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Genomes and GenesSpecies | Osteoporotic Fractures in Men - MrOS RenewalSummaryPrincipal Investigator: Elizabeth Barrett-Connor Affiliation: University of California Country: USA Abstract: The Osteoporotic Fractures in Men (MrOS) study was formed primarily to quantify the determinants of fracture in men. Importantly, the MrOS cohort also provides a seminal opportunity to study men as they progress through a critical period of life in which problems of aging remain poorly understood. In 2000-2002, 5995 community-dwelling men ages 65 years and older (mean age: 72 years at baseline) were enrolled from 6 diverse US communities. After 5 years of follow-up, participant retention is excellent (99% of those alive remain active). We propose a new clinic visit and continued follow-up of the cohort to expand our understanding of risk factors for falls, fractures (particularly hip fracture) and other consequences of aging. At baseline, both areal (from DXA) and volumetric (from QCT) skeletal assessments were obtained. We propose to repeat the same assessments in the planned visit to identify the densitometric and biomechanical risk factors for hip fracture, as well as to characterize bone geometry changes that underlie skeletal fragility. Further, we will use the QCT scans to quantify femoral strength by finite element modeling (FEM), and assess the usefulness of FEM for fracture prediction. Additional follow-up of the cohort and repeat measures of muscle strength (grip strength, leg power), physical performance (gait speed, chair stands, and narrow walk), and self-reported physical activity will enable us to establish the extent and nature of change in activity and physical performance, identify biological predictors of these changes, and clarify the possibly joint effects of physical activity and physical performance on fracture risk. To objectively quantify physical activity we propose to obtain accelerometry measures at the new clinic visit. Using serum archived at baseline, we will test the hypothesis that renal function, vitamin D, parathyroid hormone have important effects on skeletal health, physical function and fracture risk, and will determine if lower sex steroid levels increase men's risk of skeletal deterioration and fracture, decline in physical function, and deterioration in quality of life. Combined with the considerable data and biologic specimens already collected, additional measures and extended follow-up in the MrOS cohort allows us to expand the understanding of hip fractures, the most devastating type of fracture in men, as well as address other health issues of compelling public health and clinical importance to older US men. Funding Period: 1999-09-30 - 2012-07-31 more information: NIH RePORT Top Publications
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Association of 25-hydroxyvitamin D with prevalent osteoarthritis of the hip in elderly men: the osteoporotic fractures in men studyR K Chaganti
University of California, San Francisco, CA, USA
Arthritis Rheum 62:511-4. 2010..To examine the cross-sectional association of serum levels of 25-hydroxyvitamin D, or 25(OH)D, with prevalent radiographic hip osteoarthritis (OA) in elderly men...
Association of a high mobility group gene (HMGA2) variant with bone mineral densityAllison Kuipers
Department of Epidemiology, Crabtree Hall, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
Bone 45:295-300. 2009..Additional research is needed to better understand the role of HMGA2 in the regulation of bone metabolism...- A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older menKristine E Ensrud
Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
J Am Geriatr Soc 57:492-8. 2009.... - Behavioral correlates of sleep-disordered breathing in older menEric J Kezirian
Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, San Francisco, California, USA
Sleep 32:253-61. 2009.... - Vitamin D deficiency in older menEric Orwoll
Bone and Mineral Unit, Oregon Health and Sciences University, Portland, Oregon 97239, USA
J Clin Endocrinol Metab 94:1214-22. 2009..Vitamin D deficiency is not adequately evaluated in older men... - The association of bone mineral density with prostate cancer risk in the Osteoporotic Fractures in Men (MrOS) StudyGhada N Farhat
University of Pittsburgh, Department of Epidemiology and Division of Cancer Prevention and Population Science, University of Pittsburgh Medical Center, Cancer Pavilion, Suite 4C, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
Cancer Epidemiol Biomarkers Prev 18:148-54. 2009..However, no associations were observed with low-grade disease. Our results provide support for an inverse association between BMD and PCa risk. Possible pathophyisological mechanisms linking BMD and PCa should be elucidated... - Genetic variations in sex steroid-related genes as predictors of serum estrogen levels in menAnna L Eriksson
Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine Gothenburg University, SE 413 45 Gothenburg, Sweden
J Clin Endocrinol Metab 94:1033-41. 2009..The risk of many conditions, including prostate cancer, breast cancer, and osteoporosis, is associated with serum levels of sex steroids... - Finite element analysis of the proximal femur and hip fracture risk in older menEric S Orwoll
Bone and Mineral Unit, Oregon Health and Science University, Portland Oregon 97239, USA
J Bone Miner Res 24:475-83. 2009..1, 95% CI: 1.6-6.1). These results provide insight into hip fracture etiology and demonstrate the ability of FE-based biomechanical analysis of QCT scans to prospectively predict hip fractures in men... - Trochanteric soft tissue thickness and hip fracture in older menCarrie M Nielson
Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Clin Endocrinol Metab 94:491-6. 2009..The effect of trochanteric soft tissue thickness on the risk of incident hip fracture has not been evaluated in men... - The association between sleep duration and obesity in older adultsS R Patel
Division of Pulmonary, Critical Care, and Sleep Medicine and Center for Clinical Investigation, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA
Int J Obes (Lond) 32:1825-34. 2008..In this study, the cross-sectional associations between sleep duration measured objectively and measures of weight and body composition were assessed in two cohorts of older adults... - Reduced renal function and sleep-disordered breathing in community-dwelling elderly menMuna T Canales
Division of Renal Diseases and Hypertension, Department of Medicine, University of Minnesota, Minneapolis, MN, USA
Sleep Med 9:637-45. 2008..Sleep-disordered breathing (SDB) may increase the risk of cardiovascular disease (CVD) and death in chronic kidney disease (CKD). However, the association between mild reductions in renal function and SDB is uncertain... - Acid-suppressive medications and risk of bone loss and fracture in older adultsElaine W Yu
Endocrine Division, Massachusetts General Hospital, Thier 1101, 50 Blossom Street, Boston, MA 02114, USA
Calcif Tissue Int 83:251-9. 2008..The use of PPIs in older women, and perhaps older men with low calcium intake, may be associated with a modestly increased risk of nonspine fracture... - Kidney function and cognitive performance and decline in older menYelena Slinin
Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
J Am Geriatr Soc 56:2082-8. 2008..To examine the association between kidney function and cognitive impairment and decline in elderly men... - Antiepileptic drug use and rates of hip bone loss in older men: a prospective studyK E Ensrud
VA Medical Center, One Veterans Drive 111 0, Minneapolis, MN 55417, USA
Neurology 71:723-30. 2008..To test the hypotheses that older community dwelling men taking non-enzyme-inducing antiepileptic drugs (NEIAEDs) and those taking enzyme-inducing antiepileptic drugs (EIAEDs) have increased rates of hip bone loss... - Peripheral arterial disease is associated with higher rates of hip bone loss and increased fracture risk in older menTracie C Collins
University of Minnesota, Department of Medicine, 717 Delaware St SE, Suite 166, Minneapolis, MN 55414, USA
Circulation 119:2305-12. 2009..Peripheral arterial disease (PAD) and osteoporosis are chronic illnesses that increase in prevalence with aging and certain metabolic disorders. The association between PAD, rates of bone loss, and fracture risk in older men is uncertain... - Association between sleep architecture and measures of body compositionMadhu N Rao
Division of Endocrinology, University of California San Francisco, San Francisco, CA 94110, USA
Sleep 32:483-90. 2009..To determine whether slow wave sleep (SWS) is inversely associated with body mass index (BMI) and other measures of body composition... - High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older menLaura M Yerges
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Bone Miner Res 24:2039-49. 2009.... - 25-Hydroxyvitamin D levels and cognitive performance and decline in elderly menY Slinin
One Veterans Dr 111J, Minneapolis, MN 55417, USA
Neurology 74:33-41. 2010..To test the hypothesis that lower 25-hydroxyvitamin D [25(OH)D] levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline... - Consistency of leg extension power assessments in older men: the Osteoporotic Fractures in Men (MrOS) StudyTerri Blackwell
California Pacific Medical Center Research Institute, San Francisco, California, USA
Am J Phys Med Rehabil 88:934-40. 2009..The effect of time and fatigue should be considered when performing this measurement. The Nottingham power rig provided a reproducible measure of leg extension power in this multisite study of older men... - Histories including number of falls may improve risk prediction for certain non-vertebral fractures in older menK A Faulkner
University of Pittsburgh, Pittsburgh, Pennsylvania 15217, USA
Inj Prev 15:307-11. 2009..To determine whether information on number of falls on a falls history screen predicts risk of non-vertebral and hip fracture... - Sleep disturbances and frailty status in older community-dwelling menKristine E Ensrud
Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
J Am Geriatr Soc 57:2085-93. 2009..To test the hypothesis that sleep disturbances are independently associated with frailty status in older men... - Sex hormones and frailty in older men: the osteoporotic fractures in men (MrOS) studyPeggy M Cawthon
Research Institute, California Pacific Medical Center, San Francisco, California 94107 1728, USA
J Clin Endocrinol Metab 94:3806-15. 2009..As men age, the prevalence of frailty increases whereas levels of androgens decline. Little is known about the relation between these factors... - Sex steroids, periodontal health, and tooth loss in older menE S Orwoll
Bone and Mineral Unit, Oregon Health and Science University, CR113, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
J Dent Res 88:704-8. 2009..Although periodontitis, progression of periodontitis, and tooth loss are common in older men, they were not associated with sex steroids... - A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremiaWei Tian
Department of Medicine, Divisions of Nephrology and Hypertension, and Endocrinology and Metabolism, Oregon Health and Science University, Portland, OR 97239, USA
Proc Natl Acad Sci U S A 106:14034-9. 2009..These data suggest that this polymorphism affects TRPV4 function in vivo and likely influences systemic water balance on a population-wide basis... - The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older menErin S LeBlanc
Bone and Mineral Unit, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
J Clin Endocrinol Metab 94:3337-46. 2009..The relationship between sex steroids and fracture is poorly understood... - Nocturnal Arrhythmias across a spectrum of obstructive and central sleep-disordered breathing in older men: outcomes of sleep disorders in older men (MrOS sleep) studyReena Mehra
Departmentof Medicine, Division of Pulmonary, Case Western Reserve University School of Medicine, Center for Clinical Investigatio, Cleveland, Ohio 44106 6003, USA
Arch Intern Med 169:1147-55. 2009..We studied the association between sleep-disordered breathing (SDB) with nocturnal atrial fibrillation or flutter (AF) and complex ventricular ectopy (CVE) in older men... - Periodontal health of older men: the MrOS dental studyKATHY R PHIPPS
Oregon Health and Science University, Portland, OR, USA
Gerodontology 26:122-9. 2009..The purpose of this study was to evaluate the prevalence and severity of periodontitis in men of 65+ years and identify demographic and lifestyle factors associated with its presence... - Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and XChing Yu Cheng
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
PLoS Genet 5:e1000490. 2009..27; genome-wide score = 3.46). Further mapping studies with dense sets of markers will be necessary to identify the alleles in these regions of chromosomes X and 5 that may be associated with variation in BMI... - Greater adipose tissue infiltration in skeletal muscle among older men of African ancestryIva Miljkovic
Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, 130 North Bellefield Avenue, Room 542, Pittsburgh, PA 15213, USA
J Clin Endocrinol Metab 94:2735-42. 2009..Skeletal muscle fat has been identified as an important depot that increases with aging and may contribute to the development of diabetes... - Serum 25-hydroxyvitamin D levels and rate of hip bone loss in older menKristine E Ensrud
Center for Chronic Disease Outcomes Research, VA Medical Center, One Veterans Drive 111 0, Minneapolis, MN 55417, USA
J Clin Endocrinol Metab 94:2773-80. 2009..Vitamin D deficiency is common among older adults, but the association between 25-hydroxyvitamin D [25(OH)D] levels and rates of bone loss is uncertain... - Association between sleep and physical function in older men: the osteoporotic fractures in men sleep studyThuy Tien L Dam
Department of Medicine, University of California at San Diego, La Jolla, California, USA
J Am Geriatr Soc 56:1665-73. 2008..To determine whether sleep quality is associated with physical function in older men... - Single-point assessment of warfarin use and risk of osteoporosis in elderly menClaudine Woo
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA
J Am Geriatr Soc 56:1171-6. 2008..To determine whether warfarin use, assessed at a single point in time, is associated with bone mineral density (BMD), rates of bone loss, and fracture risk in older men... 
Prevalence, severity, and health correlates of lower urinary tract symptoms among older men: the MrOS studyBrent C Taylor
Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
Urology 68:804-9. 2006..The association of LUTS severity with poor health warrants increased clinical attention...- Endogenous testosterone levels, physical performance, and fall risk in older menEric Orwoll
Bone and Mineral Unit, Oregon Health and Science University, Portland, USA
Arch Intern Med 166:2124-31. 2006..Gonadal steroid levels decline with age in men. Whether low testosterone levels affect the development of common age-related disorders, including physical functioning and falling, is unclear... - Predictors of non-spine fracture in elderly men: the MrOS studyCora E Lewis
University of Alabama, Birmingham, AL 35205, USA
J Bone Miner Res 22:211-9. 2007..1 years. Six clinical risk factors predicted fracture risk independent of hip BMD: tricyclic antidepressant use, previous fracture, inability to complete a narrow walk trial, falls in previous year, age > or =80 years, and depressed mood... - BMD and risk of hip and nonvertebral fractures in older men: a prospective study and comparison with older womenSteven R Cummings
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
J Bone Miner Res 21:1550-6. 2006..As in women, lumbar spine BMD in men is only weakly associated with risk of hip fracture. Regardless of whether sex-specific or female reference values were used, T scores indicated different risks of fractures in men than in women... - Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. menLynn M Marshall
Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Bone Miner Res 21:1197-206. 2006..Relations of femoral neck dimensions and vBMD to age differed from those in the shaft, indicating that patterns of bone modeling and remodeling in the neck and shaft are distinct... - Association of testosterone and estradiol deficiency with osteoporosis and rapid bone loss in older menHoward A Fink
Geriatric Research Eduction and Clinical Center, Veterans Affairs Medical Center, One Veterans Drive, Box 11G, Minneapolis, MN 55417, USA
J Clin Endocrinol Metab 91:3908-15. 2006..The clinical value of measuring testosterone and estradiol in older men with osteoporosis and of measuring bone mineral density (BMD) in older men with testosterone or estradiol deficiency is uncertain... - Testosterone and estradiol among older menEric Orwoll
CR113, Oregon Health and Science University, 3181 SW Sam Jackson Park, Portland, Oregon 97239, USA
J Clin Endocrinol Metab 91:1336-44. 2006..Testosterone and estradiol levels decline with age in men. This change may affect multiple clinical outcomes, but there have been few reports of the distribution and correlates of testosterone and estradiol concentrations in elderly men... - Correlates and prevalence of prostatitis in a large community-based cohort of older menNicholas A Daniels
Division of General Internal Medicine, Department of Medicine, University of California, School of Medicine, San Francisco, California 94115, USA
Urology 66:964-70. 2005..To describe the prevalence and correlates of self-reported history of prostatitis in terms of lower urinary tract symptoms and associated dissatisfaction in community-dwelling older men... - Association between Parkinson's disease and low bone density and falls in older men: the osteoporotic fractures in men studyHoward A Fink
Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
J Am Geriatr Soc 53:1559-64. 2005..To examine the association between Parkinson's disease (PD) and bone mineral density (BMD) and risk of falls... - Overview of recruitment for the osteoporotic fractures in men study (MrOS)Janet Babich Blank
Oregon Health and Science University, 3181 SW Sam Jackson Park Road CR107, Portland, OR 97239, USA
Contemp Clin Trials 26:557-68. 2005..Through a coordinated approach of developing and refining recruitment strategies and materials, sites were able to adapt their original strategies and complete recruitment ahead of schedule... - Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study--a large observational study of the determinants of fracture in older menEric Orwoll
Oregon Health and Science University, CR 113, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Contemp Clin Trials 26:569-85. 2005..The MrOS cohort should provide valuable information concerning the determinants of fracture in men and should help set the stage for the development of effective methods to identify those at risk... - New QCT analysis approach shows the importance of fall orientation on femoral neck strengthR Dana Carpenter
Bone and Joint Center, VA Palo Alto Health Care System, Palo Alto, California, USA
J Bone Miner Res 20:1533-42. 2005..A new image analysis technique showed that the strength of the femoral neck in 37 males varied significantly along the neck axis and that bending strength varied by a factor of up to 2.8 for different loading directions... - Factors associated with the lumbar spine and proximal femur bone mineral density in older menJane A Cauley
Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Crabtree Hall A524, Pittsburgh, PA 15261, USA
Osteoporos Int 16:1525-37. 2005..Identification of these correlates could improve methods to identify men at risk for fracture and improve our understanding of fracture etiology... - Incident fall risk and physical activity and physical performance among older men: the Osteoporotic Fractures in Men StudyBenjamin K S Chan
Department of Endocrinology, School of Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
Am J Epidemiol 165:696-703. 2007..69, 0.85). Partitioning components of activity showed no association between fall risk and leisure activities but a positive association with household activities (for highest quartile vs.lowest: relative risk = 1.17, 95% CI: 1.07, 1.28)... - Quantitative ultrasound predicts hip and non-spine fracture in men: the MrOS studyD C Bauer
UCSF, San Francisco, CA 94107, USA
Osteoporos Int 18:771-7. 2007..We studied 5,607 older men and found that QUS predicts hip and any non-spine fracture risk nearly as well as BMD. Combined measurements of QUS and BMD are not superior to either measurement alone... - Alcohol use, physical performance, and functional limitations in older menPeggy M Cawthon
Research Institute, California Pacific Medical Center, San Francisco, California 94107, USA
J Am Geriatr Soc 55:212-20. 2007..To describe associations between recent alcohol intake, physical performance, and functional limitations in older men... - Association between depressive symptoms and sleep disturbances in community-dwelling older menMisti L Paudel
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
J Am Geriatr Soc 56:1228-35. 2008..To examine the association between depressive symptoms and subjective and objective measures of sleep in community-dwelling older men... - Loop diuretic use and increased rates of hip bone loss in older men: the Osteoporotic Fractures in Men StudyLionel S Lim
Department of Internal Medicine, Griffin Hospital, 130 Division St, Derby, CT 06418, USA
Arch Intern Med 168:735-40. 2008..Studies examining the association between loop diuretics and bone mineral density (BMD) are lacking, particularly those involving men... - The association of testosterone levels with overall sleep quality, sleep architecture, and sleep-disordered breathingElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA 92093 0607, USA
J Clin Endocrinol Metab 93:2602-9. 2008.... - Renal function and rate of hip bone loss in older men: the Osteoporotic Fractures in Men StudyA Ishani
Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, MN, USA
Osteoporos Int 19:1549-56. 2008..Future randomized controlled trials should test whether interventions in this high risk population are effective in preventing bone loss and decreasing fracture incidence... - Physical performance and risk of hip fractures in older menPeggy Mannen Cawthon
Research Institute, California Pacific Medical Center, San Francisco, California 94107 1762, USA
J Bone Miner Res 23:1037-44. 2008..The repeated chair stands exam should be considered in clinical settings for evaluation of hip fracture risk. Concurrent poor performance on multiple physical function exams is associated with an increased risk of hip fractures... - Association of Parkinson's disease with accelerated bone loss, fractures and mortality in older men: the Osteoporotic Fractures in Men (MrOS) studyH A Fink
Geriatric Research Education and Clinical Center, VA Medical Center, Minneapolis, MN, USA
Osteoporos Int 19:1277-82. 2008..1% vs. 0.4%), proportion of incident non-spine fractures (14.9% vs. 7.2%) and mortality (34.8% vs. 9.5%)... - High-trauma fractures and low bone mineral density in older women and menDawn C Mackey
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
JAMA 298:2381-8. 2007..It is widely believed that fractures resulting from high trauma are not osteoporotic; however, this assumption has not been studied prospectively... - Rate and circumstances of clinical vertebral fractures in older menS S Freitas
Department of Medicine, Oregon Health and Science University, Portland, OR, USA
Osteoporos Int 19:615-23. 2008..Fractures were more common in the most elderly men, and were usually associated with falls and other low-energy trauma... - Race and ethnic variation in proximal femur structure and BMD among older menLynn M Marshall
Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland Oregon, USA
J Bone Miner Res 23:121-30. 2008..All had similar stature-adjusted mean femoral neck volume, but black and Asian men had thicker cortices and higher trabecular vBMD, which may increase bone strength... - Cost-effectiveness of bone densitometry followed by treatment of osteoporosis in older menJohn T Schousboe
Rheumatology, Park Nicollet Health Services, Minneapolis, MN 55416, USA
JAMA 298:629-37. 2007..Osteoporotic fractures are common among elderly men... - Frailty in older men: prevalence, progression, and relationship with mortalityPeggy M Cawthon
Research Institute, California Pacific Medical Center, San Francisco, California 94107 1762, USA
J Am Geriatr Soc 55:1216-23. 2007..To describe the association between frailty and health status, the progression of frailty, and the relationship between frailty and mortality in older men... - Association of low bone mineral density with selective serotonin reuptake inhibitor use by older menElizabeth M Haney
Department of Medicine, Oregon Health and Science University, Mailcode L 475, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
Arch Intern Med 167:1246-51. 2007..Osteoblasts and osteocytes express functional serotonin transporters; serotonin transporter gene disruption in mice results in osteopenia; and SSRI use has been associated with increased risk of hip fracture... - Demographic factors associated with the diet quality of older US men: baseline data from the Osteoporotic Fractures in Men (MrOS) studyJ Shannon
Oregon Health and Science University, Portland, OR, USA
Public Health Nutr 10:810-8. 2007..The objectives of the current analyses are to describe the diet quality of a cohort of men >65 years of age, and identify lifestyle factors associated with poor diet quality... - Voluntary weight reduction in older men increases hip bone loss: the osteoporotic fractures in men studyKristine E Ensrud
Department of Medicine 111 0, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, Minnesota 55417, USA
J Clin Endocrinol Metab 90:1998-2004. 2005..7%/yr in those with weight loss; test for trend, P < 0.001). Older men who experience weight loss have increased rates of hip bone loss, even among overweight and obese men undergoing voluntary weight reduction...