BEHAVIORAL, ERP AND EEG ASYMMETRY IN AFFECTIVE DISORDERS

Summary

Principal Investigator: G E Bruder
Affiliation: Columbia University
Country: USA
Abstract: The long-range objectives are to clarify the nature of abnormalities of cerebral laterality in diagnostic subtypes of affective illness, and to assess the potential value of behavioral and electrophysiologic measures of hemispheric asymmetry for predicting therapeutic response to treatment with antidepressants. Specific aims are: (1) to bring together, in a collaborative study at Columbia (NYSPI) and Yale (CMHC), a battery of laterality tests that show potential for identifying pathologically distinct subtypes of depression; (2) to obtain converging evidence from EEG and event-related potential (ERP) measures so as to evaluate three models hypothesized to account for abnormal cerebral laterality in depression -- the right frontal inhibition, asymmetric hemispheric arousal, and left anterior/right posterior inactivation models; (3) to expand our electrode array in order to begin to localize ERP sources that relate to hemispheric function in depression; (4) to extend our measurements of brain ERPs in patients having a bipolar disorder with mania. Three studies are proposed to accomplish these aims. The first will test depressed patients and normal controls from NYSPI and CMHC on a battery of laterality tests including: dichotic complex tones, dichotic fused words and syllables, visual dot enumeration, and a free-field faces task. A separate sample of 100 depressed patients and 30 normal controls will be tested at each center. A second study will record electrophysiologic measures in 60 of the patients and all 30 controls at NYSPI. The measures include: resting EEG alpha and ERPs recorded during the dichotic complex tone and visuospatial tests. ERPs of an additional 30 depressed patients and all 30 controls will also be recorded in a RT attention paradigm so as to provide measures of attention-related cortical activation. A third study will test 40 patients having a bipolar disorder with mania. These patients will be tested in a manic and a euthymic state so as to further investigate changes in hemispheric asymmetry accompanying these emotional states.
Funding Period: 1982-09-28 - 1996-08-31
more information: NIH RePORT

Top Publications

  1. pmc Neuroanatomical correlates of religiosity and spirituality: a study in adults at high and low familial risk for depression
    Lisa Miller
    Teachers College, Columbia University, New York, New York2Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York
    JAMA Psychiatry 71:128-35. 2014
  2. pmc Identifying electrode bridging from electrical distance distributions: a survey of publicly-available EEG data using a new method
    Daniel M Alschuler
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY, USA Electronic address
    Clin Neurophysiol 125:484-90. 2014
  3. pmc Neuronal generators of posterior EEG alpha reflect individual differences in prioritizing personal spirituality
    C E Tenke
    Division of Cognitive Neuroscience, NYS Psychiatric Institute, New York, NY, United States Columbia University, College of Physicians and Surgeons, New York, NY, United States Electronic address
    Biol Psychol 94:426-32. 2013
  4. pmc Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions
    Craig E Tenke
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY, USA
    Clin Neurophysiol 123:2328-45. 2012
  5. pmc Neuropsychological characteristics as predictors of SSRI treatment response in depressed subjects
    Marianne Gorlyn
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY, USA
    J Neural Transm 115:1213-9. 2008
  6. pmc Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms
    Craig E Tenke
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Psychophysiology 47:133-46. 2010
  7. pmc Reduced brain responses to novel sounds in depression: P3 findings in a novelty oddball task
    Gerard E Bruder
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Psychiatry Res 170:218-23. 2009
  8. pmc Current source density measures of electroencephalographic alpha predict antidepressant treatment response
    Craig E Tenke
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 70:388-94. 2011
  9. pmc Relationship of resting EEG with anatomical MRI measures in individuals at high and low risk for depression
    Gerard E Bruder
    Department of Psychiatry, Columbia College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York 10032, USA
    Hum Brain Mapp 33:1325-33. 2012
  10. pmc Electroencephalographic alpha measures predict therapeutic response to a selective serotonin reuptake inhibitor antidepressant: pre- and post-treatment findings
    Gerard E Bruder
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Biol Psychiatry 63:1171-7. 2008

Scientific Experts

  • G E Bruder
  • C E Tenke
  • Lisa Miller
  • Daniel M Alschuler
  • Marianne Gorlyn
  • Myrna M Weissman
  • Priya Wickramaratne
  • Xuejun Hao
  • J├╝rgen Kayser
  • Bradley S Peterson
  • Ravi Bansal
  • Michael F Grunebaum
  • Jonathan W Stewart
  • Bonnie P Taylor
  • Gil Zalsman
  • J John Mann
  • Maria A Oquendo
  • John G Keilp

Detail Information

Publications14

  1. pmc Neuroanatomical correlates of religiosity and spirituality: a study in adults at high and low familial risk for depression
    Lisa Miller
    Teachers College, Columbia University, New York, New York2Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York
    JAMA Psychiatry 71:128-35. 2014
    ....
  2. pmc Identifying electrode bridging from electrical distance distributions: a survey of publicly-available EEG data using a new method
    Daniel M Alschuler
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY, USA Electronic address
    Clin Neurophysiol 125:484-90. 2014
    ..We therefore sought to determine the prevalence of electrode bridging and its potential impact on the EEG literature...
  3. pmc Neuronal generators of posterior EEG alpha reflect individual differences in prioritizing personal spirituality
    C E Tenke
    Division of Cognitive Neuroscience, NYS Psychiatric Institute, New York, NY, United States Columbia University, College of Physicians and Surgeons, New York, NY, United States Electronic address
    Biol Psychol 94:426-32. 2013
    ..EEG differences were particularly well-defined for participants with lifetime depression. Findings extend the view of alpha as a marker for affective processes, suggesting an association with the ontogenesis of spirituality. ..
  4. pmc Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions
    Craig E Tenke
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY, USA
    Clin Neurophysiol 123:2328-45. 2012
    ..CSD methods thereby provide a global empirical and biophysical context for generator localization, spanning scales from intracortical to scalp recordings...
  5. pmc Neuropsychological characteristics as predictors of SSRI treatment response in depressed subjects
    Marianne Gorlyn
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY, USA
    J Neural Transm 115:1213-9. 2008
    ..Cognitive slowing may mediate the working memory and executive function deficits found in nonresponders. These findings can inform exploration for pharmacogenetic endophenotypes...
  6. pmc Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms
    Craig E Tenke
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Psychophysiology 47:133-46. 2010
    ..Compatible CSD-PCA findings were also confirmed for the original low-density sample. Results are consistent with a reduced novelty response in clinical depression, involving the early phase of the frontocentral novelty P3...
  7. pmc Reduced brain responses to novel sounds in depression: P3 findings in a novelty oddball task
    Gerard E Bruder
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Psychiatry Res 170:218-23. 2009
    ..Nor was there a group difference in the earlier N1 or N2 potentials. The novelty P3 reduction in depressed patients is indicative of a deficit in orienting of attention and evaluation of novel environmental sounds...
  8. pmc Current source density measures of electroencephalographic alpha predict antidepressant treatment response
    Craig E Tenke
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 70:388-94. 2011
    ..This study replicates and extends findings relating pretreatment electroencephalographic (EEG) alpha to treatment outcomes for serotonergic medications...
  9. pmc Relationship of resting EEG with anatomical MRI measures in individuals at high and low risk for depression
    Gerard E Bruder
    Department of Psychiatry, Columbia College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York 10032, USA
    Hum Brain Mapp 33:1325-33. 2012
    ..Thus, alpha asymmetry, alone or in combination with MRI, may be a marker of vulnerability for a familial form of depression...
  10. pmc Electroencephalographic alpha measures predict therapeutic response to a selective serotonin reuptake inhibitor antidepressant: pre- and post-treatment findings
    Gerard E Bruder
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Biol Psychiatry 63:1171-7. 2008
    ....
  11. pmc Hemispatial PCA dissociates temporal from parietal ERP generator patterns: CSD components in healthy adults and depressed patients during a dichotic oddball task
    Craig E Tenke
    Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Psychophysiol 67:1-16. 2008
    ..Results are consistent with prior reports of P3 reduction in depression and implicate distinct parietal and temporal generators of P3 when using a dichotic oddball paradigm...
  12. pmc Predicting therapeutic response to secondary treatment with bupropion: dichotic listening tests of functional brain asymmetry
    Gerard E Bruder
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, United States
    Psychiatry Res 153:137-43. 2007
    ....
  13. pmc Grandchildren at high and low risk for depression differ in EEG measures of regional brain asymmetry
    Gerard E Bruder
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 62:1317-23. 2007
    ..Resting electroencephalogram (EEG) was measured in grandchildren participating in a multigenerational high-risk study...