EPIDEMIOLOGY OF CHRONIC PELVIC PAIN

Summary

Principal Investigator: J Quentin Clemens
Abstract: DESCRIPTION (Provided by Applicant): The primary aim of this application is to obtain novel information about chronic pelvic pain of bladder origin (CPPBO) in order to determine the magnitude of the problem and its cost to society. This study builds on our ongoing collaborative work with the NIH Chronic Prostatitis Collaborative Clinical Research Study, in which demographics, risk factors, quality of life, and health resource utilization are being evaluated in men with chronic voiding symptoms and pelvic pain. These studies are ongoing, and we will utilize similar methods in men and women in order to obtain consistent data for comparison between the sexes. The specific aims are: 1) to assess the prevalence and incidence of CPPBO. A clinically useful definition of the syndrome will be described, and this definition will be used to assess the prevalence of the syndrome in a large, diverse patient population. Using the same definition, the incidence of new cases will subsequently be determined over a three-year time period; 2) to determine risk factors for the development of CPPBO. A case-control study will be performed using age- and gender-matched controls in order to evaluate for medical conditions and lifestyle factors which are associated with the syndrome; and 3) to evaluate the effect of CPPBO on patient quality of life and health resource utilization. To conduct this study, two populations will be utilized. A database of patients from the Kaiser Permanente Foundation Hospitals in Oregon will be used to assess population prevalence and incidence rates and direct medical costs. Questionnaires will be mailed to a random sample of the Kaiser Permanente patients to obtain detailed information about symptoms and quality of life (QOL). In addition, patients diagnosed with CPPBO at the Northwestern Memorial Faculty Foundation Urology Clinic will undergo a more extensive questionnaire evaluation to analyze medical and lifestyle risk factors for the presence of CPPBO and to obtain additional QOL and health resource utilization information. Answers from the Urology clinic patients will be compared with those of age-and gender-matched controls in a case-control study design. This project will provide novel, population-based epidemiologic information about chronic pelvic pain of bladder origin in both men and women, and will help to further define the public health burden of this extremely common condition.
Funding Period: 2001-09-15 - 2006-08-31
more information: NIH RePORT

Top Publications

  1. ncbi Prevalence and incidence of interstitial cystitis in a managed care population
    J Quentin Clemens
    Department of Urology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    J Urol 173:98-102; discussion 102. 2005
  2. pmc Prevalence and severity of undiagnosed urinary incontinence in women
    Lauren P Wallner
    Department of Urology, University of Michigan, Ann Arbor, MI 48109 5330, USA
    Am J Med 122:1037-42. 2009
  3. ncbi Prevalence of interstitial cystitis symptoms in a managed care population
    J Quentin Clemens
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 174:576-80. 2005
  4. ncbi Incidence and clinical characteristics of National Institutes of Health type III prostatitis in the community
    J Quentin Clemens
    Department of Urology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Tarry 11 715, Chicago, IL 60611, USA
    J Urol 174:2319-22. 2005
  5. ncbi Prevalence of and risk factors for prostatitis: population based assessment using physician assigned diagnoses
    J Quentin Clemens
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 178:1333-7. 2007
  6. ncbi Incidence and clinical characteristics of interstitial cystitis in the community
    Ronak Patel
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Int Urogynecol J Pelvic Floor Dysfunct 19:1093-6. 2008
  7. pmc Costs of interstitial cystitis in a managed care population
    J Quentin Clemens
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 71:776-80; discussion 780-1. 2008
  8. pmc Mental health diagnoses in patients with interstitial cystitis/painful bladder syndrome and chronic prostatitis/chronic pelvic pain syndrome: a case/control study
    J Quentin Clemens
    Department of Urology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 5330, USA
    J Urol 180:1378-82. 2008
  9. pmc Comparison of economic impact of chronic prostatitis/chronic pelvic pain syndrome and interstitial cystitis/painful bladder syndrome
    J Quentin Clemens
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Urology 73:743-6. 2009

Scientific Experts

  • J Quentin Clemens
  • Lauren P Wallner
  • Richard T Meenan
  • Elizabeth A Calhoun
  • Ronak Patel
  • Aruna V Sarma
  • Maureen C O'Keefe Rosetti
  • Sima Porten
  • Maureen C O'Keeffe Rosetti
  • Terry Kimes

Detail Information

Publications9

  1. ncbi Prevalence and incidence of interstitial cystitis in a managed care population
    J Quentin Clemens
    Department of Urology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    J Urol 173:98-102; discussion 102. 2005
    ..We calculated the prevalence and incidence of physician diagnosed interstitial cystitis (IC) in men and women in a managed care population in the Pacific Northwest...
  2. pmc Prevalence and severity of undiagnosed urinary incontinence in women
    Lauren P Wallner
    Department of Urology, University of Michigan, Ann Arbor, MI 48109 5330, USA
    Am J Med 122:1037-42. 2009
    ..Therefore, the purpose of this study was to quantify the prevalence of urinary incontinence in undiagnosed women in a managed care population...
  3. ncbi Prevalence of interstitial cystitis symptoms in a managed care population
    J Quentin Clemens
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 174:576-80. 2005
    ..We calculated the prevalence of symptoms typically associated with interstitial cystitis (IC) in men and women in a managed care population in the Pacific Northwest...
  4. ncbi Incidence and clinical characteristics of National Institutes of Health type III prostatitis in the community
    J Quentin Clemens
    Department of Urology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Tarry 11 715, Chicago, IL 60611, USA
    J Urol 174:2319-22. 2005
    ..We used coded physician diagnoses and subsequent chart reviews to estimate the incidence and clinical characteristics of physician diagnosed National Institutes of Health (NIH) type III prostatitis...
  5. ncbi Prevalence of and risk factors for prostatitis: population based assessment using physician assigned diagnoses
    J Quentin Clemens
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 178:1333-7. 2007
    ..Subjects were male enrollees in the Kaiser Permanente Northwest, Portland, Oregon health maintenance organization...
  6. ncbi Incidence and clinical characteristics of interstitial cystitis in the community
    Ronak Patel
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Int Urogynecol J Pelvic Floor Dysfunct 19:1093-6. 2008
    ..IC is an uncommon diagnosis in the community setting, with an incidence rate of 15 per 100,000 women per year...
  7. pmc Costs of interstitial cystitis in a managed care population
    J Quentin Clemens
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 71:776-80; discussion 780-1. 2008
    ..To assess the direct medical costs, medication, and procedure use associated with interstitial cystitis (IC) in women in the Kaiser Permanente Northwest (KPNW) managed care population...
  8. pmc Mental health diagnoses in patients with interstitial cystitis/painful bladder syndrome and chronic prostatitis/chronic pelvic pain syndrome: a case/control study
    J Quentin Clemens
    Department of Urology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 5330, USA
    J Urol 180:1378-82. 2008
    ..We compared the rate of mental health disorders in male and female patients with pelvic pain and control subjects...
  9. pmc Comparison of economic impact of chronic prostatitis/chronic pelvic pain syndrome and interstitial cystitis/painful bladder syndrome
    J Quentin Clemens
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Urology 73:743-6. 2009
    ..Furthermore, no direct comparisons of the costs of these 2 conditions have been performed. Such a comparison is relevant because the distinction between the 2 conditions is not always clear...