Data Coordinating Center for Sleep Heart Health

Summary

Principal Investigator: J M Samet
Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA
Abstract: DESCRIPTION (provided by applicant): This application presents a plan for continuing the Coordinating Center (CC) for the Sleep Heart Health Study (SHHS) within the Center for Clinical Trials and Departments of Epidemiology and Biostatistics of the Johns Hopkins Bloomberg School of Public Health. The SHHS was started in 1994 as a multicenter prospective cohort study of the cardiovascular consequences of sleep-disordered breathing (SDB). A cohort of 6441 persons, drawn from various ongoing studies was enrolled and had an overnight in-home polysomnogram (PSG); 3295 participants had a second PSG 5 years later. Funds are being requested to continue follow-up of the SHHS cohort in a companion application: "The Sleep Heart Health Study (SHHS)." The CC was housed at the University of Washington School of Public Health for the initial five years of the SHHS and was then transferred to Johns Hopkins for the subsequent five years of funding. During the first four years of CC operations at Johns Hopkins, the SHHS data base was migrated to the CCT, a data system and forms were put in place in support of the second wave of polysomnograms (PSGs), data analysis was carried out, and other administration functions were maintained, including committee operations. During the four years of funding requested with this application, the focus of the SHHS will be on completing follow-up of the cohort and carrying out analyses to address the study's original hypotheses related to sleep-disordered breathing (SDB) and risk for cardiovascular disease, including hypertension and acute cardiovascular events and stroke. Accordingly, during the requested four years of support, the CC will carry out the following functions: 1) continue to maintain the SHHS data base, adding follow-up information as it is developed by the SHHS field sites and the Adjudication Committee; 2) provide central analyses of the SHHS data, particularly for the longitudinal analyses focusing on the study's primary hypotheses; 3) coordinate operations of the SHHS committees including the Steering Committee and its subcommittees, the Presentation and Publications Subcommittee, and the Morbidity and Mortality Subcommittee; 4) maintain the SHHS website and respond to requests for data access and sharing; 5) schedule and staff the required annual Observational Safety and Monitoring Board (OSMB) meetings; and 6) coordinate the closing down of the study at the end of the SHHS.
Funding Period: 1999-09-30 - 2009-08-31
more information: NIH RePORT

Top Publications

  1. pmc Genome-wide association of body fat distribution in African ancestry populations suggests new loci
    Ching Ti Liu
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 9:e1003681. 2013
  2. pmc Vascular inflammation and sleep disordered breathing in a community-based cohort
    Hassan A Chami
    Department of Medicine, American University of Beirut, Beirut, Lebanon
    Sleep 36:763-768C. 2013
  3. pmc Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project
    Kiran Musunuru
    Broad Institute, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e36473. 2012
  4. pmc CUBN is a gene locus for albuminuria
    Carsten A Böger
    Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany
    J Am Soc Nephrol 22:555-70. 2011
  5. pmc A novel approach to prediction of mild obstructive sleep disordered breathing in a population-based sample: the Sleep Heart Health Study
    Brian Caffo
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Sleep 33:1641-8. 2010
  6. pmc Progressive changes in cortical state before and after spontaneous arousals from sleep in elderly and middle-aged women
    E N Bruce
    Center for Biomedical Engineering, University of Kentucky, Lexington, KY, USA
    Neuroscience 175:184-97. 2011
  7. pmc Mutual information analysis of EEG signals indicates age-related changes in cortical interdependence during sleep in middle-aged versus elderly women
    Pravitha Ramanand
    Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506 0070, USA
    J Clin Neurophysiol 27:274-84. 2010
  8. pmc European ancestry as a risk factor for atrial fibrillation in African Americans
    Gregory M Marcus
    Electrophysiology Section, Division of Cardiology, University of California, San Francisco, 500 Parnassus Ave, MUE 434, San Francisco, CA 94143 1354, USA
    Circulation 122:2009-15. 2010
  9. pmc Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study
    Daniel J Gottlieb
    VA Boston Healthcare System, and Boston University School of Medicine, 715 Albany Street, Boston, MA 02118 2394, USA
    Circulation 122:352-60. 2010
  10. pmc Candidate gene association resource (CARe): design, methods, and proof of concept
    Kiran Musunuru
    Broad Institute, Cambridge, MA 02142, USA
    Circ Cardiovasc Genet 3:267-75. 2010

Scientific Experts

Detail Information

Publications43

  1. pmc Genome-wide association of body fat distribution in African ancestry populations suggests new loci
    Ching Ti Liu
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 9:e1003681. 2013
    ..These findings reinforce the concept that there are fat distribution loci that are independent of generalized adiposity...
  2. pmc Vascular inflammation and sleep disordered breathing in a community-based cohort
    Hassan A Chami
    Department of Medicine, American University of Beirut, Beirut, Lebanon
    Sleep 36:763-768C. 2013
    ..The pathophysiologic mechanisms remain unclear, but enhanced vascular inflammation is implicated. We sought to evaluate the association of sleep disordered breathing with biomarkers of inflammation...
  3. pmc Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project
    Kiran Musunuru
    Broad Institute, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e36473. 2012
    ....
  4. pmc CUBN is a gene locus for albuminuria
    Carsten A Böger
    Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany
    J Am Soc Nephrol 22:555-70. 2011
    ..In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes...
  5. pmc A novel approach to prediction of mild obstructive sleep disordered breathing in a population-based sample: the Sleep Heart Health Study
    Brian Caffo
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Sleep 33:1641-8. 2010
    ..66 and 0.70, respectively). In rank order, the following variables had the largest impact on prediction performance: neck circumference, body mass index, age, snoring frequency, waist circumference, and snoring loudness...
  6. pmc Progressive changes in cortical state before and after spontaneous arousals from sleep in elderly and middle-aged women
    E N Bruce
    Center for Biomedical Engineering, University of Kentucky, Lexington, KY, USA
    Neuroscience 175:184-97. 2011
    ....
  7. pmc Mutual information analysis of EEG signals indicates age-related changes in cortical interdependence during sleep in middle-aged versus elderly women
    Pravitha Ramanand
    Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506 0070, USA
    J Clin Neurophysiol 27:274-84. 2010
    ..The loss of synchronization between neural activities during sleep in the elderly may make these women more susceptible to localized disturbances that could lead to frequent arousals...
  8. pmc European ancestry as a risk factor for atrial fibrillation in African Americans
    Gregory M Marcus
    Electrophysiology Section, Division of Cardiology, University of California, San Francisco, 500 Parnassus Ave, MUE 434, San Francisco, CA 94143 1354, USA
    Circulation 122:2009-15. 2010
    ..Because African Americans have varying degrees of European ancestry, we sought to test the hypothesis that European ancestry is an independent risk factor for AF...
  9. pmc Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study
    Daniel J Gottlieb
    VA Boston Healthcare System, and Boston University School of Medicine, 715 Albany Street, Boston, MA 02118 2394, USA
    Circulation 122:352-60. 2010
    ..The objective of this study was to assess the relation of obstructive sleep apnea to incident coronary heart disease and heart failure in a general community sample of adult men and women...
  10. pmc Candidate gene association resource (CARe): design, methods, and proof of concept
    Kiran Musunuru
    Broad Institute, Cambridge, MA 02142, USA
    Circ Cardiovasc Genet 3:267-75. 2010
    ..The goals of CARe include the discovery of new variants associated with traits using a candidate gene approach and the discovery of new variants using the genome-wide association mapping approach specifically in African Americans...
  11. pmc Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study
    Susan Redline
    Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115M, USA
    Am J Respir Crit Care Med 182:269-77. 2010
    ....
  12. pmc Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
    Ervin R Fox
    Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA
    Hum Mol Genet 20:2273-84. 2011
    ..More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity...
  13. pmc Association of incident cardiovascular disease with progression of sleep-disordered breathing
    Hassan A Chami
    The Pulmonary Center, Boston University School of Medicine, 72 E Concord Street, Boston, MA 02118, USA
    Circulation 123:1280-6. 2011
    ..However, a reverse causal pathway whereby incident CVD causes or worsens sleep-disordered breathing has not been studied...
  14. pmc Incidence of restless legs syndrome and its correlates
    Pooja Budhiraja
    Southern Arizona VA Healthcare System, 3601 S 6th Ave, Tucson, Arizona 85723, USA
    J Clin Sleep Med 8:119-24. 2012
    ..Restless legs syndrome (RLS) is a common sensorimotor disorder whose incidence is not known. The aim of the study was to determine the incidence and correlates of RLS in a population-based sample...
  15. pmc Nocturia, sleep-disordered breathing, and cardiovascular morbidity in a community-based cohort
    Sairam Parthasarathy
    Department of Medicine, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 7:e30969. 2012
    ..Our aims were to determine whether an association between nocturia and cardiovascular morbidity exists that is independent of SDB. We also determined whether nocturia is independently associated with SDB...
  16. pmc Identification of patients with sleep disordered breathing: comparing the four-variable screening tool, STOP, STOP-Bang, and Epworth Sleepiness Scales
    Graciela E Silva
    College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ 85004 0698, USA
    J Clin Sleep Med 7:467-72. 2011
    ..This study evaluated the abilities of the 4-Variable screening tool, STOP, STOP-Bang, and ESS questionnaires in identifying subjects at risk for SDB...
  17. pmc Triggering of nocturnal arrhythmias by sleep-disordered breathing events
    Ken Monahan
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Am Coll Cardiol 54:1797-804. 2009
    ..This study sought to evaluate respiratory disturbances as potential triggers for arrhythmia in patients with sleep-disordered breathing (SDB)...
  18. pmc Genetic association for renal traits among participants of African ancestry reveals new loci for renal function
    Ching Ti Liu
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002264. 2011
    ..We identified several SNPs in association with eGFR in African Ancestry individuals, as well as 3 suggestive loci for UACR and eGFR. Functional genetic studies support a role for kcnq1 in glomerular development in zebrafish...
  19. pmc Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele
    Adrienne Tin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Hum Mol Genet 20:4056-68. 2011
    ..Our data support the importance of multi-ethnic GWAS in the identification of novel risk loci as well as functional variants...
  20. pmc Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium
    Bogdan Pasaniuc
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS Genet 7:e1001371. 2011
    ..Our methods and our publicly available software are broadly applicable to GWAS in admixed populations...
  21. pmc Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium
    Xiaofeng Zhu
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Hum Mol Genet 20:2285-95. 2011
    ..Our study highlights that admixture mapping analysis can help identify genetic variants missed by genome-wide association studies because of drastically reduced number of tests in the whole genome...
  22. ncbi Subjective and objective sleep quality and aging in the sleep heart health study
    Mark L Unruh
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    J Am Geriatr Soc 56:1218-27. 2008
    ..To examine the extent to which subjective and objective sleep quality are related to age independent of chronic health conditions...
  23. ncbi Progression and regression of sleep-disordered breathing with changes in weight: the Sleep Heart Health Study
    Anne B Newman
    Department of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:2408-13. 2005
    ..This study aims to determine the relationship between change in weight and progression or remission of SDB by polysomnography...
  24. pmc Longitudinal evaluation of sleep-disordered breathing and sleep symptoms with change in quality of life: the Sleep Heart Health Study (SHHS)
    Graciela E Silva
    College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ 85004 0698, USA
    Sleep 32:1049-57. 2009
    ..The present study evaluates the association among changes in sleep disordered breathing, sleep symptoms, and quality of life over time...
  25. ncbi Sleep apnea in patients on conventional thrice-weekly hemodialysis: comparison with matched controls from the Sleep Heart Health Study
    Mark L Unruh
    University of Pittsburgh Medical Center, Renal Electrolyte Division, 3550 Terrace Street, A909 Scaife Hall, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 17:3503-9. 2006
    ..The potential mechanisms for the higher likelihood of SDB in the HD population must be identified to provide specific prevention and therapy...
  26. ncbi Association of usual sleep duration with hypertension: the Sleep Heart Health Study
    Daniel J Gottlieb
    The Pulmonary Center, Boston University School of Medicine, 715 Albany Street, R 304, Boston, MA 02118 2394, USA
    Sleep 29:1009-14. 2006
    ..This study assesses the relationship between usual sleep duration and hypertension in a community-based cohort...
  27. ncbi Obstructive sleep apnea-hypopnea and neurocognitive functioning in the Sleep Heart Health Study
    Stuart F Quan
    Department of Medicine, Arizona Respiratory, Sleep Disorders and General Clinical Research Centers, University of Arizona College of Medicine, 1501 North Campbell, Room 2305 Tucson, AZ 85724, USA
    Sleep Med 7:498-507. 2006
    ..In clinical samples, patients with OSAH frequently are found to have deficits in neuropsychological function. However, the nature and severity of these abnormalities in non-clinical populations is less well defined...
  28. pmc Association of nocturnal arrhythmias with sleep-disordered breathing: The Sleep Heart Health Study
    Reena Mehra
    Department of Medicine and Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Respir Crit Care Med 173:910-6. 2006
    ..Sleep-disordered breathing recurrent intermittent hypoxia and sympathetic nervous system activity surges provide the milieu for cardiac arrhythmia development...
  29. ncbi Polysomnographic predictors of blood pressure and hypertension: is one index best?
    Susan Redline
    Case Western Reserve University, Cleveland, OH, USA
    Sleep 28:1122-30. 2005
    ..This study addresses the relative merits of using alternative polysomnography indexes by characterizing the consistency and strength of the association of each index with blood pressure and hypertension...
  30. ncbi Haptoglobin phenotype, sleep-disordered breathing, and the prevalence of cardiovascular disease: the Sleep Heart Health Study
    Andrew P Levy
    Rappaport Faculty of Medicine, Technion lsrael Institute of Technology, Haifa, Israel
    Sleep 28:207-13. 2005
    ..We therefore sought to determine whether sleep-disordered breathing and cardiovascular disease are more strongly associated among people with the unfavorable haptoglobin phenotype...
  31. ncbi Predictors of heartburn during sleep in a large prospective cohort study
    Ronnie Fass
    Section of Gastroenterology, Department of Medicine, Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ, USA
    Chest 127:1658-66. 2005
    ..The aim of this study was to determine the clinical predictors of heartburn during sleep in a large prospective cohort study...
  32. ncbi Association of sleep time with diabetes mellitus and impaired glucose tolerance
    Daniel J Gottlieb
    The Pulmonary Center, Boston University School of Medicine, VA Boston Healthcare System, 715 Albany St, Mail Stop R 304, Boston, MA 02118, USA
    Arch Intern Med 165:863-7. 2005
    ....
  33. ncbi Association of physical activity with sleep-disordered breathing
    Stuart F Quan
    Arizona Respiratory Center, University of Arizona Health Sciences Center, 1501 N Campbell, Tucson, AZ 85724, USA
    Sleep Breath 11:149-57. 2007
    ..A program of regular vigorous physical activity of at least 3 h per week may be a useful adjunctive treatment modality for SDB, but this association needs confirmation with a prospective clinical trial...
  34. ncbi Relation of sleep-disordered breathing to carotid plaque and intima-media thickness
    Keattiyoat Wattanakit
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 South 2nd Street, Minneapolis, MN 55454, United States
    Atherosclerosis 197:125-31. 2008
    ..Sleep-disordered breathing (SDB) is associated with clinical cardiovascular disease (CVD), but its relation to subclinical atherosclerosis remains to be determined...
  35. pmc Sample entropy tracks changes in electroencephalogram power spectrum with sleep state and aging
    Eugene N Bruce
    Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506 0070, USA
    J Clin Neurophysiol 26:257-66. 2009
    ..029) and rapid eye movement (P = 0.001), suggesting that cortical state is shifted toward alertness in elderly subjects in these sleep states compared with the middle-aged subjects...
  36. pmc Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health Study
    John W Winkelman
    Harvard Medical School, Boston, MA, USA
    Sleep 32:772-8. 2009
    ..The objective of this study was to analyze sleep by PSG in a population-based sample with symptoms of RLS...
  37. pmc Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health Study
    GEORGE T O'CONNOR
    Pulmonary Center, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Am J Respir Crit Care Med 179:1159-64. 2009
    ..Cross-sectional epidemiologic studies show an association between sleep-disordered breathing and hypertension, but only one cohort study has examined sleep-disordered breathing as a risk factor for incident hypertension...
  38. pmc Sleep disordered breathing and hypertension: does self-reported sleepiness modify the association?
    Vishesh K Kapur
    Department of Medicine, University of Washington, Seattle, WA, USA
    Sleep 31:1127-32. 2008
    ..We explore whether self-reported sleepiness modifies the relationship between sleep disordered breathing and prevalent hypertension...
  39. pmc Left ventricular morphology and systolic function in sleep-disordered breathing: the Sleep Heart Health Study
    Hassan A Chami
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Circulation 117:2599-607. 2008
    ..We assessed the relation of SDB to LV morphology and systolic function in a community-based sample of middle-aged and older adults...
  40. doi Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study
    John W Winkelman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 1505 Commonwealth Avenue, Brighton, MA 02135, USA
    Neurology 70:35-42. 2008
    ..We evaluated the cross-sectional association between restless legs syndrome (RLS) and prevalent cardiovascular disease (CVD) in a large community-based sample of middle-aged and elderly subjects...
  41. pmc Relationship between reported and measured sleep times: the sleep heart health study (SHHS)
    Graciela E Silva
    College of Nursing and Healthcare Innovation, Arizona State University, Phoenix, AZ 85004 0698, USA
    J Clin Sleep Med 3:622-30. 2007
    ..This study compared sleep times from polysomnography (PSG) with self-reports of habitual sleep and sleep estimated on the morning after a PSG in adults...
  42. ncbi Associations of sleep-disordered breathing and cerebral changes on MRI
    John Robbins
    Department of Medicine, University of California Davis, Sacramento, CA 95817, USA
    J Clin Sleep Med 1:159-65. 2005
    ..This study tested the significance of associations of SDB with evidence of brain injury or ischemia determined by cerebral magnetic resonance imaging (MRI) studies...
  43. ncbi Age-dependent associations between sleep-disordered breathing and hypertension: importance of discriminating between systolic/diastolic hypertension and isolated systolic hypertension in the Sleep Heart Health Study
    Donald C Haas
    Mount Sinai School of Medicine, New York, NY, USA
    Circulation 111:614-21. 2005
    ..Prior investigations may have underestimated an association between SDB and systolic/diastolic hypertension in the elderly by categorizing individuals with ISH as simply hypertensive...