NEUROBIOLOGY OF BINGE-TYPE BEHAVIOR

Summary

Principal Investigator: REBECCA CORWIN
Affiliation: Pennsylvania State University
Country: USA
Abstract: Neurological mechanisms relevant to intermittent episodes of behavioral excess are not well understood, but bear investigation due to the contribution of this kind of behavior to health problems such as disordered eating, obesity and substance abuse. We have developed a unique rat bingeing protocol, which we have been using to examine the neurobiology associated with repeated intermittent excessive fat intake that is maintained over extended periods of time. Peptides that regulate fat intake under non-binge conditions are without effect when rats binge on fat. In contrast, recent results from my laboratory show that the GABA-B agonist baclofen reduces fat intake in our protocol, while having no effect in non-bingeing protocols. Others have reported that baclofen reduces self-administration of abused drugs. This suggests that the neurobiology of bingeing is different from that of non-binge behavior, but may share similarities with the neurobiology of substance abuse. Therefore, we will use baclofen to test the overall hypothesis guiding this research, i.e. that GABA-B receptors have a role in binge-type eating. The following Specific Aims will be addressed: AIM 1: To test the hypothesis that GABA-B ligands will differentially affect fat consumption in bingeing and non-bingeing rats. Hypotheses: a) Lower dosages of baclofen will reduce food intake to a greater extent in bingeing rats than in non-bingeing rats; Lower dosages of baclofen will reduce food intake to a greater extent in females than in males; b) Baclofen-induced reductions in binge intake will be mediated centrally; GABA-B receptor blockade will stimulate binge intake; c) Dosages of GABA-B ligands that affect food intake will not affect general behavioral activity in the bingeing rats. AIM 2: To test the hypothesis that baclofen-induced reductions in fat intake are enhanced with repeated bingeing. Hypothesis: Lower dosages of baclofen will reduce food intake to a greater extent in rats that have repeatedly binged than in rats that have engaged in fewer binge episodes. AIM 3: To test the hypothesis that the VTA is a sensitive site of action for baclofen-induced reductions in bingeing. Hypothesis: Lower doses of baclofen will reduce bingeing when infused into the VTA than when infused into the striatum or substantia nigra. These studies are the first to examine the contribution of GABA-B receptors to bingeing and will provide new insight into the neurobiology of bingeing-related disorders
Funding Period: 2004-05-12 - 2009-02-28
more information: NIH RePORT

Top Publications

  1. doi Factors affecting the ability of baclofen to reduce fat intake in rats
    Francis H E Wojnicki
    aDepartment of Nutritional Sciences, College of Health and Human Development bDepartment of Kinesiology, Pennsylvania State University, University Park, Pennsylvania, USA
    Behav Pharmacol 25:166-72. 2014
  2. pmc Environments predicting intermittent shortening access reduce operant performance but not home cage binge size in rats
    F H E Wojnicki
    The Pennsylvania State University, Nutritional Sciences, 110 Chandlee Laboratory, University Park, PA 16802, United States
    Physiol Behav 116:35-43. 2013
  3. ncbi Rodent models of binge eating: are they models of addiction?
    Rebecca L W Corwin
    Nutritional Sciences Department, The Pennsylvania State University College of Health and Human Development, 110 Chandlee Laboratory, University Park, PA 16802, USA
    ILAR J 53:23-34. 2012
  4. pmc Baclofen-induced reductions in optional food intake depend upon food composition
    F H E Wojnicki
    The Pennsylvania State University, College of Health and Human Development, Nutritional Sciences Department, 110 Chandlee Laboratory, University Park, PA 16802, USA
    Appetite 64:62-70. 2013
  5. pmc 2-Hydroxyestradiol enhances binge onset in female rats and reduces prefrontal cortical dopamine in male rats
    R K Babbs
    Pennsylvania State University, IGDP Physiology, 110 Chandlee Laboratory, University Park, PA 16802, USA
    Horm Behav 63:88-96. 2013
  6. pmc Assessing binge eating. An analysis of data previously collected in bingeing rats
    R K Babbs
    110 Chandlee Laboratory, IGDP Physiology, Pennsylvania State University, University Park, PA 16802, USA
    Appetite 59:478-82. 2012
  7. pmc Effect of 2-hydroxyestradiol on binge intake in rats
    R K Babbs
    Pennsylvania State University, IGDP Physiology, 110 Chandlee Laboratory, University Park, PA 16802, USA
    Physiol Behav 103:508-12. 2011
  8. pmc Feeding and reward: perspectives from three rat models of binge eating
    Rebecca L Corwin
    Nutritional Sciences Dept, College of Health and Human Development, The Pennsylvania State University, University Park, PA 16802, United States
    Physiol Behav 104:87-97. 2011
  9. pmc Individual effects of estradiol and progesterone on food intake and body weight in ovariectomized binge rats
    Zhiping Yu
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Physiol Behav 104:687-93. 2011
  10. pmc Fat emulsion composition alters intake and the effects of baclofen
    Y Wang
    The Pennsylvania State University, Department of Food Science, United States
    Appetite 57:628-34. 2011

Scientific Experts

  • REBECCA CORWIN
  • R K Babbs
  • F H E Wojnicki
  • Zhiping Yu
  • Francis H E Wojnicki
  • Y Wang
  • G Charny
  • Nori Geary
  • K J Wong
  • R E Rao
  • Ariel Buda-Levin
  • Shane D Brown
  • D C Wilt
  • J N Coupland
  • F H W Wojnicki
  • S Ghosh
  • D S Johnson
  • J Coupland
  • J G Stine
  • D C S Roberts

Detail Information

Publications24

  1. doi Factors affecting the ability of baclofen to reduce fat intake in rats
    Francis H E Wojnicki
    aDepartment of Nutritional Sciences, College of Health and Human Development bDepartment of Kinesiology, Pennsylvania State University, University Park, Pennsylvania, USA
    Behav Pharmacol 25:166-72. 2014
    ..In summary, the type of fat, the presentation mode (one fat presented alone or two fats simultaneously), and the time between baclofen administration and intake all influence the ability of baclofen to reduce fat intake. ..
  2. pmc Environments predicting intermittent shortening access reduce operant performance but not home cage binge size in rats
    F H E Wojnicki
    The Pennsylvania State University, Nutritional Sciences, 110 Chandlee Laboratory, University Park, PA 16802, United States
    Physiol Behav 116:35-43. 2013
    ..These data indicate that intermittent access will generate binge-type eating in the home cage independent of cue predictability. However, predictable cues in the home cage reduce operant responding independent of intermittent access...
  3. ncbi Rodent models of binge eating: are they models of addiction?
    Rebecca L W Corwin
    Nutritional Sciences Department, The Pennsylvania State University College of Health and Human Development, 110 Chandlee Laboratory, University Park, PA 16802, USA
    ILAR J 53:23-34. 2012
    ....
  4. pmc Baclofen-induced reductions in optional food intake depend upon food composition
    F H E Wojnicki
    The Pennsylvania State University, College of Health and Human Development, Nutritional Sciences Department, 110 Chandlee Laboratory, University Park, PA 16802, USA
    Appetite 64:62-70. 2013
    ..Based upon these results, caution is urged when interpreting results obtained with products using different thickening agents. Systematic research is needed when designing products used in rat models of food intake...
  5. pmc 2-Hydroxyestradiol enhances binge onset in female rats and reduces prefrontal cortical dopamine in male rats
    R K Babbs
    Pennsylvania State University, IGDP Physiology, 110 Chandlee Laboratory, University Park, PA 16802, USA
    Horm Behav 63:88-96. 2013
    ..05). Together, these studies indicate that 2-hydroxyestradiol can exacerbate bingeing as it develops and can suppress dopamine signaling in the prefrontal cortex once bingeing is established...
  6. pmc Assessing binge eating. An analysis of data previously collected in bingeing rats
    R K Babbs
    110 Chandlee Laboratory, IGDP Physiology, Pennsylvania State University, University Park, PA 16802, USA
    Appetite 59:478-82. 2012
    ..The results indicate that both intake and escalation are useful measures. However, their limitations need to be taken into consideration when attempting to operationalize binge-type eating in animal models...
  7. pmc Effect of 2-hydroxyestradiol on binge intake in rats
    R K Babbs
    Pennsylvania State University, IGDP Physiology, 110 Chandlee Laboratory, University Park, PA 16802, USA
    Physiol Behav 103:508-12. 2011
    ..03). Furthermore, this effect seemed to be more subtle in females than in males. Thus, 2OHE2 appears to exacerbate binge size. These data suggest a novel biological mechanism for sex differences in the risk of eating disorders...
  8. pmc Feeding and reward: perspectives from three rat models of binge eating
    Rebecca L Corwin
    Nutritional Sciences Dept, College of Health and Human Development, The Pennsylvania State University, University Park, PA 16802, United States
    Physiol Behav 104:87-97. 2011
    ..These findings may be important in understanding how overeating can influence behavior and brain chemistry...
  9. pmc Individual effects of estradiol and progesterone on food intake and body weight in ovariectomized binge rats
    Zhiping Yu
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Physiol Behav 104:687-93. 2011
    ....
  10. pmc Fat emulsion composition alters intake and the effects of baclofen
    Y Wang
    The Pennsylvania State University, Department of Food Science, United States
    Appetite 57:628-34. 2011
    ....
  11. ncbi The face of uncertainty eats
    Rebecca L W Corwin
    Nutritional Sciences Department, College of Health and Human Development, The Pennsylvania State University, USA
    Curr Drug Abuse Rev 4:174-81. 2011
    ..Food addiction" may not be "addiction" to food at all; it may be a response to uncertainty within environments of food abundance...
  12. pmc Reinforcing efficacy of fat, as assessed by progressive ratio responding, depends upon availability not amount consumed
    F H E Wojnicki
    Pennsylvania State University, Nutritional Sciences, 110 Chandlee Laboratory, University Park, PA 16802, USA
    Physiol Behav 100:316-21. 2010
    ..e. bingeing), increases the reinforcing efficacy of solid shortening; and (2) the type of PR schedule is critical in delineating differences between the groups...
  13. doi Baclofen, raclopride, and naltrexone differentially affect intake of fat and sucrose under limited access conditions
    Rebecca L Corwin
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, Chandlee Laboratory University Park, Pennsylvania 16802, USA
    Behav Pharmacol 20:537-48. 2009
    ..SCH 23390 reduced intake in a nonspecific manner. The results indicate the involvement of GABAB receptors in fat but not sucrose intake, and of D2 receptor dysfunction in rats with a history of bingeing on fat...
  14. pmc Baclofen reduces fat intake under binge-type conditions
    Ariel Buda-Levin
    The Pennsylvania State University, College of Health and Human Development, Nutritional Sciences Department, University Park, 16802, USA
    Physiol Behav 86:176-84. 2005
    ..Furthermore, these results indicate that bingeing, as modeled in our protocol, is different from other forms of food intake and may share similarities with substance abuse...
  15. pmc Bingeing rats: a model of intermittent excessive behavior?
    Rebecca L Corwin
    Department of Nutritional Sciences, The Pennsylvania State University, 126 S Henderson, University Park, PA 16802, USA
    Appetite 46:11-5. 2006
    ..Research from this laboratory using a limited access binge-type eating protocol may provide new insight into IEB...
  16. pmc Effects of baclofen on operant performance for food pellets and vegetable shortening after a history of binge-type behavior in non-food deprived rats
    F H E Wojnicki
    Pennsylvania State University, Nutritional Sciences, 126 S Henderson, University Park, PA 16802, United States
    Pharmacol Biochem Behav 84:197-206. 2006
    ..These results indicate that intermittent episodes of bingeing on fat can increase the reinforcing efficacy of fat and that GABAB receptor activation can attenuate this effect...
  17. ncbi Liquid sucrose bingeing in rats depends on the access schedule, concentration and delivery system
    F H E Wojnicki
    The Pennsylvania State University, College of Health and Human Development, Nutritional Sciences Department, 126 S Henderson, University Park, PA 16802, USA
    Physiol Behav 92:566-74. 2007
    ..These results demonstrate that brief, intermittent access to low and moderate concentrations of sucrose can promote binge-type behavior, and the characteristics of the drinking apparatus can affect sucrose intake...
  18. pmc Baclofen, raclopride, and naltrexone differentially reduce solid fat emulsion intake under limited access conditions
    R E Rao
    The Pennsylvania State University, Nutritional Sciences Department, University Park, PA 16801, United States
    Pharmacol Biochem Behav 89:581-90. 2008
    ....
  19. pmc Binge-type behavior in rats consuming trans-fat-free shortening
    F H E Wojnicki
    The Pennsylvania State University, College of Health and Human Development, Nutritional Sciences Department, 126 S Henderson, University Park, PA 16802, USA
    Physiol Behav 94:627-9. 2008
    ..Thus, binge-type behavior in the present behavioral model depends upon the schedule of access, not the presence of trans-fats in the shortening...
  20. pmc Ovarian hormones inhibit fat intake under binge-type conditions in ovariectomized rats
    Zhiping Yu
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Physiol Behav 95:501-7. 2008
    ..These results indicate that the normal cyclic inhibitory influence of ovarian hormones on eating, but not their normal tonic inhibitory influence, is disrupted by conditions leading to binge-type eating...
  21. pmc Access conditions affect binge-type shortening consumption in rats
    F H E Wojnicki
    The Pennsylvania State University, Nutritional Sciences Department, 126 S Henderson, University Park, PA 16802, USA
    Physiol Behav 95:649-57. 2008
    ..These results demonstrate that while intermittent access is necessary and sufficient to stimulate binge-type eating in rats, the behavioral history can modulate binge size...
  22. pmc Symposium overview--Food addiction: fact or fiction?
    Rebecca L Corwin
    The Pennsylvania State University, Nutritional Sciences Department, University Park, PA 16802, USA
    J Nutr 139:617-9. 2009
    ..The topic of food addiction bears study, therefore, to develop fresh approaches to clinical intervention and to advance our understanding of basic mechanisms involved in loss of control...
  23. pmc Baclofen, raclopride, and naltrexone differentially affect intake of fat/sucrose mixtures under limited access conditions
    K J Wong
    The Pennsylvania State University, Nutritional Sciences Dept, 110 Chandlee Laboratory, University Park, PA 16802, USA
    Pharmacol Biochem Behav 92:528-36. 2009
    ..These results also suggest that brief bouts of food consumption involving fatty, sugar-rich foods may prove to be particularly resistant to pharmacological intervention...
  24. pmc Too much of a good thing: neurobiology of non-homeostatic eating and drug abuse
    Rebecca L Corwin
    The Pennsylvania State University, College of Health and Human Development, Nutritional Sciences Department, University Park, 16802, USA
    Physiol Behav 86:5-8. 2005
    ..The various talks illustrated that boundaries need not exist among research fields, and that communication among the various areas enhances the research effort...