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Genomes and GenesSpecies | Molecular Epidemiology and Gene-Environment InteractionSummaryPrincipal Investigator: Zuo Feng Zhang Affiliation: University of California Country: USA Abstract: This planning grant of molecular epidemiology presents a multidisciplinary approach to an important aspect of molecular epidemiology: gene-environment interaction. Crosstalk among the multidisciplinary team and collaborations to integrate novel technologies and/or methodologies into epidemiologic research are planned. The investigators will explore air pollution-related genetic susceptibility and instability for future population studies of gene-environment interactions on the risk of airborne pollutant-related diseases such as asthma, chronic obstructive pulmonary disease (COPD), and airway cancers. They will develop microarray gene chips to measure the genetic susceptibility (genotypes) and instability as measured by gene expression, and explore new statistical methodology to deal with exposure, genetic susceptibility, gene expression and related illnesses. The specific aims of the project are: Aim 1. To establish a multidisciplinary team and to increase crosstalk in order to foster collaborations to integrate novel technologies and methodologies into molecular epidemiology; and Aim 2. To conduct 3 pilot studies to identify allelic variants (polymorphisms) of environmental disease susceptibility genes; to examine air pollution-related global gene expressions; and to explore the related statistical methodology to analyze data with exposures, genotypes and gene expression matrix in order to foster future population-based molecular epidemiological studies of gene-environment interaction in determining the risk of environmentallyinduced diseases. The planned University of California at Los Angeles (UCLA) Molecular Epidemiology Project in Environmental Genome Projects builds upon existing resources and researches of the Southern California Particle Center and Supersite (SCPCS) and the UCLA Center for Occupational and Environmental Health (COEH). It takes advantage of the wide range of expertise and skill in epidemiology, molecular biology, environmental health sciences, toxicology, occupational medicine, and biostatistics/bioinformatics. The planning grant will address critical research questions in a broad-based effort to understand the mechanism of air pollution and its related susceptibility genotypes and gene expressions, to explore gene-environmental interactions, and to develop more effective methods for the identification of high risk individuals for prevention of air pollution-related diseases. Funding Period: 2002-08-01 - 2007-03-31 more information: NIH RePORT Top Publications
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Publications
Radiotherapy for oral cancer as a risk factor for second primary cancersMia Hashibe
International Agency for Research on Cancer, Lyon, France
Cancer Lett 220:185-95. 2005..Further studies that account for chemotherapy and examine frequency and duration of radiotherapy would be of interest in confirming the observed association...- Associations between beer, wine, and liquor consumption and lung cancer risk: a meta-analysisChun Chao
Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California 91101 2453, USA
Cancer Epidemiol Biomarkers Prev 16:2436-47. 2007..We conducted dose-specific meta-analyses and dose-response meta-regression to summarize findings from the current literature on the association between consumption of beer, wine, or liquor and lung cancer risk... 
A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancersYuan Chin Amy Lee
Department of Epidemiology, University of California at Los Angeles School of Public Health, Los Angeles, CA 90095 1772, USA
Int J Cancer 122:1630-8. 2008..We observed weaker associations between the LIG1 haplotypes and UADT cancers. Our findings suggest the LIG1 haplotypes may affect the risk of lung and UADT cancers...
Dietary flavonoid intake and lung cancer--a population-based case-control studyYan Cui
Office of Health Assessment and Epidemiology, Los Angeles County Department of Public Health, Los Angeles, California, USA
Cancer 112:2241-8. 2008..To investigate the associations between commonly consumed flavonoid compounds and lung cancer, the authors conducted a population-based case-control study of 558 lung cancer cases and a group of 837 controls...- Involuntary smoking and head and neck cancer risk: pooled analysis in the International Head and Neck Cancer Epidemiology ConsortiumYuan Chin Amy Lee
Lifestyle, Environment and Cancer Group, IARC, 150 cours Albert Thomas, 69008 Lyon, France
Cancer Epidemiol Biomarkers Prev 17:1974-81. 2008..These results are consistent with those for active smoking and suggest that elimination of involuntary smoking exposure might reduce head and neck cancer risk among never smokers... - Family history of cancer: pooled analysis in the International Head and Neck Cancer Epidemiology ConsortiumEva Negri
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Int J Cancer 124:394-401. 2009..0, 95% CI 0.9-1.1). Familial factors play a role in the etiology of HNC. In both subjects with and without family history of HNC, avoidance of tobacco and alcohol exposure may be the best way to avoid HNC... - Associations between variants of the 8q24 chromosome and nine smoking-related cancer sitesSungshim Lani Park
Department of Epidemiology, University of California at Los Angeles School of Public Health, 71 225 CHS, Box 951772, 650 Charles E Young Drive South, Los Angeles, CA 90095 1772, USA
Cancer Epidemiol Biomarkers Prev 17:3193-202. 2008..Functional and large epidemiologic studies should be conducted to further investigate the association of 8q24 SNPs with smoking-related cancers... - Type of alcoholic beverage and risk of head and neck cancer--a pooled analysis within the INHANCE ConsortiumMark P Purdue
National Cancer Institute, Bethesda, Maryland, USA
Am J Epidemiol 169:132-42. 2009..Given the presence of heterogeneity in study-specific results, their findings should be interpreted with caution... - Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology ConsortiumMia Hashibe
IARC, Lifestyle, Environment and Cancer Group, Genetics and Epidemiology Cluster, Lyon, France
Cancer Epidemiol Biomarkers Prev 18:541-50. 2009..The magnitude of risk conferred by the interaction between tobacco and alcohol use on the risk of head and neck cancers is not clear because studies have used various methods to quantify the excess head and neck cancer burden... - Marijuana smoking and the risk of head and neck cancer: pooled analysis in the INHANCE consortiumJulien Berthiller
Lifestyle, Environment and Cancer Group, IARC, 69008 Lyon, France
Cancer Epidemiol Biomarkers Prev 18:1544-51. 2009..Because tobacco is a major risk factor for HNC, large studies with substantial numbers of never tobacco users could help to clarify whether marijuana smoking is independently associated with HNC risk... - Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology ConsortiumMia Hashibe
Gene Environment Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
J Natl Cancer Inst 99:777-89. 2007.... - Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese populationLi Na Mu
Department of Epidemiology, Fudan University School of Public Health, Shanghai, China
Cancer Causes Control 18:665-75. 2007..The objective of this study was to evaluate the effects of polymorphisms of the MTHFR gene on the risk of primary liver cancer and their possible effect modifications on various environmental risk factors... - Radiotherapy for primary thyroid cancer as a risk factor for second primary cancersShu-Chun Chuang
Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, 71-225 CHS, Box 951772, Los Angeles, CA 90095, USA
Cancer Lett 238:42-52. 2006..Radiation therapy for adult patients with thyroid cancer might be associated with a reduced risk of second primary thyroid cancer... - Epidemiologic review of marijuana use and cancer riskMia Hashibe
International Agency for Research on Cancer, 69008 Lyon, France
Alcohol 35:265-75. 2005..Despite the challenges, elucidation of the association between marijuana use and cancer risk is important in weighing the benefits and risks of medical marijuana use and to clarify the impact of marijuana use on public health... - Polymorphism of Xeroderma Pigmentosum group G and the risk of lung cancer and squamous cell carcinomas of the oropharynx, larynx and esophagusYan Cui
Department of Epidemiology, University of California at Los Angeles, Los Angeles, CA 90095, USA
Int J Cancer 118:714-20. 2006..7, 38). In conclusion, our study suggests that the XPG Asp1104Asp genotype may be associated with decreased susceptibility to lung cancer and SCCOLE... - Dietary selenium intake and genetic polymorphisms of the GSTP1 and p53 genes on the risk of esophageal squamous cell carcinomaLin Cai
Department of Epidemiology, School of Public Health, University of California at Los Angeles, 71 225 CHS, Box 951772, 650 Charles Young Drive, Los Angeles, California 90095 1772, USA
Cancer Epidemiol Biomarkers Prev 15:294-300. 2006..49-8.66 for smokers and 6.19; 95% CI, 1.83-20.9 for drinkers). Our study suggests that the effect of dietary selenium on the risk of ESCC may be modulated by tobacco smoking, alcohol drinking, and p53 Pro/Pro and GSTP1 Ile/Ile genotypes... - NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysisChun Chao
Gene Environment Epidemiology Group, IARC, 150, cours Albert Thomas, 69372 Lyon Cedex 08, France
Cancer Epidemiol Biomarkers Prev 15:979-87. 2006..Such effects of the NQO1 polymorphism seem to be modified by ethnicity and smoking status... - Survival rates of invasive breast cancer among ethnic Chinese women born in East Asia and the United StatesShu-Chun Chuang
Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA
Asian Pac J Cancer Prev 7:221-6. 2006.... - Protective effects of plasma carotenoids on the risk of bladder cancerRayjean J Hung
Department of Epidemiology, University of California-Los Angeles, Los Angeles, CA, USA
J Urol 176:1192-7. 2006..1) in smokers with lower zeaxanthin. CONCLUSIONS: Our results show protective effects of carotenoids on bladder cancer. They suggest that bladder cancer may be a preventable disease through nutritional intervention, especially in smokers... - Marijuana use and the risk of lung and upper aerodigestive tract cancers: results of a population-based case-control studyMia Hashibe
IARC, Lyon, France
Cancer Epidemiol Biomarkers Prev 15:1829-34. 2006.... - Joint association of polymorphism of the FGFR4 gene and mutation TP53 gene with bladder cancer prognosisY C Yang
Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA
Br J Cancer 95:1455-8. 2006..Neither the polymorphism nor TP53 mutation status was an independent predictor of prognosis, but they might act jointly on the disease-specific survival of patients... - Genetic variation in immune regulation and DNA repair pathways and stomach cancer in ChinaShehnaz K Hussain
Department of Epidemiology, University of California Los Angeles School of Public Health, Los Angeles, CA 90095 1772, USA
Cancer Epidemiol Biomarkers Prev 18:2304-9. 2009..45; 95% CI, 0.20-1.04) were associated with reduced stomach cancer risk. In conclusion, PTGS2 and ERCC5 were associated with stomach cancer risk in a Chinese population...