VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA

Summary

Principal Investigator: K S Cadenhead
Affiliation: University of California
Country: USA
Abstract: In the renewal application/Vulnerability Markers in Prodromal Schizophrenia," the first specific aim is to identify vulnerability markers for psychosis that are present in the prodromal phase and first episode of schizophrenia using 1) clinical, 2) neurophysiological, and 3) neurocognitive measures. Other aims are to increase our understanding of neurodevelopmental processes in individuals in the early stages of schizophrenia, to better understand pre-psychotic symptomatology and to determine the validity and efficiency of vulnerability markers in predicting evolution of psychosis and functional outcome. Increased knowledge regarding the onset of psychosis may help to better identify individuals who are at-risk for psychosis and provide insight into the neurodevelopmental processes that occur in this stage. Additional aims include assessment of at-risk individuals who do not make the transition to psychosis to better understand potential protective factors, decrease the rate of false positives, and decrease disability. Major hypotheses: 1) The at-risk and first episode groups will demonstrate abnormalities when compared to normals on measures of prepulse inhibition; visual masking; P50 gating; and neurocognition; 2) The trait- related deficits will be stable over time; and 3) The clinical and information processing measures will be differentially correlated with each other and one or more factors will predict psychotic conversion and functional outcome in the at-risk sample. The current proposal is unique in that it combines the current knowledge of clinical and demographic risk factors for schizophrenia with the rapidly emerging data on vulnerability markers, or endophenotypes, that are associated with schizophrenia. The use of brain-based vulnerability markers may help to identify neurobiologically and clinically meaningful subgroups within this heterogeneous population in the early stages of schizophrenia and determine which subjects would benefit from early treatment. Greater knowledge regarding protective factors and early indicators of functional outcome may also lead to targeted treatments in the early phase of the illness. Appropriate intervention at this early stage could possibly prevent or delay the development of a psychotic illness along with clinical and functional deterioration. The disruption of social networks, education and occupational activity and the high incidence of suicide and crime that often accompany psychosis might be reduced or averted.
Funding Period: 1999-12-01 - 2011-04-30
more information: NIH RePORT

Top Publications

  1. ncbi How does studying schizotypal personality disorder inform us about the prodrome of schizophrenia?
    Katherine Seeber
    Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Curr Psychiatry Rep 7:41-50. 2005
  2. ncbi P50 suppression in individuals at risk for schizophrenia: the convergence of clinical, familial, and vulnerability marker risk assessment
    Kristin S Cadenhead
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0810, USA
    Biol Psychiatry 57:1504-9. 2005
  3. pmc Risk and protection in prodromal schizophrenia: ethical implications for clinical practice and future research
    Nasra Haroun
    University of California, San Diego, USA
    Schizophr Bull 32:166-78. 2006
  4. pmc Cannabis abuse and risk for psychosis in a prodromal sample
    Karin Kristensen
    Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, USA
    Psychiatry Res 151:151-4. 2007
  5. pmc Social functioning in young people at risk for schizophrenia
    Jacob S Ballon
    University of California, San Diego, Department of Psychiatry, San Diego, CA 92093 0810, USA
    Psychiatry Res 151:29-35. 2007
  6. pmc Neurocognitive deficits in the (putative) prodrome and first episode of psychosis
    A D Eastvold
    University of Utah, USA
    Schizophr Res 93:266-77. 2007
  7. pmc Obstetrical complications in people at risk for developing schizophrenia
    Jacob S Ballon
    Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, United States
    Schizophr Res 98:307-11. 2008
  8. pmc Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study
    Scott W Woods
    PRIME Prodromal Research Clinic, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Schizophr Bull 35:894-908. 2009
  9. pmc Course of neurocognitive deficits in the prodrome and first episode of schizophrenia
    Carol Jahshan
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California, San Diego, USA
    Neuropsychology 24:109-20. 2010

Scientific Experts

  • Scott Woods
  • K S Cadenhead
  • Jacob S Ballon
  • Carol Jahshan
  • Karin Kristensen
  • A D Eastvold
  • Nasra Haroun
  • Katherine Seeber
  • Shahrokh Golshan
  • Robert K Heaton
  • Katherine A Dean
  • Iliana I Marks
  • R K Heaton
  • Tejal Kaur
  • Laura Dunn
  • Ansar Haroun

Detail Information

Publications9

  1. ncbi How does studying schizotypal personality disorder inform us about the prodrome of schizophrenia?
    Katherine Seeber
    Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Curr Psychiatry Rep 7:41-50. 2005
    ..The current review details a strategy for researching the schizophrenia prodrome by using information gained from research in schizotypal personality disorder...
  2. ncbi P50 suppression in individuals at risk for schizophrenia: the convergence of clinical, familial, and vulnerability marker risk assessment
    Kristin S Cadenhead
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0810, USA
    Biol Psychiatry 57:1504-9. 2005
    ..The aim of the present study was to determine whether individuals "at risk" for schizophrenia have deficits in P50 suppression, a preattentive measure of sensory gating...
  3. pmc Risk and protection in prodromal schizophrenia: ethical implications for clinical practice and future research
    Nasra Haroun
    University of California, San Diego, USA
    Schizophr Bull 32:166-78. 2006
    ..Finally, our data strengthen the evidence base available to inform the discussion of ethical issues relevant to this important research area...
  4. pmc Cannabis abuse and risk for psychosis in a prodromal sample
    Karin Kristensen
    Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, USA
    Psychiatry Res 151:151-4. 2007
    ....
  5. pmc Social functioning in young people at risk for schizophrenia
    Jacob S Ballon
    University of California, San Diego, Department of Psychiatry, San Diego, CA 92093 0810, USA
    Psychiatry Res 151:29-35. 2007
    ..Individuals at risk for schizophrenia have significant functional deficits which may be potential indicators of increased vulnerability for psychosis...
  6. pmc Neurocognitive deficits in the (putative) prodrome and first episode of psychosis
    A D Eastvold
    University of Utah, USA
    Schizophr Res 93:266-77. 2007
    ..The identification of brain based neurocognitive vulnerability markers for schizophrenia may contribute to the development of an at risk algorithm with greater predictive accuracy...
  7. pmc Obstetrical complications in people at risk for developing schizophrenia
    Jacob S Ballon
    Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, United States
    Schizophr Res 98:307-11. 2008
    ..Obstetrical complications may be an important risk factor in identifying vulnerable subjects and ultimately may, along with other risk factors, be part of an algorithm for determining likelihood of developing schizophrenia...
  8. pmc Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study
    Scott W Woods
    PRIME Prodromal Research Clinic, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Schizophr Bull 35:894-908. 2009
    ..The strong evidence of diagnostic validity for the prodromal risk syndrome for first psychosis raises the question of its evaluation for inclusion in Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition)...
  9. pmc Course of neurocognitive deficits in the prodrome and first episode of schizophrenia
    Carol Jahshan
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California, San Diego, USA
    Neuropsychology 24:109-20. 2010
    ....