NEUROBIOLOGY OF BINGE-TYPE BEHAVIOR

Summary

Principal Investigator: REBECCA CORWIN
Affiliation: Pennsylvania State University
Country: USA
Abstract: Neurological mechanisms relevant to intermittent episodes of behavioral excess are not well understood, but bear investigation due to the contribution of this kind of behavior to health problems such as disordered eating, obesity and substance abuse. We have developed a unique rat bingeing protocol, which we have been using to examine the neurobiology associated with repeated intermittent excessive fat intake that is maintained over extended periods of time. Peptides that regulate fat intake under non-binge conditions are without effect when rats binge on fat. In contrast, recent results from my laboratory show that the GABA-B agonist baclofen reduces fat intake in our protocol, while having no effect in non-bingeing protocols. Others have reported that baclofen reduces self-administration of abused drugs. This suggests that the neurobiology of bingeing is different from that of non-binge behavior, but may share similarities with the neurobiology of substance abuse. Therefore, we will use baclofen to test the overall hypothesis guiding this research, i.e. that GABA-B receptors have a role in binge-type eating. The following Specific Aims will be addressed: AIM 1: To test the hypothesis that GABA-B ligands will differentially affect fat consumption in bingeing and non-bingeing rats. Hypotheses: a) Lower dosages of baclofen will reduce food intake to a greater extent in bingeing rats than in non-bingeing rats; Lower dosages of baclofen will reduce food intake to a greater extent in females than in males; b) Baclofen-induced reductions in binge intake will be mediated centrally; GABA-B receptor blockade will stimulate binge intake; c) Dosages of GABA-B ligands that affect food intake will not affect general behavioral activity in the bingeing rats. AIM 2: To test the hypothesis that baclofen-induced reductions in fat intake are enhanced with repeated bingeing. Hypothesis: Lower dosages of baclofen will reduce food intake to a greater extent in rats that have repeatedly binged than in rats that have engaged in fewer binge episodes. AIM 3: To test the hypothesis that the VTA is a sensitive site of action for baclofen-induced reductions in bingeing. Hypothesis: Lower doses of baclofen will reduce bingeing when infused into the VTA than when infused into the striatum or substantia nigra. These studies are the first to examine the contribution of GABA-B receptors to bingeing and will provide new insight into the neurobiology of bingeing-related disorders
Funding Period: 2004-05-12 - 2009-02-28
more information: NIH RePORT

Top Publications

  1. ncbi Too much of a good thing: neurobiology of non-homeostatic eating and drug abuse
    Rebecca L Corwin
    The Pennsylvania State University, College of Health and Human Development, Nutritional Sciences Department, University Park, 16802, USA
    Physiol Behav 86:5-8. 2005
  2. ncbi Baclofen, raclopride, and naltrexone differentially affect intake of fat/sucrose mixtures under limited access conditions
    K J Wong
    The Pennsylvania State University, Nutritional Sciences Dept, 110 Chandlee Laboratory, University Park, PA 16802, USA
    Pharmacol Biochem Behav 92:528-36. 2009
  3. ncbi Symposium overview--Food addiction: fact or fiction?
    Rebecca L Corwin
    The Pennsylvania State University, Nutritional Sciences Department, University Park, PA 16802, USA
    J Nutr 139:617-9. 2009
  4. ncbi Access conditions affect binge-type shortening consumption in rats
    F H E Wojnicki
    The Pennsylvania State University, Nutritional Sciences Department, 126 S Henderson, University Park, PA 16802, USA
    Physiol Behav 95:649-57. 2008
  5. ncbi Ovarian hormones inhibit fat intake under binge-type conditions in ovariectomized rats
    Zhiping Yu
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Physiol Behav 95:501-7. 2008
  6. ncbi Binge-type behavior in rats consuming trans-fat-free shortening
    F H E Wojnicki
    The Pennsylvania State University, College of Health and Human Development, Nutritional Sciences Department, 126 S Henderson, University Park, PA 16802, USA
    Physiol Behav 94:627-9. 2008
  7. ncbi Baclofen, raclopride, and naltrexone differentially reduce solid fat emulsion intake under limited access conditions
    R E Rao
    The Pennsylvania State University, Nutritional Sciences Department, University Park, PA 16801, United States
    Pharmacol Biochem Behav 89:581-90. 2008
  8. ncbi Liquid sucrose bingeing in rats depends on the access schedule, concentration and delivery system
    F H E Wojnicki
    The Pennsylvania State University, College of Health and Human Development, Nutritional Sciences Department, 126 S Henderson, University Park, PA 16802, USA
    Physiol Behav 92:566-74. 2007
  9. ncbi Effects of baclofen on operant performance for food pellets and vegetable shortening after a history of binge-type behavior in non-food deprived rats
    F H E Wojnicki
    Pennsylvania State University, Nutritional Sciences, 126 S Henderson, University Park, PA 16802, United States
    Pharmacol Biochem Behav 84:197-206. 2006
  10. ncbi Bingeing rats: a model of intermittent excessive behavior?
    Rebecca L Corwin
    Department of Nutritional Sciences, The Pennsylvania State University, 126 S Henderson, University Park, PA 16802, USA
    Appetite 46:11-5. 2006

Scientific Experts

  • REBECCA CORWIN
  • F H E Wojnicki
  • K J Wong
  • Zhiping Yu
  • R E Rao
  • Ariel Buda-Levin
  • F H W Wojnicki
  • D S Johnson
  • J Coupland
  • S Ghosh
  • Nori Geary
  • G Charny
  • J G Stine
  • D C S Roberts
  • Francis H E Wojnicki

Detail Information

Publications12

  1. ncbi Too much of a good thing: neurobiology of non-homeostatic eating and drug abuse
    Rebecca L Corwin
    The Pennsylvania State University, College of Health and Human Development, Nutritional Sciences Department, University Park, 16802, USA
    Physiol Behav 86:5-8. 2005
    ..The various talks illustrated that boundaries need not exist among research fields, and that communication among the various areas enhances the research effort...
  2. ncbi Baclofen, raclopride, and naltrexone differentially affect intake of fat/sucrose mixtures under limited access conditions
    K J Wong
    The Pennsylvania State University, Nutritional Sciences Dept, 110 Chandlee Laboratory, University Park, PA 16802, USA
    Pharmacol Biochem Behav 92:528-36. 2009
    ..These results also suggest that brief bouts of food consumption involving fatty, sugar-rich foods may prove to be particularly resistant to pharmacological intervention...
  3. ncbi Symposium overview--Food addiction: fact or fiction?
    Rebecca L Corwin
    The Pennsylvania State University, Nutritional Sciences Department, University Park, PA 16802, USA
    J Nutr 139:617-9. 2009
    ..The topic of food addiction bears study, therefore, to develop fresh approaches to clinical intervention and to advance our understanding of basic mechanisms involved in loss of control...
  4. ncbi Access conditions affect binge-type shortening consumption in rats
    F H E Wojnicki
    The Pennsylvania State University, Nutritional Sciences Department, 126 S Henderson, University Park, PA 16802, USA
    Physiol Behav 95:649-57. 2008
    ..These results demonstrate that while intermittent access is necessary and sufficient to stimulate binge-type eating in rats, the behavioral history can modulate binge size...
  5. ncbi Ovarian hormones inhibit fat intake under binge-type conditions in ovariectomized rats
    Zhiping Yu
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Physiol Behav 95:501-7. 2008
    ..These results indicate that the normal cyclic inhibitory influence of ovarian hormones on eating, but not their normal tonic inhibitory influence, is disrupted by conditions leading to binge-type eating...
  6. ncbi Binge-type behavior in rats consuming trans-fat-free shortening
    F H E Wojnicki
    The Pennsylvania State University, College of Health and Human Development, Nutritional Sciences Department, 126 S Henderson, University Park, PA 16802, USA
    Physiol Behav 94:627-9. 2008
    ..Thus, binge-type behavior in the present behavioral model depends upon the schedule of access, not the presence of trans-fats in the shortening...
  7. ncbi Baclofen, raclopride, and naltrexone differentially reduce solid fat emulsion intake under limited access conditions
    R E Rao
    The Pennsylvania State University, Nutritional Sciences Department, University Park, PA 16801, United States
    Pharmacol Biochem Behav 89:581-90. 2008
    ....
  8. ncbi Liquid sucrose bingeing in rats depends on the access schedule, concentration and delivery system
    F H E Wojnicki
    The Pennsylvania State University, College of Health and Human Development, Nutritional Sciences Department, 126 S Henderson, University Park, PA 16802, USA
    Physiol Behav 92:566-74. 2007
    ..These results demonstrate that brief, intermittent access to low and moderate concentrations of sucrose can promote binge-type behavior, and the characteristics of the drinking apparatus can affect sucrose intake...
  9. ncbi Effects of baclofen on operant performance for food pellets and vegetable shortening after a history of binge-type behavior in non-food deprived rats
    F H E Wojnicki
    Pennsylvania State University, Nutritional Sciences, 126 S Henderson, University Park, PA 16802, United States
    Pharmacol Biochem Behav 84:197-206. 2006
    ..These results indicate that intermittent episodes of bingeing on fat can increase the reinforcing efficacy of fat and that GABAB receptor activation can attenuate this effect...
  10. ncbi Bingeing rats: a model of intermittent excessive behavior?
    Rebecca L Corwin
    Department of Nutritional Sciences, The Pennsylvania State University, 126 S Henderson, University Park, PA 16802, USA
    Appetite 46:11-5. 2006
    ..Research from this laboratory using a limited access binge-type eating protocol may provide new insight into IEB...
  11. ncbi Baclofen reduces fat intake under binge-type conditions
    Ariel Buda-Levin
    The Pennsylvania State University, College of Health and Human Development, Nutritional Sciences Department, University Park, 16802, USA
    Physiol Behav 86:176-84. 2005
    ..Furthermore, these results indicate that bingeing, as modeled in our protocol, is different from other forms of food intake and may share similarities with substance abuse...
  12. ncbi Baclofen, raclopride, and naltrexone differentially affect intake of fat and sucrose under limited access conditions
    Rebecca L Corwin
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, Chandlee Laboratory University Park, Pennsylvania 16802, USA
    Behav Pharmacol 20:537-48. 2009
    ..SCH 23390 reduced intake in a nonspecific manner. The results indicate the involvement of GABAB receptors in fat but not sucrose intake, and of D2 receptor dysfunction in rats with a history of bingeing on fat...