Molecular Epidemiology and Gene-Environment Interaction

Summary

Principal Investigator: Zuo Feng Zhang
Affiliation: University of California
Country: USA
Abstract: This planning grant of molecular epidemiology presents a multidisciplinary approach to an important aspect of molecular epidemiology: gene-environment interaction. Crosstalk among the multidisciplinary team and collaborations to integrate novel technologies and/or methodologies into epidemiologic research are planned. The investigators will explore air pollution-related genetic susceptibility and instability for future population studies of gene-environment interactions on the risk of airborne pollutant-related diseases such as asthma, chronic obstructive pulmonary disease (COPD), and airway cancers. They will develop microarray gene chips to measure the genetic susceptibility (genotypes) and instability as measured by gene expression, and explore new statistical methodology to deal with exposure, genetic susceptibility, gene expression and related illnesses. The specific aims of the project are: Aim 1. To establish a multidisciplinary team and to increase crosstalk in order to foster collaborations to integrate novel technologies and methodologies into molecular epidemiology; and Aim 2. To conduct 3 pilot studies to identify allelic variants (polymorphisms) of environmental disease susceptibility genes; to examine air pollution-related global gene expressions; and to explore the related statistical methodology to analyze data with exposures, genotypes and gene expression matrix in order to foster future population-based molecular epidemiological studies of gene-environment interaction in determining the risk of environmentallyinduced diseases. The planned University of California at Los Angeles (UCLA) Molecular Epidemiology Project in Environmental Genome Projects builds upon existing resources and researches of the Southern California Particle Center and Supersite (SCPCS) and the UCLA Center for Occupational and Environmental Health (COEH). It takes advantage of the wide range of expertise and skill in epidemiology, molecular biology, environmental health sciences, toxicology, occupational medicine, and biostatistics/bioinformatics. The planning grant will address critical research questions in a broad-based effort to understand the mechanism of air pollution and its related susceptibility genotypes and gene expressions, to explore gene-environmental interactions, and to develop more effective methods for the identification of high risk individuals for prevention of air pollution-related diseases.
Funding Period: 2002-08-01 - 2007-03-31
more information: NIH RePORT

Top Publications

  1. ncbi Radiotherapy for oral cancer as a risk factor for second primary cancers
    Mia Hashibe
    International Agency for Research on Cancer, Lyon, France
    Cancer Lett 220:185-95. 2005
  2. ncbi Associations between beer, wine, and liquor consumption and lung cancer risk: a meta-analysis
    Chun Chao
    Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California 91101 2453, USA
    Cancer Epidemiol Biomarkers Prev 16:2436-47. 2007
  3. pmc A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancers
    Yuan Chin Amy Lee
    Department of Epidemiology, University of California at Los Angeles School of Public Health, Los Angeles, CA 90095 1772, USA
    Int J Cancer 122:1630-8. 2008
  4. doi Dietary flavonoid intake and lung cancer--a population-based case-control study
    Yan Cui
    Office of Health Assessment and Epidemiology, Los Angeles County Department of Public Health, Los Angeles, California, USA
    Cancer 112:2241-8. 2008
  5. pmc Involuntary smoking and head and neck cancer risk: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Yuan Chin Amy Lee
    Lifestyle, Environment and Cancer Group, IARC, 150 cours Albert Thomas, 69008 Lyon, France
    Cancer Epidemiol Biomarkers Prev 17:1974-81. 2008
  6. pmc Family history of cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Eva Negri
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Int J Cancer 124:394-401. 2009
  7. pmc Associations between variants of the 8q24 chromosome and nine smoking-related cancer sites
    Sungshim Lani Park
    Department of Epidemiology, University of California at Los Angeles School of Public Health, 71 225 CHS, Box 951772, 650 Charles E Young Drive South, Los Angeles, CA 90095 1772, USA
    Cancer Epidemiol Biomarkers Prev 17:3193-202. 2008
  8. pmc Type of alcoholic beverage and risk of head and neck cancer--a pooled analysis within the INHANCE Consortium
    Mark P Purdue
    National Cancer Institute, Bethesda, Maryland, USA
    Am J Epidemiol 169:132-42. 2009
  9. pmc Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Mia Hashibe
    IARC, Lifestyle, Environment and Cancer Group, Genetics and Epidemiology Cluster, Lyon, France
    Cancer Epidemiol Biomarkers Prev 18:541-50. 2009
  10. pmc Marijuana smoking and the risk of head and neck cancer: pooled analysis in the INHANCE consortium
    Julien Berthiller
    Lifestyle, Environment and Cancer Group, IARC, 69008 Lyon, France
    Cancer Epidemiol Biomarkers Prev 18:1544-51. 2009

Scientific Experts

  • M P Purdue
  • L N Mu
  • Chun Chao
  • M Hashibe
  • Zuo Feng Zhang
  • Yuan Chin Amy Lee
  • Sander Greenland
  • Hal Morgenstern
  • Lin Cai
  • Julien Berthiller
  • Donald P Tashkin
  • Yan Cui
  • Shu Chun Chuang
  • Paul Brennan
  • Gilles Ferro
  • Ana Menezes
  • Joshua Muscat
  • Philip Lazarus
  • Leticia Fernandez
  • Shehnaz K Hussain
  • Erich M Sturgis
  • Elena Matos
  • Alexander W Daudt
  • Qingyi Wei
  • Paolo Boffetta
  • Sergio Koifman
  • Maria Paula Curado
  • Nai Chieh Y You
  • Sungshim Lani Park
  • Jenny T Mao
  • Shun Zhang Yu
  • Wendy Cozen
  • Thomas M Mack
  • Qing Yi Lu
  • Wei Cao
  • Eva Negri
  • Jin Kou Zhao
  • Qingwu Jiang
  • JianYu Rao
  • Deborah M Winn
  • Eleonora Fabianova
  • Peter Rudnai
  • Bao Guo Ding
  • Victor W√ľnsch-Filho
  • Jose Eluf-Neto
  • David Zaridze
  • Richard B Hayes
  • Shen Chih Chang
  • Dana Mates
  • Victor E Reuter
  • Allan Pantuck
  • David Heber
  • Jian Yu Rao
  • Y C Yang
  • Anh D Le
  • Rayjean J Hung
  • Carlo La Vecchia
  • Juan J Lence
  • Chu Chen
  • Victor Wunsch Filho
  • Jose Eluf Neto
  • Yiren Wang
  • Rolando Herrero
  • Renato Talamini
  • Stephen M Schwartz
  • Silvia Franceschi
  • Xavier Castellsague
  • Sam S Oh
  • Jolanta Lissowska
  • Luigino Dal Maso
  • Jeanette C Papp
  • Binh Y Goldstein
  • Andrew F Olshan
  • Neonilia Szeszenia-Dabrowska
  • Oxana Shangina
  • Hua Wang
  • Fabio Levi
  • Ming Lan Lu
  • Can Qing Yu
  • Janet Sinsheimer
  • Simin Liu
  • Arie Belldegrun
  • Jeanette Papp
  • Leslie J Ng
  • Carlos Cordon-Cardo
  • Neonila Szeszenia-Dabrowska
  • Jinkou Zhao
  • A Pantuck
  • Nai chieh Yuko You
  • R A Figlin

Detail Information

Publications22

  1. ncbi Radiotherapy for oral cancer as a risk factor for second primary cancers
    Mia Hashibe
    International Agency for Research on Cancer, Lyon, France
    Cancer Lett 220:185-95. 2005
    ..Further studies that account for chemotherapy and examine frequency and duration of radiotherapy would be of interest in confirming the observed association...
  2. ncbi Associations between beer, wine, and liquor consumption and lung cancer risk: a meta-analysis
    Chun Chao
    Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California 91101 2453, USA
    Cancer Epidemiol Biomarkers Prev 16:2436-47. 2007
    ..We conducted dose-specific meta-analyses and dose-response meta-regression to summarize findings from the current literature on the association between consumption of beer, wine, or liquor and lung cancer risk...
  3. pmc A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancers
    Yuan Chin Amy Lee
    Department of Epidemiology, University of California at Los Angeles School of Public Health, Los Angeles, CA 90095 1772, USA
    Int J Cancer 122:1630-8. 2008
    ..We observed weaker associations between the LIG1 haplotypes and UADT cancers. Our findings suggest the LIG1 haplotypes may affect the risk of lung and UADT cancers...
  4. doi Dietary flavonoid intake and lung cancer--a population-based case-control study
    Yan Cui
    Office of Health Assessment and Epidemiology, Los Angeles County Department of Public Health, Los Angeles, California, USA
    Cancer 112:2241-8. 2008
    ..To investigate the associations between commonly consumed flavonoid compounds and lung cancer, the authors conducted a population-based case-control study of 558 lung cancer cases and a group of 837 controls...
  5. pmc Involuntary smoking and head and neck cancer risk: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Yuan Chin Amy Lee
    Lifestyle, Environment and Cancer Group, IARC, 150 cours Albert Thomas, 69008 Lyon, France
    Cancer Epidemiol Biomarkers Prev 17:1974-81. 2008
    ..These results are consistent with those for active smoking and suggest that elimination of involuntary smoking exposure might reduce head and neck cancer risk among never smokers...
  6. pmc Family history of cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Eva Negri
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Int J Cancer 124:394-401. 2009
    ..0, 95% CI 0.9-1.1). Familial factors play a role in the etiology of HNC. In both subjects with and without family history of HNC, avoidance of tobacco and alcohol exposure may be the best way to avoid HNC...
  7. pmc Associations between variants of the 8q24 chromosome and nine smoking-related cancer sites
    Sungshim Lani Park
    Department of Epidemiology, University of California at Los Angeles School of Public Health, 71 225 CHS, Box 951772, 650 Charles E Young Drive South, Los Angeles, CA 90095 1772, USA
    Cancer Epidemiol Biomarkers Prev 17:3193-202. 2008
    ..Functional and large epidemiologic studies should be conducted to further investigate the association of 8q24 SNPs with smoking-related cancers...
  8. pmc Type of alcoholic beverage and risk of head and neck cancer--a pooled analysis within the INHANCE Consortium
    Mark P Purdue
    National Cancer Institute, Bethesda, Maryland, USA
    Am J Epidemiol 169:132-42. 2009
    ..Given the presence of heterogeneity in study-specific results, their findings should be interpreted with caution...
  9. pmc Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Mia Hashibe
    IARC, Lifestyle, Environment and Cancer Group, Genetics and Epidemiology Cluster, Lyon, France
    Cancer Epidemiol Biomarkers Prev 18:541-50. 2009
    ..The magnitude of risk conferred by the interaction between tobacco and alcohol use on the risk of head and neck cancers is not clear because studies have used various methods to quantify the excess head and neck cancer burden...
  10. pmc Marijuana smoking and the risk of head and neck cancer: pooled analysis in the INHANCE consortium
    Julien Berthiller
    Lifestyle, Environment and Cancer Group, IARC, 69008 Lyon, France
    Cancer Epidemiol Biomarkers Prev 18:1544-51. 2009
    ..Because tobacco is a major risk factor for HNC, large studies with substantial numbers of never tobacco users could help to clarify whether marijuana smoking is independently associated with HNC risk...
  11. ncbi Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Mia Hashibe
    Gene Environment Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
    J Natl Cancer Inst 99:777-89. 2007
    ....
  12. ncbi Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese population
    Li Na Mu
    Department of Epidemiology, Fudan University School of Public Health, Shanghai, China
    Cancer Causes Control 18:665-75. 2007
    ..The objective of this study was to evaluate the effects of polymorphisms of the MTHFR gene on the risk of primary liver cancer and their possible effect modifications on various environmental risk factors...
  13. ncbi Radiotherapy for primary thyroid cancer as a risk factor for second primary cancers
    Shu Chun Chuang
    Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, 71 225 CHS, Box 951772, Los Angeles, CA 90095, USA
    Cancer Lett 238:42-52. 2006
    ..Radiation therapy for adult patients with thyroid cancer might be associated with a reduced risk of second primary thyroid cancer...
  14. ncbi Epidemiologic review of marijuana use and cancer risk
    Mia Hashibe
    International Agency for Research on Cancer, 69008 Lyon, France
    Alcohol 35:265-75. 2005
    ..Despite the challenges, elucidation of the association between marijuana use and cancer risk is important in weighing the benefits and risks of medical marijuana use and to clarify the impact of marijuana use on public health...
  15. ncbi Polymorphism of Xeroderma Pigmentosum group G and the risk of lung cancer and squamous cell carcinomas of the oropharynx, larynx and esophagus
    Yan Cui
    Department of Epidemiology, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Int J Cancer 118:714-20. 2006
    ..7, 38). In conclusion, our study suggests that the XPG Asp1104Asp genotype may be associated with decreased susceptibility to lung cancer and SCCOLE...
  16. ncbi Dietary selenium intake and genetic polymorphisms of the GSTP1 and p53 genes on the risk of esophageal squamous cell carcinoma
    Lin Cai
    Department of Epidemiology, School of Public Health, University of California at Los Angeles, 71 225 CHS, Box 951772, 650 Charles Young Drive, Los Angeles, California 90095 1772, USA
    Cancer Epidemiol Biomarkers Prev 15:294-300. 2006
    ..49-8.66 for smokers and 6.19; 95% CI, 1.83-20.9 for drinkers). Our study suggests that the effect of dietary selenium on the risk of ESCC may be modulated by tobacco smoking, alcohol drinking, and p53 Pro/Pro and GSTP1 Ile/Ile genotypes...
  17. ncbi NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis
    Chun Chao
    Gene Environment Epidemiology Group, IARC, 150, cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 15:979-87. 2006
    ..We conducted meta-analyses focusing on three cancer sites (lung, bladder, and colorectum) to summarize the findings from the current literature and to explore sources of heterogeneity...
  18. ncbi Survival rates of invasive breast cancer among ethnic Chinese women born in East Asia and the United States
    Shu Chun Chuang
    Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA
    Asian Pac J Cancer Prev 7:221-6. 2006
    ..The main purpose of this study is to explore the difference of breast cancer survival rates between the two populations and compare the survival rates to those of Caucasians born in the US...
  19. ncbi Protective effects of plasma carotenoids on the risk of bladder cancer
    Rayjean J Hung
    Department of Epidemiology, University of California Los Angeles, Los Angeles, CA, USA
    J Urol 176:1192-7. 2006
    ..We examined the associations between plasma micronutrients and bladder cancer risk, and evaluated the combined effects of carotenoid and cigarette smoke...
  20. ncbi Marijuana use and the risk of lung and upper aerodigestive tract cancers: results of a population-based case-control study
    Mia Hashibe
    IARC, Lyon, France
    Cancer Epidemiol Biomarkers Prev 15:1829-34. 2006
    ..We conducted a population-based case-control study of the association between marijuana use and the risk of lung and upper aerodigestive tract cancers in Los Angeles...
  21. pmc Joint association of polymorphism of the FGFR4 gene and mutation TP53 gene with bladder cancer prognosis
    Y C Yang
    Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA
    Br J Cancer 95:1455-8. 2006
    ..Neither the polymorphism nor TP53 mutation status was an independent predictor of prognosis, but they might act jointly on the disease-specific survival of patients...
  22. pmc Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China
    Shehnaz K Hussain
    Department of Epidemiology, University of California Los Angeles School of Public Health, Los Angeles, CA 90095 1772, USA
    Cancer Epidemiol Biomarkers Prev 18:2304-9. 2009
    ..45; 95% CI, 0.20-1.04) were associated with reduced stomach cancer risk. In conclusion, PTGS2 and ERCC5 were associated with stomach cancer risk in a Chinese population...