ADVANCED GLAUCOMA INTERVENTION STUDY

Summary

Principal Investigator: PAUL LICHTER
Abstract: This is an application for 4 1/2 years of support for the clinical center at the University of Michigan to continue participation in the ongoing multicenter Advanced Glaucoma Intervention Study (AGIS). The principal goat of AGIS is to assess systematically the long-range outcomes of sequences of interventions in eyes with primary open-angle glaucoma that have failed initial medical treatment. Between April 1, 1988 and March 31, 1991 AGIS has enrolled 575 eyes of 435 patients. Each eye has been randomly assigned to one of two intervention sequences: i) trabeculectomy (T) followed by argon Laser trabeculoplasty (ALT) should T fail and followed by a second T should ALT fait; and 2) ALT followed by T should ALT fail and followed by another T should the first T fail. The interventions are supplemented with medical treatment as needed. As of March 31, 1991 follow-up ranged from 0 to 36 months. Less than five percent of follow-up exams, scheduled at 6-month intervals, have been missed. Data are being collected on visual function. toss, intervention failure, complications, need for supplemental medical therapy, compliance with medical therapy, and quality of Life. The prognostic values of ocular and non-ocular medical factors and personal factors are being studied. The study plans 1) to continue patient recruitment until 790 eyes are enrolled, a goal that is expected to be reached between April 1 and November 30, 1992, and 2) to continue patient follow-up until November 30, 1996, so that follow-up will ultimately range from a minimum of 4 to 4 2/3 years to a maximum of 8 2/3 years. A coordinating center collects, processes, and analyzes study date and coordinates study activities. A Policy and Treatment Effects Monitoring Board supervises the conduct of the study and monitors study outcomes. Submitted with the Georgetown University Lead application are: 1) the AGIS research plan, detailing study rationale, design and methods, 2) the plans for continued patient recruitment and follow-up, and 3) study accomplishments to date, including examples of data analyses. Between April 1, 1988 and March 31, 1991 this clinical center has enrolled 46 eyes of 35 patients. The present application details the qualifications of this clinical center for continued participation, including our ability to recruit and retain patients and to adhere to the study definitions, criteria, and procedures.
Funding Period: 1987-09-01 - 2001-06-30
more information: NIH RePORT

Top Publications

  1. pmc Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002654. 2012
  2. pmc Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia
    Megan Ulmer
    Duke University Center for Human Genetics, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 53:4468-74. 2012
  3. pmc CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States
    Louis R Pasquale
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Ophthalmol 155:342-353.e5. 2013
  4. pmc Estrogen pathway polymorphisms in relation to primary open angle glaucoma: an analysis accounting for gender from the United States
    Louis R Pasquale
    Department of Ophthalmology, Mass Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 19:1471-81. 2013
  5. pmc Genome-wide association study and meta-analysis of intraocular pressure
    A Bilge Ozel
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Hum Genet 133:41-57. 2014
  6. pmc Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss
    Stephanie J Loomis
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
    Ophthalmology 121:508-16. 2014

Detail Information

Publications6

  1. pmc Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002654. 2012
    ..009). These results suggest that neuro-protective therapies targeting TGF-beta signaling could be effective for multiple forms of glaucoma...
  2. pmc Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia
    Megan Ulmer
    Duke University Center for Human Genetics, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 53:4468-74. 2012
    ....
  3. pmc CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States
    Louis R Pasquale
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Ophthalmol 155:342-353.e5. 2013
    ....
  4. pmc Estrogen pathway polymorphisms in relation to primary open angle glaucoma: an analysis accounting for gender from the United States
    Louis R Pasquale
    Department of Ophthalmology, Mass Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 19:1471-81. 2013
    ..We assessed the association between an estrogen metabolism single nucleotide polymorphism (SNP) panel in relation to primary open angle glaucoma (POAG), accounting for gender...
  5. pmc Genome-wide association study and meta-analysis of intraocular pressure
    A Bilge Ozel
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Hum Genet 133:41-57. 2014
    ..These results confirm the involvement of common variants in multiple genomic regions in regulating IOP and/or glaucoma risk...
  6. pmc Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss
    Stephanie J Loomis
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
    Ophthalmology 121:508-16. 2014
    ..The aim of this study was to assess the association between CAV1/CAV2 single nucleotide polymorphisms (SNPs) and POAG in a large case-control dataset and to explore associations by gender and pattern of visual field (VF) loss further...