Molecular Epidemiology and Gene-Environment Interaction

Summary

Principal Investigator: Zuo Feng Zhang
Affiliation: University of California
Country: USA
Abstract: This planning grant of molecular epidemiology presents a multidisciplinary approach to an important aspect of molecular epidemiology: gene-environment interaction. Crosstalk among the multidisciplinary team and collaborations to integrate novel technologies and/or methodologies into epidemiologic research are planned. The investigators will explore air pollution-related genetic susceptibility and instability for future population studies of gene-environment interactions on the risk of airborne pollutant-related diseases such as asthma, chronic obstructive pulmonary disease (COPD), and airway cancers. They will develop microarray gene chips to measure the genetic susceptibility (genotypes) and instability as measured by gene expression, and explore new statistical methodology to deal with exposure, genetic susceptibility, gene expression and related illnesses. The specific aims of the project are: Aim 1. To establish a multidisciplinary team and to increase crosstalk in order to foster collaborations to integrate novel technologies and methodologies into molecular epidemiology; and Aim 2. To conduct 3 pilot studies to identify allelic variants (polymorphisms) of environmental disease susceptibility genes; to examine air pollution-related global gene expressions; and to explore the related statistical methodology to analyze data with exposures, genotypes and gene expression matrix in order to foster future population-based molecular epidemiological studies of gene-environment interaction in determining the risk of environmentallyinduced diseases. The planned University of California at Los Angeles (UCLA) Molecular Epidemiology Project in Environmental Genome Projects builds upon existing resources and researches of the Southern California Particle Center and Supersite (SCPCS) and the UCLA Center for Occupational and Environmental Health (COEH). It takes advantage of the wide range of expertise and skill in epidemiology, molecular biology, environmental health sciences, toxicology, occupational medicine, and biostatistics/bioinformatics. The planning grant will address critical research questions in a broad-based effort to understand the mechanism of air pollution and its related susceptibility genotypes and gene expressions, to explore gene-environmental interactions, and to develop more effective methods for the identification of high risk individuals for prevention of air pollution-related diseases.
Funding Period: 2002-08-01 - 2007-03-31
more information: NIH RePORT

Top Publications

  1. pmc Nutrient-based dietary patterns and the risk of head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium
    V Edefonti
    Section of Medical Statistics and Biometry Giulio A Maccacaro, Department of Occupational and Environmental Health, University of Milan, Milan, Italy
    Ann Oncol 23:1869-80. 2012
  2. pmc Body mass index change in adulthood and lung and upper aerodigestive tract cancers
    Heather P Tarleton
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095 1772, USA
    Int J Cancer 131:1407-16. 2012
  3. pmc Indoor air pollution and risk of lung cancer among Chinese female non-smokers
    Lina Mu
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, SUNY, 270 Farber Hall, Buffalo, NY 14214, USA
    Cancer Causes Control 24:439-50. 2013
  4. pmc Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer--a case-control study in a Chinese population
    Ajay A Myneni
    Department of Social and Preventive, School of Public Health and Health Professions, State University of New York SUNY at Buffalo, Buffalo, NY 14221, USA
    Lung Cancer 80:131-7. 2013
  5. pmc Raw garlic consumption as a protective factor for lung cancer, a population-based case-control study in a Chinese population
    Zi Yi Jin
    Department of Non communicable Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China
    Cancer Prev Res (Phila) 6:711-8. 2013
  6. pmc Elevated liver enzymes in individuals with undiagnosed diabetes in the U.S
    Christie Y Jeon
    Center for Cancer Prevention and Control Research, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA
    J Diabetes Complications 27:333-9. 2013
  7. pmc Genetic variants of peroxisome proliferator-activated receptor δ are associated with gastric cancer
    Christie Jeon
    Department of Medicine, Cedars Sinai Medical Center, 8700 Beverly Blvd, SCCT 1S33, Los Angeles, CA, 90048, USA
    Dig Dis Sci 58:2881-6. 2013
  8. pmc Exposure to secondhand tobacco smoke and lung cancer by histological type: A pooled analysis of the International Lung Cancer Consortium (ILCCO)
    Claire H Kim
    Department of Epidemiology Fielding School of Public Health, University of California at Los Angeles UCLA, 71 225 CHS, 650 Charles E Young Drive, South, Los Angeles, CA
    Int J Cancer 135:1918-30. 2014
  9. pmc Association of marijuana smoking with oropharyngeal and oral tongue cancers: pooled analysis from the INHANCE consortium
    Morgan A Marks
    Authors Affiliations Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville Johns Hopkins School of Medicine Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland Department of Community Health, School of Medicine, Brown University, Providence, Rhode Island International Agency of Research on Cancer Hospices Civils de Lyon, Pole Information Medicale Evaluation Recherche Universite Lyon 1, Equipe d Accueil 4129 International Prevention Research Institute, Lyon, France Fred Hutchinson Cancer Research Cancer, Seattle, Washington University of Iowa College of Public Health, Iowa City, Iowa School of Public Health, University of North Carolina, Chapel Hill, North Carolina Department of Head and Neck Surgery and Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas UCLA School of Public Health, Los Angeles, California Departments of Epidemiology and Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan Penn State College of Medicine, Hershey, Pennsylvania Boston University School of Public Health, Boston, Massachusetts Faculdade de Saude Publica, Universidade de Sao Paulo, Sao Paulo Escola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro Universidade Federal de Pelotas, Pelotas Hospital de Clinicas de Porto Alegre, Port Alegre, Brazil Institute Oncology Angel H Roffo, University of Buenos Aires, Buenos Aires, Brazil
    Cancer Epidemiol Biomarkers Prev 23:160-71. 2014
  10. pmc Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium
    Emanuele Leoncini
    Section of Hygiene, Institute of Public Health, Universita Cattolica del Sacro Cuore, Rome, Italy
    Eur J Epidemiol 29:35-48. 2014

Scientific Experts

  • Zuo Feng Zhang
  • Gilles Ferro
  • STEPHEN MARC SCHWARTZ
  • M P Purdue
  • L N Mu
  • M Hashibe
  • Chun Chao
  • Hal Morgenstern
  • Yuan Chin Amy Lee
  • Shen Chih Chang
  • Paolo Boffetta
  • Philip Lazarus
  • Paul Brennan
  • Shu Chun Chuang
  • Lin Cai
  • Joshua Muscat
  • Sander Greenland
  • Peter Rudnai
  • Eleonora Fabianova
  • Carlo La Vecchia
  • Elena Matos
  • Ana Menezes
  • Leticia Fernandez
  • Alexander W Daudt
  • Sergio Koifman
  • Sungshim Lani Park
  • Donald P Tashkin
  • Andrew F Olshan
  • Chu Chen
  • Luigino Dal Maso
  • Dana Mates
  • Fabio Levi
  • Richard B Hayes
  • Deborah M Winn
  • David Zaridze
  • Maria Paula Curado
  • Jenny T Mao
  • Nai Chieh Y You
  • Julien Berthiller
  • Qing Yi Lu
  • Heather P Tarleton
  • Keitaro Matsuo
  • Karl Kelsey
  • Jolanta Lissowska
  • Renato Talamini
  • Jin Kou Zhao
  • Qingwu Jiang
  • Erich M Sturgis
  • Qingyi Wei
  • Jian Yu Rao
  • Wendy Cozen
  • Thomas M Mack
  • Shun Zhang Yu
  • Rayjean J Hung
  • Hermann Brenner
  • Neonila Szeszenia-Dabrowska
  • Silvia Franceschi
  • Rolando Herrero
  • Xavier Castellsague
  • JianYu Rao
  • Guo Pei Yu
  • Victor Wünsch-Filho
  • Binh Y Goldstein
  • Shehnaz K Hussain
  • Jose Eluf-Neto
  • Thomas L Vaughan
  • Yan Cui
  • Stefania Boccia
  • MICHAEL MCCLEAN
  • STIMSON SCHANTZ
  • Yanli Li
  • Angeline S Andrew
  • Eric J Duell
  • Adeline Seow
  • Jeanette C Papp
  • Hua Wang
  • Simone Benhamou
  • Jinkou Zhao
  • Sam S Oh
  • Bao Guo Ding
  • Victor E Reuter
  • Allan Pantuck
  • Wei Cao
  • Claire H Kim
  • Emanuele Leoncini
  • Morgan A Marks
  • Tingting Yang
  • Zi Yi Jin
  • Ariana Znaor
  • Ajay A Myneni

Detail Information

Publications44

  1. pmc Nutrient-based dietary patterns and the risk of head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium
    V Edefonti
    Section of Medical Statistics and Biometry Giulio A Maccacaro, Department of Occupational and Environmental Health, University of Milan, Milan, Italy
    Ann Oncol 23:1869-80. 2012
    ..The association between dietary patterns and head and neck cancer has rarely been addressed...
  2. pmc Body mass index change in adulthood and lung and upper aerodigestive tract cancers
    Heather P Tarleton
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095 1772, USA
    Int J Cancer 131:1407-16. 2012
    ..The observed inverse associations between adulthood BMI gain and lung and UADT cancers indicate a potential role for body weight-related biological pathways in the development of lung and UADT cancers...
  3. pmc Indoor air pollution and risk of lung cancer among Chinese female non-smokers
    Lina Mu
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, SUNY, 270 Farber Hall, Buffalo, NY 14214, USA
    Cancer Causes Control 24:439-50. 2013
    ..To investigate indoor particulate matter (PM) level and various indoor air pollution exposure, and to examine their relationships with risk of lung cancer in an urban Chinese population, with a focus on non-smoking women...
  4. pmc Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer--a case-control study in a Chinese population
    Ajay A Myneni
    Department of Social and Preventive, School of Public Health and Health Professions, State University of New York SUNY at Buffalo, Buffalo, NY 14221, USA
    Lung Cancer 80:131-7. 2013
    ....
  5. pmc Raw garlic consumption as a protective factor for lung cancer, a population-based case-control study in a Chinese population
    Zi Yi Jin
    Department of Non communicable Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China
    Cancer Prev Res (Phila) 6:711-8. 2013
    ..Effective components in garlic in lung cancer chemoprevention warrant further in-depth investigation...
  6. pmc Elevated liver enzymes in individuals with undiagnosed diabetes in the U.S
    Christie Y Jeon
    Center for Cancer Prevention and Control Research, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA
    J Diabetes Complications 27:333-9. 2013
    ..We investigated the association of diabetes diagnosis and medication type with liver injury in individuals with clinical diabetes...
  7. pmc Genetic variants of peroxisome proliferator-activated receptor δ are associated with gastric cancer
    Christie Jeon
    Department of Medicine, Cedars Sinai Medical Center, 8700 Beverly Blvd, SCCT 1S33, Los Angeles, CA, 90048, USA
    Dig Dis Sci 58:2881-6. 2013
    ..Peroxisome proliferator-activated receptors (PPAR) are implicated in pathogenesis of insulin resistance and cancers of the digestive system...
  8. pmc Exposure to secondhand tobacco smoke and lung cancer by histological type: A pooled analysis of the International Lung Cancer Consortium (ILCCO)
    Claire H Kim
    Department of Epidemiology Fielding School of Public Health, University of California at Los Angeles UCLA, 71 225 CHS, 650 Charles E Young Drive, South, Los Angeles, CA
    Int J Cancer 135:1918-30. 2014
    ....
  9. pmc Association of marijuana smoking with oropharyngeal and oral tongue cancers: pooled analysis from the INHANCE consortium
    Morgan A Marks
    Authors Affiliations Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville Johns Hopkins School of Medicine Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland Department of Community Health, School of Medicine, Brown University, Providence, Rhode Island International Agency of Research on Cancer Hospices Civils de Lyon, Pole Information Medicale Evaluation Recherche Universite Lyon 1, Equipe d Accueil 4129 International Prevention Research Institute, Lyon, France Fred Hutchinson Cancer Research Cancer, Seattle, Washington University of Iowa College of Public Health, Iowa City, Iowa School of Public Health, University of North Carolina, Chapel Hill, North Carolina Department of Head and Neck Surgery and Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas UCLA School of Public Health, Los Angeles, California Departments of Epidemiology and Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan Penn State College of Medicine, Hershey, Pennsylvania Boston University School of Public Health, Boston, Massachusetts Faculdade de Saude Publica, Universidade de Sao Paulo, Sao Paulo Escola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro Universidade Federal de Pelotas, Pelotas Hospital de Clinicas de Porto Alegre, Port Alegre, Brazil Institute Oncology Angel H Roffo, University of Buenos Aires, Buenos Aires, Brazil
    Cancer Epidemiol Biomarkers Prev 23:160-71. 2014
    ..The incidence of oropharyngeal and oral tongue cancers has increased over the last 20 years which parallels increased use of marijuana among individuals born after 1950...
  10. pmc Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium
    Emanuele Leoncini
    Section of Hygiene, Institute of Public Health, Universita Cattolica del Sacro Cuore, Rome, Italy
    Eur J Epidemiol 29:35-48. 2014
    ..Further studies designed to elucidate the mechanism of such association would be warranted...
  11. pmc Tobacco smoking, NBS1 polymorphisms, and survival in lung and upper aerodigestive tract cancers with semi-Bayes adjustment for hazard ratio variation
    Tingting Yang
    Zhejiang Provincial CDC, Hangzhou, Zhejiang, People s Republic of China
    Cancer Causes Control 25:11-23. 2014
    ..Although single nucleotide polymorphisms (SNPs) of NBS1 have been associated with susceptibility to lung and upper aerodigestive tract (UADT) cancers, their relations to cancer survival and measures of effect are largely unknown...
  12. pmc Genetic variation at 8q24, family history of cancer, and upper gastrointestinal cancers in a Chinese population
    Heather P Tarleton
    Department of Health and Human Sciences, Loyola Marymount University, Los Angeles, CA, USA
    Fam Cancer 13:45-56. 2014
    ..00; 95% CI 1.15-3.47). These findings suggest that inherited susceptibility to liver cancer may exist in the Taixing population and that variation at 8q24 might be a genetic component of that inherited susceptibility...
  13. pmc In-home coal and wood use and lung cancer risk: a pooled analysis of the International Lung Cancer Consortium
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
    Environ Health Perspect 118:1743-7. 2010
    ..Recently, the International Agency for Research on Cancer classified indoor emissions from household coal combustion as a human carcinogen (group 1) and from biomass fuel (primarily wood) as a probable human carcinogen (group 2A)...
  14. pmc Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium
    Mia M Gaudet
    Department of Epidemiology and Population Health and of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, NY, USA
    Int J Epidemiol 39:1091-102. 2010
    ....
  15. pmc Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium
    Therese Truong
    Genetic Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France
    J Natl Cancer Inst 102:959-71. 2010
    ....
  16. pmc Coffee and tea intake and risk of head and neck cancer: pooled analysis in the international head and neck cancer epidemiology consortium
    Carlotta Galeone
    Istituto di Ricerche Farmacologiche Mario Negri, Universita degli Studi di Milano, Milan, Italy
    Cancer Epidemiol Biomarkers Prev 19:1723-36. 2010
    ..Only a few studies have explored the relation between coffee and tea intake and head and neck cancers, with inconsistent results...
  17. pmc Alcohol consumption and cancers of the oral cavity and pharynx from 1988 to 2009: an update
    Binh Y Goldstein
    Department of Epidemiology, UCLA School of Public Health, Los Angeles, California 90095 1772, USA
    Eur J Cancer Prev 19:431-65. 2010
    ..A large number of studies on joint exposure to alcohol and tobacco consumption show a greater than multiplicative synergistic effect...
  18. pmc Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population
    Yanli Li
    Department of Social and Preventive Medicine, The State University of New York at Buffalo, NY 14214 8001, USA
    Cancer Epidemiol 35:362-8. 2011
    ....
  19. pmc Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium
    Shu Chun Chuang
    Imperial College London, London, UK
    Cancer Causes Control 23:69-88. 2012
    ..01) was positively associated with HNC risk. Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR = 0.90, 95% CI = 0.84-0.97)...
  20. pmc History of diabetes and risk of head and neck cancer: a pooled analysis from the international head and neck cancer epidemiology consortium
    Marni Stott-Miller
    Fred Hutchinson Cancer Research Center, Mailstop M4 C308, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 21:294-304. 2012
    ..A history of diabetes is associated with an increased risk of several types of cancers. Whether diabetes is a risk factor for head and neck cancer (HNC) has received little attention...
  21. pmc Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers
    Sam S Oh
    Department of Epidemiology, University of California, Los Angeles UCLA School of Public Health, Los Angeles, CA, USA
    Int J Cancer 127:2169-82. 2010
    ....
  22. pmc Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China
    Shehnaz K Hussain
    Department of Epidemiology, University of California Los Angeles School of Public Health, Los Angeles, CA 90095 1772, USA
    Cancer Epidemiol Biomarkers Prev 18:2304-9. 2009
    ..45; 95% CI, 0.20-1.04) were associated with reduced stomach cancer risk. In conclusion, PTGS2 and ERCC5 were associated with stomach cancer risk in a Chinese population...
  23. pmc Joint association of polymorphism of the FGFR4 gene and mutation TP53 gene with bladder cancer prognosis
    Y C Yang
    Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA
    Br J Cancer 95:1455-8. 2006
    ..Neither the polymorphism nor TP53 mutation status was an independent predictor of prognosis, but they might act jointly on the disease-specific survival of patients...
  24. ncbi Marijuana use and the risk of lung and upper aerodigestive tract cancers: results of a population-based case-control study
    Mia Hashibe
    IARC, Lyon, France
    Cancer Epidemiol Biomarkers Prev 15:1829-34. 2006
    ..We conducted a population-based case-control study of the association between marijuana use and the risk of lung and upper aerodigestive tract cancers in Los Angeles...
  25. ncbi Protective effects of plasma carotenoids on the risk of bladder cancer
    Rayjean J Hung
    Department of Epidemiology, University of California Los Angeles, Los Angeles, CA, USA
    J Urol 176:1192-7. 2006
    ..We examined the associations between plasma micronutrients and bladder cancer risk, and evaluated the combined effects of carotenoid and cigarette smoke...
  26. ncbi Survival rates of invasive breast cancer among ethnic Chinese women born in East Asia and the United States
    Shu Chun Chuang
    Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA
    Asian Pac J Cancer Prev 7:221-6. 2006
    ..The main purpose of this study is to explore the difference of breast cancer survival rates between the two populations and compare the survival rates to those of Caucasians born in the US...
  27. ncbi NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis
    Chun Chao
    Gene Environment Epidemiology Group, IARC, 150, cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 15:979-87. 2006
    ..We conducted meta-analyses focusing on three cancer sites (lung, bladder, and colorectum) to summarize the findings from the current literature and to explore sources of heterogeneity...
  28. ncbi Dietary selenium intake and genetic polymorphisms of the GSTP1 and p53 genes on the risk of esophageal squamous cell carcinoma
    Lin Cai
    Department of Epidemiology, School of Public Health, University of California at Los Angeles, 71 225 CHS, Box 951772, 650 Charles Young Drive, Los Angeles, California 90095 1772, USA
    Cancer Epidemiol Biomarkers Prev 15:294-300. 2006
    ..49-8.66 for smokers and 6.19; 95% CI, 1.83-20.9 for drinkers). Our study suggests that the effect of dietary selenium on the risk of ESCC may be modulated by tobacco smoking, alcohol drinking, and p53 Pro/Pro and GSTP1 Ile/Ile genotypes...
  29. ncbi Polymorphism of Xeroderma Pigmentosum group G and the risk of lung cancer and squamous cell carcinomas of the oropharynx, larynx and esophagus
    Yan Cui
    Department of Epidemiology, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Int J Cancer 118:714-20. 2006
    ..7, 38). In conclusion, our study suggests that the XPG Asp1104Asp genotype may be associated with decreased susceptibility to lung cancer and SCCOLE...
  30. ncbi Epidemiologic review of marijuana use and cancer risk
    Mia Hashibe
    International Agency for Research on Cancer, 69008 Lyon, France
    Alcohol 35:265-75. 2005
    ..Despite the challenges, elucidation of the association between marijuana use and cancer risk is important in weighing the benefits and risks of medical marijuana use and to clarify the impact of marijuana use on public health...
  31. ncbi Radiotherapy for primary thyroid cancer as a risk factor for second primary cancers
    Shu Chun Chuang
    Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, 71 225 CHS, Box 951772, Los Angeles, CA 90095, USA
    Cancer Lett 238:42-52. 2006
    ..Radiation therapy for adult patients with thyroid cancer might be associated with a reduced risk of second primary thyroid cancer...
  32. ncbi Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese population
    Li Na Mu
    Department of Epidemiology, Fudan University School of Public Health, Shanghai, China
    Cancer Causes Control 18:665-75. 2007
    ..The objective of this study was to evaluate the effects of polymorphisms of the MTHFR gene on the risk of primary liver cancer and their possible effect modifications on various environmental risk factors...
  33. ncbi Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Mia Hashibe
    Gene Environment Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
    J Natl Cancer Inst 99:777-89. 2007
    ....
  34. pmc Marijuana smoking and the risk of head and neck cancer: pooled analysis in the INHANCE consortium
    Julien Berthiller
    Lifestyle, Environment and Cancer Group, IARC, 69008 Lyon, France
    Cancer Epidemiol Biomarkers Prev 18:1544-51. 2009
    ..Because tobacco is a major risk factor for HNC, large studies with substantial numbers of never tobacco users could help to clarify whether marijuana smoking is independently associated with HNC risk...
  35. pmc Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Mia Hashibe
    IARC, Lifestyle, Environment and Cancer Group, Genetics and Epidemiology Cluster, Lyon, France
    Cancer Epidemiol Biomarkers Prev 18:541-50. 2009
    ..The magnitude of risk conferred by the interaction between tobacco and alcohol use on the risk of head and neck cancers is not clear because studies have used various methods to quantify the excess head and neck cancer burden...
  36. pmc Type of alcoholic beverage and risk of head and neck cancer--a pooled analysis within the INHANCE Consortium
    Mark P Purdue
    National Cancer Institute, Bethesda, Maryland, USA
    Am J Epidemiol 169:132-42. 2009
    ..Given the presence of heterogeneity in study-specific results, their findings should be interpreted with caution...
  37. pmc Family history of cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Eva Negri
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Int J Cancer 124:394-401. 2009
    ..0, 95% CI 0.9-1.1). Familial factors play a role in the etiology of HNC. In both subjects with and without family history of HNC, avoidance of tobacco and alcohol exposure may be the best way to avoid HNC...
  38. pmc Associations between variants of the 8q24 chromosome and nine smoking-related cancer sites
    Sungshim Lani Park
    Department of Epidemiology, University of California at Los Angeles School of Public Health, 71 225 CHS, Box 951772, 650 Charles E Young Drive South, Los Angeles, CA 90095 1772, USA
    Cancer Epidemiol Biomarkers Prev 17:3193-202. 2008
    ..Functional and large epidemiologic studies should be conducted to further investigate the association of 8q24 SNPs with smoking-related cancers...
  39. pmc Involuntary smoking and head and neck cancer risk: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Yuan Chin Amy Lee
    Lifestyle, Environment and Cancer Group, IARC, 150 cours Albert Thomas, 69008 Lyon, France
    Cancer Epidemiol Biomarkers Prev 17:1974-81. 2008
    ..These results are consistent with those for active smoking and suggest that elimination of involuntary smoking exposure might reduce head and neck cancer risk among never smokers...
  40. ncbi Dietary flavonoid intake and lung cancer--a population-based case-control study
    Yan Cui
    Office of Health Assessment and Epidemiology, Los Angeles County Department of Public Health, Los Angeles, California, USA
    Cancer 112:2241-8. 2008
    ..To investigate the associations between commonly consumed flavonoid compounds and lung cancer, the authors conducted a population-based case-control study of 558 lung cancer cases and a group of 837 controls...
  41. pmc A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancers
    Yuan Chin Amy Lee
    Department of Epidemiology, University of California at Los Angeles School of Public Health, Los Angeles, CA 90095 1772, USA
    Int J Cancer 122:1630-8. 2008
    ..We observed weaker associations between the LIG1 haplotypes and UADT cancers. Our findings suggest the LIG1 haplotypes may affect the risk of lung and UADT cancers...
  42. ncbi Associations between beer, wine, and liquor consumption and lung cancer risk: a meta-analysis
    Chun Chao
    Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California 91101 2453, USA
    Cancer Epidemiol Biomarkers Prev 16:2436-47. 2007
    ..We conducted dose-specific meta-analyses and dose-response meta-regression to summarize findings from the current literature on the association between consumption of beer, wine, or liquor and lung cancer risk...
  43. ncbi Radiotherapy for oral cancer as a risk factor for second primary cancers
    Mia Hashibe
    International Agency for Research on Cancer, Lyon, France
    Cancer Lett 220:185-95. 2005
    ..Further studies that account for chemotherapy and examine frequency and duration of radiotherapy would be of interest in confirming the observed association...