Data Coordinating Center for Sleep Heart Health

Summary

Principal Investigator: J M Samet
Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA
Abstract: This application presents a plan for continuing the Coordinating Center (CC) for the Sleep Heart Health Study (SHHS) within the Center for Clinical Trials and Departments of Epidemiology and Biostatistics of the Johns Hopkins Bloomberg School of Public Health. The SHHS was started in 1994 as a multicenter prospective cohort study of the cardiovascular consequences of sleep-disordered breathing (SDB). A cohort of 6441 persons, drawn from various ongoing studies was enrolled and had an overnight in-home polysomnogram (PSG); 3295 participants had a second PSG 5 years later. Funds are being requested to continue follow-up of the SHHS cohort in a companion application: "The Sleep Heart Health Study (SHHS)." The CC was housed at the University of Washington School of Public Health for the initial five years of the SHHS and was then transferred to Johns Hopkins for the subsequent five years of funding. During the first four years of CC operations at Johns Hopkins, the SHHS data base was migrated to the CCT, a data system and forms were put in place in support of the second wave of polysomnograms (PSGs), data analysis was carried out, and other administration functions were maintained, including committee operations. During the four years of funding requested with this application, the focus of the SHHS will be on completing follow-up of the cohort and carrying out analyses to address the study's original hypotheses related to sleep-disordered breathing (SDB) and risk for cardiovascular disease, including hypertension and acute cardiovascular events and stroke. Accordingly, during the requested four years of support, the CC will carry out the following functions: 1) continue to maintain the SHHS data base, adding follow-up information as it is developed by the SHHS field sites and the Adjudication Committee; 2) provide central analyses of the SHHS data, particularly for the longitudinal analyses focusing on the study's primary hypotheses; 3) coordinate operations of the SHHS committees including the Steering Committee and its subcommittees, the Presentation and Publications Subcommittee, and the Morbidity and Mortality Subcommittee; 4) maintain the SHHS website and respond to requests for data access and sharing; 5) schedule and staff the required annual Observational Safety and Monitoring Board (OSMB) meetings; and 6) coordinate the closing down of the study at the end of the SHHS.
Funding Period: 1999-09-30 - 2009-08-31
more information: NIH RePORT

Top Publications

  1. ncbi Age-dependent associations between sleep-disordered breathing and hypertension: importance of discriminating between systolic/diastolic hypertension and isolated systolic hypertension in the Sleep Heart Health Study
    Donald C Haas
    Mount Sinai School of Medicine, New York, NY, USA
    Circulation 111:614-21. 2005
  2. ncbi Associations of sleep-disordered breathing and cerebral changes on MRI
    John Robbins
    Department of Medicine, University of California Davis, Sacramento, CA 95817, USA
    J Clin Sleep Med 1:159-65. 2005
  3. ncbi Relationship between reported and measured sleep times: the sleep heart health study (SHHS)
    Graciela E Silva
    College of Nursing and Healthcare Innovation, Arizona State University, Phoenix, AZ 85004 0698, USA
    J Clin Sleep Med 3:622-30. 2007
  4. ncbi Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study
    John W Winkelman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 1505 Commonwealth Avenue, Brighton, MA 02135, USA
    Neurology 70:35-42. 2008
  5. ncbi Left ventricular morphology and systolic function in sleep-disordered breathing: the Sleep Heart Health Study
    Hassan A Chami
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Circulation 117:2599-607. 2008
  6. ncbi Subjective and objective sleep quality and aging in the sleep heart health study
    Mark L Unruh
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    J Am Geriatr Soc 56:1218-27. 2008
  7. ncbi Sleep disordered breathing and hypertension: does self-reported sleepiness modify the association?
    Vishesh K Kapur
    Department of Medicine, University of Washington, Seattle, WA, USA
    Sleep 31:1127-32. 2008
  8. ncbi Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health Study
    GEORGE T O'CONNOR
    Pulmonary Center, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Am J Respir Crit Care Med 179:1159-64. 2009
  9. ncbi Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health Study
    John W Winkelman
    Harvard Medical School, Boston, MA, USA
    Sleep 32:772-8. 2009
  10. ncbi Sample entropy tracks changes in electroencephalogram power spectrum with sleep state and aging
    Eugene N Bruce
    Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506 0070, USA
    J Clin Neurophysiol 26:257-66. 2009

Scientific Experts

Detail Information

Publications22

  1. ncbi Age-dependent associations between sleep-disordered breathing and hypertension: importance of discriminating between systolic/diastolic hypertension and isolated systolic hypertension in the Sleep Heart Health Study
    Donald C Haas
    Mount Sinai School of Medicine, New York, NY, USA
    Circulation 111:614-21. 2005
    ..These findings have implications for SDB screening and treatment. Distinguishing between hypertensive subtypes reveals a stronger association between SDB and hypertension for those aged <60 years than previously reported...
  2. ncbi Associations of sleep-disordered breathing and cerebral changes on MRI
    John Robbins
    Department of Medicine, University of California Davis, Sacramento, CA 95817, USA
    J Clin Sleep Med 1:159-65. 2005
    ..This study tested the significance of associations of SDB with evidence of brain injury or ischemia determined by cerebral magnetic resonance imaging (MRI) studies...
  3. ncbi Relationship between reported and measured sleep times: the sleep heart health study (SHHS)
    Graciela E Silva
    College of Nursing and Healthcare Innovation, Arizona State University, Phoenix, AZ 85004 0698, USA
    J Clin Sleep Med 3:622-30. 2007
    ..This study compared sleep times from polysomnography (PSG) with self-reports of habitual sleep and sleep estimated on the morning after a PSG in adults...
  4. ncbi Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study
    John W Winkelman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 1505 Commonwealth Avenue, Brighton, MA 02135, USA
    Neurology 70:35-42. 2008
    ..We evaluated the cross-sectional association between restless legs syndrome (RLS) and prevalent cardiovascular disease (CVD) in a large community-based sample of middle-aged and elderly subjects...
  5. ncbi Left ventricular morphology and systolic function in sleep-disordered breathing: the Sleep Heart Health Study
    Hassan A Chami
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Circulation 117:2599-607. 2008
    ..We assessed the relation of SDB to LV morphology and systolic function in a community-based sample of middle-aged and older adults...
  6. ncbi Subjective and objective sleep quality and aging in the sleep heart health study
    Mark L Unruh
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    J Am Geriatr Soc 56:1218-27. 2008
    ..To examine the extent to which subjective and objective sleep quality are related to age independent of chronic health conditions...
  7. ncbi Sleep disordered breathing and hypertension: does self-reported sleepiness modify the association?
    Vishesh K Kapur
    Department of Medicine, University of Washington, Seattle, WA, USA
    Sleep 31:1127-32. 2008
    ..We explore whether self-reported sleepiness modifies the relationship between sleep disordered breathing and prevalent hypertension...
  8. ncbi Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health Study
    GEORGE T O'CONNOR
    Pulmonary Center, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Am J Respir Crit Care Med 179:1159-64. 2009
    ..Cross-sectional epidemiologic studies show an association between sleep-disordered breathing and hypertension, but only one cohort study has examined sleep-disordered breathing as a risk factor for incident hypertension...
  9. ncbi Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health Study
    John W Winkelman
    Harvard Medical School, Boston, MA, USA
    Sleep 32:772-8. 2009
    ..The objective of this study was to analyze sleep by PSG in a population-based sample with symptoms of RLS...
  10. ncbi Sample entropy tracks changes in electroencephalogram power spectrum with sleep state and aging
    Eugene N Bruce
    Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506 0070, USA
    J Clin Neurophysiol 26:257-66. 2009
    ..029) and rapid eye movement (P = 0.001), suggesting that cortical state is shifted toward alertness in elderly subjects in these sleep states compared with the middle-aged subjects...
  11. ncbi Relation of sleep-disordered breathing to carotid plaque and intima-media thickness
    Keattiyoat Wattanakit
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 South 2nd Street, Minneapolis, MN 55454, United States
    Atherosclerosis 197:125-31. 2008
    ..Sleep-disordered breathing (SDB) is associated with clinical cardiovascular disease (CVD), but its relation to subclinical atherosclerosis remains to be determined...
  12. ncbi Association of physical activity with sleep-disordered breathing
    Stuart F Quan
    Arizona Respiratory Center, University of Arizona Health Sciences Center, 1501 N Campbell, Tucson, AZ 85724, USA
    Sleep Breath 11:149-57. 2007
    ..A program of regular vigorous physical activity of at least 3 h per week may be a useful adjunctive treatment modality for SDB, but this association needs confirmation with a prospective clinical trial...
  13. ncbi Association of sleep time with diabetes mellitus and impaired glucose tolerance
    Daniel J Gottlieb
    The Pulmonary Center, Boston University School of Medicine, VA Boston Healthcare System, 715 Albany St, Mail Stop R 304, Boston, MA 02118, USA
    Arch Intern Med 165:863-7. 2005
    ....
  14. ncbi Predictors of heartburn during sleep in a large prospective cohort study
    Ronnie Fass
    Section of Gastroenterology, Department of Medicine, Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ, USA
    Chest 127:1658-66. 2005
    ..The aim of this study was to determine the clinical predictors of heartburn during sleep in a large prospective cohort study...
  15. ncbi Haptoglobin phenotype, sleep-disordered breathing, and the prevalence of cardiovascular disease: the Sleep Heart Health Study
    Andrew P Levy
    Rappaport Faculty of Medicine, Technion-lsrael Institute of Technology, Haifa, Israel
    Sleep 28:207-13. 2005
    ..These findings could be due to the absence of association or to survivor bias in these cross-sectional analyses...
  16. ncbi Polysomnographic predictors of blood pressure and hypertension: is one index best?
    Susan Redline
    Case Western Reserve University, Cleveland, OH, USA
    Sleep 28:1122-30. 2005
    ..This study addresses the relative merits of using alternative polysomnography indexes by characterizing the consistency and strength of the association of each index with blood pressure and hypertension...
  17. ncbi Progression and regression of sleep-disordered breathing with changes in weight: the Sleep Heart Health Study
    Anne B Newman
    Department of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:2408-13. 2005
    ..This study aims to determine the relationship between change in weight and progression or remission of SDB by polysomnography...
  18. ncbi Association of nocturnal arrhythmias with sleep-disordered breathing: The Sleep Heart Health Study
    Reena Mehra
    Department of Medicine and Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Respir Crit Care Med 173:910-6. 2006
    ..Sleep-disordered breathing recurrent intermittent hypoxia and sympathetic nervous system activity surges provide the milieu for cardiac arrhythmia development...
  19. ncbi Obstructive sleep apnea-hypopnea and neurocognitive functioning in the Sleep Heart Health Study
    Stuart F Quan
    Department of Medicine, Arizona Respiratory, Sleep Disorders and General Clinical Research Centers, University of Arizona College of Medicine, 1501 North Campbell, Room 2305 Tucson, AZ 85724, USA
    Sleep Med 7:498-507. 2006
    ..In clinical samples, patients with OSAH frequently are found to have deficits in neuropsychological function. However, the nature and severity of these abnormalities in non-clinical populations is less well defined...
  20. ncbi Association of usual sleep duration with hypertension: the Sleep Heart Health Study
    Daniel J Gottlieb
    The Pulmonary Center, Boston University School of Medicine, 715 Albany Street, R 304, Boston, MA 02118 2394, USA
    Sleep 29:1009-14. 2006
    ..This study assesses the relationship between usual sleep duration and hypertension in a community-based cohort...
  21. ncbi Sleep apnea in patients on conventional thrice-weekly hemodialysis: comparison with matched controls from the Sleep Heart Health Study
    Mark L Unruh
    University of Pittsburgh Medical Center, Renal Electrolyte Division, 3550 Terrace Street, A909 Scaife Hall, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 17:3503-9. 2006
    ..The potential mechanisms for the higher likelihood of SDB in the HD population must be identified to provide specific prevention and therapy...
  22. ncbi Longitudinal evaluation of sleep-disordered breathing and sleep symptoms with change in quality of life: the Sleep Heart Health Study (SHHS)
    Graciela E Silva
    College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ 85004 0698, USA
    Sleep 32:1049-57. 2009
    ..The present study evaluates the association among changes in sleep disordered breathing, sleep symptoms, and quality of life over time...