Osteoporotic Fractures in Men - MrOS Renewal

Summary

Principal Investigator: Elizabeth Barrett-Connor
Affiliation: University of California
Country: USA
Abstract: The Osteoporotic Fractures in Men (MrOS) study was formed primarily to quantify the determinants of fracture in men. Importantly, the MrOS cohort also provides a seminal opportunity to study men as they progress through a critical period of life in which problems of aging remain poorly understood. In 2000-2002, 5995 community-dwelling men ages 65 years and older (mean age: 72 years at baseline) were enrolled from 6 diverse US communities. After 5 years of follow-up, participant retention is excellent (99% of those alive remain active). We propose a new clinic visit and continued follow-up of the cohort to expand our understanding of risk factors for falls, fractures (particularly hip fracture) and other consequences of aging. At baseline, both areal (from DXA) and volumetric (from QCT) skeletal assessments were obtained. We propose to repeat the same assessments in the planned visit to identify the densitometric and biomechanical risk factors for hip fracture, as well as to characterize bone geometry changes that underlie skeletal fragility. Further, we will use the QCT scans to quantify femoral strength by finite element modeling (FEM), and assess the usefulness of FEM for fracture prediction. Additional follow-up of the cohort and repeat measures of muscle strength (grip strength, leg power), physical performance (gait speed, chair stands, and narrow walk), and self-reported physical activity will enable us to establish the extent and nature of change in activity and physical performance, identify biological predictors of these changes, and clarify the possibly joint effects of physical activity and physical performance on fracture risk. To objectively quantify physical activity we propose to obtain accelerometry measures at the new clinic visit. Using serum archived at baseline, we will test the hypothesis that renal function, vitamin D, parathyroid hormone have important effects on skeletal health, physical function and fracture risk, and will determine if lower sex steroid levels increase men's risk of skeletal deterioration and fracture, decline in physical function, and deterioration in quality of life. Combined with the considerable data and biologic specimens already collected, additional measures and extended follow-up in the MrOS cohort allows us to expand the understanding of hip fractures, the most devastating type of fracture in men, as well as address other health issues of compelling public health and clinical importance to older US men.
Funding Period: 1999-09-30 - 2012-07-31
more information: NIH RePORT

Top Publications

  1. pmc Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men
    Jean Y Tang
    Children s Hospital of Oakland Research Institute, USA
    Cancer Causes Control 21:387-91. 2010
  2. pmc Circulating 25-hydroxyvitamin D levels and frailty in older men: the osteoporotic fractures in men study
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 59:101-6. 2011
  3. pmc Mortality risk in older men associated with changes in weight, lean mass, and fat mass
    Christine G Lee
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    J Am Geriatr Soc 59:233-40. 2011
  4. pmc Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry St, Lobby 5, Ste 5700, San Francisco, CA 94107 1762, USA
    JAMA 305:2184-92. 2011
  5. pmc Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts
    Shalender Bhasin
    Sections of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA
    J Clin Endocrinol Metab 96:2430-9. 2011
  6. pmc Rib fracture as a predictor of future fractures in young and older postmenopausal women: National Osteoporosis Risk Assessment (NORA)
    S G Sajjan
    Merck and Co, Inc, West Point, PA, USA
    Osteoporos Int 23:821-8. 2012
  7. pmc Insulin sensitizers may attenuate lean mass loss in older men with diabetes
    Christine G Lee
    Oregon Health and ScienceUniversity, Portland, Oregon, USA
    Diabetes Care 34:2381-6. 2011
  8. pmc Rare coding variants in ALPL are associated with low serum alkaline phosphatase and low bone mineral density
    Carrie M Nielson
    Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR 37239, USA
    J Bone Miner Res 27:93-103. 2012
  9. pmc Does the use of ACE inhibitors or angiotensin receptor blockers affect bone loss in older men?
    T Kwok
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, ROC
    Osteoporos Int 23:2159-67. 2012
  10. pmc Associations between sleep architecture and sleep-disordered breathing and cognition in older community-dwelling men: the Osteoporotic Fractures in Men Sleep Study
    Terri Blackwell
    Research Institute, California Pacific Medical Center, San Francisco, California, USA
    J Am Geriatr Soc 59:2217-25. 2011

Detail Information

Publications177 found, 100 shown here

  1. pmc Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men
    Jean Y Tang
    Children s Hospital of Oakland Research Institute, USA
    Cancer Causes Control 21:387-91. 2010
    ..026) compared to those in the lowest quintile. Our results suggest that a diagnosis of NMSC is not a surrogate for adequate 25(OH)D levels or increased UV exposure, and high 25(OH)D levels may be associated with a reduced risk of NMSC...
  2. pmc Circulating 25-hydroxyvitamin D levels and frailty in older men: the osteoporotic fractures in men study
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 59:101-6. 2011
    ..To determine the cross-sectional and longitudinal associations between 25-hydroxyvitamin D (25(OH)D) levels and frailty status in older men...
  3. pmc Mortality risk in older men associated with changes in weight, lean mass, and fat mass
    Christine G Lee
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    J Am Geriatr Soc 59:233-40. 2011
    ..To evaluate risk of all-cause mortality associated with changes in body weight, total lean mass, and total fat mass in older men...
  4. pmc Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry St, Lobby 5, Ste 5700, San Francisco, CA 94107 1762, USA
    JAMA 305:2184-92. 2011
    ..It is not known if low BMD, central to fracture prediction in older adults, identifies fracture risk in patients with DM...
  5. pmc Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts
    Shalender Bhasin
    Sections of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA
    J Clin Endocrinol Metab 96:2430-9. 2011
    ..We established reference ranges for total testosterone (TT) and free testosterone (FT) in a community-based sample of men...
  6. pmc Rib fracture as a predictor of future fractures in young and older postmenopausal women: National Osteoporosis Risk Assessment (NORA)
    S G Sajjan
    Merck and Co, Inc, West Point, PA, USA
    Osteoporos Int 23:821-8. 2012
    ..4-fold increase in risk of any new clinical fracture in 155,031 postmenopausal women. A rib fracture history suggests osteoporosis and should be considered when evaluating patients for interventions to prevent fractures...
  7. pmc Insulin sensitizers may attenuate lean mass loss in older men with diabetes
    Christine G Lee
    Oregon Health and ScienceUniversity, Portland, Oregon, USA
    Diabetes Care 34:2381-6. 2011
    ..To examine longitudinal changes in total and appendicular lean body mass in older men with impaired fasting glucose (IFG) or diabetes and to determine whether these changes differ by diabetes treatment...
  8. pmc Rare coding variants in ALPL are associated with low serum alkaline phosphatase and low bone mineral density
    Carrie M Nielson
    Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR 37239, USA
    J Bone Miner Res 27:93-103. 2012
    ..Multiple rare ALPL coding variants are present in the general population, and nonsynonymous coding variants may be responsible for heritable differences in mineralization and thus BMD...
  9. pmc Does the use of ACE inhibitors or angiotensin receptor blockers affect bone loss in older men?
    T Kwok
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, ROC
    Osteoporos Int 23:2159-67. 2012
    ..Use of angiotensin II AT1 receptor blockers (ARB) was not significantly associated with bone loss...
  10. pmc Associations between sleep architecture and sleep-disordered breathing and cognition in older community-dwelling men: the Osteoporotic Fractures in Men Sleep Study
    Terri Blackwell
    Research Institute, California Pacific Medical Center, San Francisco, California, USA
    J Am Geriatr Soc 59:2217-25. 2011
    ..To examine the association between sleep architecture, sleep-disordered breathing, and cognition in older men...
  11. pmc The association of race/ethnicity with objectively measured sleep characteristics in older men
    Yeonsu Song
    Department of Physiological Nursing, School of Nursing, University of California, San Francisco, CA 94107, USA
    Behav Sleep Med 10:54-69. 2011
    ..Hispanic men slept longer (6.7 hr) at night than Black (6.1 hr) and Asian American men (6.1 hr). This study supports significant variations in sleep characteristics in older men by race/ethnicity...
  12. pmc Inferior physical performance test results of 10,998 men in the MrOS Study is associated with high fracture risk
    Björn E Rosengren
    Clinical and Molecular Osteoporosis Research Unit, Department of Orthopaedics and Clinical Sciences, Lund University, Malmo, Sweden
    Age Ageing 41:339-44. 2012
    ..most fractures are preceded by falls...
  13. pmc Cost-effectiveness of bone densitometry among Caucasian women and men without a prior fracture according to age and body weight
    J T Schousboe
    Park Nicollet Institute, Minneapolis, MN, USA
    Osteoporos Int 24:163-77. 2013
    ..Among women aged 55-65 years and men aged 55-75 years without a prior fracture, body weight can be used to identify those for whom bone densitometry is cost-effective...
  14. pmc Association of intact parathyroid hormone levels with subsequent hip BMD loss: the Osteoporotic Fractures in Men (MrOS) Study
    Jeffrey R Curtis
    Department of Medicine, Division of Clinical Immunology Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Endocrinol Metab 97:1937-44. 2012
    ..This association was evaluated in relation to conditions related to higher iPTH [e.g. decreased renal function, low serum 25-hydroxyvitamin D (25[OH]D)]...
  15. pmc Change in hip bone mineral density and risk of subsequent fractures in older men
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, CA, USA
    J Bone Miner Res 27:2179-88. 2012
    ..6; 95% CI 1.1-6.4). Total hip BMD change produced similar results. Accelerated decrease in BMD is a strong, independent risk factor for hip and other nonspine fractures in men...
  16. pmc Distribution of bone density in the proximal femur and its association with hip fracture risk in older men: the osteoporotic fractures in men (MrOS) study
    Lang Yang
    NIHR Biomedical Research Unit for Musculoskeletal Disease, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
    J Bone Miner Res 27:2314-24. 2012
    ..05) better than TH aBMD alone or TH aBMD plus age. These findings confirm that both cortical and trabecular bone contribute to hip fracture risk and highlight trabecular vBMD at the FN and TR as an independent risk factor...
  17. pmc The association of concurrent vitamin D and sex hormone deficiency with bone loss and fracture risk in older men: the osteoporotic fractures in men (MrOS) study
    Elizabeth Barrett-Connor
    Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, USA
    J Bone Miner Res 27:2306-13. 2012
    ..In summary, adverse skeletal effects of low sex steroid levels were more pronounced in older men with low VitD levels. The presence of low VitD in the presence of low BioE/high SHBG may contribute substantially to poor skeletal health...
  18. pmc Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men
    J M Zmuda
    Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    Osteoporos Int 22:1079-90. 2011
    ..SNPs in TGFBR3, SOST, KL, CALCR, LEP, CSF1R, PTN, GNRH2, FGFR2, and MEPE were associated with vBMD and SNPs in CYP11B1, DVL2, DLX5, WNT4, and PAX7 were associated with CSA in independent study samples (p < 0.005)...
  19. pmc The association of serum 25-hydroxyvitamin D with indicators of bone quality in men of Caucasian and African ancestry
    K E Barbour
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Osteoporos Int 22:2475-85. 2011
    ....
  20. pmc Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium
    H J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 19:254-64. 2011
    ..To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes...
  21. pmc Absence of AVPR2 copy number variation in eunatremic and dysnatremic subjects in non-Hispanic Caucasian populations
    Yi Fu
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    Physiol Genomics 40:121-7. 2010
    ..e., less than unity) in one male African American subject. Reanalysis of the original comparative genomic hybridization data revealed bona fide CNVs flanking-but not incorporating-the AVPR2 gene, consistent with our new genotyping data...
  22. pmc Estimates of the proportion of older white men who would be recommended for pharmacologic treatment by the new US National Osteoporosis Foundation guidelines
    Meghan G Donaldson
    San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA 94107, USA
    J Bone Miner Res 25:1506-11. 2010
    ..Application of the new NOF guidelines would result in recommending a very large proportion of white men in the United States for pharmacologic treatment of osteoporosis, for many of whom the efficacy of treatment is unknown...
  23. pmc Correlates of trabecular and cortical volumetric bone mineral density of the radius and tibia in older men: the Osteoporotic Fractures in Men Study
    Kamil E Barbour
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Bone Miner Res 25:1017-28. 2010
    ..An ascertainment of potential risk factors associated with trabecular and cortical vBMD may lead to better understanding and preventive efforts for osteoporosis in men...
  24. pmc Racial differences in atrial fibrillation prevalence and left atrial size
    Gregory M Marcus
    Division of Cardiology, University of California, San Francisco, CA, USA
    Am J Med 123:375.e1-7. 2010
    ....
  25. pmc Serum phosphorus levels and the spectrum of ankle-brachial index in older men: the Osteoporotic Fractures in Men (MrOS) study
    Jerry Meng
    Division of Nephrology, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Am J Epidemiol 171:909-16. 2010
    ..These associations may explain the link between serum phosphorus levels and CVD events...
  26. pmc Progression of lower urinary tract symptoms in older men: a community based study
    J Kellogg Parsons
    Division of Urologic Oncology, Moores Comprehensive Cancer Center, University of California San Diego, La Jolla, San Francisco, California, USA
    J Urol 183:1915-20. 2010
    ..Lower urinary tract symptom progression in community dwelling older men is not well described...
  27. pmc Sex hormones and the risk of incident prostate cancer
    Nicholas A Daniels
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94115, USA
    Urology 76:1034-40. 2010
    ..To assess whether sex hormone levels are associated with subsequent development of prostate cancer...
  28. pmc Muscle power and physical activity are associated with bone strength in older men: The osteoporotic fractures in men study
    Julie M Cousins
    School of Kinesiology, Laboratory for Musculoskeletal Health, University of Minnesota, Minneapolis, MN 55455, USA
    Bone 47:205-11. 2010
    ..008). Similar results were found at both the distal and midshaft of the radius. The findings of this study suggest the importance of maintaining levels of physical activity and muscle strength in older men to prevent bone fragility...
  29. pmc Associations of estradiol and testosterone with serum phosphorus in older men: the Osteoporotic Fractures in Men study
    Jerry Meng
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
    Kidney Int 78:415-22. 2010
    ..The mechanism responsible for the association of testosterone with serum phosphorus remains to be determined...
  30. pmc Sex steroid hormones in older men: longitudinal associations with 4.5-year change in hip bone mineral density--the osteoporotic fractures in men study
    Jane A Cauley
    University of Pittsburgh, Department of Epidemiology, 130 DeSoto Street, Crabtree A524, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 95:4314-23. 2010
    ..There is limited information on the association between sex hormones and bone loss in older men...
  31. pmc Correlates of trabecular and cortical volumetric bone mineral density at the femoral neck and lumbar spine: the osteoporotic fractures in men study (MrOS)
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Bone Miner Res 25:1958-71. 2010
    ..There was no relationship between sex hormones and femoral neck trabecular vBMD. Our conclusion is that correlates of trabecular vBMD and cortical vBMD appear to differ in older men...
  32. pmc Bone strength measured by peripheral quantitative computed tomography and the risk of nonvertebral fractures: the osteoporotic fractures in men (MrOS) study
    Yahtyng Sheu
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Bone Miner Res 26:63-71. 2011
    ..73 to 0.80). Peripheral bone strength measures are associated with fracture risk and may improve our ability to identify older men at high risk of fracture...
  33. pmc Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men
    Peggy M Cawthon
    California Pacific Medical Center Research Institute, California Pacific Medical Center, San Francisco, California 94107 1762, USA
    J Clin Endocrinol Metab 95:4625-34. 2010
    ..Low 25-hydroxyvitamin D [25(OH)D] and high PTH may contribute to increased mortality risk in older adults...
  34. pmc Evidence for geographical and racial variation in serum sex steroid levels in older men
    Eric S Orwoll
    Bone and Mineral Unit, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 95:E151-60. 2010
    ..We designed an international study to determine the degree to which geography and race influence sex steroid levels in older men...
  35. pmc BMI and fracture risk in older men: the osteoporotic fractures in men study (MrOS)
    Carrie M Nielson
    School of Medicine, Oregon Health and Science University, Portland, OR, USA
    J Bone Miner Res 26:496-502. 2011
    ..90-2.28, for obese II). Obesity is common among older men, and when BMD is held constant, it is associated with an increased risk of fracture. This association is at least partially explained by worse physical function in obese men...
  36. pmc Back pain, neurogenic symptoms, and physical function in relation to spondylolisthesis among elderly men
    Patrick J Denard
    Department of Orthopaedics and Rehabilitation, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239 3098, USA
    Spine J 10:865-73. 2010
    ..Comparisons of the frequency of back pain, neurogenic symptoms, and functional limitations specifically among elderly men with and without spondylolisthesis are needed...
  37. pmc Statin use and risk of prostate cancer in the prospective Osteoporotic Fractures in Men (MrOS) Study
    June M Chan
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94158 9001, USA
    Cancer Epidemiol Biomarkers Prev 21:1886-8. 2012
    ..Statins are a common medication for cholesterol control that may also have effects on cancer-related pathways. The evidence of an association between statins and prostate cancer risk remains ambiguous...
  38. pmc Serum albumin in relation to change in muscle mass, muscle strength, and muscle power in older men
    Caryn K Snyder
    Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, Oregon
    J Am Geriatr Soc 60:1663-72. 2012
    ..To investigate the relationship between serum albumin and change in muscle mass, grip strength, and leg power...
  39. pmc Inferior physical performance tests in 10,998 men in the MrOS study is associated with recurrent falls
    Magnus K Karlsson
    Department of Clinical Science and Orthopaedics, Skane University Hospital, Lund University, SE 205 20 Malmo, Sweden
    Age Ageing 41:740-6. 2012
    ..recurrent fallers are at especially high risk for injuries...
  40. pmc Cystatin C and frailty in older men
    Allyson Hart
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota
    J Am Geriatr Soc 61:1530-6. 2013
    ..To determine whether higher cystatin C would be associated with greater frailty in men aged 65 and older...
  41. pmc Association of stressful life events with incident falls and fractures in older men: the Osteoporotic Fractures in Men (MrOS) Study
    Howard A Fink
    VA Medical Center, Geriatric Research Education and Clinical Center, One Veterans Drive, 11 G, Minneapolis, MN 55417, USA
    Age Ageing 43:103-8. 2014
    ..small, retrospective studies suggest that major life events and/or sudden emotional stress may increase fall and fracture risk. The current study examines these associations prospectively...
  42. pmc Race/ethnic differences in associations between bone mineral density and fracture history in older men
    M H Shin
    Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea
    Osteoporos Int 25:837-45. 2014
    ..Low BMD was associated with a higher prevalence of fracture in all cohorts, and the magnitude of the BMD differences by fracture status was similar across groups...
  43. pmc Association between sleep duration and 24-hour urine free cortisol in the MrOS Sleep Study
    Madhu N Rao
    Division of Endocrinology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e75205. 2013
    ..Specifically, objective versus subjective methods of measuring habitual sleep duration may account for the conflicting results found in epidemiological studies...
  44. pmc Periodic leg movements are associated with reduced sleep quality in older men: the MrOS Sleep Study
    David M Claman
    University of California, San Francisco, San Francisco, CA
    J Clin Sleep Med 9:1109-17. 2013
    ..Since sleep differs in men and women, we now investigate the association between PLMS and PSG indices of sleep quality in a large community-based sample of older men...
  45. pmc Frailty and hip osteoarthritis in men in the MrOS cohort
    Barton L Wise
    Department of Medicine, Center for Musculoskeletal Health, 4625 2nd Avenue, Suite 1002, University of California at Davis Medical Center, Sacramento, CA 95817
    J Gerontol A Biol Sci Med Sci 69:602-8. 2014
    ..This study examined the association of hip osteoarthritis to frailty status in a longitudinal observational cohort of older men in the Osteoporotic Fractures in Men Study...
  46. doi International and ethnic variability of falls in older men
    Magnus K Karlsson
    1Clinical and Molecular Osteoporosis Research Unit, Department of Orthopaedics and Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden
    Scand J Public Health 42:194-200. 2014
    ..Fallers and especially recurrent fallers are at high risk for injuries. The aim of this study was to evaluate fall epidemiology in older men with special attention to the influence of age, ethnicity and country of residence...
  47. pmc Peripheral nerve function and lower extremity muscle power in older men
    Rachel E Ward
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA
    Arch Phys Med Rehabil 95:726-33. 2014
    ..To assess whether sensorimotor peripheral nerve function is associated with muscle power in community-dwelling older men...
  48. pmc Periodic limb movements during sleep and cardiac arrhythmia in older men (MrOS sleep)
    Brian B Koo
    Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH
    J Clin Sleep Med 10:7-11. 2014
    ..To determine if periodic limb movements during sleep (PLMS) are associated with nocturnal cardiac arrhythmia...
  49. pmc Sleep disturbances and risk of falls in older community-dwelling men: the outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study
    Katie L Stone
    Research Institute, California Pacific Medical Center, San Francisco, California
    J Am Geriatr Soc 62:299-305. 2014
    ..To test the hypothesis that subjective and objective sleep disturbances are associated with risk of incident falls in older men...
  50. pmc Kyphosis and paraspinal muscle composition in older men: a cross-sectional study for the osteoporotic fractures in men (MrOS) research group
    Wendy B Katzman
    Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA 94158, USA
    BMC Musculoskelet Disord 15:19. 2014
    ..We previously reported that poor paraspinal muscle composition contributes to more severe kyphosis in a cohort of both older men and women...
  51. ncbi Association Between Thyroid Function and Objective and Subjective Sleep Quality in Older Men: The Osteoporotic Fractures in Men (MrOS) Study
    Haruko Akatsu
    Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, Stanford, California
    Endocr Pract 20:576-86. 2014
    ..83 to 2.39), and 83% had increased risk of SL ≥60 minutes (RR, 1.83; 95% CI, 0.65 to 5.14) (all P>.05).Conclusion: Neither subclinical hypothyroidism nor hyperthyroidism is significantly associated with decreased sleep quality. ..
  52. pmc Genetic modifiers of cognitive maintenance among older adults
    Jennifer S Yokoyama
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, California
    Hum Brain Mapp 35:4556-65. 2014
    ..Identify genetic factors associated with cognitive maintenance in late life and assess their association with gray matter (GM) volume in brain networks affected in aging...
  53. pmc The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates
    Stephanie A Studenski
    Baltimore Longitudinal Study of Aging, National Institute on Aging, 3001 S Hanover Street, Fifth Floor, Baltimore MD 21225
    J Gerontol A Biol Sci Med Sci 69:547-58. 2014
    ..Details of the Project and its findings are presented in four accompanying manuscripts...
  54. pmc Inflammation, sleep disturbances, and depressed mood among community-dwelling older men
    Stephen F Smagula
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States
    J Psychosom Res 76:368-73. 2014
    ..In late life, age-related immunoregulation changes may modify the inflammation-depression relationship...
  55. pmc High hip fracture risk in men with severe aortic calcification: MrOS study
    Pawel Szulc
    Institut National de la Santé et de la Recherche Médicale INSERM Unité Mixte de Recherche UMR 1033, University of Lyon, Lyon, France
    J Bone Miner Res 29:968-75. 2014
    ..These findings suggest that AAC assessment may be a useful method for identification of older men at high risk of hip fracture...
  56. pmc Public health impact of osteoporosis
    Jane A Cauley
    DRPH, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261
    J Gerontol A Biol Sci Med Sci 68:1243-51. 2013
    ..To describe the public health impact of osteoporosis including the magnitude of the problem and important consequences of osteoporotic fractures...
  57. pmc Estimated GFR and risk of hip fracture in older men: comparison of associations using cystatin C and creatinine
    Kristine E Ensrud
    Department of Medicine, University of Minnesota, Minneapolis, MN Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN Center for Chronic Disease Outcomes Research, VA Health Care System, Minneapolis, MN Electronic address
    Am J Kidney Dis 63:31-9. 2014
    ..Whether estimated glomerular filtration rate (eGFR) based on cystatin C (eGFRcys) is superior in predicting hip fracture risk to eGFR based on creatinine (eGFRcr) or the combination (eGFR(cr-cys)) also is uncertain...
  58. pmc A prospective study of thyroid function, bone loss, and fractures in older men: The MrOS study
    Avantika C Waring
    Division of Endocrinology and Metabolism, University of California, San Francisco, San Francisco, CA, USA
    J Bone Miner Res 28:472-9. 2013
    ..We conclude that although neither TSH nor FT4 are associated with bone loss, lower serum TSH may be associated with an increased risk of hip fractures in older men...
  59. pmc Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies
    Lu Wang
    Brigham and Women s Hospital, Boston, MA 02215, USA
    Circ Cardiovasc Qual Outcomes 5:819-29. 2012
    ..Vitamin D status has been linked to the risk of cardiovascular disease (CVD). However, the optimal 25-hydroxy-vitamin D (25[OH]-vitamin D) levels for potential cardiovascular health benefits remain unclear...
  60. pmc Performance of FRAX in a cohort of community-dwelling, ambulatory older men: the Osteoporotic Fractures in Men (MrOS) study
    B Ettinger
    Department of Medicine, University of California, San Francisco, CA, USA
    Osteoporos Int 24:1185-93. 2013
    ..We evaluated performance of FRAX in older men who participated in the Osteoporotic Fractures in Men (MrOS) study...
  61. pmc Relationships between serum and urine phosphorus with all-cause and cardiovascular mortality: the Osteoporotic Fractures in Men (MrOS) Study
    Julie R Dominguez
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA 92161, USA
    Am J Kidney Dis 61:555-63. 2013
    ..Whether urine phosphorus-creatinine ratio (a marker of intestinal absorption) or urine fractional excretion of phosphorus (FEPi; a marker of urinary phosphorus handling) is associated with risk of mortality or CVD is uncertain...
  62. pmc Association between body size and composition and erectile dysfunction in older men: Osteoporotic Fractures in Men Study
    Pranav S Garimella
    Department of Medicine, John H Stroger, Jr Hospital of Cook County, Chicago, Illinois, USA
    J Am Geriatr Soc 61:46-54. 2013
    ..To examine the association between body size and composition and erectile dysfunction (ED) in older men...
  63. pmc Functional polymorphisms affecting the clinically important arginine-137 residue of AVPR2 do not influence serum sodium concentration at the population level
    Yi Fu
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR 97239, USA
    Physiol Genomics 45:210-6. 2013
    ..06%. We conclude that these disease-associated variants are exceedingly uncommon and do not contribute broadly to interindividual variability in serum sodium concentration or to its heritability...
  64. pmc Abdominal myosteatosis is independently associated with hyperinsulinemia and insulin resistance among older men without diabetes
    Iva Miljkovic
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 21:2118-25. 2013
    ..It remains unclear if myosteatosis is associated to glucose and insulin homeostasis independent of total and central adiposity...
  65. pmc Common genetic variants in ARNTL and NPAS2 and at chromosome 12p13 are associated with objectively measured sleep traits in the elderly
    Daniel S Evans
    California Pacific Medical Center Research Institute, San Francisco, CA 94107 1728, USA
    Sleep 36:431-46. 2013
    ..To determine the association between common genetic variation in the clock gene pathway and objectively measured acti-graphic sleep and activity rhythm traits...
  66. pmc Abdominal body composition measured by quantitative computed tomography and risk of non-spine fractures: the Osteoporotic Fractures in Men (MrOS) Study
    Y Sheu
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    Osteoporos Int 24:2231-41. 2013
    ..Among various adipose tissues and muscle groups, lower psoas muscle volume and higher fatty infiltration of abdominal muscle contribute to higher fracture risk independent of BMD...
  67. pmc Obstructive sleep apnea during rapid eye movement sleep, daytime sleepiness, and quality of life in older men in Osteoporotic Fractures in Men (MrOS) Sleep Study
    Akram Khan
    Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Clin Sleep Med 9:191-8. 2013
    ....
  68. pmc The burden of urinary incontinence and urinary bother among elderly prostate cancer survivors
    Ryan P Kopp
    Division of Urologic Oncology, UC San Diego Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093 0987, USA
    Eur Urol 64:672-9. 2013
    ..Data describing urinary health in elderly, community-dwelling prostate cancer (PCa) survivors are limited...
  69. pmc Comparisons of immunoassay and mass spectrometry measurements of serum estradiol levels and their influence on clinical association studies in men
    Claes Ohlsson
    Centre for Bone and Arthritis Research, Sahlgrenska Academy, University of Gothenburg, Vita Stråket 11, SE 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 98:E1097-102. 2013
    ..Different measurement techniques may be responsible for the conflicting results of associations between serum E2 and clinical phenotypes in men...
  70. pmc Association of serum fibroblast growth factor 23 (FGF23) and incident fractures in older men: the Osteoporotic Fractures in Men (MrOS) study
    Nancy E Lane
    University of California at Davis, Sacramento, CA, USA
    J Bone Miner Res 28:2325-32. 2013
    ..Serum FGF23 levels are not associated with incident fractures in elderly men overall. However, higher levels of serum FGF23 are associated with fracture risk in those with poor renal function...
  71. pmc Objective assessment of activity, energy expenditure, and functional limitations in older men: the Osteoporotic Fractures in Men study
    Peggy M Cawthon
    California Pacific Medical Center Research Institute, 185 Berry Street, Lobby 5, Suite 5700, San Francisco, CA 94107 1762
    J Gerontol A Biol Sci Med Sci 68:1518-24. 2013
    ..The relationship between objectively assessed activity, energy expenditure, and the development of functional limitations is unknown...
  72. pmc Total sleep time and other sleep characteristics measured by actigraphy do not predict incident hypertension in a cohort of community-dwelling older men
    Maple M Fung
    San Diego Veterans Affairs Healthcare System, Medicine Service, 3550 La Jolla Village Dr, San Diego, CA, USA
    J Clin Sleep Med 9:585-91. 2013
    ..To evaluate whether actigraphy-measured total sleep time and other sleep characteristics predict incident hypertension in older men...
  73. pmc Objective measures of physical activity, fractures and falls: the osteoporotic fractures in men study
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Am Geriatr Soc 61:1080-8. 2013
    ..To determine the association between objectively measured physical activity (PA), fractures, and falls...
  74. pmc What analytic method should clinicians use to derive spine T-scores and predict incident fractures in men? Results from the MrOS study
    K E Hansen
    Rheumatology Division, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Room 4124 MFCB, 1685 Highland Avenue, Madison, WI, 53705, USA
    Osteoporos Int 25:2181-8. 2014
    ..In men for whom hip imaging is not possible, the lowest vertebral body T-score improves the ability to diagnose osteoporosis in men who are likely to have an incident fragility fracture...
  75. pmc Self-reported weight at birth predicts measures of femoral size but not volumetric BMD in eldery men: MrOS
    M Kassim Javaid
    NIHR Musculoskeletal BRU, University of Oxford, Oxford, United Kingdom
    J Bone Miner Res 26:1802-7. 2011
    ..Further research exploring the association between early developmental factors and lifetime fracture risk is needed and may inform primary preventative strategies for fracture prevention...
  76. pmc Association of the ACTN3 genotype and physical functioning with age in older adults
    Matthew J Delmonico
    Department of Epidemiology, University of Pittsburg, Pittsburg, PA, USA
    J Gerontol A Biol Sci Med Sci 63:1227-34. 2008
    ..The purpose of this study was to examine the association of the alpha-actinin-3 (ACTN3) R577X polymorphism on muscle function and physical performance in older adults...
  77. ncbi Alcohol intake and its relationship with bone mineral density, falls, and fracture risk in older men
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107, USA
    J Am Geriatr Soc 54:1649-57. 2006
    ..To examine the association between alcohol intake and problem drinking history and bone mineral density (BMD), falls and fracture risk...
  78. doi An evaluation of osteoporosis screening tools for the osteoporotic fractures in men (MrOS) study
    H S Lynn
    Department of Biostatistics, School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
    Osteoporos Int 19:1087-92. 2008
    ..OST and MOST were examined among 4658 US Caucasian and 1914 Hong Kong Chinese men. Both tools have high negative predictive values, accurately screening out men with low risk, and saving a third of DXA tests...
  79. pmc Renal function and sleep-disordered breathing in older men
    Muna T Canales
    Department of Medicine, University of Florida, Division of Nephrology, Hypertension and Renal Transplantation, Gainesville, FL 32610, USA
    Nephrol Dial Transplant 23:3908-14. 2008
    ..Sleep-disordered breathing (SDB) is common in severe chronic kidney disease (CKD) and may contribute to morbidity and mortality in this population. However, the association between mild to moderate CKD and likelihood of SDB is uncertain...
  80. pmc Normocalcemic hyperparathyroidism and hypoparathyroidism in two community-based nonreferral populations
    Natalie E Cusano
    Department of Medicine, Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Endocrinol Metab 98:2734-41. 2013
    ..At diagnosis, patients demonstrate features seen in hypercalcemic primary hyperparathyroidism. Normocalcemic hypoparathyroidism has been discovered after hypocalcemia unmasked after bisphosphonate administration...
  81. ncbi Identification of vertebral fracture and non-osteoporotic short vertebral height in men: the MrOS study
    Lynne Ferrar
    Academic Unit of Bone Metabolism, University of Sheffield, United Kingdom
    J Bone Miner Res 22:1434-41. 2007
    ..Non-osteoporotic SVH may mimic VF but is excluded in ABQ. In men, this led to discordance between ABQ and other methods, but SVH was not linked to low bone density. Exclusion of SVH could reduce false positives...
  82. pmc Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
    J Bone Miner Res 23:1326-33. 2008
    ....
  83. pmc Lower urinary tract symptoms increase the risk of falls in older men
    J Kellogg Parsons
    Department of Surgery, Division of Urology, University of California, San Diego, CA, USA
    BJU Int 104:63-8. 2009
    ..Because of the serious consequences of falls, these results might justify the routine assessment of LUTS with a validated questionnaire in the primary care of this population...
  84. pmc Prevalence and correlates of sleep-disordered breathing in older men: osteoporotic fractures in men sleep study
    Reena Mehra
    San Francisco Coordinating Center, University of California San Francisco at San Diego, USA
    J Am Geriatr Soc 55:1356-64. 2007
    ..To determine the prevalence and distribution of sleep-disordered breathing and associated correlates in a large cohort of older men using several standardized definitions...
  85. pmc Diffuse idiopathic skeletal hyperostosis and its relation to back pain among older men: the MrOS Study
    Kathleen F Holton
    Department of Orthopaedics and Rehabilitation, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Semin Arthritis Rheum 41:131-8. 2011
    ..To estimate the prevalence of diffuse idiopathic skeletal hyperostosis (DISH) in a cross-sectional study of elderly men age 65 to 100 years and to examine back and neck pain as possible correlates of DISH...
  86. pmc Reliability and validity of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in older men
    Adam P Spira
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 67:433-9. 2012
    ..These measures, however, have not been comprehensively evaluated for their psychometrics in older men. We determined the internal consistency reliability and construct validity of the PSQI and ESS in a sample of older men...
  87. pmc Prediction of new clinical vertebral fractures in elderly men using finite element analysis of CT scans
    Xiang Wang
    Department of Mechanical Engineering, University of California, Berkeley, Berkeley, CA, USA
    J Bone Miner Res 27:808-16. 2012
    ..82, p = 0.05). We conclude that, compared to areal BMD by DXA, vertebral compressive strength and volumetric BMD consistently improved vertebral fracture risk assessment in this cohort of elderly men...
  88. pmc Thyroid function and mortality in older men: a prospective study
    Avantika C Waring
    Department of Medicine, University of California, San Francisco, 400 Parnassus Avenue, A 550, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 97:862-70. 2012
    ..Mild abnormalities of thyroid function have been associated with both beneficial and detrimental effects on mortality...
  89. pmc Bone mass and strength in older men with type 2 diabetes: the Osteoporotic Fractures in Men Study
    Moira A Petit
    School of Kinesiology, Laboratory for Musculoskeletal Health, University of Minnesota, Minneapolis, MN, USA
    J Bone Miner Res 25:285-91. 2010
    ..These data demonstrate that older men with T2DM have bone strength that is low relative to body weight at the cortical-rich midshaft of the radius despite no difference in cortical vBMD...
  90. pmc Loss of hip BMD in older men: the osteoporotic fractures in men (MrOS) study
    Peggy M Cawthon
    California Pacific Medical Center, Research Institute, San Francisco Coordinating Center, 185 Berry Street, Lobby 5, Suite 5700, San Francisco, CA 94107 1728, USA
    J Bone Miner Res 24:1728-35. 2009
    ..Older men and those with lower BMD lose bone more rapidly, offering potential explanation for the increasing risk of fracture with advancing age...
  91. pmc Association of sleep characteristics and cognition in older community-dwelling men: the MrOS sleep study
    Terri Blackwell
    Research Institute, California Pacific Medical Center, San Francisco, CA 94107, USA
    Sleep 34:1347-56. 2011
    ..To examine the association of objectively and subjectively measured sleep characteristics with cognition in older men...
  92. pmc Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men
    Laura M Yerges
    Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Bone Miner Res 25:330-8. 2010
    ..These findings identify novel genetic variants for cortical and trabecular vBMD and raise the possibility that some genetic loci may be unique for each bone compartment...
  93. pmc Factors that may influence the classification of sleep-wake by wrist actigraphy: the MrOS Sleep Study
    Terri Blackwell
    California Pacific Medical Center Research Institute, San Francisco, CA, USA
    J Clin Sleep Med 7:357-67. 2011
    ..Associations of measurement error for TST (PSG-actigraphy) with demographics, medical history, exam data, and sleep characteristics were examined...
  94. pmc Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus
    Christine G Lee
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    J Am Geriatr Soc 59:1217-24. 2011
    ..To examine the associations between insulin resistance and changes in body composition in older men without diabetes mellitus...
  95. pmc Obesity increases and physical activity decreases lower urinary tract symptom risk in older men: the Osteoporotic Fractures in Men study
    J Kellogg Parsons
    Division of Urology, University of California San Diego, San Diego, CA, USA
    Eur Urol 60:1173-80. 2011
    ..Two potential targets for preventing chronic lower urinary tract symptoms (LUTS) in older men are obesity and physical activity...
  96. pmc Metabolic syndrome and physical performance in elderly men: the osteoporotic fractures in men study
    Susan A Everson-Rose
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 59:1376-84. 2011
    ..To examine the association between metabolic syndrome (MetS) and objective measures of physical performance...
  97. pmc Higher testosterone levels are associated with less loss of lean body mass in older men
    Erin S LeBlanc
    Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon 97227, USA
    J Clin Endocrinol Metab 96:3855-63. 2011
    ..Little information exists about longitudinal changes in body composition and physical function in relation to sex hormone levels in older men...
  98. pmc Decreased slow wave sleep increases risk of developing hypertension in elderly men
    Maple M Fung
    San Diego Veterans Affairs Healthcare System, Medicine Service, San Diego, CA 92161, USA
    Hypertension 58:596-603. 2011
    ..Selective deprivation of SWS may contribute to adverse blood pressure in older men...
  99. pmc Diffuse idiopathic skeletal hyperostosis (DISH): relation to vertebral fractures and bone density
    G Diederichs
    Department of Radiology and Biomedical Imaging, Musculoskeletal and Quantitative Imaging Research Group, University of California, China Basin Landing, 185 Berry Street, San Francisco, CA 94107, USA
    Osteoporos Int 22:1789-97. 2011
    ..Paravertebral calcifications should be considered in patients with DISH when interpreting BMD measurements because both dual X-ray absorptiometry (DXA) and quantitative CT (QCT) densitometry may not be reliable...