BIPOLAR DISORDER IN LATE LIFE

Summary

Principal Investigator: John Beyer
Abstract: There is a paucity of information on late life bipolar disorder. Unlike bipolar disorder in the young, familial factors are less important in the elderly. In fact, available data suggests that elderly bipolar patients are a distinct group. Vascular factors may be of more importance than genetic factors in the development of bipolar disorder in late life. We have in the last four years developed information on MRI changes, clinical features, and retrospective data on treatment response of elderly bipolar subjects compared with younger bipolar subjects and age-matched controls. Further, our preliminary data utilizing DTI has suggested structural changes in the frontal regions of multi-aged bipolar patients. In this renewal we aim to obtain data on the course and outcome of bipolar disorder, as well as to extend our understanding of MRI/DTI changes by characterizing the location of these changes, their impact on the fibre tracts connecting the frontal and striatal cortex and evaluating the course of response and the effect of MRI changes on treatment outcome. This research is unique and is likely to enhance our understanding of the phenomenology, course, outcome and relationship of MRI changes to the pathophysiology of bipolar disorder in late life.
Funding Period: 1998-03-15 - 2009-12-31
more information: NIH RePORT

Top Publications

  1. pmc Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology
    Cheryl Ann Teh
    Neuroscience and Behavioral Disorders Program, Duke National University of Singapore Graduate School of Medicine, Singapore, Singapore
    PLoS ONE 7:e38469. 2012
  2. pmc The relationship of bipolar disorder lifetime duration and vascular burden to cognition in older adults
    Ariel G Gildengers
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 12:851-8. 2010
  3. pmc Variability in frontotemporal brain structure: the importance of recruitment of African Americans in neuroscience research
    Nneka Isamah
    The Duke Neuropsychiatric Imaging Research Laboratory, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 5:e13642. 2010
  4. pmc Hyperintense MRI lesions in bipolar disorder: A meta-analysis and review
    John L Beyer
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Int Rev Psychiatry 21:394-409. 2009
  5. pmc Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystonia
    Nicole Calakos
    Center for Translational Neuroscience, Box 2900, Research Dr, Duke University Medical Center, Durham, NC 27710, USA
    J Med Genet 47:646-50. 2010
  6. ncbi Gray and white matter brain volumes in older adults with bipolar disorder
    John L Beyer
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Neuropsychiatric Imaging Research Laboratory, USA
    Int J Geriatr Psychiatry 24:1445-52. 2009
  7. pmc Temporal lobe volume in bipolar disorder: relationship with diagnosis and antipsychotic medication use
    Lindsay D Jones
    The Neuropsychiatric Imaging Research Laboratory, Duke University, Durham, North Carolina, United States
    J Affect Disord 114:50-7. 2009
  8. pmc Stressful life events in older bipolar patients
    John L Beyer
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Int J Geriatr Psychiatry 23:1271-5. 2008
  9. pmc The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychiatry Res 155:173-7. 2007
  10. ncbi Medical comorbidity in a bipolar outpatient clinical population
    John Beyer
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 30:401-4. 2005

Scientific Experts

  • John Beyer
  • Warren Taylor
  • Nicole Calakos
  • Cheryl Ann Teh
  • James MacFall
  • Ariel G Gildengers
  • Nneka Isamah
  • Martha E Payne
  • Lindsay D Jones
  • Allison Ashley-Koch
  • Margaratha Kuchibhatla
  • Ranga Krishnan
  • Tih Shih Lee
  • David C Steffens
  • Jody Miller
  • Ellen M Whyte
  • Herbert C Schulberg
  • Laura Davan
  • K Ranga Krishnan
  • Christine Jacobson
  • Philipp Dines
  • David Oslin
  • Nabil Kotbi
  • Richard Weisler
  • Mark Kunik
  • Roger Weiss
  • Warachal Faison
  • Robert C Young
  • Luis Ramirez
  • Ruben Gur
  • Marna Barrett
  • Rayan K Al Jurdi
  • Kari L Seals
  • Sibel Klimstra
  • Michael Thase
  • Peijun Chen
  • Mike Mani
  • Patrick Connelly
  • Tarik Rajji
  • Dielle Miranda
  • Bijan Etemad
  • Patricia Marino
  • Paul J Moberg
  • Martha Sajatovic
  • Adriana V Hyams
  • Martha L Bruce
  • Joel Streim
  • Joe Kwentus
  • Tracey Holsinger
  • Kristin Cassidy
  • Laszlo Gyulai
  • Thomas Ten Have
  • Benoit H Mulsant
  • Rebecca L Greenberg
  • K Ranga R Krishnan
  • Denise F Messer
  • James R MacFall

Detail Information

Publications10

  1. pmc Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology
    Cheryl Ann Teh
    Neuroscience and Behavioral Disorders Program, Duke National University of Singapore Graduate School of Medicine, Singapore, Singapore
    PLoS ONE 7:e38469. 2012
    ..Furthermore we did not find significant differences in other brain regions that have been reported by other authors. Nor did we find a significant effect of BDNF on these measurements...
  2. pmc The relationship of bipolar disorder lifetime duration and vascular burden to cognition in older adults
    Ariel G Gildengers
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 12:851-8. 2010
    ..We also examine whether there are negative, synergistic effects between lifetime duration of BD and vascular disease burden on cognition...
  3. pmc Variability in frontotemporal brain structure: the importance of recruitment of African Americans in neuroscience research
    Nneka Isamah
    The Duke Neuropsychiatric Imaging Research Laboratory, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 5:e13642. 2010
    ....
  4. pmc Hyperintense MRI lesions in bipolar disorder: A meta-analysis and review
    John L Beyer
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Int Rev Psychiatry 21:394-409. 2009
    ..This study was conducted to use meta-analytic techniques to investigate the association of hyperintensities and bipolar illness and to evaluate the current state of the literature...
  5. pmc Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystonia
    Nicole Calakos
    Center for Translational Neuroscience, Box 2900, Research Dr, Duke University Medical Center, Durham, NC 27710, USA
    J Med Genet 47:646-50. 2010
    ..Because of the established role of the TOR1A gene in heritable generalised dystonia (DYT1), a potential genetic contribution of TOR1A to the more prevalent and diverse presentations of late onset, focal dystonia has been suggested...
  6. ncbi Gray and white matter brain volumes in older adults with bipolar disorder
    John L Beyer
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Neuropsychiatric Imaging Research Laboratory, USA
    Int J Geriatr Psychiatry 24:1445-52. 2009
    ..This study assessed the presence of gray matter volume, and the potential for regional volumetric differences in older adults with bipolar disorder...
  7. pmc Temporal lobe volume in bipolar disorder: relationship with diagnosis and antipsychotic medication use
    Lindsay D Jones
    The Neuropsychiatric Imaging Research Laboratory, Duke University, Durham, North Carolina, United States
    J Affect Disord 114:50-7. 2009
    ..We tested for differences in temporal lobe volume in bipolar disorder and the relationship between these volumes and psychotropic medication use...
  8. pmc Stressful life events in older bipolar patients
    John L Beyer
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Int J Geriatr Psychiatry 23:1271-5. 2008
    ..Few studies have examined SLE in older bipolar patients. We wanted to assess the impact of SLE in late life bipolar disorder..
  9. pmc The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychiatry Res 155:173-7. 2007
    ..5T brain MRI and genotyping. After controlling for demographics, Val158 allele homozygotes exhibited significantly smaller temporal lobe and hippocampal volumes, with a trend for smaller amygdala volumes...
  10. ncbi Medical comorbidity in a bipolar outpatient clinical population
    John Beyer
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 30:401-4. 2005
    ..In conclusion, comorbid medical illnesses are common in bipolar outpatients, increasing with age. HIV rates may be increased relative to population norms. Their presence compounds the severity of the illness at time of presentation...