BEHAVIORAL, ERP AND EEG ASYMMETRY IN AFFECTIVE DISORDERS

Summary

Principal Investigator: G E Bruder
Affiliation: Columbia University
Country: USA
Abstract: Converging evidence from perceptual asymmetry, electrophysiologic, and neuroimaging studies support the hypothesis that depressive disorders involve both left prefrontal and right temporoparietal hypoactivation. Perceptual and electrophysiologic asymmetries are related to important clinical features of depression, i.e., diagnostic subtype, comorbidity with anxiety, and responsiveness to antidepressants. The major focus of the next project period will be on development and evaluation of behavioral, EEG and event-related potential (ERP) measures for predicting clinical response to antidepressants. One aim is to evaluate hypothesized differences in hemispheric asymmetry between patients who respond to a selective serotonin reuptake inhibitor (SSRI) and those who do not. ERPs will be recorded during continuous recognition memory tests with word and face stimuli to provide physiologic measures of lateralized medial temporal and frontal function. Regional measures Df EEG hemispheric asymmetry will be examined not only in a resting state but also during psychometrically matched verbal and spatial tasks. We will also continue to use dichotic word and complex tone tests for assessing perceptual asymmetries. A second aim is to evaluate alternative hypotheses relating antidepressant response to bilateral frontal lobe function, particularly to dorsolateral and medial frontal function. For this purpose ERPs will be recorded during a novelty oddball paradigm, which provides a physiologic probe of frontal function, i.e., the novelty P3. Neuropsychological tests will be independently performed to assess frontal lobe function. Testing a large sample of depressed patients will allow further evaluation of these behavioral and electrophysiologic tests as predictors of therapeutic response to antidepressants and will provide a more definitive determination of gender effects. We will also take advantage of ongoing crossover studies to begin to examine the potential of these tests for predicting response to alternative treatments for SSRI non-responders. These aims contribute to the long range goal of identifying more homogeneous subtypes of depression with distinctive clinical features and characteristic alterations of regional brain asymmetry.
Funding Period: 1982-09-28 - 2008-03-31
more information: NIH RePORT

Top Publications

  1. pmc Neuroanatomical correlates of religiosity and spirituality: a study in adults at high and low familial risk for depression
    Lisa Miller
    Teachers College, Columbia University, New York, New York2Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York
    JAMA Psychiatry 71:128-35. 2014
  2. pmc Identifying electrode bridging from electrical distance distributions: a survey of publicly-available EEG data using a new method
    Daniel M Alschuler
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY, USA Electronic address
    Clin Neurophysiol 125:484-90. 2014
  3. pmc Neuronal generators of posterior EEG alpha reflect individual differences in prioritizing personal spirituality
    C E Tenke
    Division of Cognitive Neuroscience, NYS Psychiatric Institute, New York, NY, United States Columbia University, College of Physicians and Surgeons, New York, NY, United States Electronic address
    Biol Psychol 94:426-32. 2013
  4. pmc Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions
    Craig E Tenke
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY, USA
    Clin Neurophysiol 123:2328-45. 2012
  5. pmc Neuropsychological characteristics as predictors of SSRI treatment response in depressed subjects
    Marianne Gorlyn
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY, USA
    J Neural Transm 115:1213-9. 2008
  6. pmc Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms
    Craig E Tenke
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Psychophysiology 47:133-46. 2010
  7. pmc Reduced brain responses to novel sounds in depression: P3 findings in a novelty oddball task
    Gerard E Bruder
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Psychiatry Res 170:218-23. 2009
  8. pmc Current source density measures of electroencephalographic alpha predict antidepressant treatment response
    Craig E Tenke
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 70:388-94. 2011
  9. pmc Relationship of resting EEG with anatomical MRI measures in individuals at high and low risk for depression
    Gerard E Bruder
    Department of Psychiatry, Columbia College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York 10032, USA
    Hum Brain Mapp 33:1325-33. 2012
  10. pmc Electroencephalographic alpha measures predict therapeutic response to a selective serotonin reuptake inhibitor antidepressant: pre- and post-treatment findings
    Gerard E Bruder
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Biol Psychiatry 63:1171-7. 2008

Scientific Experts

  • G E Bruder
  • C E Tenke
  • Daniel M Alschuler
  • Lisa Miller
  • Marianne Gorlyn
  • Priya Wickramaratne
  • Myrna M Weissman
  • Xuejun Hao
  • J├╝rgen Kayser
  • Bradley S Peterson
  • Ravi Bansal
  • Michael F Grunebaum
  • John G Keilp
  • Maria A Oquendo
  • Bonnie P Taylor
  • Jonathan W Stewart
  • J John Mann
  • Gil Zalsman

Detail Information

Publications14

  1. pmc Neuroanatomical correlates of religiosity and spirituality: a study in adults at high and low familial risk for depression
    Lisa Miller
    Teachers College, Columbia University, New York, New York2Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York
    JAMA Psychiatry 71:128-35. 2014
    ....
  2. pmc Identifying electrode bridging from electrical distance distributions: a survey of publicly-available EEG data using a new method
    Daniel M Alschuler
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY, USA Electronic address
    Clin Neurophysiol 125:484-90. 2014
    ..We therefore sought to determine the prevalence of electrode bridging and its potential impact on the EEG literature...
  3. pmc Neuronal generators of posterior EEG alpha reflect individual differences in prioritizing personal spirituality
    C E Tenke
    Division of Cognitive Neuroscience, NYS Psychiatric Institute, New York, NY, United States Columbia University, College of Physicians and Surgeons, New York, NY, United States Electronic address
    Biol Psychol 94:426-32. 2013
    ..EEG differences were particularly well-defined for participants with lifetime depression. Findings extend the view of alpha as a marker for affective processes, suggesting an association with the ontogenesis of spirituality. ..
  4. pmc Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions
    Craig E Tenke
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY, USA
    Clin Neurophysiol 123:2328-45. 2012
    ..CSD methods thereby provide a global empirical and biophysical context for generator localization, spanning scales from intracortical to scalp recordings...
  5. pmc Neuropsychological characteristics as predictors of SSRI treatment response in depressed subjects
    Marianne Gorlyn
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY, USA
    J Neural Transm 115:1213-9. 2008
    ..Cognitive slowing may mediate the working memory and executive function deficits found in nonresponders. These findings can inform exploration for pharmacogenetic endophenotypes...
  6. pmc Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms
    Craig E Tenke
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Psychophysiology 47:133-46. 2010
    ..Compatible CSD-PCA findings were also confirmed for the original low-density sample. Results are consistent with a reduced novelty response in clinical depression, involving the early phase of the frontocentral novelty P3...
  7. pmc Reduced brain responses to novel sounds in depression: P3 findings in a novelty oddball task
    Gerard E Bruder
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Psychiatry Res 170:218-23. 2009
    ..Nor was there a group difference in the earlier N1 or N2 potentials. The novelty P3 reduction in depressed patients is indicative of a deficit in orienting of attention and evaluation of novel environmental sounds...
  8. pmc Current source density measures of electroencephalographic alpha predict antidepressant treatment response
    Craig E Tenke
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 70:388-94. 2011
    ..This study replicates and extends findings relating pretreatment electroencephalographic (EEG) alpha to treatment outcomes for serotonergic medications...
  9. pmc Relationship of resting EEG with anatomical MRI measures in individuals at high and low risk for depression
    Gerard E Bruder
    Department of Psychiatry, Columbia College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York 10032, USA
    Hum Brain Mapp 33:1325-33. 2012
    ..Thus, alpha asymmetry, alone or in combination with MRI, may be a marker of vulnerability for a familial form of depression...
  10. pmc Electroencephalographic alpha measures predict therapeutic response to a selective serotonin reuptake inhibitor antidepressant: pre- and post-treatment findings
    Gerard E Bruder
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Biol Psychiatry 63:1171-7. 2008
    ....
  11. pmc Hemispatial PCA dissociates temporal from parietal ERP generator patterns: CSD components in healthy adults and depressed patients during a dichotic oddball task
    Craig E Tenke
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Psychophysiol 67:1-16. 2008
    ..Results are consistent with prior reports of P3 reduction in depression and implicate distinct parietal and temporal generators of P3 when using a dichotic oddball paradigm...
  12. pmc Predicting therapeutic response to secondary treatment with bupropion: dichotic listening tests of functional brain asymmetry
    Gerard E Bruder
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, United States
    Psychiatry Res 153:137-43. 2007
    ....
  13. pmc Grandchildren at high and low risk for depression differ in EEG measures of regional brain asymmetry
    Gerard E Bruder
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 62:1317-23. 2007
    ..Resting electroencephalogram (EEG) was measured in grandchildren participating in a multigenerational high-risk study...