Pelvic Floor Disorders Network - Duke University Clinical Site

Summary

Principal Investigator: Anthony G Visco
Abstract: DESCRIPTION (provided by applicant): Pelvic floor disorders research at Duke University Medical Center (DUMC) is sophisticated and comprehensive with committed investigators addressing issues of great importance to women. DUMC has a tradition of excellence in clinical care, training and research in pelvic floor disorders and includes one of the nation's first accredited fellowship programs in the field. DUMC offers detailed evaluation and treatment in a high-volume, multidisciplinary setting that serves as a tertiary referral center for women across the southeast US. Each of the five Duke urogynecology investigators is fellowship-trained with expertise in both surgical and non-surgical management of urinary incontinence (Ul), pelvic organ prolapse (POP), fecal incontinence, and defecatory dysfunction. Last year, our Division cared for more than 1550 new patients and performed more than 400 surgical procedures for Ul and 270 for POP. Our patient population is 80% Caucasian, 15% African American, 2% Asian and 2% Hispanic, from both suburban and rural communities with stable care and follow-up patterns. DUMC is the hub of a multidisciplinary team of outstanding collaborative investigators in urogynecology, urology, colorectal surgery, gastroenterology, maternal-fetal medicine, physical therapy and epidemiology. DUMC offers a wide range of diagnostic resources: multi-channel urodynamic testing, video urodynamics, cystoscopy, defecography, pelvic MRI, endoanal ultrasound, and needle electromyography. During the current PFDN cycle, DUMC-initiated three active RCTs: 1. Anticholinergic vs Botox RCT (ABC, Dr. Visco, currently enrolling), Interstim vs Botox RCT (ROSETTA, Dr. Amundsen, full protocol), and a RCT evaluating transvaginal mesh for prolapse repair (Dr. Weidner, mini-protocol planned for fall of 2010. DUMC has consistently been a high recruitment site across a wide range of non-surgical and surgical studies with unparalleled retention rates. We have proven our ability to support and successfully complete large-scale, multi-centered investigations through our robust clinical practice and exceptional research infrastructure. Accordingly, Duke University Medical Center is well equipped and uniquely qualified to continue as a valuable and productive member of the Pelvic Floor Disorders Network. RELEVANCE: Female pelvic floor disorders represent a major public health burden given their high prevalence, impairment of quality of life, and substantial economic costs. As part of the Pelvic Floor Disorders Network, Duke University Medical Center is committed to actively participating in innovative clinical trials aimed at improving the evaluation and treatment of pelvic floor disorders through high-quality, high-impact clinical research.
Funding Period: 2001-09-01 - 2016-06-30
more information: NIH RePORT

Top Publications

  1. pmc Symptom outcomes important to women with anal incontinence: a conceptual framework
    Vivian W Sung
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Alpert Medical School of Brown University, Providence, Rhode Island the Division of Urogynecology, Department of Obstetrics and Gynecology, University of New, Mexico, Albuquerque, New Mexico the Program for Research in Survey Methodology, RTI International, Research Triangle Park, North Carolina the Division of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Pennsylvania Health System Department, Philadelphia, Pennsylvania the Center for Urogynecology and Reconstructive Pelvic Surgery, Obstetrics, Gynecology and Women s, Health Institute, Cleveland Clinic, Cleveland, Ohio the Women s Center for Bladder and Pelvic Health, Department of Obstetrics and Gynecology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania the Department of Reproductive Medicine, UC San Diego Health Systems, San Diego, California the Birmingham and Atlanta Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs Medical Center, Division of Gerontology, Geriatrics, and Palliative Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama the Division of Urogynecology, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland
    Obstet Gynecol 123:1023-30. 2014
  2. pmc Continence pessary compared with behavioral therapy or combined therapy for stress incontinence: a randomized controlled trial
    Holly E Richter
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Obstet Gynecol 115:609-17. 2010
  3. pmc Effects of colpocleisis on bowel symptoms among women with severe pelvic organ prolapse
    Robert E Gutman
    Department of Obstetrics and Gynecology, Washington Hospital Center, Washington, DC, USA
    Int Urogynecol J 21:461-6. 2010
  4. pmc The questionnaire for urinary incontinence diagnosis (QUID): validity and responsiveness to change in women undergoing non-surgical therapies for treatment of stress predominant urinary incontinence
    Catherine S Bradley
    Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Neurourol Urodyn 29:727-34. 2010
  5. pmc Pelvic organ support among primiparous women in the first year after childbirth
    Victoria L Handa
    Department of Gynecology and Obstetrics, Johns Hopkins University, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Int Urogynecol J Pelvic Floor Dysfunct 20:1407-11. 2009
  6. pmc Defining success after surgery for pelvic organ prolapse
    Matthew D Barber
    Obstetrics, Gynecology, and Women s Health Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Obstet Gynecol 114:600-9. 2009
  7. pmc Measurements from image-based three dimensional pelvic floor reconstruction: a study of inter- and intraobserver reliability
    Lennox Hoyte
    University of South Florida, College of Medicine, Division of Urogynecology and Pelvic Reconstructive Surgery, Tampa General Hospital, Urogynecology Division, Tampa, Florida 33606 3508, USA
    J Magn Reson Imaging 30:344-50. 2009
  8. pmc Incontinence pessaries: size, POPQ measures, and successful fitting
    Charles W Nager
    Department of Reproductive Medicine, University of California, San Diego, San Diego, CA, USA
    Int Urogynecol J Pelvic Floor Dysfunct 20:1023-8. 2009
  9. pmc Fecal incontinence in US adults: epidemiology and risk factors
    William E Whitehead
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Gastroenterology 137:512-7, 517.e1-2. 2009
  10. pmc The minimum important differences for the urinary scales of the Pelvic Floor Distress Inventory and Pelvic Floor Impact Questionnaire
    Matthew D Barber
    Obstetrics, Gynecology, and Women s Health Institute, Cleveland Clinic, Cleveland, OH, USA
    Am J Obstet Gynecol 200:580.e1-7. 2009

Research Grants

  1. DRUG DEPENDENCE CLINICAL RESEARCH PROGRAM
    Reese T Jones; Fiscal Year: 2013

Detail Information

Publications68

  1. pmc Symptom outcomes important to women with anal incontinence: a conceptual framework
    Vivian W Sung
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Alpert Medical School of Brown University, Providence, Rhode Island the Division of Urogynecology, Department of Obstetrics and Gynecology, University of New, Mexico, Albuquerque, New Mexico the Program for Research in Survey Methodology, RTI International, Research Triangle Park, North Carolina the Division of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Pennsylvania Health System Department, Philadelphia, Pennsylvania the Center for Urogynecology and Reconstructive Pelvic Surgery, Obstetrics, Gynecology and Women s, Health Institute, Cleveland Clinic, Cleveland, Ohio the Women s Center for Bladder and Pelvic Health, Department of Obstetrics and Gynecology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania the Department of Reproductive Medicine, UC San Diego Health Systems, San Diego, California the Birmingham and Atlanta Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs Medical Center, Division of Gerontology, Geriatrics, and Palliative Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama the Division of Urogynecology, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland
    Obstet Gynecol 123:1023-30. 2014
    ..To develop a framework that describes the most important symptom outcomes for anal incontinence treatment from the patient perspective...
  2. pmc Continence pessary compared with behavioral therapy or combined therapy for stress incontinence: a randomized controlled trial
    Holly E Richter
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Obstet Gynecol 115:609-17. 2010
    ..To compare the effectiveness of a continence pessary to evidence-based behavioral therapy for stress incontinence and to assess whether combined pessary and behavioral therapy is superior to single-modality therapy...
  3. pmc Effects of colpocleisis on bowel symptoms among women with severe pelvic organ prolapse
    Robert E Gutman
    Department of Obstetrics and Gynecology, Washington Hospital Center, Washington, DC, USA
    Int Urogynecol J 21:461-6. 2010
    ..Our objective was to evaluate bowel symptoms after colpocleisis...
  4. pmc The questionnaire for urinary incontinence diagnosis (QUID): validity and responsiveness to change in women undergoing non-surgical therapies for treatment of stress predominant urinary incontinence
    Catherine S Bradley
    Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Neurourol Urodyn 29:727-34. 2010
    ..This study's objective was to evaluate QUID validity and responsiveness when used as a clinical trial outcome measure...
  5. pmc Pelvic organ support among primiparous women in the first year after childbirth
    Victoria L Handa
    Department of Gynecology and Obstetrics, Johns Hopkins University, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Int Urogynecol J Pelvic Floor Dysfunct 20:1407-11. 2009
    ..This study describes pelvic organ support after childbirth...
  6. pmc Defining success after surgery for pelvic organ prolapse
    Matthew D Barber
    Obstetrics, Gynecology, and Women s Health Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Obstet Gynecol 114:600-9. 2009
    ..To describe pelvic organ prolapse surgical success rates using a variety of definitions with differing requirements for anatomic, symptomatic, or re-treatment outcomes...
  7. pmc Measurements from image-based three dimensional pelvic floor reconstruction: a study of inter- and intraobserver reliability
    Lennox Hoyte
    University of South Florida, College of Medicine, Division of Urogynecology and Pelvic Reconstructive Surgery, Tampa General Hospital, Urogynecology Division, Tampa, Florida 33606 3508, USA
    J Magn Reson Imaging 30:344-50. 2009
    ..To describe inter- and intraobserver reliability of 3D measurements of female pelvic floor structures...
  8. pmc Incontinence pessaries: size, POPQ measures, and successful fitting
    Charles W Nager
    Department of Reproductive Medicine, University of California, San Diego, San Diego, CA, USA
    Int Urogynecol J Pelvic Floor Dysfunct 20:1023-8. 2009
    ..The aim of the study was to determine whether successful incontinence pessary fitting or pessary size can be predicted by specific POPQ measurements in women without advanced pelvic organ prolapse...
  9. pmc Fecal incontinence in US adults: epidemiology and risk factors
    William E Whitehead
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Gastroenterology 137:512-7, 517.e1-2. 2009
    ..The study aims were to estimate the prevalence of different types and frequencies of fecal incontinence (FI), describe demographic factors, and identify risk factors...
  10. pmc The minimum important differences for the urinary scales of the Pelvic Floor Distress Inventory and Pelvic Floor Impact Questionnaire
    Matthew D Barber
    Obstetrics, Gynecology, and Women s Health Institute, Cleveland Clinic, Cleveland, OH, USA
    Am J Obstet Gynecol 200:580.e1-7. 2009
    ....
  11. pmc Outcomes following vaginal prolapse repair and mid urethral sling (OPUS) trial--design and methods
    John Wei
    Department of Urology, University of Michigan, Ann Arbor, Michigan, USA
    Clin Trials 6:162-71. 2009
    ....
  12. pmc Operations and pelvic muscle training in the management of apical support loss (OPTIMAL) trial: design and methods
    Matthew D Barber
    Obstetrics, Gynecology, and Women s Health Institute, Cleveland Clinic, Cleveland OH 44195, USA
    Contemp Clin Trials 30:178-89. 2009
    ....
  13. pmc Risk factors for mesh/suture erosion following sacral colpopexy
    Geoffrey W Cundiff
    Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada
    Am J Obstet Gynecol 199:688.e1-5. 2008
    ..The purpose of this study was to identify risks for mesh/suture erosions following abdominal sacral colpopexy (ASC)...
  14. pmc Magnetic resonance assessment of pelvic anatomy and pelvic floor disorders after childbirth
    Victoria L Handa
    Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Int Urogynecol J Pelvic Floor Dysfunct 20:133-9. 2009
    ..Dimensions of the bony pelvis do not differ substantially between primiparous women with and without postpartum urinary incontinence, fecal incontinence and prolapse...
  15. pmc Obesity and outcomes after sacrocolpopexy
    Catherine S Bradley
    Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Am J Obstet Gynecol 199:690.e1-8. 2008
    ..The purpose of this study was to compare outcomes after sacrocolpopexy (SC) between obese and healthy-weight women...
  16. pmc Prevalence of symptomatic pelvic floor disorders in US women
    Ingrid Nygaard
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132 2209, USA
    JAMA 300:1311-6. 2008
    ..No national prevalence estimates derived from the same population-based sample exists for multiple pelvic floor disorders in women in the United States...
  17. pmc Correlation between levator ani muscle injuries on magnetic resonance imaging and fecal incontinence, pelvic organ prolapse, and urinary incontinence in primiparous women
    Marta E Heilbrun
    Department of Radiology, University of Utah, Salt Lake City, UT, USA
    Am J Obstet Gynecol 202:488.e1-6. 2010
    ....
  18. pmc Quantification of vaginal support: are continuous summary scores better than POPQ stage?
    Linda Brubaker
    Department of Obstetrics and Gynecology and Urology, Loyola University, Chicago, IL, USA
    Am J Obstet Gynecol 203:512.e1-6. 2010
    ..This analysis compared 3 continuous variables as summary support loss (SL) scores with pelvic organ prolapse (POP) quantification (POPQ) ordinal stages...
  19. pmc Comparison of 2 transvaginal surgical approaches and perioperative behavioral therapy for apical vaginal prolapse: the OPTIMAL randomized trial
    Matthew D Barber
    Obstetrics Gynecology and Women s Health Institute, Cleveland Clinic, Cleveland, Ohio
    JAMA 311:1023-34. 2014
    ..Little is known about their comparative efficacy and safety, and it is unknown whether perioperative behavioral therapy with pelvic floor muscle training (BPMT) improves outcomes of prolapse surgery...
  20. pmc The Refractory Overactive Bladder: Sacral NEuromodulation vs. BoTulinum Toxin Assessment: ROSETTA trial
    Cindy L Amundsen
    Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA Electronic address
    Contemp Clin Trials 37:272-83. 2014
    ..Enrollment began in March, 2012 with anticipated end to recruitment in mid 2014...
  21. pmc A model for predicting the risk of de novo stress urinary incontinence in women undergoing pelvic organ prolapse surgery
    J Eric Jelovsek
    Obstetrics, Gynecology and Women s Health Institute and Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio the Department of Obstetrics and Gynecology and Urology, Stritch School of Medicine, Loyola University Chicago, Chicago, Illinois the Departments of Obstetrics and Gynecology and Surgery, University of New Mexico Health Sciences Center, Albuquerque, New Mexico the Departments of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, University of Pennsylvania, Philadelphia, Pennsylvania, University of Utah, Salt Lake City, Utah, Women and Infants Hospital, Providence, Rhode Island, Kaiser Permanente, San Diego, California, and Duke University Medical Center, Durham, North Carolina the Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania RTI International, Research Triangle Park, North Carolina and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
    Obstet Gynecol 123:279-87. 2014
    ....
  22. pmc Long-term outcomes following abdominal sacrocolpopexy for pelvic organ prolapse
    Ingrid Nygaard
    University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132, USA
    JAMA 309:2016-24. 2013
    ..More than 225 000 surgeries are performed annually in the United States for pelvic organ prolapse (POP). Abdominal sacrocolpopexy is considered the most durable POP surgery, but little is known about safety and long-term effectiveness...
  23. pmc The pelvic floor complication scale: a new instrument for reconstructive pelvic surgery
    Robert E Gutman
    Department of Obstetrics and Gynecology, Washington Hospital Center, Georgetown University, Washington, DC, USA
    Am J Obstet Gynecol 208:81.e1-9. 2013
    ..The purpose of this study was to develop and test a unique, new pelvic floor surgery complication scale and compare it with an existing validated measure...
  24. pmc Anticholinergic therapy vs. onabotulinumtoxina for urgency urinary incontinence
    Anthony G Visco
    Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27707, USA
    N Engl J Med 367:1803-13. 2012
    ..Anticholinergic medications and onabotulinumtoxinA are used to treat urgency urinary incontinence, but data directly comparing the two types of therapy are needed...
  25. pmc Predictors of success and satisfaction of nonsurgical therapy for stress urinary incontinence
    Joseph Schaffer
    University of Texas Southwestern, Dallas, TX, USA
    Obstet Gynecol 120:91-7. 2012
    ..To identify factors that may predict success and satisfaction in women undergoing nonsurgical therapy for stress urinary incontinence...
  26. pmc Validation of the activities assessment scale in women undergoing pelvic reconstructive surgery
    Matthew D Barber
    Obstetrics, Gynecology, and Women s Health Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Female Pelvic Med Reconstr Surg 18:205-10. 2012
    ..We evaluated the psychometric characteristics of the AAS in women who underwent vaginal surgery for pelvic organ prolapse (POP) and stress urinary incontinence (SUI)...
  27. pmc Validation of the surgical pain scales in women undergoing pelvic reconstructive surgery
    Matthew D Barber
    Obstetrics, Gynecology, and Women s Health Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Female Pelvic Med Reconstr Surg 18:198-204. 2012
    ..Our objective was to evaluate the psychometric properties of SPS in women undergoing vaginal surgery for pelvic organ prolapse and stress urinary incontinence...
  28. pmc A midurethral sling to reduce incontinence after vaginal prolapse repair
    John T Wei
    Department of Urology, University of Michigan, Ann Arbor, MI 48109 2800, USA
    N Engl J Med 366:2358-67. 2012
    ..Women without stress urinary incontinence undergoing vaginal surgery for pelvic-organ prolapse are at risk for postoperative urinary incontinence. A midurethral sling may be placed at the time of prolapse repair to reduce this risk...
  29. pmc Pelvic floor disorders clinical trials: participant recruitment and retention
    Linda Brubaker
    Loyola University Chicago Stritch School of Medicine, Chicago, IL, USA
    Int Urogynecol J 24:73-9. 2013
    ..We used a focus-group methodology to gather information about women's knowledge and attitudes regarding research participation...
  30. pmc Pelvic floor symptoms improve similarly after pessary and behavioral treatment for stress incontinence
    Kimberly Kenton
    Departments of Obstetrics and Gynecology and Urology, Loyola University Chicago, IL, USA
    Female Pelvic Med Reconstr Surg 18:118-21. 2012
    ..The objective of this study was to determine if differences exist in pelvic symptom distress and impact on women randomized to pessary versus behavioral therapy for treatment of stress urinary incontinence (SUI)...
  31. pmc Anticholinergic versus botulinum toxin A comparison trial for the treatment of bothersome urge urinary incontinence: ABC trial
    Anthony G Visco
    Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Contemp Clin Trials 33:184-96. 2012
    ..The results have the potential to fundamentally change the therapeutic approach to this condition...
  32. ncbi Segmentations of MRI images of the female pelvic floor: a study of inter- and intra-reader reliability
    Lennox Hoyte
    University of South Florida, College of Medicine, Division of Urogynecology and Pelvic Reconstructive Surgery, Tampa General Hospital, Urogynecology Division, Tampa, Florida, USA
    J Magn Reson Imaging 33:684-91. 2011
    ..To describe the inter- and intra-operator reliability of segmentations of female pelvic floor structures...
  33. pmc Further validation of the short form versions of the Pelvic Floor Distress Inventory (PFDI) and Pelvic Floor Impact Questionnaire (PFIQ)
    Matthew D Barber
    Obstetrics, Gynecology, and Women s Health Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Neurourol Urodyn 30:541-6. 2011
    ..To evaluate validity and responsiveness of PFDI and PFIQ short forms across four multi-center studies and develop conversion formulas between short and long versions...
  34. pmc Reproducibility of dynamic MR imaging pelvic measurements: a multi-institutional study
    Mark E Lockhart
    Department of Radiology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Radiology 249:534-40. 2008
    ..To assess the reproducibility of bone and soft-tissue pelvimetry measurements obtained from dynamic magnetic resonance (MR) imaging studies in primiparous women across multiple centers...
  35. pmc Enhancing participation of older women in surgical trials
    Patricia S Goode
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Am Coll Surg 207:303-11. 2008
    ..Older participants are often excluded from clinical trials, precluding a representative sample...
  36. pmc Gastrointestinal complications following abdominal sacrocolpopexy for advanced pelvic organ prolapse
    William E Whitehead
    Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
    Am J Obstet Gynecol 197:78.e1-7. 2007
    ..The aims of this secondary analysis of the "Colpopexy And Urinary Reduction Efforts" (CARE) study were to estimate the incidence of postoperative gastrointestinal complications and identify risk factors...
  37. ncbi Spanish language translation of pelvic floor disorders instruments
    Amy E Young
    Department of Obstetrics and Gynecology, Baylor College of Medicine, 1706 Dryden, Suite 1100, Houston, TX 77030, USA
    Int Urogynecol J Pelvic Floor Dysfunct 18:1171-8. 2007
    ..Strict translation techniques and testing yielded valid Spanish translations of instruments assessing pelvic symptoms/functional life impact in women with pelvic floor disorders...
  38. ncbi Risk factors for fecal and urinary incontinence after childbirth: the childbirth and pelvic symptoms study
    Kathryn L Burgio
    University of Alabama at Birmingham, Birmingham, Alabama, and Birmingham VA Medical Center, Birmingham, Alabama 35233, USA
    Am J Gastroenterol 102:1998-2004. 2007
    ..To identify risk factors for postpartum FI and UI...
  39. ncbi The effect of age on short-term outcomes after abdominal surgery for pelvic organ prolapse
    Holly E Richter
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Am Geriatr Soc 55:857-63. 2007
    ..To compare perioperative morbidity and 1-year outcomes of older and younger women undergoing surgery for pelvic organ prolapse (POP)...
  40. ncbi Prolapse severity, symptoms and impact on quality of life among women planning sacrocolpopexy
    M P Fitzgerald
    Loyola University Medical Center, Maywood, IL, USA
    Int J Gynaecol Obstet 98:24-8. 2007
    ..To explore the relationship between severity of pelvic organ prolapse (POP), symptoms of pelvic dysfunction and quality of life using validated measures...
  41. ncbi Anal sphincter laceration at vaginal delivery: is this event coded accurately?
    Linda Brubaker
    Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, Illinois, USA
    Obstet Gynecol 109:1141-5. 2007
    ..To determine the error rate for discharge coding of anal sphincter laceration at vaginal delivery in a cohort of primiparous women...
  42. ncbi Pelvic-floor muscle function in women with pelvic organ prolapse
    Diane F Borello-France
    Department of Physical Therapy, 111 Health Sciences Bldg, Duquesne University, Pittsburgh, PA 15282, USA
    Phys Ther 87:399-407. 2007
    ..The purpose of this study was to determine whether pelvic organ prolapse severity, pelvic symptoms, quality of life, and sexual function differ based on pelvic-floor muscle function in women planning to have prolapse surgery...
  43. ncbi Non-surgical management of stress urinary incontinence: ambulatory treatments for leakage associated with stress (ATLAS) trial
    Holly E Richter
    Department of Obstetrics and Gynecology, Division of Women s Pelvic Medicine and Reconstructive Surgery, University of Alabama at Birmingham, Bermingham, Alabama 35249 7333, USA
    Clin Trials 4:92-101. 2007
    ..Non-surgical treatment for stress urinary incontinence (SUI) is recommended as first-line therapy, yet few prospective studies and no randomized trials compare the most common non-surgical treatments for SUI...
  44. ncbi Risk factors for anal sphincter tear during vaginal delivery
    Mary P Fitzgerald
    Loyola University Medical Center, Division of Female Pelvic Medicine and Reconstructive Surgery, Maywood, IL 60153, USA
    Obstet Gynecol 109:29-34. 2007
    ..To identify risk factors associated with anal sphincter tear during vaginal delivery and to identify opportunities for preventing this cause of fecal incontinence in young women...
  45. ncbi Endoanal ultrasound findings and fecal incontinence symptoms in women with and without recognized anal sphincter tears
    Holly E Richter
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7333, and Division of Radiology, Magee Womens Hospital, Pittsburgh, Pennsylvania, USA
    Obstet Gynecol 108:1394-401. 2006
    ..To estimate whether endoanal ultrasound findings are more prevalent in primiparous women with a history of anal sphincter tear than in women without this history and whether the findings are associated with fecal incontinence symptoms...
  46. ncbi Fecal and urinary incontinence in primiparous women
    Diane Borello-France
    Duquesne University, Department of Physical Therapy, Pittsburgh, Pennsylvania 15282, USA
    Obstet Gynecol 108:863-72. 2006
    ..To prospectively investigate the relationship between anal sphincter tears and postpartum fecal and urinary incontinence...
  47. ncbi Bowel symptoms in women planning surgery for pelvic organ prolapse
    Catherine S Bradley
    Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Am J Obstet Gynecol 195:1814-9. 2006
    ..The objective of the study was to measure associations between bowel symptoms and prolapse...
  48. ncbi Physical activity in women planning sacrocolpopexy
    Ingrid Nygaard
    Department of Obstetrics and Gynecology, University of Utah College of Medicine, UT 84132, USA
    Int Urogynecol J Pelvic Floor Dysfunct 18:33-7. 2007
    ..28) or work outside home (p=0.89). Although prolapse stage is associated with interference with recreation (p=0.02), this association is not consistently positive : stage II, 42%; stage III, 22%; and stage IV, 32%...
  49. ncbi Abdominal sacrocolpopexy with Burch colposuspension to reduce urinary stress incontinence
    Linda Brubaker
    Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, Ill, USA
    N Engl J Med 354:1557-66. 2006
    ....
  50. ncbi A multicentered comparison of measurements obtained with microtip and external water pressure transducers
    Andrew F Hundley
    Division of Female Pelvic Medicine and Reconstructive Pelvic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Int Urogynecol J Pelvic Floor Dysfunct 17:400-6. 2006
    ....
  51. ncbi Teaching and practicing of pelvic floor muscle exercises in primiparous women during pregnancy and the postpartum period
    Paul Fine
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA
    Am J Obstet Gynecol 197:107.e1-5. 2007
    ..The purpose of this study was to describe the teaching and practicing of pelvic floor muscle exercise (PFME) before and after delivery...
  52. ncbi Lower urinary tract symptoms, quality of life and pelvic organ prolapse: irritative bladder and obstructive voiding symptoms in women planning to undergo abdominal sacrocolpopexy for advanced pelvic organ prolapse
    Holly E Richter
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Urol 178:965-9; discussion 969. 2007
    ..We compared lower urinary tract and voiding symptoms in women with and without symptoms of stress urinary incontinence who were planning to undergo abdominal sacrocolpopexy for pelvic organ prolapse...
  53. pmc Pelvic support, pelvic symptoms, and patient satisfaction after colpocleisis
    M P Fitzgerald
    Division of Female Pelvic Medicine and Reconstructive Surgery, Loyola University Medical Center, 2160 South First Avenue, Bldg 103, Room 1004, Maywood, IL, 60153, USA
    Int Urogynecol J Pelvic Floor Dysfunct 19:1603-9. 2008
    ..Colpocleisis was effective in resolving prolapse and pelvic symptoms and was associated with high patient satisfaction...
  54. pmc Optimism in women undergoing abdominal sacrocolpopexy for pelvic organ prolapse
    Patricia A Wren
    Department of Wellness, Health Promotion, and Injury Prevention, School of Health Sciences, Oakland University, Rochester, MI 48309, USA
    J Am Coll Surg 207:240-5. 2008
    ..This study sought to explore the relationship between optimism, prolapse severity, and symptoms before operation; and examine whether optimism predicts postsurgical functional status, treatment satisfaction, and treatment success...
  55. pmc Two-year outcomes after sacrocolpopexy with and without burch to prevent stress urinary incontinence
    Linda Brubaker
    Department of Obstetrics and Gynecology and Urology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    Obstet Gynecol 112:49-55. 2008
    ..To report anatomic and functional outcomes 2 years after sacrocolpopexy in stress-continent women with or without prophylactic Burch colposuspension...
  56. ncbi The correlation of voiding variables between non-instrumented uroflowmetery and pressure-flow studies in women with pelvic organ prolapse
    Elizabeth Mueller
    Department of Urology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Neurourol Urodyn 27:515-21. 2008
    ..To (1) correlate peak and maximum flow rates from non-instrumented flow (NIF) and pressure-flow studies (PFS) in women with pelvic organ prolapse (POP); (2) measure the impact of voided volume and degree of prolapse on correlations...
  57. pmc Refractory idiopathic urge urinary incontinence and botulinum A injection
    Linda Brubaker
    Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Urol 180:217-22. 2008
    ..We compared 200 U intradetrusor botulinum toxin A vs placebo in women with refractory idiopathic urge incontinence...
  58. pmc Changes in physical activity after abdominal sacrocolpopexy for advanced pelvic organ prolapse
    Ingrid Nygaard
    Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA
    Am J Obstet Gynecol 198:570.e1-5. 2008
    ..The objective of the study was to describe changes in physical activity 1 year after sacrocolpopexy for pelvic organ prolapse...
  59. pmc Sexual function 6 months after first delivery
    Linda Brubaker
    Department of Obstetrics Gynecology and Urology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Obstet Gynecol 111:1040-4. 2008
    ..To explore the association of anal sphincter laceration and sexual function 6 months postpartum in the Childbirth and Pelvic Symptoms (CAPS) cohort...
  60. pmc Racial differences in pelvic anatomy by magnetic resonance imaging
    Victoria L Handa
    Department of Gynecology and Obstetrics, Johns Hopkins University, Baltimore, Maryland, USA
    Obstet Gynecol 111:914-20. 2008
    ..To use static and dynamic magnetic resonance imaging (MRI) to compare dimensions of the bony pelvis and soft tissue structures in a sample of African-American and white women...
  61. pmc The role of preoperative urodynamic testing in stress-continent women undergoing sacrocolpopexy: the Colpopexy and Urinary Reduction Efforts (CARE) randomized surgical trial
    Anthony G Visco
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Duke University Medical Center, P O Box 3192, Durham, NC 27710, USA
    Int Urogynecol J Pelvic Floor Dysfunct 19:607-14. 2008
    ..Future research is warranted in this patient population to evaluate other treatment options to refine predictions and further reduce the risk of postoperative stress incontinence...
  62. ncbi Bladder symptoms 1 year after abdominal sacrocolpopexy with and without Burch colposuspension in women without preoperative stress incontinence symptoms
    Kathryn L Burgio
    Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA
    Am J Obstet Gynecol 197:647.e1-6. 2007
    ..The objective of the study was to examine changes in bladder symptoms 1 year after abdominal sacrocolpopexy (ASC) with vs without Burch colposuspension...
  63. ncbi Bowel symptoms in women 1 year after sacrocolpopexy
    Catherine S Bradley
    Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Am J Obstet Gynecol 197:642.e1-8. 2007
    ..The objective of the study was to evaluate changes in bowel symptoms after sacrocolpopexy...
  64. pmc The impact of fecal and urinary incontinence on quality of life 6 months after childbirth
    Victoria L Handa
    Johns Hopkins University, Baltimore, MD
    Am J Obstet Gynecol 197:636.e1-6. 2007
    ..The objective of the study was to investigate the impact of postpartum fecal incontinence (FI) and urinary incontinence (UI) on quality of life (QOL)...
  65. pmc Sexual function before and after sacrocolpopexy for pelvic organ prolapse
    Victoria L Handa
    Department of Obstetrics and Gynecology, Johns Hopkins University, Baltimore, MD, USA
    Am J Obstet Gynecol 197:629.e1-6. 2007
    ..The objective of the study was to describe sexual function before and after sacrocolpopexy...
  66. ncbi Risk factors for sonographic internal anal sphincter gaps 6-12 months after delivery complicated by anal sphincter tear
    Catherine S Bradley
    Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA, USA
    Am J Obstet Gynecol 197:310.e1-5. 2007
    ..The objective of the study was to identify risk factors for internal anal sphincter (IAS) gaps on postpartum endoanal ultrasound in women with obstetric anal sphincter tear...
  67. ncbi Does urethral competence affect urodynamic voiding parameters in women with prolapse?
    Ingrid Nygaard
    Department of Obstetrics and Gynecology, University of Utah College of Medicine, Salt Lake City, UT 84132, USA
    Neurourol Urodyn 26:1030-5. 2007
    ..To (1) compare voiding parameters and (2) correlate symptoms and urodynamic findings in women with pelvic organ prolapse (POP) and varying degrees of urethral competence...
  68. ncbi Colpocleisis: a review
    Mary P Fitzgerald
    Loyola University Medical Center, 2160 South First Avenue, Bld 103, Room 1004, Maywood, IL 60153, USA
    Int Urogynecol J Pelvic Floor Dysfunct 17:261-71. 2006
    ..To summarize published data about colpocleisis and to highlight areas about which data are lacking...

Research Grants30

  1. DRUG DEPENDENCE CLINICAL RESEARCH PROGRAM
    Reese T Jones; Fiscal Year: 2013
    ..abstract_text> ..