Genomes and Genes
Molecular Epidemiology and Gene-Environment Interaction
Principal Investigator: Zuo Feng Zhang
Affiliation: University of California
Abstract: This planning grant of molecular epidemiology presents a multidisciplinary approach to an important aspect of molecular epidemiology: gene-environment interaction. Crosstalk among the multidisciplinary team and collaborations to integrate novel technologies and/or methodologies into epidemiologic research are planned. The investigators will explore air pollution-related genetic susceptibility and instability for future population studies of gene-environment interactions on the risk of airborne pollutant-related diseases such as asthma, chronic obstructive pulmonary disease (COPD), and airway cancers. They will develop microarray gene chips to measure the genetic susceptibility (genotypes) and instability as measured by gene expression, and explore new statistical methodology to deal with exposure, genetic susceptibility, gene expression and related illnesses. The specific aims of the project are: Aim 1. To establish a multidisciplinary team and to increase crosstalk in order to foster collaborations to integrate novel technologies and methodologies into molecular epidemiology; and Aim 2. To conduct 3 pilot studies to identify allelic variants (polymorphisms) of environmental disease susceptibility genes; to examine air pollution-related global gene expressions; and to explore the related statistical methodology to analyze data with exposures, genotypes and gene expression matrix in order to foster future population-based molecular epidemiological studies of gene-environment interaction in determining the risk of environmentallyinduced diseases. The planned University of California at Los Angeles (UCLA) Molecular Epidemiology Project in Environmental Genome Projects builds upon existing resources and researches of the Southern California Particle Center and Supersite (SCPCS) and the UCLA Center for Occupational and Environmental Health (COEH). It takes advantage of the wide range of expertise and skill in epidemiology, molecular biology, environmental health sciences, toxicology, occupational medicine, and biostatistics/bioinformatics. The planning grant will address critical research questions in a broad-based effort to understand the mechanism of air pollution and its related susceptibility genotypes and gene expressions, to explore gene-environmental interactions, and to develop more effective methods for the identification of high risk individuals for prevention of air pollution-related diseases.
Funding Period: 2002-08-01 - 2007-03-31
more information: NIH RePORT
- Nutrient-based dietary patterns and the risk of head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology consortiumV Edefonti
Section of Medical Statistics and Biometry Giulio A Maccacaro, Department of Occupational and Environmental Health, University of Milan, Milan, Italy
Ann Oncol 23:1869-80. 2012..The association between dietary patterns and head and neck cancer has rarely been addressed...
- Body mass index change in adulthood and lung and upper aerodigestive tract cancersHeather P Tarleton
Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095 1772, USA
Int J Cancer 131:1407-16. 2012..The observed inverse associations between adulthood BMI gain and lung and UADT cancers indicate a potential role for body weight-related biological pathways in the development of lung and UADT cancers...
- Indoor air pollution and risk of lung cancer among Chinese female non-smokersLina Mu
Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, SUNY, 270 Farber Hall, Buffalo, NY 14214, USA
Cancer Causes Control 24:439-50. 2013..To investigate indoor particulate matter (PM) level and various indoor air pollution exposure, and to examine their relationships with risk of lung cancer in an urban Chinese population, with a focus on non-smoking women...
- Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer--a case-control study in a Chinese populationAjay A Myneni
Department of Social and Preventive, School of Public Health and Health Professions, State University of New York SUNY at Buffalo, Buffalo, NY 14221, USA
Lung Cancer 80:131-7. 2013....
- Raw garlic consumption as a protective factor for lung cancer, a population-based case-control study in a Chinese populationZi Yi Jin
Department of Non communicable Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China
Cancer Prev Res (Phila) 6:711-8. 2013..Effective components in garlic in lung cancer chemoprevention warrant further in-depth investigation...
- Elevated liver enzymes in individuals with undiagnosed diabetes in the U.SChristie Y Jeon
Center for Cancer Prevention and Control Research, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA
J Diabetes Complications 27:333-9. 2013..We investigated the association of diabetes diagnosis and medication type with liver injury in individuals with clinical diabetes...
- Genetic variants of peroxisome proliferator-activated receptor δ are associated with gastric cancerChristie Jeon
Department of Medicine, Cedars Sinai Medical Center, 8700 Beverly Blvd, SCCT 1S33, Los Angeles, CA, 90048, USA
Dig Dis Sci 58:2881-6. 2013..Peroxisome proliferator-activated receptors (PPAR) are implicated in pathogenesis of insulin resistance and cancers of the digestive system...
- Exposure to secondhand tobacco smoke and lung cancer by histological type: A pooled analysis of the International Lung Cancer Consortium (ILCCO)Claire H Kim
Department of Epidemiology Fielding School of Public Health, University of California at Los Angeles UCLA, 71 225 CHS, 650 Charles E Young Drive, South, Los Angeles, CA
Int J Cancer 135:1918-30. 2014....
- Association of marijuana smoking with oropharyngeal and oral tongue cancers: pooled analysis from the INHANCE consortiumMorgan A Marks
Authors Affiliations Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville Johns Hopkins School of Medicine Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland Department of Community Health, School of Medicine, Brown University, Providence, Rhode Island International Agency of Research on Cancer Hospices Civils de Lyon, Pole Information Medicale Evaluation Recherche Universite Lyon 1, Equipe d Accueil 4129 International Prevention Research Institute, Lyon, France Fred Hutchinson Cancer Research Cancer, Seattle, Washington University of Iowa College of Public Health, Iowa City, Iowa School of Public Health, University of North Carolina, Chapel Hill, North Carolina Department of Head and Neck Surgery and Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas UCLA School of Public Health, Los Angeles, California Departments of Epidemiology and Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan Penn State College of Medicine, Hershey, Pennsylvania Boston University School of Public Health, Boston, Massachusetts Faculdade de Saude Publica, Universidade de Sao Paulo, Sao Paulo Escola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro Universidade Federal de Pelotas, Pelotas Hospital de Clinicas de Porto Alegre, Port Alegre, Brazil Institute Oncology Angel H Roffo, University of Buenos Aires, Buenos Aires, Brazil
Cancer Epidemiol Biomarkers Prev 23:160-71. 2014..The incidence of oropharyngeal and oral tongue cancers has increased over the last 20 years which parallels increased use of marijuana among individuals born after 1950...
- Adult height and head and neck cancer: a pooled analysis within the INHANCE ConsortiumEmanuele Leoncini
Section of Hygiene, Institute of Public Health, Universita Cattolica del Sacro Cuore, Rome, Italy
Eur J Epidemiol 29:35-48. 2014..Further studies designed to elucidate the mechanism of such association would be warranted...
- Tobacco smoking, NBS1 polymorphisms, and survival in lung and upper aerodigestive tract cancers with semi-Bayes adjustment for hazard ratio variationTingting Yang
Zhejiang Provincial CDC, Hangzhou, Zhejiang, People s Republic of China
Cancer Causes Control 25:11-23. 2014..Although single nucleotide polymorphisms (SNPs) of NBS1 have been associated with susceptibility to lung and upper aerodigestive tract (UADT) cancers, their relations to cancer survival and measures of effect are largely unknown...
- Genetic variation at 8q24, family history of cancer, and upper gastrointestinal cancers in a Chinese populationHeather P Tarleton
Department of Health and Human Sciences, Loyola Marymount University, Los Angeles, CA, USA
Fam Cancer 13:45-56. 2014..00; 95% CI 1.15-3.47). These findings suggest that inherited susceptibility to liver cancer may exist in the Taixing population and that variation at 8q24 might be a genetic component of that inherited susceptibility...
- In-home coal and wood use and lung cancer risk: a pooled analysis of the International Lung Cancer ConsortiumH Dean Hosgood
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
Environ Health Perspect 118:1743-7. 2010..Recently, the International Agency for Research on Cancer classified indoor emissions from household coal combustion as a human carcinogen (group 1) and from biomass fuel (primarily wood) as a probable human carcinogen (group 2A)...
- Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) ConsortiumMia M Gaudet
Department of Epidemiology and Population Health and of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, NY, USA
Int J Epidemiol 39:1091-102. 2010....
- Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer ConsortiumTherese Truong
Genetic Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France
J Natl Cancer Inst 102:959-71. 2010....
- Coffee and tea intake and risk of head and neck cancer: pooled analysis in the international head and neck cancer epidemiology consortiumCarlotta Galeone
Istituto di Ricerche Farmacologiche Mario Negri, Universita degli Studi di Milano, Milan, Italy
Cancer Epidemiol Biomarkers Prev 19:1723-36. 2010..Only a few studies have explored the relation between coffee and tea intake and head and neck cancers, with inconsistent results...
- Alcohol consumption and cancers of the oral cavity and pharynx from 1988 to 2009: an updateBinh Y Goldstein
Department of Epidemiology, UCLA School of Public Health, Los Angeles, California 90095 1772, USA
Eur J Cancer Prev 19:431-65. 2010..A large number of studies on joint exposure to alcohol and tobacco consumption show a greater than multiplicative synergistic effect...
- Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese populationYanli Li
Department of Social and Preventive Medicine, The State University of New York at Buffalo, NY 14214 8001, USA
Cancer Epidemiol 35:362-8. 2011....
- Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortiumShu Chun Chuang
Imperial College London, London, UK
Cancer Causes Control 23:69-88. 2012..01) was positively associated with HNC risk. Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR = 0.90, 95% CI = 0.84-0.97)...
- History of diabetes and risk of head and neck cancer: a pooled analysis from the international head and neck cancer epidemiology consortiumMarni Stott-Miller
Fred Hutchinson Cancer Research Center, Mailstop M4 C308, 1100 Fairview Ave N, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 21:294-304. 2012..A history of diabetes is associated with an increased risk of several types of cancers. Whether diabetes is a risk factor for head and neck cancer (HNC) has received little attention...
- Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancersSam S Oh
Department of Epidemiology, University of California, Los Angeles UCLA School of Public Health, Los Angeles, CA, USA
Int J Cancer 127:2169-82. 2010....
- Genetic variation in immune regulation and DNA repair pathways and stomach cancer in ChinaShehnaz K Hussain
Department of Epidemiology, University of California Los Angeles School of Public Health, Los Angeles, CA 90095 1772, USA
Cancer Epidemiol Biomarkers Prev 18:2304-9. 2009..45; 95% CI, 0.20-1.04) were associated with reduced stomach cancer risk. In conclusion, PTGS2 and ERCC5 were associated with stomach cancer risk in a Chinese population...
- Joint association of polymorphism of the FGFR4 gene and mutation TP53 gene with bladder cancer prognosisY C Yang
Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA
Br J Cancer 95:1455-8. 2006..Neither the polymorphism nor TP53 mutation status was an independent predictor of prognosis, but they might act jointly on the disease-specific survival of patients...
- Marijuana use and the risk of lung and upper aerodigestive tract cancers: results of a population-based case-control studyMia Hashibe
IARC, Lyon, France
Cancer Epidemiol Biomarkers Prev 15:1829-34. 2006..We conducted a population-based case-control study of the association between marijuana use and the risk of lung and upper aerodigestive tract cancers in Los Angeles...
- Protective effects of plasma carotenoids on the risk of bladder cancerRayjean J Hung
Department of Epidemiology, University of California Los Angeles, Los Angeles, CA, USA
J Urol 176:1192-7. 2006..We examined the associations between plasma micronutrients and bladder cancer risk, and evaluated the combined effects of carotenoid and cigarette smoke...
- Survival rates of invasive breast cancer among ethnic Chinese women born in East Asia and the United StatesShu Chun Chuang
Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA
Asian Pac J Cancer Prev 7:221-6. 2006..The main purpose of this study is to explore the difference of breast cancer survival rates between the two populations and compare the survival rates to those of Caucasians born in the US...
- NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysisChun Chao
Gene Environment Epidemiology Group, IARC, 150, cours Albert Thomas, 69372 Lyon Cedex 08, France
Cancer Epidemiol Biomarkers Prev 15:979-87. 2006..We conducted meta-analyses focusing on three cancer sites (lung, bladder, and colorectum) to summarize the findings from the current literature and to explore sources of heterogeneity...
- Dietary selenium intake and genetic polymorphisms of the GSTP1 and p53 genes on the risk of esophageal squamous cell carcinomaLin Cai
Department of Epidemiology, School of Public Health, University of California at Los Angeles, 71 225 CHS, Box 951772, 650 Charles Young Drive, Los Angeles, California 90095 1772, USA
Cancer Epidemiol Biomarkers Prev 15:294-300. 2006..49-8.66 for smokers and 6.19; 95% CI, 1.83-20.9 for drinkers). Our study suggests that the effect of dietary selenium on the risk of ESCC may be modulated by tobacco smoking, alcohol drinking, and p53 Pro/Pro and GSTP1 Ile/Ile genotypes...
- Polymorphism of Xeroderma Pigmentosum group G and the risk of lung cancer and squamous cell carcinomas of the oropharynx, larynx and esophagusYan Cui
Department of Epidemiology, University of California at Los Angeles, Los Angeles, CA 90095, USA
Int J Cancer 118:714-20. 2006..7, 38). In conclusion, our study suggests that the XPG Asp1104Asp genotype may be associated with decreased susceptibility to lung cancer and SCCOLE...
- Epidemiologic review of marijuana use and cancer riskMia Hashibe
International Agency for Research on Cancer, 69008 Lyon, France
Alcohol 35:265-75. 2005..Despite the challenges, elucidation of the association between marijuana use and cancer risk is important in weighing the benefits and risks of medical marijuana use and to clarify the impact of marijuana use on public health...
- Radiotherapy for primary thyroid cancer as a risk factor for second primary cancersShu Chun Chuang
Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, 71 225 CHS, Box 951772, Los Angeles, CA 90095, USA
Cancer Lett 238:42-52. 2006..Radiation therapy for adult patients with thyroid cancer might be associated with a reduced risk of second primary thyroid cancer...
- Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese populationLi Na Mu
Department of Epidemiology, Fudan University School of Public Health, Shanghai, China
Cancer Causes Control 18:665-75. 2007..The objective of this study was to evaluate the effects of polymorphisms of the MTHFR gene on the risk of primary liver cancer and their possible effect modifications on various environmental risk factors...
- Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology ConsortiumMia Hashibe
Gene Environment Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
J Natl Cancer Inst 99:777-89. 2007....
- Marijuana smoking and the risk of head and neck cancer: pooled analysis in the INHANCE consortiumJulien Berthiller
Lifestyle, Environment and Cancer Group, IARC, 69008 Lyon, France
Cancer Epidemiol Biomarkers Prev 18:1544-51. 2009..Because tobacco is a major risk factor for HNC, large studies with substantial numbers of never tobacco users could help to clarify whether marijuana smoking is independently associated with HNC risk...
- Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology ConsortiumMia Hashibe
IARC, Lifestyle, Environment and Cancer Group, Genetics and Epidemiology Cluster, Lyon, France
Cancer Epidemiol Biomarkers Prev 18:541-50. 2009..The magnitude of risk conferred by the interaction between tobacco and alcohol use on the risk of head and neck cancers is not clear because studies have used various methods to quantify the excess head and neck cancer burden...
- Type of alcoholic beverage and risk of head and neck cancer--a pooled analysis within the INHANCE ConsortiumMark P Purdue
National Cancer Institute, Bethesda, Maryland, USA
Am J Epidemiol 169:132-42. 2009..Given the presence of heterogeneity in study-specific results, their findings should be interpreted with caution...
- Family history of cancer: pooled analysis in the International Head and Neck Cancer Epidemiology ConsortiumEva Negri
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Int J Cancer 124:394-401. 2009..0, 95% CI 0.9-1.1). Familial factors play a role in the etiology of HNC. In both subjects with and without family history of HNC, avoidance of tobacco and alcohol exposure may be the best way to avoid HNC...
- Associations between variants of the 8q24 chromosome and nine smoking-related cancer sitesSungshim Lani Park
Department of Epidemiology, University of California at Los Angeles School of Public Health, 71 225 CHS, Box 951772, 650 Charles E Young Drive South, Los Angeles, CA 90095 1772, USA
Cancer Epidemiol Biomarkers Prev 17:3193-202. 2008..Functional and large epidemiologic studies should be conducted to further investigate the association of 8q24 SNPs with smoking-related cancers...
- Involuntary smoking and head and neck cancer risk: pooled analysis in the International Head and Neck Cancer Epidemiology ConsortiumYuan Chin Amy Lee
Lifestyle, Environment and Cancer Group, IARC, 150 cours Albert Thomas, 69008 Lyon, France
Cancer Epidemiol Biomarkers Prev 17:1974-81. 2008..These results are consistent with those for active smoking and suggest that elimination of involuntary smoking exposure might reduce head and neck cancer risk among never smokers...
- Dietary flavonoid intake and lung cancer--a population-based case-control studyYan Cui
Office of Health Assessment and Epidemiology, Los Angeles County Department of Public Health, Los Angeles, California, USA
Cancer 112:2241-8. 2008..To investigate the associations between commonly consumed flavonoid compounds and lung cancer, the authors conducted a population-based case-control study of 558 lung cancer cases and a group of 837 controls...
- A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancersYuan Chin Amy Lee
Department of Epidemiology, University of California at Los Angeles School of Public Health, Los Angeles, CA 90095 1772, USA
Int J Cancer 122:1630-8. 2008..We observed weaker associations between the LIG1 haplotypes and UADT cancers. Our findings suggest the LIG1 haplotypes may affect the risk of lung and UADT cancers...
- Associations between beer, wine, and liquor consumption and lung cancer risk: a meta-analysisChun Chao
Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California 91101 2453, USA
Cancer Epidemiol Biomarkers Prev 16:2436-47. 2007..We conducted dose-specific meta-analyses and dose-response meta-regression to summarize findings from the current literature on the association between consumption of beer, wine, or liquor and lung cancer risk...
- Radiotherapy for oral cancer as a risk factor for second primary cancersMia Hashibe
International Agency for Research on Cancer, Lyon, France
Cancer Lett 220:185-95. 2005..Further studies that account for chemotherapy and examine frequency and duration of radiotherapy would be of interest in confirming the observed association...