Method Development for the Analysis of PBDEs in Human Placenta Tissue

Summary

Principal Investigator: An Li
Affiliation: University of Illinois at Chicago
Country: USA
Abstract: A large number of human placenta samples have been collected from a multi-racial cohort children health study at the Boston Medical Center and another study entitled "Family and Children of Ukraine". The work proposed here is a small project aimed at developing a laboratory procedure for the analysis of polybrominated diphenyl ethers (PBDEs) in human placental tissues. The work will include three tasks: analytical method development and validation, examination on the integrity of stored samples, and a preliminary data collection. We will explore the applicability of a matrix solid-phase dispersion (MSPD) method and compare it with the standard and conventional procedures. Analytical sensitivity enhancement will be through the optimization of the GC injection process using a programmable temperature vaporization (PTV) large volume injector. The result of this work will be needed to initiate future comprehensive studies on prenatal exposure of human to PBDEs. A laboratory procedure is to be developed in order to understand how a wide-spread environmental pollutant affects the health of human fetus before babies are born.
Funding Period: 2007-06-08 - 2009-03-31
more information: NIH RePORT

Top Publications

  1. pmc Optimization of the matrix solid phase dispersion extraction procedure for the analysis of polybrominated diphenyl ethers in human placenta
    R M A Priyanthi S Dassanayake
    School of Public Health, University of Illinois at Chicago, 2121 West Taylor Street, Chicago, Illinois 60612, USA
    Anal Chem 81:9795-801. 2009

Detail Information

Publications1

  1. pmc Optimization of the matrix solid phase dispersion extraction procedure for the analysis of polybrominated diphenyl ethers in human placenta
    R M A Priyanthi S Dassanayake
    School of Public Health, University of Illinois at Chicago, 2121 West Taylor Street, Chicago, Illinois 60612, USA
    Anal Chem 81:9795-801. 2009
    ..Twenty two PBDEs were detected in all of the five samples collected in Chicago in 2008. This is the first description of PBDEs detected in human placentas in the U.S...