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Species | Data Coordinating Center for Sleep Heart HealthSummaryPrincipal Investigator: J M Samet Affiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Abstract: This application presents a plan for continuing the Coordinating Center (CC) for the Sleep Heart Health Study (SHHS) within the Center for Clinical Trials and Departments of Epidemiology and Biostatistics of the Johns Hopkins Bloomberg School of Public Health. The SHHS was started in 1994 as a multicenter prospective cohort study of the cardiovascular consequences of sleep-disordered breathing (SDB). A cohort of 6441 persons, drawn from various ongoing studies was enrolled and had an overnight in-home polysomnogram (PSG); 3295 participants had a second PSG 5 years later. Funds are being requested to continue follow-up of the SHHS cohort in a companion application: "The Sleep Heart Health Study (SHHS)." The CC was housed at the University of Washington School of Public Health for the initial five years of the SHHS and was then transferred to Johns Hopkins for the subsequent five years of funding. During the first four years of CC operations at Johns Hopkins, the SHHS data base was migrated to the CCT, a data system and forms were put in place in support of the second wave of polysomnograms (PSGs), data analysis was carried out, and other administration functions were maintained, including committee operations. During the four years of funding requested with this application, the focus of the SHHS will be on completing follow-up of the cohort and carrying out analyses to address the study's original hypotheses related to sleep-disordered breathing (SDB) and risk for cardiovascular disease, including hypertension and acute cardiovascular events and stroke. Accordingly, during the requested four years of support, the CC will carry out the following functions: 1) continue to maintain the SHHS data base, adding follow-up information as it is developed by the SHHS field sites and the Adjudication Committee; 2) provide central analyses of the SHHS data, particularly for the longitudinal analyses focusing on the study's primary hypotheses; 3) coordinate operations of the SHHS committees including the Steering Committee and its subcommittees, the Presentation and Publications Subcommittee, and the Morbidity and Mortality Subcommittee; 4) maintain the SHHS website and respond to requests for data access and sharing; 5) schedule and staff the required annual Observational Safety and Monitoring Board (OSMB) meetings; and 6) coordinate the closing down of the study at the end of the SHHS. Funding Period: 1999-09-30 - 2009-08-31 more information: NIH RePORT Top Publications
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Publications
Age-dependent associations between sleep-disordered breathing and hypertension: importance of discriminating between systolic/diastolic hypertension and isolated systolic hypertension in the Sleep Heart Health StudyDonald C Haas
Mount Sinai School of Medicine, New York, NY, USA
Circulation 111:614-21. 2005..These findings have implications for SDB screening and treatment. Distinguishing between hypertensive subtypes reveals a stronger association between SDB and hypertension for those aged <60 years than previously reported...- Associations of sleep-disordered breathing and cerebral changes on MRIJohn Robbins
Department of Medicine, University of California Davis, Sacramento, CA 95817, USA
J Clin Sleep Med 1:159-65. 2005..This study tested the significance of associations of SDB with evidence of brain injury or ischemia determined by cerebral magnetic resonance imaging (MRI) studies... 
Relationship between reported and measured sleep times: the sleep heart health study (SHHS)Graciela E Silva
College of Nursing and Healthcare Innovation, Arizona State University, Phoenix, AZ 85004 0698, USA
J Clin Sleep Med 3:622-30. 2007..This study compared sleep times from polysomnography (PSG) with self-reports of habitual sleep and sleep estimated on the morning after a PSG in adults...
Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health StudyJohn W Winkelman
Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 1505 Commonwealth Avenue, Brighton, MA 02135, USA
Neurology 70:35-42. 2008..We evaluated the cross-sectional association between restless legs syndrome (RLS) and prevalent cardiovascular disease (CVD) in a large community-based sample of middle-aged and elderly subjects...- Left ventricular morphology and systolic function in sleep-disordered breathing: the Sleep Heart Health StudyHassan A Chami
Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Circulation 117:2599-607. 2008..We assessed the relation of SDB to LV morphology and systolic function in a community-based sample of middle-aged and older adults... - Subjective and objective sleep quality and aging in the sleep heart health studyMark L Unruh
Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
J Am Geriatr Soc 56:1218-27. 2008..To examine the extent to which subjective and objective sleep quality are related to age independent of chronic health conditions... - Sleep disordered breathing and hypertension: does self-reported sleepiness modify the association?Vishesh K Kapur
Department of Medicine, University of Washington, Seattle, WA, USA
Sleep 31:1127-32. 2008..We explore whether self-reported sleepiness modifies the relationship between sleep disordered breathing and prevalent hypertension... - Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health StudyGEORGE T O'CONNOR
Pulmonary Center, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
Am J Respir Crit Care Med 179:1159-64. 2009..Cross-sectional epidemiologic studies show an association between sleep-disordered breathing and hypertension, but only one cohort study has examined sleep-disordered breathing as a risk factor for incident hypertension... - Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health StudyJohn W Winkelman
Harvard Medical School, Boston, MA, USA
Sleep 32:772-8. 2009..The objective of this study was to analyze sleep by PSG in a population-based sample with symptoms of RLS... - Sample entropy tracks changes in electroencephalogram power spectrum with sleep state and agingEugene N Bruce
Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506 0070, USA
J Clin Neurophysiol 26:257-66. 2009..029) and rapid eye movement (P = 0.001), suggesting that cortical state is shifted toward alertness in elderly subjects in these sleep states compared with the middle-aged subjects... - Relation of sleep-disordered breathing to carotid plaque and intima-media thicknessKeattiyoat Wattanakit
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 South 2nd Street, Minneapolis, MN 55454, United States
Atherosclerosis 197:125-31. 2008..Sleep-disordered breathing (SDB) is associated with clinical cardiovascular disease (CVD), but its relation to subclinical atherosclerosis remains to be determined... - Association of physical activity with sleep-disordered breathingStuart F Quan
Arizona Respiratory Center, University of Arizona Health Sciences Center, 1501 N Campbell, Tucson, AZ 85724, USA
Sleep Breath 11:149-57. 2007..A program of regular vigorous physical activity of at least 3 h per week may be a useful adjunctive treatment modality for SDB, but this association needs confirmation with a prospective clinical trial... - Association of sleep time with diabetes mellitus and impaired glucose toleranceDaniel J Gottlieb
The Pulmonary Center, Boston University School of Medicine, VA Boston Healthcare System, 715 Albany St, Mail Stop R 304, Boston, MA 02118, USA
Arch Intern Med 165:863-7. 2005.... - Predictors of heartburn during sleep in a large prospective cohort studyRonnie Fass
Section of Gastroenterology, Department of Medicine, Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ, USA
Chest 127:1658-66. 2005..The aim of this study was to determine the clinical predictors of heartburn during sleep in a large prospective cohort study... - Haptoglobin phenotype, sleep-disordered breathing, and the prevalence of cardiovascular disease: the Sleep Heart Health StudyAndrew P Levy
Rappaport Faculty of Medicine, Technion-lsrael Institute of Technology, Haifa, Israel
Sleep 28:207-13. 2005..These findings could be due to the absence of association or to survivor bias in these cross-sectional analyses... - Polysomnographic predictors of blood pressure and hypertension: is one index best?Susan Redline
Case Western Reserve University, Cleveland, OH, USA
Sleep 28:1122-30. 2005..This study addresses the relative merits of using alternative polysomnography indexes by characterizing the consistency and strength of the association of each index with blood pressure and hypertension... - Progression and regression of sleep-disordered breathing with changes in weight: the Sleep Heart Health StudyAnne B Newman
Department of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Arch Intern Med 165:2408-13. 2005..This study aims to determine the relationship between change in weight and progression or remission of SDB by polysomnography... - Association of nocturnal arrhythmias with sleep-disordered breathing: The Sleep Heart Health StudyReena Mehra
Department of Medicine and Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA
Am J Respir Crit Care Med 173:910-6. 2006..Sleep-disordered breathing recurrent intermittent hypoxia and sympathetic nervous system activity surges provide the milieu for cardiac arrhythmia development... - Obstructive sleep apnea-hypopnea and neurocognitive functioning in the Sleep Heart Health StudyStuart F Quan
Department of Medicine, Arizona Respiratory, Sleep Disorders and General Clinical Research Centers, University of Arizona College of Medicine, 1501 North Campbell, Room 2305 Tucson, AZ 85724, USA
Sleep Med 7:498-507. 2006..In clinical samples, patients with OSAH frequently are found to have deficits in neuropsychological function. However, the nature and severity of these abnormalities in non-clinical populations is less well defined... - Association of usual sleep duration with hypertension: the Sleep Heart Health StudyDaniel J Gottlieb
The Pulmonary Center, Boston University School of Medicine, 715 Albany Street, R 304, Boston, MA 02118 2394, USA
Sleep 29:1009-14. 2006..This study assesses the relationship between usual sleep duration and hypertension in a community-based cohort... - Sleep apnea in patients on conventional thrice-weekly hemodialysis: comparison with matched controls from the Sleep Heart Health StudyMark L Unruh
University of Pittsburgh Medical Center, Renal Electrolyte Division, 3550 Terrace Street, A909 Scaife Hall, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 17:3503-9. 2006..The potential mechanisms for the higher likelihood of SDB in the HD population must be identified to provide specific prevention and therapy... - Longitudinal evaluation of sleep-disordered breathing and sleep symptoms with change in quality of life: the Sleep Heart Health Study (SHHS)Graciela E Silva
College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ 85004 0698, USA
Sleep 32:1049-57. 2009..The present study evaluates the association among changes in sleep disordered breathing, sleep symptoms, and quality of life over time...