EARLY TMT RETINOPATHY OF PREMATURITY HEADQUARTER GRANT

Summary

Principal Investigator: WILLIAM GOOD
Affiliation: Smith-Kettlewell Eye Research Institute
Country: USA
Abstract: Retinopathy of prematurity (ROP) is a potentially blinding disease of premature infants in which retinal blood vessels fail to develop properly. A multicentered clinical trial (CRYO-ROP Study) sponsored by the National Eye Institute demonstrated that peripheral retinal ablation at a defined stage of the disease reduced the risk of unfavorable structural outcome (i.e., retinal detachment); however, over 47.1 percent of treated eyes had vision greater than 20/200 at 5 1/2 years. The CRYO-ROP Study also defined a number of risk factors for unfavorable visual and structural outcome in ROP. Despite these advances, ROP remains a leading cause of blindness in children. More effective treatment is required in order to further reduce the rate of blindness. It is hypothesized that earlier treatment of ROP will improve the visual and structural outcome in infants with ROP. Peripheral retinal ablation will be administered to infants who develop prethreshold ROP (ROP that is severe, but not as advanced as threshold ROP as defined by the CRYO-ROP Study). To minimize the risk of treating eyes unnecessarily, since ROP may regress spontaneously in some cases, we will apply a risk management analysis program (RM-ROP2) to eyes with prethreshold disease and enroll infants with a 15 percent or greater risk of an unfavorable structural outcome for treatment. The RM-ROP2 utilizes a number of risk factors to calculate the probability of an eye having an unfavorable structural outcome. Prethreshold infants with a 15 percent or higher risk of an unfavorable outcome will be randomized. One eye will receive earlier treatment and the other will receive conventionally-timed treatment, as defined by the CRYO-ROP Study if required. Outcome will be determined at a 6 month post-term ophthalmologic examination and at a 9 month post-term visual assessment examination.
Funding Period: 1999-09-30 - 2009-09-29
more information: NIH RePORT

Top Publications

  1. ncbi The incidence and course of retinopathy of prematurity: findings from the early treatment for retinopathy of prematurity study
    William V Good
    Smith Kettlewell Eye Research Institute, 2318 Fillmore St, San Francisco, CA 94115, USA
    Pediatrics 116:15-23. 2005
  2. ncbi Prevalence of myopia at 9 months in infants with high-risk prethreshold retinopathy of prematurity
    Bradley V Davitt
    Department of Ophthalmology, Cardinal Glennon Children s Hospital, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Ophthalmology 112:1564-8. 2005
  3. ncbi Outcome of eyes developing retinal detachment during the Early Treatment for Retinopathy of Prematurity Study (ETROP)
    Michael X Repka
    Wilmer Eye Institute, Wilmer 233, 600 N Wolfe Street, Baltimore, MD 21287 9028, USA
    Arch Ophthalmol 124:24-30. 2006
  4. ncbi Tubedown-1 (Tbdn-1) suppression in oxygen-induced retinopathy and in retinopathy of prematurity
    Robert L Gendron
    Division of Basic Medical Sciences, Department of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Mol Vis 12:108-16. 2006
  5. pmc The Early Treatment for Retinopathy Of Prematurity Study: structural findings at age 2 years
    William V Good
    Smith Kettlewell Eye Research Institute, 2318 Fillmore Street, San Francisco, CA 94115, USA
    Br J Ophthalmol 90:1378-82. 2006
  6. doi Progression of myopia and high myopia in the early treatment for retinopathy of prematurity study: findings to 3 years of age
    Graham E Quinn
    Division of Pediatric Ophthalmology, Children s Hospital of Philadelphia and Scheie Eye Institute, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Ophthalmology 115:1058-1064.e1. 2008
  7. pmc Astigmatism in the Early Treatment for Retinopathy Of Prematurity Study: findings to 3 years of age
    Bradley V Davitt
    Department of Ophthalmology, Cardinal Glennon Children s Medical Center, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Ophthalmology 116:332-9. 2009
  8. doi Recognition acuity, grating acuity, contrast sensitivity, and visual fields in 6-year-old children
    Deborah D Hargadon
    Department of Ophthalmology and Vision Science, University of Arizona, 655 N Alvernon Way, Ste 108, Tucson, AZ 85711, USA
    Arch Ophthalmol 128:70-4. 2010

Scientific Experts

Detail Information

Publications8

  1. ncbi The incidence and course of retinopathy of prematurity: findings from the early treatment for retinopathy of prematurity study
    William V Good
    Smith Kettlewell Eye Research Institute, 2318 Fillmore St, San Francisco, CA 94115, USA
    Pediatrics 116:15-23. 2005
    ....
  2. ncbi Prevalence of myopia at 9 months in infants with high-risk prethreshold retinopathy of prematurity
    Bradley V Davitt
    Department of Ophthalmology, Cardinal Glennon Children s Hospital, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Ophthalmology 112:1564-8. 2005
    ..To examine the prevalence of myopia and high myopia at 9 months corrected age in premature infants who participated in the multicenter randomized trial of Early Treatment for Retinopathy of Prematurity (ETROP)...
  3. ncbi Outcome of eyes developing retinal detachment during the Early Treatment for Retinopathy of Prematurity Study (ETROP)
    Michael X Repka
    Wilmer Eye Institute, Wilmer 233, 600 N Wolfe Street, Baltimore, MD 21287 9028, USA
    Arch Ophthalmol 124:24-30. 2006
    ..At 9 months corrected age, retinal examinations were performed and visual acuities were assessed by masked testers using grating acuity...
  4. ncbi Tubedown-1 (Tbdn-1) suppression in oxygen-induced retinopathy and in retinopathy of prematurity
    Robert L Gendron
    Division of Basic Medical Sciences, Department of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Mol Vis 12:108-16. 2006
    ..The purpose of the present study was to determine if the expression pattern of Tbdn-1 is altered during oxygen-induced retinal neovascularization in mice and in a specimen of stage 3 human ROP...
  5. pmc The Early Treatment for Retinopathy Of Prematurity Study: structural findings at age 2 years
    William V Good
    Smith Kettlewell Eye Research Institute, 2318 Fillmore Street, San Francisco, CA 94115, USA
    Br J Ophthalmol 90:1378-82. 2006
    ..To determine whether earlier treatment of high-risk, prethreshold retinopathy of prematurity (ROP) improves retinal structural outcome at 2 years of age...
  6. doi Progression of myopia and high myopia in the early treatment for retinopathy of prematurity study: findings to 3 years of age
    Graham E Quinn
    Division of Pediatric Ophthalmology, Children s Hospital of Philadelphia and Scheie Eye Institute, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Ophthalmology 115:1058-1064.e1. 2008
    ....
  7. pmc Astigmatism in the Early Treatment for Retinopathy Of Prematurity Study: findings to 3 years of age
    Bradley V Davitt
    Department of Ophthalmology, Cardinal Glennon Children s Medical Center, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Ophthalmology 116:332-9. 2009
    ....
  8. doi Recognition acuity, grating acuity, contrast sensitivity, and visual fields in 6-year-old children
    Deborah D Hargadon
    Department of Ophthalmology and Vision Science, University of Arizona, 655 N Alvernon Way, Ste 108, Tucson, AZ 85711, USA
    Arch Ophthalmol 128:70-4. 2010
    ..To measure monocular distance visual acuity (VA), grating VA, contrast sensitivity, and visual field extent in full-term, 6-year-old children...