ENVIRONMENTAL AND MOLECULAR EPIDEMIOLOGY TRAINING GRANT

Summary

Principal Investigator: Harvey Checkoway
Abstract: DESCRIPTION (Provided by Applicant) This application is for a renewal of training grant: "Environmental and Molecular Epidemiology" that originally was established in 1990. There remains a nation-wide need for trained epidemiologists to address the increasingly complex challenges of elucidating the etiologies of environmentally-related diseases. Especially noteworthy challenges include determination of health hazards associated with low-level toxicant exposures and characterization of gene/environment interactions to identify, susceptible subgroups in the population. The goal of the training grant is to provide training to pre- and postdoctoral epidemiologists in the methods and substantive knowledge characteristic of environmental epidemiology and the related environmental sciences of toxicology, molecular genetics, and environmental exposure assessment. The ultimate objective of the training program is to prepare health professionals to function effectively in research and teaching careers. The Environmental and Molecular Epidemiology Training Grant is comprised of two tracks: 1) a general environmental epidemiology track and 2) a molecular epidemiology track. The investigators are seeking support for 4 pre- and 1 postdoctoral trainees on the general environmental epidemiology track, and for 3 pre- and 1 postdoctoral trainees on the molecular epidemiology track. A new feature will be a postdoctoral traineeship on the general track that will support a fellow in the Occupational and Environmental Medicine Program in the Department of Environmental Health. Pre-doctoral trainees will pursue doctorate (Ph.D.) degree, in epidemiology; the period of support will range from 2-5 years. Postdoctoral trainees will be eligible, but not required to seek, MS or MPH degrees in epidemiology or environmental health, toxicology option. The exception will be the occupational and environmental medicine fellow who will be required to complete the MPH degree in environmental health. Postdoctoral support will be for 2-3 years. The common feature of the training for all trainees will be a focus on environmental determinants of disease, with programs of course work and research experience tailored to fit trainees' backgrounds and specific interests. The molecular epidemiology track will emphasize the application of molecular and biochemical toxicology methods to epidemiologic research. The postdoctoral molecular epidemiology trainee will be required to have a prior doctorate in toxicology, biochemistry, molecular biology, or a related discipline. In addition to resources available in the Departments of Epidemiology and Environmental Health, significant research opportunities are provided by the NIEHS-funded Center for Ecogenetics and Environmental Health, the Fred Hutchinson Cancer Research Center, the NIEHS-funded Center for Child Environmental Health, the UW Superfund Basic Research Program Project, the UW/EPA Northwest Center for Particulate Matter Air Pollution Research, and the NIOSH-sponsored Agricultural safety and Health Center. Numerous training grant faculty either direct or are directly affiliated with one or more of these research centers. During the first 10 years of support, trainees have been successful in obtaining, appropriate classroom and research experience, including securing extramural research funding. This training grant will continue to enhance trainees' credentials necessary for productive research and teaching careers in environmental epidemiology.
Funding Period: 1990-07-01 - 2007-06-30
more information: NIH RePORT

Top Publications

  1. pmc Parental smoking and risk of childhood brain tumors by functional polymorphisms in polycyclic aromatic hydrocarbon metabolism genes
    Jessica L Barrington-Trimis
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California, United States of America
    PLoS ONE 8:e79110. 2013
  2. pmc Biomarkers of sensitivity and exposure in Washington state pesticide handlers
    Jonathan N Hofmann
    Division of Cancer Epidemilogy and Genetics, National Cancer Institute, Bethesda, MD, USA
    Adv Exp Med Biol 660:19-27. 2010
  3. ncbi Lung cancer risk among female textile workers exposed to endotoxin
    George Astrakianakis
    Departments of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    J Natl Cancer Inst 99:357-64. 2007
  4. pmc Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma
    Laura S Gold
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Epidemiol 33:276-80. 2009
  5. pmc Proximity to traffic, inflammation, and immune function among women in the Seattle, Washington, area
    Lori A Williams
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98109 1024, USA
    Environ Health Perspect 117:373-8. 2009
  6. pmc Dust and chemical exposures, and miscarriage risk among women textile workers in Shanghai, China
    E Y Wong
    Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195 7234, USA
    Occup Environ Med 66:161-8. 2009
  7. pmc Serum organochlorine pesticide residues and risk of testicular germ cell carcinoma: a population-based case-control study
    Mary L Biggs
    Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Box 354922, Seattle, WA 98195 4922, USA
    Cancer Epidemiol Biomarkers Prev 17:2012-8. 2008
  8. pmc A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio
    Irva Hertz-Picciotto
    Department of Public Health Sciences, School of Medicine, TB 168, University of California Davis, Davis, CA 95616, USA
    Environ Health 7:37. 2008
  9. pmc Occupational risk factors for endometrial cancer among textile workers in Shanghai, China
    Karen J Wernli
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington 9810, USA
    Am J Ind Med 51:673-9. 2008
  10. pmc Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers
    Jonathan N Hofmann
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Environ Health Perspect 117:1402-8. 2009

Scientific Experts

Detail Information

Publications39

  1. pmc Parental smoking and risk of childhood brain tumors by functional polymorphisms in polycyclic aromatic hydrocarbon metabolism genes
    Jessica L Barrington-Trimis
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California, United States of America
    PLoS ONE 8:e79110. 2013
    ....
  2. pmc Biomarkers of sensitivity and exposure in Washington state pesticide handlers
    Jonathan N Hofmann
    Division of Cancer Epidemilogy and Genetics, National Cancer Institute, Bethesda, MD, USA
    Adv Exp Med Biol 660:19-27. 2010
    ..Recent work assessing newer and more sensitive biomarkers of OP exposure is also discussed briefly in this chapter...
  3. ncbi Lung cancer risk among female textile workers exposed to endotoxin
    George Astrakianakis
    Departments of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    J Natl Cancer Inst 99:357-64. 2007
    ..We examine the association between endotoxin exposure and lung cancer risk in a cohort of female textile workers...
  4. pmc Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma
    Laura S Gold
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Epidemiol 33:276-80. 2009
    ....
  5. pmc Proximity to traffic, inflammation, and immune function among women in the Seattle, Washington, area
    Lori A Williams
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98109 1024, USA
    Environ Health Perspect 117:373-8. 2009
    ..Traffic-related air pollution has been associated with adverse health outcomes, and the immune system may be a biologic mediator of health effects...
  6. pmc Dust and chemical exposures, and miscarriage risk among women textile workers in Shanghai, China
    E Y Wong
    Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195 7234, USA
    Occup Environ Med 66:161-8. 2009
    ..To investigate possible associations between miscarriage and occupational exposures in the Shanghai textile industry...
  7. pmc Serum organochlorine pesticide residues and risk of testicular germ cell carcinoma: a population-based case-control study
    Mary L Biggs
    Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Box 354922, Seattle, WA 98195 4922, USA
    Cancer Epidemiol Biomarkers Prev 17:2012-8. 2008
    ..Due to uncertainty regarding how well organochlorine levels measured in adulthood reflect exposures during early life, further research is needed using exposure measurements collected in utero or during infancy...
  8. pmc A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio
    Irva Hertz-Picciotto
    Department of Public Health Sciences, School of Medicine, TB 168, University of California Davis, Davis, CA 95616, USA
    Environ Health 7:37. 2008
    ..PCBs are related to a class of compounds known as dioxins, specifically 2,3,7,8-TCDD (tetrachloro-dibenzodioxin), which has been implicated as a cause of altered sex ratio, especially in relation to paternal exposures...
  9. pmc Occupational risk factors for endometrial cancer among textile workers in Shanghai, China
    Karen J Wernli
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington 9810, USA
    Am J Ind Med 51:673-9. 2008
    ..A case-cohort study was conducted to investigate associations between occupational exposures and endometrial cancer nested within a large cohort of textile workers in Shanghai, China...
  10. pmc Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers
    Jonathan N Hofmann
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Environ Health Perspect 117:1402-8. 2009
    ..However, few human studies have investigated associations between PON1 status and intermediate end points, such as serum cholinesterase [butyrylcholinesterase (BuChE)] inhibition, among OP-exposed individuals...
  11. pmc Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State
    Jonathan N Hofmann
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Occup Environ Med 67:375-86. 2010
    ..To identify potential risk factors for serum cholinesterase (BuChE) inhibition among agricultural pesticide handlers exposed to organophosphate (OP) and N-methyl-carbamate (CB) insecticides...
  12. pmc Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Environ Health Perspect 118:144-9. 2010
    ..Insecticides that target the nervous system may play a role in the development of childhood brain tumors (CBTs). Constitutive genetic variation affects metabolism of these chemicals...
  13. pmc Physical activity, physical exertion, and miscarriage risk in women textile workers in Shanghai, China
    Eva Y Wong
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Am J Ind Med 53:497-505. 2010
    ..Strenuous occupational physical activity and physical demands may be risk factors for adverse reproductive outcomes...
  14. pmc A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age
    Todd A Jusko
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 2233, USA
    Environ Res 110:388-95. 2010
    ..Whether developmental PCB exposure influences immunologic development in humans has received little study...
  15. pmc Development of a computer-based survey instrument for organophosphate and N-methyl-carbamate exposure assessment among agricultural pesticide handlers
    Jonathan N Hofmann
    Department of Epidemiology, University of Washington, Seattle, 98195 7236, USA
    Ann Occup Hyg 54:640-50. 2010
    ....
  16. pmc Lung cancer and occupational exposures other than cotton dust and endotoxin among women textile workers in Shanghai, China
    H Checkoway
    Department of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle, WA 98195 7234, USA
    Occup Environ Med 68:425-9. 2011
    ....
  17. pmc Maternal and early postnatal polychlorinated biphenyl exposure in relation to total serum immunoglobulin concentrations in 6-month-old infants
    Todd A Jusko
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709 2233, USA
    J Immunotoxicol 8:95-100. 2011
    ....
  18. ncbi Fine particulate matter (PM₂.₅) air pollution and immune status among women in the Seattle area
    Lori Williams
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA
    Arch Environ Occup Health 66:155-65. 2011
    ..If additional studies confirm our findings, then future health effect assessments for PM₂.₅ should consider changes in cellular immunity as an endpoint that may lead to overt clinical disease...
  19. pmc Childhood brain tumors and maternal cured meat consumption in pregnancy: differential effect by glutathione S-transferases
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, PO Box 19024, 1100 Fairview Avenue North, MS M4 C308, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 20:2413-9. 2011
    ..We explored whether this possible association was modified by fetal genetic polymorphisms in genes coding for glutathione S-transferases (GSTs) that may inactivate nitroso compounds...
  20. pmc Blood lead concentrations < 10 microg/dL and child intelligence at 6 years of age
    Todd A Jusko
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    Environ Health Perspect 116:243-8. 2008
    ..Few studies provide data directly relevant to the question of whether blood lead concentrations < 10 microg/dL adversely affect children's cognitive function...
  21. ncbi Family cancer history and risk of brain tumors in children: results of the SEARCH international brain tumor study
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Causes Control 19:641-8. 2008
    ..To examine whether childhood brain tumors (CBTs) are associated with a family history of brain tumors or other cancers in an international case-control study...
  22. pmc Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1)
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Environ Health Perspect 113:909-13. 2005
    ..Larger studies that measure plasma PON1 levels and incorporate more accurate estimates of pesticide exposure will be required to confirm these observations...
  23. ncbi Factors associated with objective (actigraphic) and subjective sleep quality in young adult women
    Shelley S Tworoger
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Psychosom Res 59:11-9. 2005
    ..The aim of this study was to describe factors associated with actigraphic and subjective sleep quality in young women...
  24. ncbi Soy protein containing isoflavones does not decrease colorectal epithelial cell proliferation in a randomized controlled trial
    Kenneth F Adams
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Clin Nutr 82:620-6. 2005
    ..Colorectal epithelial cell proliferation has been used extensively as an intermediate endpoint biomarker for colorectal neoplasia...
  25. ncbi Reproductive history, occupational exposures, and thyroid cancer risk among women textile workers in Shanghai, China
    E Y Wong
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    Int Arch Occup Environ Health 79:251-8. 2006
    ..We conducted a case-cohort study nested in a cohort of 267,400 female textile workers in Shanghai, China, who had been followed for cancer incidence during 1989-1998...
  26. ncbi Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett's oesophagus: a prospective study
    Thomas L Vaughan
    Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, Seattle, WA 98109, USA
    Lancet Oncol 6:945-52. 2005
    ..We aimed to assess the role of NSAID in the development of oesophageal adenocarcinoma and precursor lesions in people with Barrett's oesophagus--a metaplastic disorder that confers a high risk of oesophageal adenocarcinoma...
  27. ncbi Nonsteroidal anti-inflammatory drugs and risk of Parkinson's disease
    Thanh G Ton
    Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA
    Mov Disord 21:964-9. 2006
    ..Our results provide only limited support for the hypothesis that use of aspirin may reduce the risk of this disease, and no indication of protection from other NSAIDs...
  28. ncbi Brain tumors and occupational exposures in a cohort of female textile workers in Shanghai, China
    Laura S Gold
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N PO Box 19024 Seattle, WA 98109, USA
    Scand J Work Environ Health 32:178-84. 2006
    ..This study assessed the associations between brain tumors and specific processes and exposures among female textile workers in Shanghai, China...
  29. pmc Maternal DDT exposures in relation to fetal and 5-year growth
    Todd A Jusko
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Epidemiology 17:692-700. 2006
    ..Furthermore, only a portion of these studies have investigated in utero exposures and growth during childhood...
  30. pmc Calcium channel blockers and beta-blockers in relation to Parkinson's disease
    Thanh G N Ton
    Department of Epidemiology, University of Washington, Box 357236, Seattle, WA 98195 7326, USA
    Parkinsonism Relat Disord 13:165-9. 2007
    ..The weakness of these associations and the absence of additional influence of dose or duration of use argue against any causal interpretation...
  31. pmc Response to: "What is the meaning of non-linear dose-response relationships between blood lead concentrations and IQ?"
    Todd A Jusko
    Neurotoxicology 27:1123-5. 2006
  32. pmc Response to comments on "What is the meaning of non-linear dose-response relationships between blood lead concentration and IQ?"
    Teresa S Bowers
    Gradient Corporation, 20 University Road, Cambridge, MA 02138, United States
    Neurotoxicology 27:1123. 2006
  33. ncbi Long-term exposure to air pollution and incidence of cardiovascular events in women
    Kristin A Miller
    Department of Epidemiology, University of Washington, Seattle, USA
    N Engl J Med 356:447-58. 2007
    ..We examined the association of long-term exposure to particulate matter of less than 2.5 microm in aerodynamic diameter (PM2.5) with cardiovascular events...
  34. ncbi Cholecystokinin C-45T polymorphism and smoking cessation in women
    Thanh G Ton
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, WA 98109 1024, USA
    Nicotine Tob Res 9:147-51. 2007
    ..Our results fail to support prior evidence of an association of the CCK C-45T polymorphism with the ability to quit smoking...
  35. ncbi Systemic autoimmune disease mortality and occupational exposures
    L S Gold
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Arthritis Rheum 56:3189-201. 2007
    ..To generate hypotheses regarding occupational exposures that may cause systemic autoimmune diseases...
  36. pmc Newborn screening archives as a specimen source for epidemiologic studies: feasibility and potential for bias
    Susan Searles Nielsen
    Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109 1024, USA
    Ann Epidemiol 18:58-64. 2008
    ..To evaluate the feasibility of obtaining dried blood spots (DBS) from newborn screening archives for subjects in epidemiologic studies and using these specimens for genotyping, and to evaluate the potential for bias in their use...
  37. ncbi Environmental risk factors of disease in the Cameron Park Colonia, a Hispanic community along the Texas-Mexico border
    Irma N Ramos
    School of Public Health and Information Sciences, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    J Immigr Minor Health 10:345-51. 2008
    ....
  38. ncbi Baby care products: possible sources of infant phthalate exposure
    Sheela Sathyanarayana
    Department of Occupational and Environmental Health Sciences, Division of General Pediatrics, Child Health Institute, University of Washington, Building 296200, NE 74th St, Seattle, WA 98115 8160, USA
    Pediatrics 121:e260-8. 2008
    ..We investigated the relationship between phthalate metabolite concentrations in infant urine and maternal reported use of dermally applied infant care products...
  39. ncbi Production of interleukin 10 and transforming growth factor beta in concomitant allergy and autoimmunity
    Sanders K Chai
    Department of Occupational and Environmental Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98195 7234, USA
    Ann Allergy Asthma Immunol 94:279-85. 2005
    ..The regulatory cytokine production capacity of individuals with concomitant allergy and T(H)1-type autoimmunity may provide insight into the role of T-cell regulation in both disorders...