Osteoporotic Fractures in Men - MrOS Renewal

Summary

Principal Investigator: Elizabeth Barrett-Connor
Affiliation: University of California
Country: USA
Abstract: The Osteoporotic Fractures in Men (MrOS) study was formed primarily to quantify the determinants of fracture in men. Importantly, the MrOS cohort also provides a seminal opportunity to study men as they progress through a critical period of life in which problems of aging remain poorly understood. In 2000-2002, 5995 community-dwelling men ages 65 years and older (mean age: 72 years at baseline) were enrolled from 6 diverse US communities. After 5 years of follow-up, participant retention is excellent (99% of those alive remain active). We propose a new clinic visit and continued follow-up of the cohort to expand our understanding of risk factors for falls, fractures (particularly hip fracture) and other consequences of aging. At baseline, both areal (from DXA) and volumetric (from QCT) skeletal assessments were obtained. We propose to repeat the same assessments in the planned visit to identify the densitometric and biomechanical risk factors for hip fracture, as well as to characterize bone geometry changes that underlie skeletal fragility. Further, we will use the QCT scans to quantify femoral strength by finite element modeling (FEM), and assess the usefulness of FEM for fracture prediction. Additional follow-up of the cohort and repeat measures of muscle strength (grip strength, leg power), physical performance (gait speed, chair stands, and narrow walk), and self-reported physical activity will enable us to establish the extent and nature of change in activity and physical performance, identify biological predictors of these changes, and clarify the possibly joint effects of physical activity and physical performance on fracture risk. To objectively quantify physical activity we propose to obtain accelerometry measures at the new clinic visit. Using serum archived at baseline, we will test the hypothesis that renal function, vitamin D, parathyroid hormone have important effects on skeletal health, physical function and fracture risk, and will determine if lower sex steroid levels increase men's risk of skeletal deterioration and fracture, decline in physical function, and deterioration in quality of life. Combined with the considerable data and biologic specimens already collected, additional measures and extended follow-up in the MrOS cohort allows us to expand the understanding of hip fractures, the most devastating type of fracture in men, as well as address other health issues of compelling public health and clinical importance to older US men.
Funding Period: 1999-09-30 - 2012-07-31
more information: NIH RePORT

Top Publications

  1. ncbi Association of 25-hydroxyvitamin D with prevalent osteoarthritis of the hip in elderly men: the osteoporotic fractures in men study
    R K Chaganti
    University of California, San Francisco, CA, USA
    Arthritis Rheum 62:511-4. 2010
  2. ncbi Association of a high mobility group gene (HMGA2) variant with bone mineral density
    Allison Kuipers
    Department of Epidemiology, Crabtree Hall, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Bone 45:295-300. 2009
  3. ncbi A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Am Geriatr Soc 57:492-8. 2009
  4. ncbi Behavioral correlates of sleep-disordered breathing in older men
    Eric J Kezirian
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, San Francisco, California, USA
    Sleep 32:253-61. 2009
  5. ncbi Vitamin D deficiency in older men
    Eric Orwoll
    Bone and Mineral Unit, Oregon Health and Sciences University, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 94:1214-22. 2009
  6. ncbi The association of bone mineral density with prostate cancer risk in the Osteoporotic Fractures in Men (MrOS) Study
    Ghada N Farhat
    University of Pittsburgh, Department of Epidemiology and Division of Cancer Prevention and Population Science, University of Pittsburgh Medical Center, Cancer Pavilion, Suite 4C, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
    Cancer Epidemiol Biomarkers Prev 18:148-54. 2009
  7. ncbi Genetic variations in sex steroid-related genes as predictors of serum estrogen levels in men
    Anna L Eriksson
    Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine Gothenburg University, SE 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 94:1033-41. 2009
  8. ncbi Finite element analysis of the proximal femur and hip fracture risk in older men
    Eric S Orwoll
    Bone and Mineral Unit, Oregon Health and Science University, Portland Oregon 97239, USA
    J Bone Miner Res 24:475-83. 2009
  9. ncbi Trochanteric soft tissue thickness and hip fracture in older men
    Carrie M Nielson
    Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Clin Endocrinol Metab 94:491-6. 2009
  10. ncbi The association between sleep duration and obesity in older adults
    S R Patel
    Division of Pulmonary, Critical Care, and Sleep Medicine and Center for Clinical Investigation, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Obes (Lond) 32:1825-34. 2008

Scientific Experts

Detail Information

Publications62

  1. ncbi Association of 25-hydroxyvitamin D with prevalent osteoarthritis of the hip in elderly men: the osteoporotic fractures in men study
    R K Chaganti
    University of California, San Francisco, CA, USA
    Arthritis Rheum 62:511-4. 2010
    ..To examine the cross-sectional association of serum levels of 25-hydroxyvitamin D, or 25(OH)D, with prevalent radiographic hip osteoarthritis (OA) in elderly men...
  2. ncbi Association of a high mobility group gene (HMGA2) variant with bone mineral density
    Allison Kuipers
    Department of Epidemiology, Crabtree Hall, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Bone 45:295-300. 2009
    ..Additional research is needed to better understand the role of HMGA2 in the regulation of bone metabolism...
  3. ncbi A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Am Geriatr Soc 57:492-8. 2009
    ....
  4. ncbi Behavioral correlates of sleep-disordered breathing in older men
    Eric J Kezirian
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, San Francisco, California, USA
    Sleep 32:253-61. 2009
    ....
  5. ncbi Vitamin D deficiency in older men
    Eric Orwoll
    Bone and Mineral Unit, Oregon Health and Sciences University, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 94:1214-22. 2009
    ..Vitamin D deficiency is not adequately evaluated in older men...
  6. ncbi The association of bone mineral density with prostate cancer risk in the Osteoporotic Fractures in Men (MrOS) Study
    Ghada N Farhat
    University of Pittsburgh, Department of Epidemiology and Division of Cancer Prevention and Population Science, University of Pittsburgh Medical Center, Cancer Pavilion, Suite 4C, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
    Cancer Epidemiol Biomarkers Prev 18:148-54. 2009
    ..However, no associations were observed with low-grade disease. Our results provide support for an inverse association between BMD and PCa risk. Possible pathophyisological mechanisms linking BMD and PCa should be elucidated...
  7. ncbi Genetic variations in sex steroid-related genes as predictors of serum estrogen levels in men
    Anna L Eriksson
    Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine Gothenburg University, SE 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 94:1033-41. 2009
    ..The risk of many conditions, including prostate cancer, breast cancer, and osteoporosis, is associated with serum levels of sex steroids...
  8. ncbi Finite element analysis of the proximal femur and hip fracture risk in older men
    Eric S Orwoll
    Bone and Mineral Unit, Oregon Health and Science University, Portland Oregon 97239, USA
    J Bone Miner Res 24:475-83. 2009
    ..1, 95% CI: 1.6-6.1). These results provide insight into hip fracture etiology and demonstrate the ability of FE-based biomechanical analysis of QCT scans to prospectively predict hip fractures in men...
  9. ncbi Trochanteric soft tissue thickness and hip fracture in older men
    Carrie M Nielson
    Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Clin Endocrinol Metab 94:491-6. 2009
    ..The effect of trochanteric soft tissue thickness on the risk of incident hip fracture has not been evaluated in men...
  10. ncbi The association between sleep duration and obesity in older adults
    S R Patel
    Division of Pulmonary, Critical Care, and Sleep Medicine and Center for Clinical Investigation, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Obes (Lond) 32:1825-34. 2008
    ..In this study, the cross-sectional associations between sleep duration measured objectively and measures of weight and body composition were assessed in two cohorts of older adults...
  11. ncbi Reduced renal function and sleep-disordered breathing in community-dwelling elderly men
    Muna T Canales
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Sleep Med 9:637-45. 2008
    ..Sleep-disordered breathing (SDB) may increase the risk of cardiovascular disease (CVD) and death in chronic kidney disease (CKD). However, the association between mild reductions in renal function and SDB is uncertain...
  12. ncbi Acid-suppressive medications and risk of bone loss and fracture in older adults
    Elaine W Yu
    Endocrine Division, Massachusetts General Hospital, Thier 1101, 50 Blossom Street, Boston, MA 02114, USA
    Calcif Tissue Int 83:251-9. 2008
    ..The use of PPIs in older women, and perhaps older men with low calcium intake, may be associated with a modestly increased risk of nonspine fracture...
  13. ncbi Kidney function and cognitive performance and decline in older men
    Yelena Slinin
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 56:2082-8. 2008
    ..To examine the association between kidney function and cognitive impairment and decline in elderly men...
  14. ncbi Antiepileptic drug use and rates of hip bone loss in older men: a prospective study
    K E Ensrud
    VA Medical Center, One Veterans Drive 111 0, Minneapolis, MN 55417, USA
    Neurology 71:723-30. 2008
    ..To test the hypotheses that older community dwelling men taking non-enzyme-inducing antiepileptic drugs (NEIAEDs) and those taking enzyme-inducing antiepileptic drugs (EIAEDs) have increased rates of hip bone loss...
  15. ncbi Peripheral arterial disease is associated with higher rates of hip bone loss and increased fracture risk in older men
    Tracie C Collins
    University of Minnesota, Department of Medicine, 717 Delaware St SE, Suite 166, Minneapolis, MN 55414, USA
    Circulation 119:2305-12. 2009
    ..Peripheral arterial disease (PAD) and osteoporosis are chronic illnesses that increase in prevalence with aging and certain metabolic disorders. The association between PAD, rates of bone loss, and fracture risk in older men is uncertain...
  16. ncbi Association between sleep architecture and measures of body composition
    Madhu N Rao
    Division of Endocrinology, University of California San Francisco, San Francisco, CA 94110, USA
    Sleep 32:483-90. 2009
    ..To determine whether slow wave sleep (SWS) is inversely associated with body mass index (BMI) and other measures of body composition...
  17. ncbi High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men
    Laura M Yerges
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:2039-49. 2009
    ....
  18. ncbi 25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men
    Y Slinin
    One Veterans Dr 111J, Minneapolis, MN 55417, USA
    Neurology 74:33-41. 2010
    ..To test the hypothesis that lower 25-hydroxyvitamin D [25(OH)D] levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline...
  19. ncbi Consistency of leg extension power assessments in older men: the Osteoporotic Fractures in Men (MrOS) Study
    Terri Blackwell
    California Pacific Medical Center Research Institute, San Francisco, California, USA
    Am J Phys Med Rehabil 88:934-40. 2009
    ..The effect of time and fatigue should be considered when performing this measurement. The Nottingham power rig provided a reproducible measure of leg extension power in this multisite study of older men...
  20. ncbi Histories including number of falls may improve risk prediction for certain non-vertebral fractures in older men
    K A Faulkner
    University of Pittsburgh, Pittsburgh, Pennsylvania 15217, USA
    Inj Prev 15:307-11. 2009
    ..To determine whether information on number of falls on a falls history screen predicts risk of non-vertebral and hip fracture...
  21. ncbi Sleep disturbances and frailty status in older community-dwelling men
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Am Geriatr Soc 57:2085-93. 2009
    ..To test the hypothesis that sleep disturbances are independently associated with frailty status in older men...
  22. ncbi Sex hormones and frailty in older men: the osteoporotic fractures in men (MrOS) study
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107 1728, USA
    J Clin Endocrinol Metab 94:3806-15. 2009
    ..As men age, the prevalence of frailty increases whereas levels of androgens decline. Little is known about the relation between these factors...
  23. ncbi Sex steroids, periodontal health, and tooth loss in older men
    E S Orwoll
    Bone and Mineral Unit, Oregon Health and Science University, CR113, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    J Dent Res 88:704-8. 2009
    ..Although periodontitis, progression of periodontitis, and tooth loss are common in older men, they were not associated with sex steroids...
  24. ncbi A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia
    Wei Tian
    Department of Medicine, Divisions of Nephrology and Hypertension, and Endocrinology and Metabolism, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 106:14034-9. 2009
    ..These data suggest that this polymorphism affects TRPV4 function in vivo and likely influences systemic water balance on a population-wide basis...
  25. ncbi The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men
    Erin S LeBlanc
    Bone and Mineral Unit, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 94:3337-46. 2009
    ..The relationship between sex steroids and fracture is poorly understood...
  26. ncbi Nocturnal Arrhythmias across a spectrum of obstructive and central sleep-disordered breathing in older men: outcomes of sleep disorders in older men (MrOS sleep) study
    Reena Mehra
    Departmentof Medicine, Division of Pulmonary, Case Western Reserve University School of Medicine, Center for Clinical Investigatio, Cleveland, Ohio 44106 6003, USA
    Arch Intern Med 169:1147-55. 2009
    ..We studied the association between sleep-disordered breathing (SDB) with nocturnal atrial fibrillation or flutter (AF) and complex ventricular ectopy (CVE) in older men...
  27. ncbi Periodontal health of older men: the MrOS dental study
    KATHY R PHIPPS
    Oregon Health and Science University, Portland, OR, USA
    Gerodontology 26:122-9. 2009
    ..The purpose of this study was to evaluate the prevalence and severity of periodontitis in men of 65+ years and identify demographic and lifestyle factors associated with its presence...
  28. ncbi Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X
    Ching Yu Cheng
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    PLoS Genet 5:e1000490. 2009
    ..27; genome-wide score = 3.46). Further mapping studies with dense sets of markers will be necessary to identify the alleles in these regions of chromosomes X and 5 that may be associated with variation in BMI...
  29. ncbi Greater adipose tissue infiltration in skeletal muscle among older men of African ancestry
    Iva Miljkovic
    Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, 130 North Bellefield Avenue, Room 542, Pittsburgh, PA 15213, USA
    J Clin Endocrinol Metab 94:2735-42. 2009
    ..Skeletal muscle fat has been identified as an important depot that increases with aging and may contribute to the development of diabetes...
  30. ncbi Serum 25-hydroxyvitamin D levels and rate of hip bone loss in older men
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, VA Medical Center, One Veterans Drive 111 0, Minneapolis, MN 55417, USA
    J Clin Endocrinol Metab 94:2773-80. 2009
    ..Vitamin D deficiency is common among older adults, but the association between 25-hydroxyvitamin D [25(OH)D] levels and rates of bone loss is uncertain...
  31. ncbi Association between sleep and physical function in older men: the osteoporotic fractures in men sleep study
    Thuy Tien L Dam
    Department of Medicine, University of California at San Diego, La Jolla, California, USA
    J Am Geriatr Soc 56:1665-73. 2008
    ..To determine whether sleep quality is associated with physical function in older men...
  32. ncbi Single-point assessment of warfarin use and risk of osteoporosis in elderly men
    Claudine Woo
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA
    J Am Geriatr Soc 56:1171-6. 2008
    ..To determine whether warfarin use, assessed at a single point in time, is associated with bone mineral density (BMD), rates of bone loss, and fracture risk in older men...
  33. ncbi Prevalence, severity, and health correlates of lower urinary tract symptoms among older men: the MrOS study
    Brent C Taylor
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Urology 68:804-9. 2006
    ..The association of LUTS severity with poor health warrants increased clinical attention...
  34. ncbi Endogenous testosterone levels, physical performance, and fall risk in older men
    Eric Orwoll
    Bone and Mineral Unit, Oregon Health and Science University, Portland, USA
    Arch Intern Med 166:2124-31. 2006
    ..Gonadal steroid levels decline with age in men. Whether low testosterone levels affect the development of common age-related disorders, including physical functioning and falling, is unclear...
  35. ncbi Predictors of non-spine fracture in elderly men: the MrOS study
    Cora E Lewis
    University of Alabama, Birmingham, AL 35205, USA
    J Bone Miner Res 22:211-9. 2007
    ..1 years. Six clinical risk factors predicted fracture risk independent of hip BMD: tricyclic antidepressant use, previous fracture, inability to complete a narrow walk trial, falls in previous year, age > or =80 years, and depressed mood...
  36. ncbi BMD and risk of hip and nonvertebral fractures in older men: a prospective study and comparison with older women
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
    J Bone Miner Res 21:1550-6. 2006
    ..As in women, lumbar spine BMD in men is only weakly associated with risk of hip fracture. Regardless of whether sex-specific or female reference values were used, T scores indicated different risks of fractures in men than in women...
  37. ncbi Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men
    Lynn M Marshall
    Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Bone Miner Res 21:1197-206. 2006
    ..Relations of femoral neck dimensions and vBMD to age differed from those in the shaft, indicating that patterns of bone modeling and remodeling in the neck and shaft are distinct...
  38. ncbi Association of testosterone and estradiol deficiency with osteoporosis and rapid bone loss in older men
    Howard A Fink
    Geriatric Research Eduction and Clinical Center, Veterans Affairs Medical Center, One Veterans Drive, Box 11G, Minneapolis, MN 55417, USA
    J Clin Endocrinol Metab 91:3908-15. 2006
    ..The clinical value of measuring testosterone and estradiol in older men with osteoporosis and of measuring bone mineral density (BMD) in older men with testosterone or estradiol deficiency is uncertain...
  39. ncbi Testosterone and estradiol among older men
    Eric Orwoll
    CR113, Oregon Health and Science University, 3181 SW Sam Jackson Park, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 91:1336-44. 2006
    ..Testosterone and estradiol levels decline with age in men. This change may affect multiple clinical outcomes, but there have been few reports of the distribution and correlates of testosterone and estradiol concentrations in elderly men...
  40. ncbi Correlates and prevalence of prostatitis in a large community-based cohort of older men
    Nicholas A Daniels
    Division of General Internal Medicine, Department of Medicine, University of California, School of Medicine, San Francisco, California 94115, USA
    Urology 66:964-70. 2005
    ..To describe the prevalence and correlates of self-reported history of prostatitis in terms of lower urinary tract symptoms and associated dissatisfaction in community-dwelling older men...
  41. ncbi Association between Parkinson's disease and low bone density and falls in older men: the osteoporotic fractures in men study
    Howard A Fink
    Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Am Geriatr Soc 53:1559-64. 2005
    ..To examine the association between Parkinson's disease (PD) and bone mineral density (BMD) and risk of falls...
  42. ncbi Overview of recruitment for the osteoporotic fractures in men study (MrOS)
    Janet Babich Blank
    Oregon Health and Science University, 3181 SW Sam Jackson Park Road CR107, Portland, OR 97239, USA
    Contemp Clin Trials 26:557-68. 2005
    ..Through a coordinated approach of developing and refining recruitment strategies and materials, sites were able to adapt their original strategies and complete recruitment ahead of schedule...
  43. ncbi Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study--a large observational study of the determinants of fracture in older men
    Eric Orwoll
    Oregon Health and Science University, CR 113, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Contemp Clin Trials 26:569-85. 2005
    ..The MrOS cohort should provide valuable information concerning the determinants of fracture in men and should help set the stage for the development of effective methods to identify those at risk...
  44. ncbi New QCT analysis approach shows the importance of fall orientation on femoral neck strength
    R Dana Carpenter
    Bone and Joint Center, VA Palo Alto Health Care System, Palo Alto, California, USA
    J Bone Miner Res 20:1533-42. 2005
    ..A new image analysis technique showed that the strength of the femoral neck in 37 males varied significantly along the neck axis and that bending strength varied by a factor of up to 2.8 for different loading directions...
  45. ncbi Factors associated with the lumbar spine and proximal femur bone mineral density in older men
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Crabtree Hall A524, Pittsburgh, PA 15261, USA
    Osteoporos Int 16:1525-37. 2005
    ..Identification of these correlates could improve methods to identify men at risk for fracture and improve our understanding of fracture etiology...
  46. ncbi Incident fall risk and physical activity and physical performance among older men: the Osteoporotic Fractures in Men Study
    Benjamin K S Chan
    Department of Endocrinology, School of Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Am J Epidemiol 165:696-703. 2007
    ..69, 0.85). Partitioning components of activity showed no association between fall risk and leisure activities but a positive association with household activities (for highest quartile vs.lowest: relative risk = 1.17, 95% CI: 1.07, 1.28)...
  47. ncbi Quantitative ultrasound predicts hip and non-spine fracture in men: the MrOS study
    D C Bauer
    UCSF, San Francisco, CA 94107, USA
    Osteoporos Int 18:771-7. 2007
    ..We studied 5,607 older men and found that QUS predicts hip and any non-spine fracture risk nearly as well as BMD. Combined measurements of QUS and BMD are not superior to either measurement alone...
  48. ncbi Alcohol use, physical performance, and functional limitations in older men
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107, USA
    J Am Geriatr Soc 55:212-20. 2007
    ..To describe associations between recent alcohol intake, physical performance, and functional limitations in older men...
  49. ncbi Association between depressive symptoms and sleep disturbances in community-dwelling older men
    Misti L Paudel
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 56:1228-35. 2008
    ..To examine the association between depressive symptoms and subjective and objective measures of sleep in community-dwelling older men...
  50. ncbi Loop diuretic use and increased rates of hip bone loss in older men: the Osteoporotic Fractures in Men Study
    Lionel S Lim
    Department of Internal Medicine, Griffin Hospital, 130 Division St, Derby, CT 06418, USA
    Arch Intern Med 168:735-40. 2008
    ..Studies examining the association between loop diuretics and bone mineral density (BMD) are lacking, particularly those involving men...
  51. ncbi The association of testosterone levels with overall sleep quality, sleep architecture, and sleep-disordered breathing
    Elizabeth Barrett-Connor
    Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA 92093 0607, USA
    J Clin Endocrinol Metab 93:2602-9. 2008
    ....
  52. ncbi Renal function and rate of hip bone loss in older men: the Osteoporotic Fractures in Men Study
    A Ishani
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, MN, USA
    Osteoporos Int 19:1549-56. 2008
    ..Future randomized controlled trials should test whether interventions in this high risk population are effective in preventing bone loss and decreasing fracture incidence...
  53. ncbi Physical performance and risk of hip fractures in older men
    Peggy Mannen Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107 1762, USA
    J Bone Miner Res 23:1037-44. 2008
    ..The repeated chair stands exam should be considered in clinical settings for evaluation of hip fracture risk. Concurrent poor performance on multiple physical function exams is associated with an increased risk of hip fractures...
  54. ncbi Association of Parkinson's disease with accelerated bone loss, fractures and mortality in older men: the Osteoporotic Fractures in Men (MrOS) study
    H A Fink
    Geriatric Research Education and Clinical Center, VA Medical Center, Minneapolis, MN, USA
    Osteoporos Int 19:1277-82. 2008
    ..1% vs. 0.4%), proportion of incident non-spine fractures (14.9% vs. 7.2%) and mortality (34.8% vs. 9.5%)...
  55. ncbi High-trauma fractures and low bone mineral density in older women and men
    Dawn C Mackey
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
    JAMA 298:2381-8. 2007
    ..It is widely believed that fractures resulting from high trauma are not osteoporotic; however, this assumption has not been studied prospectively...
  56. ncbi Rate and circumstances of clinical vertebral fractures in older men
    S S Freitas
    Department of Medicine, Oregon Health and Science University, Portland, OR, USA
    Osteoporos Int 19:615-23. 2008
    ..Fractures were more common in the most elderly men, and were usually associated with falls and other low-energy trauma...
  57. ncbi Race and ethnic variation in proximal femur structure and BMD among older men
    Lynn M Marshall
    Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland Oregon, USA
    J Bone Miner Res 23:121-30. 2008
    ..All had similar stature-adjusted mean femoral neck volume, but black and Asian men had thicker cortices and higher trabecular vBMD, which may increase bone strength...
  58. ncbi Cost-effectiveness of bone densitometry followed by treatment of osteoporosis in older men
    John T Schousboe
    Rheumatology, Park Nicollet Health Services, Minneapolis, MN 55416, USA
    JAMA 298:629-37. 2007
    ..Osteoporotic fractures are common among elderly men...
  59. ncbi Frailty in older men: prevalence, progression, and relationship with mortality
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107 1762, USA
    J Am Geriatr Soc 55:1216-23. 2007
    ..To describe the association between frailty and health status, the progression of frailty, and the relationship between frailty and mortality in older men...
  60. ncbi Association of low bone mineral density with selective serotonin reuptake inhibitor use by older men
    Elizabeth M Haney
    Department of Medicine, Oregon Health and Science University, Mailcode L 475, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Arch Intern Med 167:1246-51. 2007
    ..Osteoblasts and osteocytes express functional serotonin transporters; serotonin transporter gene disruption in mice results in osteopenia; and SSRI use has been associated with increased risk of hip fracture...
  61. ncbi Demographic factors associated with the diet quality of older US men: baseline data from the Osteoporotic Fractures in Men (MrOS) study
    J Shannon
    Oregon Health and Science University, Portland, OR, USA
    Public Health Nutr 10:810-8. 2007
    ..The objectives of the current analyses are to describe the diet quality of a cohort of men >65 years of age, and identify lifestyle factors associated with poor diet quality...
  62. ncbi Voluntary weight reduction in older men increases hip bone loss: the osteoporotic fractures in men study
    Kristine E Ensrud
    Department of Medicine 111 0, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, Minnesota 55417, USA
    J Clin Endocrinol Metab 90:1998-2004. 2005
    ..7%/yr in those with weight loss; test for trend, P < 0.001). Older men who experience weight loss have increased rates of hip bone loss, even among overweight and obese men undergoing voluntary weight reduction...