EARLY TMT RETINOPATHY OF PREMATURITY HEADQUARTER GRANT
Principal Investigator: WILLIAM GOOD
Affiliation: Smith-Kettlewell Eye Research Institute
Abstract: Retinopathy of prematurity (ROP) is a potentially blinding disease of premature infants in which retinal blood vessels fail to develop properly. A multicentered clinical trial (CRYO-ROP Study) sponsored by the National Eye Institute demonstrated that peripheral retinal ablation at a defined stage of the disease reduced the risk of unfavorable structural outcome (i.e., retinal detachment); however, over 47.1 percent of treated eyes had vision greater than 20/200 at 5 1/2 years. The CRYO-ROP Study also defined a number of risk factors for unfavorable visual and structural outcome in ROP. Despite these advances, ROP remains a leading cause of blindness in children. More effective treatment is required in order to further reduce the rate of blindness. It is hypothesized that earlier treatment of ROP will improve the visual and structural outcome in infants with ROP. Peripheral retinal ablation will be administered to infants who develop prethreshold ROP (ROP that is severe, but not as advanced as threshold ROP as defined by the CRYO-ROP Study). To minimize the risk of treating eyes unnecessarily, since ROP may regress spontaneously in some cases, we will apply a risk management analysis program (RM-ROP2) to eyes with prethreshold disease and enroll infants with a 15 percent or greater risk of an unfavorable structural outcome for treatment. The RM-ROP2 utilizes a number of risk factors to calculate the probability of an eye having an unfavorable structural outcome. Prethreshold infants with a 15 percent or higher risk of an unfavorable outcome will be randomized. One eye will receive earlier treatment and the other will receive conventionally-timed treatment, as defined by the CRYO-ROP Study if required. Outcome will be determined at a 6 month post-term ophthalmologic examination and at a 9 month post-term visual assessment examination.
Funding Period: 1999-09-30 - 2009-09-29
more information: NIH RePORT
- The incidence and course of retinopathy of prematurity: findings from the early treatment for retinopathy of prematurity studyWilliam V Good
Smith Kettlewell Eye Research Institute, 2318 Fillmore St, San Francisco, CA 94115, USA
Pediatrics 116:15-23. 2005....
- Prevalence of myopia at 9 months in infants with high-risk prethreshold retinopathy of prematurityBradley V Davitt
Department of Ophthalmology, Cardinal Glennon Children s Hospital, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
Ophthalmology 112:1564-8. 2005..To examine the prevalence of myopia and high myopia at 9 months corrected age in premature infants who participated in the multicenter randomized trial of Early Treatment for Retinopathy of Prematurity (ETROP)...
- Outcome of eyes developing retinal detachment during the Early Treatment for Retinopathy of Prematurity Study (ETROP)Michael X Repka
Wilmer Eye Institute, Wilmer 233, 600 N Wolfe Street, Baltimore, MD 21287 9028, USA
Arch Ophthalmol 124:24-30. 2006..At 9 months corrected age, retinal examinations were performed and visual acuities were assessed by masked testers using grating acuity...
- Tubedown-1 (Tbdn-1) suppression in oxygen-induced retinopathy and in retinopathy of prematurityRobert L Gendron
Division of Basic Medical Sciences, Department of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
Mol Vis 12:108-16. 2006..The purpose of the present study was to determine if the expression pattern of Tbdn-1 is altered during oxygen-induced retinal neovascularization in mice and in a specimen of stage 3 human ROP...
- The Early Treatment for Retinopathy Of Prematurity Study: structural findings at age 2 yearsWilliam V Good
Smith Kettlewell Eye Research Institute, 2318 Fillmore Street, San Francisco, CA 94115, USA
Br J Ophthalmol 90:1378-82. 2006..To determine whether earlier treatment of high-risk, prethreshold retinopathy of prematurity (ROP) improves retinal structural outcome at 2 years of age...
- Progression of myopia and high myopia in the early treatment for retinopathy of prematurity study: findings to 3 years of ageGraham E Quinn
Division of Pediatric Ophthalmology, Children s Hospital of Philadelphia and Scheie Eye Institute, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
Ophthalmology 115:1058-1064.e1. 2008....
- Astigmatism in the Early Treatment for Retinopathy Of Prematurity Study: findings to 3 years of ageBradley V Davitt
Department of Ophthalmology, Cardinal Glennon Children s Medical Center, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
Ophthalmology 116:332-9. 2009....
- Recognition acuity, grating acuity, contrast sensitivity, and visual fields in 6-year-old childrenDeborah D Hargadon
Department of Ophthalmology and Vision Science, University of Arizona, 655 N Alvernon Way, Ste 108, Tucson, AZ 85711, USA
Arch Ophthalmol 128:70-4. 2010..To measure monocular distance visual acuity (VA), grating VA, contrast sensitivity, and visual field extent in full-term, 6-year-old children...