PHARMACOLOGY & NEUROSCIENCE TRAINING IN DRUG ABUSE

Summary

Principal Investigator: STANLEY GLICK
Affiliation: Albany Medical College
Country: USA
Abstract: Continuation of the currently funded predoctoral and postdoctoral training program in the pharmacology and neuroscience of drug abuse is proposed. This five-year program will consist of funding for 3 predoctoral and 3 postdoctoral trainees per year. The program has already completed training 2 predoctoral students, and two are currently supported by this grant. Four postdoctoral trainees have been supported by this grant so far; one received an individual NRSA after one year of training, one completed the planned two years of training, and two are currently in training. Faculty participation is comprised of a) 15 training faculty who serve as mentors and who are either currently funded by NIDA or whose research programs can provide training relevant to drug abuse issues, and b) 5 resource faculty who contribute to the program via teaching and laboratory training. Approximately 27,500 square feet of laboratory space, a wide array of state-of-the art chemical, physiological and behavioral testing equipment, and approximately $3.5 million (direct) of federally sponsored research funds are designated annually for the research of the training faculty. The program for predoctoral trainees consists of a comprehensive neuropharmacology/neuroscience didactic curriculum which includes a course on the biology of addiction as well as related topics (e.g., effects of prenatal drug exposure, treatment of addiction) integrated into broader-based courses. Predoctoral trainees must complete research projects in three laboratories prior to choosing a mentor and developing a thesis project. Both predoctoral and postdoctoral trainees are required to attend an annual seminar program consisting of presentations by 20 invited speakers and all trainees must present a one hour research seminar annually as well. All trainees also are required to participate in a journal club course designed to teach them how to present effectively written research for publication and how to critique published literature. Training in ethical conduct of research is required of all trainees. The current and proposed program provides a multifaceted approach to understanding mechanisms of drug abuse and treatment through an integrated program of didactic work and an outstanding in-depth research experience. It is designed to train participants to become independent, ethical and skilled scientists able to make significant contributions in drug abuse research. Predoctoral training is expected to last 4-5 years; postdoctoral training duration is 2-3 years. All aspects of the program are administered by the director and an executive committee of administrative and training faculty.
Funding Period: 1999-09-30 - 2009-06-30
more information: NIH RePORT

Top Publications

  1. pmc 18-Methoxycoronaridine blocks context-induced reinstatement following cocaine self-administration in rats
    J E Polston
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Pharmacol Biochem Behav 103:83-94. 2012
  2. pmc Keratinocyte expression of calcitonin gene-related peptide β: implications for neuropathic and inflammatory pain mechanisms
    Quanzhi Hou
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Pain 152:2036-51. 2011
  3. pmc Music-induced context preference following cocaine conditioning in rats
    J E Polston
    Center for Neuropharmacology and Neuroscience, Albany Medical College, 43 New Scotland Avenue, Albany, NY 12208, USA
    Behav Neurosci 125:674-80. 2011
  4. pmc Music and methamphetamine: conditioned cue-induced increases in locomotor activity and dopamine release in rats
    J E Polston
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Pharmacol Biochem Behav 98:54-61. 2011
  5. pmc Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling
    Erzsebet Kokovay
    New York Neural Stem Cell Institute, Rensselaer, NY 12144, USA
    Cell Stem Cell 7:163-73. 2010
  6. pmc Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain
    Christopher A Fasano
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208 USA
    Genes Dev 23:561-74. 2009
  7. pmc Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions
    Qin Shen
    New York Neural Stem Cell Institute, Rensselaer, NY 12144, USA
    Cell Stem Cell 3:289-300. 2008
  8. pmc Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases
    Timothy J Harrigan
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurochem 106:2449-62. 2008
  9. pmc High-affinity binding of [3H]cimetidine to a heme-containing protein in rat brain
    Rebecca Stadel
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Ave, Albany, NY 12208, USA
    Drug Metab Dispos 36:614-21. 2008
  10. pmc Activation of peripheral and spinal histamine H3 receptors inhibits formalin-induced inflammation and nociception, respectively
    Keri E Cannon
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12206, USA
    Pharmacol Biochem Behav 88:122-9. 2007

Scientific Experts

  • J E Polston
  • LINDSAY HOUGH
  • Christopher A Fasano
  • Keri E Cannon
  • Erzsebet Kokovay
  • Qin Shen
  • Quanzhi Hou
  • Sally Temple
  • Badrinath Roysam
  • Yue Wang
  • Gang Lin
  • Timothy J Harrigan
  • Rebecca Stadel
  • ROBERT LAVKER
  • Lucy Gee
  • Sridar Chittur
  • Dennis Fiorino
  • Spiro Getsios
  • Elisa Borsani
  • Trisha Burdo
  • Phillip Albrecht
  • John Kessler
  • Frank Rice
  • Travis Barr
  • James Wymer
  • Udayan Guha
  • Jeff Vickers
  • Luigi Rodella
  • Elan Eisenberg
  • Susan Goderie
  • Steve Lotz
  • Yu Sun
  • Julia W Nalwalk
  • Susan K Goderie
  • Shu Mien Chuang
  • DAVID JOURD'HEUIL
  • Jun Yang
  • Alexander A Mongin
  • Iskandar F Abdullaev
  • James G Phillips
  • Frank L Rice
  • Rob Leurs
  • Paul L Chazot
  • Fiona Shenton
  • Victoria Hann

Detail Information

Publications12

  1. pmc 18-Methoxycoronaridine blocks context-induced reinstatement following cocaine self-administration in rats
    J E Polston
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Pharmacol Biochem Behav 103:83-94. 2012
    ..The fact that 18-MC blocked cue-induced reinstatement suggests that α3β4 nicotinic receptors may be involved in the mechanism of craving, and that 18-MC may help prevent relapse to drug addiction in humans...
  2. pmc Keratinocyte expression of calcitonin gene-related peptide β: implications for neuropathic and inflammatory pain mechanisms
    Quanzhi Hou
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Pain 152:2036-51. 2011
    ..Our results indicate that keratinocyte-derived CGRPβ may modulate epidermal homeostasis through autocrine/paracrine signaling and may contribute to chronic pain under pathological conditions...
  3. pmc Music-induced context preference following cocaine conditioning in rats
    J E Polston
    Center for Neuropharmacology and Neuroscience, Albany Medical College, 43 New Scotland Avenue, Albany, NY 12208, USA
    Behav Neurosci 125:674-80. 2011
    ....
  4. pmc Music and methamphetamine: conditioned cue-induced increases in locomotor activity and dopamine release in rats
    J E Polston
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Pharmacol Biochem Behav 98:54-61. 2011
    ..These findings support other evidence showing the importance of these brain regions in conditioned learning paradigms, and demonstrate that music is an effective conditioned stimulus warranting further investigation...
  5. pmc Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling
    Erzsebet Kokovay
    New York Neural Stem Cell Institute, Rensselaer, NY 12144, USA
    Cell Stem Cell 7:163-73. 2010
    ..SDF1 increases the motility of type A neuroblasts, which migrate from the SVZ toward the olfactory bulb. Thus, differential responses to SDF1 can regulate progenitor cell occupancy of and exit from the adult SVZ vascular niche...
  6. pmc Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain
    Christopher A Fasano
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208 USA
    Genes Dev 23:561-74. 2009
    ....
  7. pmc Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions
    Qin Shen
    New York Neural Stem Cell Institute, Rensselaer, NY 12144, USA
    Cell Stem Cell 3:289-300. 2008
    ....
  8. pmc Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases
    Timothy J Harrigan
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurochem 106:2449-62. 2008
    ..Taken together, these data suggest that the anion channel VRAC may contribute to microglial glutamate release and that its activity is regulated by endogenous ROS originating from NOX4...
  9. pmc High-affinity binding of [3H]cimetidine to a heme-containing protein in rat brain
    Rebecca Stadel
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Ave, Albany, NY 12208, USA
    Drug Metab Dispos 36:614-21. 2008
    ..Finally, CC12 is a new, potent inhibitor of CYP2B6 and CYP2C19 that may be a valuable tool for P450 research...
  10. pmc Activation of peripheral and spinal histamine H3 receptors inhibits formalin-induced inflammation and nociception, respectively
    Keri E Cannon
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12206, USA
    Pharmacol Biochem Behav 88:122-9. 2007
    ..Pharmacological stimulation of H3 receptors could be an important therapeutic approach for many disorders related to deep dermal or inflammatory pain...
  11. pmc CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist
    Lindsay B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Neuropharmacology 52:1244-55. 2007
    ..Elucidation of this mechanism will enhance understanding of the biochemistry of pain relief...
  12. pmc Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: potential antinociceptive targets
    Keri E Cannon
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12208, USA
    Pain 129:76-92. 2007
    ..Taken with recently published behavioral results, the present findings suggest that periarterial, peptidergic, H3R-containing A delta fibers may be sources of high threshold mechanical nociception...