysis. ..
  54. Riley T, Singh N, Pierce B, Weng Z, Baker B. Computational Modeling of T Cell Receptor Complexes. Methods Mol Biol. 2016;1414:319-40 pubmed publisher
    ..As TCRs are highly sensitive to subtle structural perturbations, there is room for improvement. Our method nonetheless generates high-quality models that can be foundational for structure-based hypotheses regarding TCR recognition. ..
  55. Chang Y, Wang A, Cronan J. Molecular cloning, DNA sequencing, and biochemical analyses of Escherichia coli glyoxylate carboligase. An enzyme of the acetohydroxy acid synthase-pyruvate oxidase family. J Biol Chem. 1993;268:3911-9 pubmed
    ..coli AHAS isozyme large and small subunits, Orf258 does not function as a Gcl subunit. Moreover, disruption of the chromosomal copy of orf258 did not affect growth on glyoxylate or glycolate. ..
  56. Petcherski A, Kimble J. LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway. Nature. 2000;405:364-8 pubmed
    ..elegans. We propose that GLP-1 and LIN-12 promote signalling by recruiting LAG-3 to target promoters, where it functions as a transcriptional activator. ..
  57. McManus M, Shimamura M, Grams J, Hajduk S. Identification of candidate mitochondrial RNA editing ligases from Trypanosoma brucei. RNA. 2001;7:167-75 pubmed
    ..These findings provide strong support for the enzymatic cascade model for kinetoplastid RNA editing...
  58. Qi P, Wickham E, Piotrowski E, Fagerquist C, Farrell H. Implication of C-terminal deletion on the structure and stability of bovine beta-casein. Protein J. 2005;24:431-44 pubmed
    ..It has been demonstrated clearly that the tail peptide beta-CN-(f193-209) is important in maintaining the hydrophobic core of beta-CN but the residual association observed argues for a minor role for other sites as well. ..
  59. Boutin J. [Melatonin binding site MT3 is QR2: state of the art]. J Soc Biol. 2007;201:97-103 pubmed
  60. Choi S, Kim J, Joo H, Min C. Identification and characterization of a novel bacterial ATP-sensitive K+ channel. J Microbiol. 2010;48:325-30 pubmed publisher
    ..Collectively, cloning and functional characterization of bacterial ion channels could be greatly facilitated by combining the in silico analysis and heterologous expression in Xenopus oocytes. ..
  61. Zhang Y, Feng X, We R, Derynck R. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature. 1996;383:168-72 pubmed
    ..These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor. ..
  62. Cates C, Michael R, Stayrook K, Harvey K, Burke Y, Randall S, et al. Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases. Cancer Lett. 1996;110:49-55 pubmed
    ..Thus, PTP(CAAXI) and PTP(CAAX2) represent a novel class of isoprenylated, oncogenic protein tyrosine phosphatases. ..
  63. Sonnenfeld M, Ward M, Nystrom G, Mosher J, Stahl S, Crews S. The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development. Development. 1997;124:4571-82 pubmed
    ..These experiments support the existence of an evolutionarily conserved, functionally diverse bHLH-PAS protein regulatory system. ..
  64. MacDougall M, Gu T, Luan X, Simmons D, Chen J. Identification of a novel isoform of mouse dentin matrix protein 1: spatial expression in mineralized tissues. J Bone Miner Res. 1998;13:422-31 pubmed
    ..Therefore, Dmp1 is not a tooth-specific protein but rather is expressed in a number of mineralizing tissues including enamel, bone, and cementum. ..
  65. Angeletti P, Engler J. Adenovirus preterminal protein binds to the CAD enzyme at active sites of viral DNA replication on the nuclear matrix. J Virol. 1998;72:2896-904 pubmed
    ..These data support the concept that the pTP-CAD interaction may allow anchorage of Ad replication complexes in the proximity of required cellular factors and may help to segregate replicated and unreplicated viral DNA. ..
  66. Alley T, Cooper M, Chen M, Kubagawa H. Genomic structure of PIR-B, the inhibitory member of the paired immunoglobulin-like receptor genes in mice. Tissue Antigens. 1998;51:224-31 pubmed
    ..A microsatellite composed of the trinucleotide repeat AAG in the intron between exons 9 and 10 provides a useful marker for studying population genetics. ..
  67. Holmbeck S, Foster M, Casimiro D, Sem D, Dyson H, Wright P. High-resolution solution structure of the retinoid X receptor DNA-binding domain. J Mol Biol. 1998;281:271-84 pubmed
    ..Other differences between the X-ray and NMR structures occur in the second zinc-binding loop, which is disordered in solution. Heteronuclear 15N NOE measurements suggest that this loop has enhanced flexibility in the free protein. ..
  68. Bruns C, Hubatsch I, Ridderström M, Mannervik B, Tainer J. Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products. J Mol Biol. 1999;288:427-39 pubmed
    ..A structural model of catalysis is presented based on these results. ..
  69. Christophe D, Christophe Hobertus C, Pichon B. Nuclear targeting of proteins: how many different signals?. Cell Signal. 2000;12:337-41 pubmed
    ..It will probably also lead to the identification of novel target sequences for importins and will demonstrate the implication of additional members of this family of proteins in nuclear transport. ..
  70. Martinez Yamout M, Legge G, Zhang O, Wright P, Dyson H. Solution structure of the cysteine-rich domain of the Escherichia coli chaperone protein DnaJ. J Mol Biol. 2000;300:805-18 pubmed
    ..The three-dimensional structure of the E. coli CR domain indicates that this sequence conservation is likely to result in a conserved structural motif. ..
  71. Li Y, Chen Z, Wang W, Baker C, Krug R. The 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo. RNA. 2001;7:920-31 pubmed
    ..In contrast, the 3'-end processing factor PABII is not required for splicing. We discuss the implications of these results for cellular and influenza viral mRNA splicing. ..
  72. Mueller Ortiz S, Wanger A, Norris S. Mycobacterial protein HbhA binds human complement component C3. Infect Immun. 2001;69:7501-11 pubmed
    ..tuberculosis and M. avium to mononuclear phagocytes through the binding of C3 and interaction with C3 receptors on mononuclear phagocytes. ..
  73. Land K, Delgadillo M, Johnson P. In vivo expression of ferredoxin in a drug resistant trichomonad increases metronidazole susceptibility. Mol Biochem Parasitol. 2002;121:153-7 pubmed
  74. Guevara Flores A, Pardo J, Rendón J. Hysteresis in thioredoxin-glutathione reductase (TGR) from the adult stage of the liver fluke Fasciola hepatica. Parasitol Int. 2011;60:156-60 pubmed publisher al. (2008) J Biol Chem 283: 17898] needs to be reevaluated. ..
  75. Chen W, Dong J, Li S, Liu Y, Wang Y, Yoon L, et al. Synthesis of Sulfotyrosine-Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc-Based Solid-Phase Strategy. Angew Chem Int Ed Engl. 2016;55:1835-8 pubmed publisher
    ..Basic ethylene glycol, serving both as solvent and reactant, transforms the fluorosulfated tyrosine peptides into sulfotyrosine peptides in high yield. ..
  76. Runyen Janecky L, Sample A, Maleniak T, West S. A divergently transcribed open reading frame is located upstream of the Pseudomonas aeruginosa vfr gene, a homolog of Escherichia coli crp. J Bacteriol. 1997;179:2802-9 pubmed
    ..Thus, the orfX mRNA cannot hybridize to the 5' end of the vfr mRNA to inhibit vfr transcription, a mechanism that has been postulated to control crp transcription in E. coli...
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