Multicenter Aids Cohort Study- Part B (Baltimore Site)

Summary

Principal Investigator: Joseph Margolick
Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA
Abstract: The Study to Help the AIDS Research Effort (SHARE) was funded by NAID and NCI in 1983 to study the natural history of infection with human immunodeficiency virus, type 1 (HIV). SHARE, along with similar sites in Chicago, Pittsburgh, and Los Angeles, forms the Multicenter AIDS Cohort Study (MACS). MACS participants, including 1447 enrolled in SHARE, have been followed semiannually since 1984 and have provided questionnaire data, physical exam data, laboratory data (including HIV serostatus and T-cell subset measurements), and a large repository of plasma, serum, cryopreserved peripheral blood mononuclear cells and other specimens. Evaluating and following the prevalent and incident cases of HIV-infection in SHARE and the MACS, has provided key insights into risk factors for infection with HIV-1, monitoring and mechanisms of progression of HIV infection once it is established, host defense against HIV, genetic factors affecting HIV pathogenesis, and use and efficacy of different therapies for HIV infection and for opportunistic pathogens. SHARE and MACS have just completed the recruitment of 1326 additional participants, including 352 in SHARE, who are younger and more non-Caucasian than the cohort previously recruited. This application requests the continuation of the follow-up of the SHARE cohort from 2004 to 2008. Expected survival and continuation in the study of HIV-infected cohort members through this time period is 88%. Specific Aims of the renewal include: determine the long-term effectiveness of highly active antiretroviral therapy (HAART); define determinants of individual responses to HAART including host genetic characteristics, co-infections (hepatitis viruses, HHV-8), immune responses to HIV, adherence, race/ethnicity; define mechanisms of host resistance to HIV infection and progression of the infection; and serve as a platform for independently funded pathogenesis studies and other collaborative research, including virological and immunological mechanisms of HIV-1 pathogenesis, laboratory correlates of disease progression or non-progression, and biological interactions between co-infections and HIV. These aims can be addressed only with continued follow-up of this extremely well-characterized cohort. SHARE and the MACS should continue to play a leading role in studies designed to lead to better treatments and preventive vaccines for HIV infection.
Funding Period: 1993-04-01 - 2009-03-31
more information: NIH RePORT

Top Publications

  1. pmc Cause-specific life expectancies after 35 years of age for human immunodeficiency syndrome-infected and human immunodeficiency syndrome-negative individuals followed simultaneously in long-term cohort studies, 1984-2008
    Nikolas Wada
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room E7648, Baltimore, MD 21205, USA
    Am J Epidemiol 177:116-25. 2013
  2. pmc Prevalence of abnormalities in vestibular function and balance among HIV-seropositive and HIV-seronegative women and men
    Helen S Cohen
    Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e38419. 2012
  3. pmc The impact of impaired kidney function and HIV infection on the risk of anemia
    Alison G Abraham
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    AIDS Res Hum Retroviruses 28:1666-71. 2012
  4. pmc Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults
    Andrew J Levine
    National Neurological AIDS Bank, Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA
    Am J Med Genet B Neuropsychiatr Genet 159:669-83. 2012
  5. pmc Comparative risk of liver-related mortality from chronic hepatitis B versus chronic hepatitis C virus infection
    Oluwaseun Falade-Nwulia
    Division of Infectious Diseases, Johns Hopkins University, Baltimore, 21287, USA
    Clin Infect Dis 55:507-13. 2012
  6. pmc A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection
    Rasmi Thomas
    Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA
    J Virol 86:6979-85. 2012
  7. pmc A simulation study of finite-sample properties of marginal structural Cox proportional hazards models
    Daniel Westreich
    Department of Obstetrics and Gynecology and Duke Global Health Institute, Duke University, Durham, NC, USA
    Stat Med 31:2098-109. 2012
  8. pmc Herpes simplex virus type 2 (HSV-2) as a coronary atherosclerosis risk factor in HIV-infected men: multicenter AIDS cohort study
    Rulin C Hechter
    Department of Epidemiology, UCLA School of Public Health, Box 951772, Los Angeles, CA 90095 1772, USA
    Atherosclerosis 223:433-6. 2012
  9. pmc Stress and mental health among midlife and older gay-identified men
    Richard G Wight
    Department of Community Health Sciences, School of Public Health, University of California, Los Angeles, CA 90095 1772, USA
    Am J Public Health 102:503-10. 2012
  10. pmc Application of syndemic theory to black men who have sex with men in the Multicenter AIDS Cohort Study
    Typhanye Penniman Dyer
    Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland, College Park, MD, USA
    J Urban Health 89:697-708. 2012

Detail Information

Publications221 found, 100 shown here

  1. pmc Cause-specific life expectancies after 35 years of age for human immunodeficiency syndrome-infected and human immunodeficiency syndrome-negative individuals followed simultaneously in long-term cohort studies, 1984-2008
    Nikolas Wada
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room E7648, Baltimore, MD 21205, USA
    Am J Epidemiol 177:116-25. 2013
    ..The results illuminate the changing face of mortality among the growing population infected with HIV...
  2. pmc Prevalence of abnormalities in vestibular function and balance among HIV-seropositive and HIV-seronegative women and men
    Helen S Cohen
    Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e38419. 2012
    ..The goals of this study were to determine the prevalences of vestibular and balance impairments among HIV-seropositive and comparable seronegative men and women and to determine if those groups differed...
  3. pmc The impact of impaired kidney function and HIV infection on the risk of anemia
    Alison G Abraham
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    AIDS Res Hum Retroviruses 28:1666-71. 2012
    ..Comorbid conditions and medication use did not explain this increase in risk. HIV infection and impaired kidney function have a combined impact on lowering hemoglobin levels, resulting in a higher risk of anemia...
  4. pmc Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults
    Andrew J Levine
    National Neurological AIDS Bank, Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA
    Am J Med Genet B Neuropsychiatr Genet 159:669-83. 2012
    ..Due to the relatively small sample size, future collaborative efforts that incorporate this dataset may still yield important findings...
  5. pmc Comparative risk of liver-related mortality from chronic hepatitis B versus chronic hepatitis C virus infection
    Oluwaseun Falade-Nwulia
    Division of Infectious Diseases, Johns Hopkins University, Baltimore, 21287, USA
    Clin Infect Dis 55:507-13. 2012
    ..This study compared rates of liver-related mortality between these 2 groups in the Multicenter AIDS Cohort Study (MACS)...
  6. pmc A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection
    Rasmi Thomas
    Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA
    J Virol 86:6979-85. 2012
    ....
  7. pmc A simulation study of finite-sample properties of marginal structural Cox proportional hazards models
    Daniel Westreich
    Department of Obstetrics and Gynecology and Duke Global Health Institute, Duke University, Durham, NC, USA
    Stat Med 31:2098-109. 2012
    ..Under realistic scenarios, marginal structural Cox proportional hazards models performed according to expectations based on large-sample theory and provided accurate estimates of the hazard ratio...
  8. pmc Herpes simplex virus type 2 (HSV-2) as a coronary atherosclerosis risk factor in HIV-infected men: multicenter AIDS cohort study
    Rulin C Hechter
    Department of Epidemiology, UCLA School of Public Health, Box 951772, Los Angeles, CA 90095 1772, USA
    Atherosclerosis 223:433-6. 2012
    ..58, 95% CI=1.06-2.36). Our findings suggest HSV-2 may be a risk factor for subclinical coronary atherosclerosis in HIV-infected men. Infection with multiple herpesviruses may contribute to the increased burden of atherosclerosis...
  9. pmc Stress and mental health among midlife and older gay-identified men
    Richard G Wight
    Department of Community Health Sciences, School of Public Health, University of California, Los Angeles, CA 90095 1772, USA
    Am J Public Health 102:503-10. 2012
    ..We also studied the mental health effects of same-sex marriage...
  10. pmc Application of syndemic theory to black men who have sex with men in the Multicenter AIDS Cohort Study
    Typhanye Penniman Dyer
    Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland, College Park, MD, USA
    J Urban Health 89:697-708. 2012
    ..46, 95% CI = 1.4-8.3). Findings support the concept of syndemics in black MSM and suggest that syndemic theory may help explain complexities that sustain HIV-related sexual transmission behaviors in this group...
  11. pmc The cumulative effects of medication use, drug use, and smoking on erectile dysfunction among men who have sex with men
    Trevor A Hart
    Department of Psychology, Ryerson University, Toronto, Canada
    J Sex Med 9:1106-13. 2012
    ..There is a need for additional research to determine the correlates of HIV+ and HIV-seronegative (HIV-) MSM, especially regarding nonantiretroviral medication use...
  12. pmc Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression
    Catherine A Brennan
    UCLA AIDS Institute and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    J Virol 86:10505-16. 2012
    ..This is the first study to identify early CTL responses to IW9 as a correlate of protection in persons with HLA-B*57...
  13. pmc Labor force participation and health-related quality of life in HIV-positive men who have sex with men: the Multicenter AIDS Cohort Study
    Sergio Rueda
    Ontario HIV Treatment Network, 1300 Yonge Street, Suite 600, Toronto, ON, M4T 1X3, Canada
    AIDS Behav 16:2350-60. 2012
    ..Policies that promote labor force participation may not only increase employment rates but also improve the health of people living with HIV...
  14. pmc Cumulative exposure to stimulants and immune function outcomes among HIV-positive and HIV-negative men in the Multicenter AIDS Cohort Study
    S Shoptaw
    Department of Family Medicine and Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Int J STD AIDS 23:576-80. 2012
    ..ART adherence is associated with a positive immune function independent of stimulant use, underscoring the influence of ART on immune health for HIV+ men who engage in stimulant use...
  15. pmc Invasive cervical cancer risk among HIV-infected women: a North American multicohort collaboration prospective study
    Alison G Abraham
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY Division of Infectious Diseases, School of Medicine, Vanderbilt University, Nashville, TN Division of Research, Kaiser Permanente Northern California, Oakland, CA Division of Infectious Diseases, University of Alabama, Birmingham, AL Ontario Treatment Network, University of Toronto, Toronto, ON, Canada Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC Department of Medicine, Johns Hopkins University, Baltimore, MD Department of Medicine, Division of Infectious Diseases Chronic Viral Illness Service, McGill University, Montreal, Quebec, Canada Department of Medicine, University of Washington, Seattle, WA Department of Health Sciences, British Columbia Centre for Excellence and HIV AIDS, Simon Fraser University, Vancouver, British Columbia, Canada Department of Clinical Pharmacy and Medicine, University of California, San Francisco, CA Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD Department of Medicine, University of Calgary, Calgary
    J Acquir Immune Defic Syndr 62:405-13. 2013
    ..Few reported prospective cohort studies have characterized the incidence of invasive cervical cancer (ICC) in HIV-infected women...
  16. pmc Serum levels of the chemokine CXCL13, genetic variation in CXCL13 and its receptor CXCR5, and HIV-associated non-hodgkin B-cell lymphoma risk
    Shehnaz K Hussain
    Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles UCLA, Los Angeles, CA 90095, USA
    Cancer Epidemiol Biomarkers Prev 22:295-307. 2013
    ....
  17. pmc Predictive accuracy of the Veterans Aging Cohort Study index for mortality with HIV infection: a North American cross cohort analysis
    Amy C Justice
    Department of Internal Medicine, Yale University and the Veterans Affairs Healthcare System, West Haven, CT 06516, USA
    J Acquir Immune Defic Syndr 62:149-63. 2013
    ....
  18. pmc HIV incidence determination in the United States: a multiassay approach
    Oliver Laeyendecker
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Infect Dis 207:232-9. 2013
    ..Accurate testing algorithms are needed for estimating human immunodeficiency virus (HIV) incidence from cross-sectional surveys...
  19. pmc Predictors of the isolated hepatitis B core antibody pattern in HIV-infected and -uninfected men in the multicenter AIDS cohort study
    Mallory D Witt
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, orrance, CA 90509, USA
    Clin Infect Dis 56:606-12. 2013
    ..The significance of hepatitis B core antibody (anti-HBc) without hepatitis B surface antigen (HBsAg) or hepatitis B surface antibody (anti-HBs) is unclear...
  20. pmc Neurologic disorders incidence in HIV+ vs HIV- men: Multicenter AIDS Cohort Study, 1996-2011
    Farrah J Mateen
    Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Neurology 79:1873-80. 2012
    ..To study the incidence and pattern of neurologic disorders in a large cohort of HIV-positive men, compared with HIV-negative men, in the era of highly active antiretroviral therapy (HAART)...
  21. doi An information criterion for marginal structural models
    Robert W Platt
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada
    Stat Med 32:1383-93. 2013
    ..In marginal structural models, as in any regression setting, correct inference depends on correct model specification. Our proposed information criterion provides a formal method for comparing model fit for different specifications...
  22. pmc U.S. trends in antiretroviral therapy use, HIV RNA plasma viral loads, and CD4 T-lymphocyte cell counts among HIV-infected persons, 2000 to 2008
    Keri N Althoff
    Johns Hopkins University, Baltimore, Maryland, USA
    Ann Intern Med 157:325-35. 2012
    ..The U.S. National HIV/AIDS Strategy targets for 2015 include "increasing access to care and improving health outcomes for persons living with HIV in the United States" (PLWH-US)...
  23. pmc Marginal structural models for case-cohort study designs to estimate the association of antiretroviral therapy initiation with incident AIDS or death
    Stephen R Cole
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 27599 7435, USA
    Am J Epidemiol 175:381-90. 2012
    ..Marginal structural model analysis of case-cohort study designs provides a cost-efficient design coupled with an accurate analytic method for research settings in which there is time-varying confounding...
  24. pmc Risk of anal cancer in HIV-infected and HIV-uninfected individuals in North America
    Michael J Silverberg
    Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA
    Clin Infect Dis 54:1026-34. 2012
    ..There are also conflicting data regarding calendar trends...
  25. pmc Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection
    Boris Julg
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute and KwaZulu Natal Research Institute for TB and HIV, University of KwaZulu Natal, Durban, South Africa
    J Infect Dis 203:803-9. 2011
    ..However, little is known about the impact of HLA class II alleles on HIV disease progression...
  26. pmc Serological immunity to adenovirus serotype 5 is not associated with risk of HIV infection: a case-control study
    Marcel E Curlin
    Vaccine and Infectious Diseases Institute, Fred Hutchinson Cancer Research Center, USA
    AIDS 25:153-8. 2011
    ..We examined the association between adenovirus serostatus and the rate of incident HIV infection in populations at elevated risk of HIV acquisition...
  27. pmc Screening low-frequency SNPS from genome-wide association study reveals a new risk allele for progression to AIDS
    Sigrid Le Clerc
    Chaire de Bioinformatique, Conservatoire National des Arts et Metiers, Paris, France
    J Acquir Immune Defic Syndr 56:279-84. 2011
    ..Seven genome-wide association studies (GWAS) have been published in AIDS, and only associations in the HLA region on chromosome 6 and CXCR6 have passed genome-wide significance...
  28. pmc Factors associated with elevated ALT in an international HIV/HBV co-infected cohort on long-term HAART
    Jennifer Audsley
    Department of Medicine, Monash University, Melbourne, Australia
    PLoS ONE 6:e26482. 2011
    ....
  29. pmc IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection
    Maureen P Martin
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, NCI Frederick, Frederick, Maryland, USA
    J Infect Dis 202:1749-53. 2010
    ..99), resistance to HIV infection (odds ratio, 0.97), or HIV disease progression (P > .05). This IL28B single-nucleotide polymorphism affects the immune response to HCV but not to HBV or HIV...
  30. doi Estimation of risk ratios in cohort studies with common outcomes: a Bayesian approach
    Haitao Chu
    Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Epidemiology 21:855-62. 2010
    ..We propose a novel Bayesian approach for the estimation of the risk ratio from the log binomial model that addresses drawbacks of existing approaches. Posterior computation can be accomplished easily using the WinBUGs code provided...
  31. pmc Virologic and immunologic response to HAART, by age and regimen class
    Keri N Althoff
    Johns Hopkins University, Baltimore, Maryland 21287, USA
    AIDS 24:2469-79. 2010
    ..To determine the impact of age and initial HAART regimen class on virologic and immunologic response within 24 months after initiation...
  32. pmc Longitudinal psychomotor speed performance in human immunodeficiency virus-seropositive individuals: impact of age and serostatus
    Ned Sacktor
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neurovirol 16:335-41. 2010
    ..Mild neurocognitive changes over time among older HIV+ individuals are likely to reflect age associated pathophysiological mechanisms including cerebrovascular risk factors...
  33. pmc Cancer incidence in the multicenter AIDS Cohort Study before and during the HAART era: 1984 to 2007
    Eric C Seaberg
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Cancer 116:5507-16. 2010
    ....
  34. pmc HBV mutations in untreated HIV-HBV co-infection using genomic length sequencing
    Jennifer Audsley
    Department of Medicine, Monash University, Melbourne, Victoria, Australia
    Virology 405:539-47. 2010
    ..Further work is needed to determine if these mutational patterns influence the differences in liver disease progression in HIV-HBV co-infected and HBV mono-infected patients...
  35. pmc Limitation of inverse probability-of-censoring weights in estimating survival in the presence of strong selection bias
    Chanelle J Howe
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, 27599 7435, USA
    Am J Epidemiol 173:569-77. 2011
    ..Approaches to improve correction methods are discussed...
  36. pmc CD4+ T-cell counts and plasma HIV-1 RNA levels beyond 5 years of highly active antiretroviral therapy
    Xiuhong Li
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 57:421-8. 2011
    ..The heterogeneity of CD4 T-cell counts and HIV-1 RNA at 5-12 years after the initiation of highly active antiretroviral therapy (HAART) remains largely uncharacterized...
  37. pmc Chronic kidney disease and estimates of kidney function in HIV infection: a cross-sectional study in the multicenter AIDS cohort study
    Michelle M Estrella
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 57:380-6. 2011
    ..Cystatin C has been proposed as an alternative marker of kidney function among HIV-infected persons in whom serum creatinine is affected by extrarenal factors...
  38. pmc The multicenter AIDS Cohort Study, 1983 to …
    R Detels
    School of Public Health, University of California, Los Angeles, United States
    Public Health 126:196-8. 2012
    ..Through May 2011, 1,490,995 specimens have been collected, 86,883 person-years of data accrued and 1195 scientific papers published in international journals...
  39. pmc Copy number variation of KIR genes influences HIV-1 control
    Kimberly Pelak
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USA
    PLoS Biol 9:e1001208. 2011
    ....
  40. pmc Factors associated with incorrect identification of recent HIV infection using the BED capture immunoassay
    Oliver Laeyendecker
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 21205, USA
    AIDS Res Hum Retroviruses 28:816-22. 2012
    ..Some men were persistently misclassified as recently infected up to 8 years after HIV seroconversion...
  41. pmc The mediating role of pain in substance use and depressive symptoms among Multicenter AIDS Cohort Study (MACS) participants
    Jennie C I Tsao
    Pediatric Pain Program, Department of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles UCLA, Los Angeles, CA 90064, USA
    Pain 152:2757-64. 2011
    ..The results underscore the need for adequate pain management, particularly among vulnerable subgroups of HIV-seropositive and HIV-seronegative men to reduce the risk of drug use and depression...
  42. pmc Platelet decline as a predictor of brain injury in HIV infection
    Ann B Ragin
    Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    J Neurovirol 17:487-95. 2011
    ..Findings from a structural brain imaging substudy of older participants, however, support a possible relationship between platelet decline and reduced gray matter...
  43. pmc JC virus antibody and viremia as predictors of progressive multifocal leukoencephalopathy in human immunodeficiency virus-1-infected individuals
    Raphael P Viscidi
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Infect Dis 53:711-5. 2011
    ..JCV viremia was not predictive of PML, but some patients showed higher anti-JCV immunoglobulin G (IgG) responses 6 months prior to diagnosis...
  44. pmc Risk factors for tuberculosis after highly active antiretroviral therapy initiation in the United States and Canada: implications for tuberculosis screening
    Timothy R Sterling
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Infect Dis 204:893-901. 2011
    ..Identifying factors associated with developing tuberculosis after HAART initiation could focus screening efforts...
  45. pmc Missing data on the estimation of the prevalence of accumulated human immunodeficiency virus drug resistance in patients treated with antiretroviral drugs in north america
    Alison G Abraham
    Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Suite E7640, Baltimore, MD 21205, USA
    Am J Epidemiol 174:727-35. 2011
    ....
  46. pmc A frailty-related phenotype before HAART initiation as an independent risk factor for AIDS or death after HAART among HIV-infected men
    Loic Desquilbet
    Ecole Nationale Veterinaire d Alfort, 7 Avenue du General de Gaulle, Maisons Alfort Cedex, France
    J Gerontol A Biol Sci Med Sci 66:1030-8. 2011
    ....
  47. pmc Universal GFR determination based on two time points during plasma iohexol disappearance
    Derek K S Ng
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Kidney Int 80:423-30. 2011
    ..73 m2 for adults and children, respectively. Thus, our proposed simple equation, developed in a combined patient group with a broad range of GFRs, may be applied universally and is independent of the injected amount of iohexol...
  48. pmc Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per microL in Europe and North America: a pooled cohort observational study
    Rebecca K Lodwick
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, London, UK
    Lancet 376:340-5. 2010
    ..We aimed to examine this by analysis of pooled data from industrialised countries...
  49. pmc Circulating mediators of inflammation and immune activation in AIDS-related non-hodgkin lymphoma
    Brian M Nolen
    University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 9:e99144. 2014
    ..The mechanisms underlying the development of AIDS-related NHL (A-NHL) are not fully understood, but likely involve persistent B-cell activation and inflammation...
  50. doi Transmission and evolution of hepatitis C virus in HCV seroconverters in HIV infected subjects
    Chengli Shen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, United States
    Virology 449:339-49. 2014
    ..Our results suggest that HCV transmission and evolution in HIV-infected subjects may not be influenced by host CD4 cell count at the time of infection. ..
  51. pmc Lower adiponectin is associated with subclinical cardiovascular disease among HIV-infected men
    Kerunne S Ketlogetswe
    Johns Hopkins University, Baltimore, Maryland, USA
    AIDS 28:901-9. 2014
    ..To examine whether altered levels of adipokines, adipose-derived peptides associated with myocardial infarction in the general population, may contribute to subclinical coronary atherosclerosis in HIV-infected persons...
  52. pmc Performance of a limiting-antigen avidity enzyme immunoassay for cross-sectional estimation of HIV incidence in the United States
    Jacob Konikoff
    Department of Biostatistics, School of Public Health, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e82772. 2013
    ..We evaluated the performance of the LAg-Avidity assay alone and in multi-assay algorithms (MAAs) that included other biomarkers...
  53. pmc Sexual risk trajectories among MSM in the United States: implications for pre-exposure prophylaxis delivery
    Heather A Pines
    Departments of Epidemiology Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA Departments of Family Medicine Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA Center for Clinical AIDS Research and Education, David Geffen School of Medicine, University of California, Los Angeles, CA David Ostrow and Associates, LLC Chicago, IL The Chicago MACS, Northwestern University, Evanston, IL Department of Behavioral and Community Health Sciences, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA and Department of Medicine, Georgetown University Medical Center, Washington, DC
    J Acquir Immune Defic Syndr 65:579-86. 2014
    ..To inform the development of targeted PrEP delivery guidelines, sexual risk trajectories among HIV-negative MSM were characterized...
  54. pmc Factors affecting the prevalence of strongly and weakly carcinogenic and lower-risk human papillomaviruses in anal specimens in a cohort of men who have sex with men (MSM)
    Dorothy J Wiley
    School of Nursing, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e79492. 2013
    ..HPVs rarely associated with malignancy are classified as lower-risk HPVs (lrHPVs)...
  55. pmc Association between U.S. state AIDS Drug Assistance Program (ADAP) features and HIV antiretroviral therapy initiation, 2001-2009
    David B Hanna
    Johns Hopkins University, Baltimore, Maryland, United States of America Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 8:e78952. 2013
    ..States differ regarding their financial contributions to and ways of implementing these programs, and it remains unclear how this interstate variability affects HIV treatment outcomes...
  56. pmc Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease
    Smita Kulkarni
    Cancer and Inflammation Program, Laboratory of Experimental Immunology and Basic Research Program, Center for Cancer Research Genetics Core, Science Applications International Corporation Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702
    Proc Natl Acad Sci U S A 110:20705-10. 2013
    ..These data illustrate a direct effect of HLA-C expression level on HIV control that cannot be attributed to other HLA loci in linkage disequilibrium with HLA-C and highlight the rich complexity of genetic interactions in human disease. ..
  57. pmc Long-term predictive value of the Framingham Risk Score for Stroke in HIV-positive vs HIV-negative men
    Farrah J Mateen
    From the Department of Neurology F J M, Massachusetts General Hospital, Boston Departments of International Health F J M, N S, and Epidemiology W S P, A G A, Bloomberg School of Public Health, and Department of Medicine, Division of Cardiology W S P, The Johns Hopkins University, Baltimore Department of Neurology N S, B R S, The Johns Hopkins Hospital, Baltimore, MD Departments of Neurology, Psychiatry, and Psychology J T B, University of Pittsburgh, PA Department of Epidemiology, School of Public Health R D, and Department of Medicine, School of Medicine R D, University of California, Los Angeles Department of Psychiatry E M, Rush University Medical Center, Chicago Feinberg School of Medicine J P P, Division of Infectious Diseases, Northwestern University, Chicago, IL and Department of Biostatistics and Epidemiology R T S, Perelman School of Medicine, University of Pennsylvania, Philadelphia
    Neurology 81:2094-102. 2013
    ..To test the predictive accuracy of the Framingham Risk Score for Stroke (FRS-S) in HIV-infected (HIV+) vs HIV-uninfected (HIV-) men...
  58. pmc HIV diversity as a biomarker for HIV incidence estimation: including a high-resolution melting diversity assay in a multiassay algorithm
    Matthew M Cousins
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Microbiol 52:115-21. 2014
    ..MAAs that include the HRM diversity assay can provide accurate HIV incidence estimates using stored blood plasma or serum samples without a requirement for CD4 cell count data. ..
  59. pmc Age, comorbidities, and AIDS predict a frailty phenotype in men who have sex with men
    Keri N Althoff
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Rm E7142, Baltimore, MD 21205
    J Gerontol A Biol Sci Med Sci 69:189-98. 2014
    ..The objective of this study was to evaluate the expression and predictors of the frailty phenotype (FP) among HIV-infected (HIV+) and HIV-uninfected (HIV-) men who have sex with men...
  60. pmc Increases in duration of first highly active antiretroviral therapy over time (1996-2009) and associated factors in the Multicenter AIDS Cohort Study
    Laurence Slama
    Tenon Hospital, Division of Infectious Diseases, Pierre and Marie Curie University, Paris, France Department of Epidemiology and Division of Endocrinology and Metabolism, John Hopkins University, Baltimore, MD School of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA L A Gay and Lesbian Center, Los Angeles, CA and Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL
    J Acquir Immune Defic Syndr 65:57-64. 2014
    ..Duration and type of initial highly active antiretroviral therapy (HAART) and factors associated with regimen switching were evaluated in the Multicenter AIDS Cohort Study...
  61. pmc Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1 infected individuals
    Suzanne Pickering
    Department of Infectious Disease, King s College School of Medicine, Guy s Hospital, London, United Kingdom
    PLoS Pathog 10:e1003895. 2014
    ..These data affirm the importance of Vpu functions for in vivo persistence of HIV-1 within infected individuals, not simply for transmission, and highlight its potential as a target for antiviral therapy. ..
  62. pmc Distinct assembly profiles of HLA-B molecules
    Syed Monem Rizvi
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109
    J Immunol 192:4967-76. 2014
    ..Together, these findings demonstrate significant variations in the assembly of HLA-B molecules and indicate influences of HLA-B-folding patterns upon infectious disease outcomes. ..
  63. pmc Late-emerging strains of HIV induce T-cell homeostasis failure by promoting bystander cell death and immune exhaustion in naïve CD4 and all CD8 T-cells
    Catherine N Kibirige
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States Electronic address
    Med Hypotheses 83:69-73. 2014
    ..These therapies could improve current anti-retroviral and cure-related treatments by boosting the immune system's own ability to combat the virus...
  64. pmc Serum microRNAs in HIV-infected individuals as pre-diagnosis biomarkers for AIDS-NHL
    Dharma R Thapa
    University of California, Los Angeles, AIDS Institute, Los Angeles, CA Departments of Obstetrics and Gynecology Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA Department of Epidemiology, University of California, Los Angeles, Fielding School of Public Health, Los Angeles, CA Departments of Epidemiology Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL and Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA
    J Acquir Immune Defic Syndr 66:229-37. 2014
    ..To determine if changes in levels of serum microRNAs (miRNAs) were seen preceding the diagnosis of AIDS-related non-Hodgkin lymphoma (AIDS-NHL)...
  65. pmc HIV therapy, metabolic and cardiovascular health are associated with glomerular hyperfiltration among men with and without HIV infection
    Derek K Ng
    aDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health bDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland cDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois dGraduate School of Public Health, Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania eLos Angeles Gay and Lesbian Center, Los Angeles, California fWelch Center for Prevention, Epidemiology and Clinical Research, Baltimore, Maryland gDepartment of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA
    AIDS 28:377-86. 2014
    ..In the Multicenter AIDS Cohort Study, we examined the extent to which hyperfiltration is present and associated with metabolic, cardiovascular, HIV and treatment risk factors among HIV-infected men...
  66. pmc Stuck in the middle: longitudinal HIV-related health disparities among men who have sex with men and women
    M Reuel Friedman
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA Center for LGBT Health Research, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA Department of Behavioral and Community Health Sciences, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA Department of Medical Social Sciences, Northwestern University, Chicago, IL Department of Family Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD and Department of Medicine, Georgetown University Medical Center, Washington, DC
    J Acquir Immune Defic Syndr 66:213-20. 2014
    ....
  67. pmc Risk factors for fatty liver in the Multicenter AIDS Cohort Study
    Jennifer C Price
    Division of Gastroenterology and Hepatology, Department of Medicine, University of California San Francisco, San Francisco, California, USA
    Am J Gastroenterol 109:695-704. 2014
    ..We determined the prevalence of and risk factors for fatty liver by comparing HIV-infected men with HIV-uninfected men who have sex with men in the Multicenter AIDS Cohort Study (MACS)...
  68. pmc LILRB2 interaction with HLA class I correlates with control of HIV-1 infection
    Arman A Bashirova
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America
    PLoS Genet 10:e1004196. 2014
    ..Thus, we propose an impact of LILRB2 on HIV-1 disease outcomes through altered regulation of DCs by LILRB2-HLA engagement...
  69. pmc Factors affecting glomerular filtration rate, as measured by iohexol disappearance, in men with or at risk for HIV infection
    Joseph B Margolick
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 9:e86311. 2014
    ....
  70. doi Cause-specific mortality among HIV-infected individuals, by CD4(+) cell count at HAART initiation, compared with HIV-uninfected individuals
    Nikolas Wada
    aDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland bDepartment of Medicine, Stroger Hospital of Cook County and Rush University cFeinberg School of Medicine, Division of Infectious Diseases, Northwestern University, Chicago, Illinois, USA
    AIDS 28:257-65. 2014
    ..To compare the proportion, timing and hazards of non-AIDS death and AIDS death among men and women who initiated HAART at different CD4 cell counts to mortality risks of HIV-uninfected persons with similar risk factors...
  71. pmc Cochlear function among HIV-seropositive and HIV-seronegative men and women
    Peter Torre
    1School of Speech, Language, and Hearing Sciences, San Diego State University, San Diego, CA 2Epidemiology and Statistics Program, National Institute on Deafness and Other Communication Disorders NIDCD, National Institutes of Health NIH, Bethesda, MD 3Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 4Department of Medicine, Division of Infectious Diseases, Georgetown University Medical Center, WA, District of Columbia and 5Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD
    Ear Hear 35:56-62. 2014
    ..The aim of the present study was to collect measures of cochlear function in a large sample of adults with, or at risk for, HIV infection, to evaluate associations between HIV status, HIV treatment, and cochlear function...
  72. pmc Incident hepatitis C virus infection in men who have sex with men: a prospective cohort analysis, 1984-2011
    Mallory D Witt
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Clin Infect Dis 57:77-84. 2013
    ..Prospective characterization of hepatitis C virus (HCV) transmission in both human immunodeficiency virus (HIV)-infected and -uninfected men who have sex with men (MSM) over the entire HIV epidemic has not been comprehensively conducted...
  73. pmc Contribution of genetic background, traditional risk factors, and HIV-related factors to coronary artery disease events in HIV-positive persons
    Margalida Rotger
    Institute of Microbiology, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    Clin Infect Dis 57:112-21. 2013
    ..The relative contribution of genetic background, HIV-related factors, antiretroviral medications, and traditional risk factors to CAD has not been fully evaluated in the setting of HIV infection...
  74. pmc Comparison of the respiratory microbiome in healthy nonsmokers and smokers
    Alison Morris
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Respir Crit Care Med 187:1067-75. 2013
    ..Results from 16S rDNA-encoding gene sequence-based, culture-independent techniques have led to conflicting conclusions about the composition of the lower respiratory tract microbiome...
  75. pmc The interaction between smoking status and highly active antiretroviral therapy (HAART) use on the risk of Kaposi's sarcoma (KS) in a cohort of HIV-infected men
    H N Luu
    Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Br J Cancer 108:1173-7. 2013
    ..We examined whether there is an interaction between smoking status and HAART use on the risk of KS development in an on-going US cohort of HIV-infected men...
  76. pmc Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts
    Priya Duggal
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Intern Med 158:235-45. 2013
    ..Chinese translation..
  77. pmc Value of a quality assessment program in optimizing cryopreservation of peripheral blood mononuclear cells in a multicenter study
    Najib Aziz
    David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Clin Vaccine Immunol 20:590-5. 2013
    ..Ongoing quality assessment helps laboratories improve protocols and performance on a real-time basis to ensure optimal cryopreservation of PBMC for future studies...
  78. pmc Widespread colonization of the lung by Tropheryma whipplei in HIV infection
    Catherine Lozupone
    Department of Chemistry and Biochemistry and Biofrontiers Institute, University of Colorado, Boulder, CO, USA
    Am J Respir Crit Care Med 187:1110-7. 2013
    ..It is unknown whether HIV infection leads to changes in basal lung microflora, which may contribute to chronic pulmonary complications that increasingly are being recognized in individuals infected with HIV...
  79. pmc Use of cardiac CT angiography imaging in an epidemiology study - the Methodology of the Multicenter AIDS Cohort Study cardiovascular disease substudy
    Yalcin Hacioglu
    Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA
    Anadolu Kardiyol Derg 13:207-14. 2013
    ..In order to present a reference for future studies, we present CTA methodology that is being used in an epidemiology study- the Multicenter AIDS Cohort Study (MACS)...
  80. pmc A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A
    Jerome Lane
    School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Hum Mol Genet 22:1903-10. 2013
    ....
  81. pmc HAART-associated dyslipidemia varies by biogeographical ancestry in the multicenter AIDS cohort study
    Matthew J Nicholaou
    Graduate School of Public Health, Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    AIDS Res Hum Retroviruses 29:871-9. 2013
    ..BGA performed better in our statistical analysis as a racial classifier but SRR remains a good clinical surrogate for BGA...
  82. pmc Lipodystrophy and inflammation predict later grip strength in HIV-infected men: the MACS Body Composition substudy
    Keith W Crawford
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    AIDS Res Hum Retroviruses 29:1138-45. 2013
    ..Inflammation, lower LBM, and lipodystrophy in HIV-infected men were associated with lower subsequent grip strength. These findings suggest that inflammation may contribute to declines in functional performance, independent of age...
  83. pmc The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts
    Matthew R Gingo
    Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 8:e58812. 2013
    ..To review the incidence of respiratory conditions and their effect on mortality in HIV-infected and uninfected individuals prior to and during the era of highly active antiretroviral therapy (HAART)...
  84. pmc Influence of HLA-C expression level on HIV control
    Richard Apps
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, Science Applications International Corporation Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Science 340:87-91. 2013
    ..In contrast, high HLA-C expression had a deleterious effect in Crohn's disease, suggesting a broader influence of HLA expression levels in human disease...
  85. pmc Acute HIV-1 seroconversion with an unusual plasma biomarker profile
    Najib Aziz
    Department of Epidemiology, Fielding School of Public Health, University of California in Los Angeles, Los Angeles, California, USA
    Clin Vaccine Immunol 20:1774-7. 2013
    ..Numerous serum cytokine concentrations were elevated during HIV-1 seroconversion. ..
  86. pmc Fc gamma receptor 3A polymorphism and risk for HIV-associated cryptococcal disease
    Soma Rohatgi
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA
    MBio 4:e00573-13. 2013
    ..neoformans pathogenesis via increased binding of C. neoformans immune complexes, resulting in increased phagocyte cargo and/or immune activation...
  87. pmc Comparison of antibodies that mediate HIV type 1 gp120 antibody-dependent cell-mediated cytotoxicity in asymptomatic HIV type 1-positive men and women
    Mariana M Mata
    1 Department of Immunology and Microbiology, Rush University Medical Center, Chicago, Illinois
    AIDS Res Hum Retroviruses 30:50-7. 2014
    ..Both sexes had significant cross-clade reactivity. Differences between men and women may become evident as disease progresses; this should be evaluated at later stages of HIV-1 infection...
  88. pmc Uptake and predictors of anal cancer screening in men who have sex with men
    Gypsyamber D'Souza
    Johns Hopkins Bloomberg School of Public Health Department of Epidemiology, Baltimore, MD 21205, USA
    Am J Public Health 103:e88-95. 2013
    ..We investigated attitudes about and acceptance of anal Papanicolaou (Pap) screening among men who have sex with men (MSM)...
  89. pmc A candidate gene approach for virally induced cancer with application to HIV-related Kaposi's sarcoma
    Brahim Aissani
    Department of Epidemiology, University of Alabama, Birmingham, AL
    Int J Cancer 134:397-404. 2014
    ..This "proof of concept" study identified human homologs involved in the regulation of type I interferon-induced signaling, cell cycle and apoptosis potentially as important determinants of HIV-KS...
  90. pmc Antiretroviral therapy-induced changes in plasma lipids and the risk of kidney dysfunction in HIV-infected men
    Alison G Abraham
    1 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
    AIDS Res Hum Retroviruses 29:1346-52. 2013
    ..Should these results be generalizable to the broader HIV population, monitoring cholesterol changes following the initiation of ART may be important in identifying HIV-infected persons at risk for kidney disease...
  91. pmc Joint effects of alcohol consumption and high-risk sexual behavior on HIV seroconversion among men who have sex with men
    Petra M Sander
    Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA
    AIDS 27:815-23. 2013
    ..To estimate the effects of alcohol consumption and number of unprotected receptive anal intercourse partners on HIV seroconversion while appropriately accounting for time-varying confounding...
  92. pmc Accelerated aging in HIV/AIDS: novel biomarkers of senescent human CD8+ T cells
    Jennifer P Chou
    Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e64702. 2013
    ..The identification and future validation of these new biomarkers may lead to fresh immune-based HIV treatments...
  93. pmc Online health-searching behavior among HIV-seropositive and HIV-seronegative men who have sex with men in the Baltimore and Washington, DC area
    Ying Li
    Division of Infectious Diseases, Department of Medicine, Georgetown University Medical Center, Washington, DC 20007, USA
    J Med Internet Res 15:e78. 2013
    ..However, there have been few studies to investigate the online health-searching behaviors among men who have sex with men (MSM) with human immunodeficiency virus (HIV)...
  94. pmc Structure of tumor necrosis factor-alpha haploblocks in European populations
    Aimee M Merino
    Department of Medicine, University of Alabama, Birmingham, AL, USA
    Immunogenetics 65:543-52. 2013
    ..We also found that the ancestral haplotype 8.1 shares a TNF block haplotype with HLA-B*4402. HLA-B*5701, a known protective allele in HIV-1 pathogenesis, occurred in a unique TNF block haplotype...
  95. pmc Trends and disparities in antiretroviral therapy initiation and virologic suppression among newly treatment-eligible HIV-infected individuals in North America, 2001-2009
    David B Hanna
    Johns Hopkins University, Baltimore, Maryland, USA
    Clin Infect Dis 56:1174-82. 2013
    ..We sought to examine trends in treatment initiation and resulting human immunodeficiency virus (HIV) virologic suppression in North America between 2001 and 2009, and demographic and geographic disparities in these outcomes...
  96. pmc Survival attributable to an exposure
    Christopher Cox
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Stat Med 28:3276-93. 2009
    ..We apply these methods to assess the effect of introducing highly active antiretroviral therapy for the treatment of clinical AIDS at the population level...