Case-Control Study of Adenoma in Sao Paulo Japanese

Summary

Principal Investigator: Loic Le Marchand
Affiliation: University of Hawaii
Country: USA
Abstract: [unreadable] DESCRIPTION (provided by applicant): Smoking, alcohol, overnutrition and a high red meat and low folate, fiber and calcium diet have been associated with colorectal cancer (CRC) and adenoma. Past work, including ours, suggests the importance of the modifying effects of genetic susceptibility factors on most of these associations. Our investigation of the rapid rise in CRC risk among Japanese migrants to Hawaii suggests that Japanese may be more genetically susceptible to the carcinogenic effects of red meat and processed meat, compared to whites, and that they may be particularly protected by a high folate intake. These results are entirely consistent with the sharp rise in CRC incidence observed in Japan over the last 30 years, presumably as a result of the westernization of the diet. However, we have identified another population of Japanese migrants in Sao Paulo, Brazil, for whom CRC rates have remained low, compared to Japanese in Japan an Hawaii, despite a high fat and red meat intake and an affluent western lifestyle. Because this anomaly might provide critical information about protective factors for CRC, we are seeking funding to conduct a colonoscopy-based case- control study of adenoma among Japanese Brazilians in Sao Paulo and to compare findings with our on- going adenoma study (CA 72520) in Hawaii Japanese (565 cases, 660 controls) and with a third (separately funded) companion study (800 cases, 800 controls) conducted in Tokyo. In Sao Paulo, a lifestyle questionnaire will be administered in-person to 550 adenoma cases and 550 endoscopically normal controls matched on age, sex, hospital and date of colonoscopy. In addition to estimating the total intake of energy, nutrients and other dietary components, consumption of meat and fish prepared by high-temperature methods and doneness of meat will be assessed. A blood sample will also be stored for the future testing of exposure markers and genes related to growth hormones, insulin resistance, carcinogen bioactivation and folate metabolism which are being assessed in the Hawaii and Tokyo studies. [unreadable] [unreadable] [unreadable]
Funding Period: 2007-07-01 - 2009-06-30
more information: NIH RePORT

Top Publications

  1. doi Validation of a quantitative FFQ for a study of diet and risk of colorectal adenoma among Japanese Brazilians
    Mohammadreza Pakseresht
    Department of Medicine, 5 10 University Terrace, University of Alberta, Edmonton, Alberta, Canada, T6G 2T4
    Public Health Nutr 16:1445-53. 2013
  2. doi Development of a quantitative food frequency questionnaire for assessing food, nutrient, and heterocyclic aromatic amines intake in Japanese Brazilians for a colorectal adenoma case-control study
    Sangita Sharma
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, USA
    Int J Food Sci Nutr 60:128-39. 2009
  3. doi Nutritional composition of dishes commonly consumed by Japanese Brazilians in São Paulo, Brazil
    Sangita Sharma
    University of North Carolina at Chapel Hill, Nutrition Research Institute, Kannapolis, North Carolina 28081, USA
    Int J Food Sci Nutr 61:549-72. 2010

Scientific Experts

  • Sangita Sharma
  • Mohammadreza Pakseresht
  • Loic Le Marchand
  • Nelson Tomio Miyajima
  • Shoichiro Tsugane
  • Motoki Iwasaki
  • Andrew Shelton

Detail Information

Publications4

  1. doi Validation of a quantitative FFQ for a study of diet and risk of colorectal adenoma among Japanese Brazilians
    Mohammadreza Pakseresht
    Department of Medicine, 5 10 University Terrace, University of Alberta, Edmonton, Alberta, Canada, T6G 2T4
    Public Health Nutr 16:1445-53. 2013
    ..To assess the validity of a 161-item quantitative FFQ (QFFQ) that was developed to evaluate dietary risk factors for a colorectal adenoma case–control study...
  2. doi Development of a quantitative food frequency questionnaire for assessing food, nutrient, and heterocyclic aromatic amines intake in Japanese Brazilians for a colorectal adenoma case-control study
    Sangita Sharma
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, USA
    Int J Food Sci Nutr 60:128-39. 2009
    ..To develop of a quantitative food frequency questionnaire (QFFQ) to assess intake of specific foods, nutrients and heterocyclic aromatic amines (HAAs) in a case-control study of colorectal adenoma...
  3. doi Nutritional composition of dishes commonly consumed by Japanese Brazilians in São Paulo, Brazil
    Sangita Sharma
    University of North Carolina at Chapel Hill, Nutrition Research Institute, Kannapolis, North Carolina 28081, USA
    Int J Food Sci Nutr 61:549-72. 2010
    ....