Regional Lung Mechanics by 3D Image Registration

Summary

Principal Investigator: J M Reinhardt
Affiliation: University of Iowa
Country: USA
Abstract: The goals of this research are to use high-resolution maps of regional lung mechanical properties to detect and follow the progression of lung disease. Pulmonary disease processes, including emphysema, interstitial fibrosis, cancer, pulmonary embolism, acute lung injury and more, alter the material properties of lung tissue and change the mechanics of the respiratory system. Furthermore, while these mechanical changes (and the disease process itself) originate at a local level, they are largely asymptomatic and invisible to currently available global measures of lung function such as pulmonary function tests until they have significantly advanced. We will use image registration to construct a high-resolution 3D map of the regional distribution of lung tissue specific volume change (related to specific compliance) and the lung tissue strain tensor between multiple respiratory-gated volumetric images of the breathing lung. The computational tools to be developed in this project will provide the ability to assess local volume, grayscale, and shape changes for arbitrary regions of interest in the lung parenchyma across the respiratory cycle. We expect that, by tracking the 3D distribution of regional lung specific volume change and the magnitude and direction of lung strain, we can examine the effects that localized pathological processes have on diseased tissue as well as surrounding normal tissue. Such information may provide new insights regarding pulmonary pathophysiology in, for instance, the proliferation of lung destruction in emphysema, the ventilation and perfusion mismatches in pulmonary emboli episodes, the effect of regional airway closure in asthma, and the regional mechanics of acute lung injury and the propagation of ventilator-associated lung injury. This information is now critical to the development and evaluation of new pulmonary disease therapies.
Funding Period: ----------------2006 - ---------------2011-
more information: NIH RePORT

Top Publications

  1. ncbi Registration-derived estimates of local lung expansion as surrogates for regional ventilation
    Joseph M Reinhardt
    Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242, USA
    Inf Process Med Imaging 20:763-74. 2007
  2. pmc A measure for characterizing sliding on lung boundaries
    Ryan E Amelon
    Department of Biomedical Engineering, University of Iowa, 1136 Seamans Center, Iowa City, IA, 52242, USA
    Ann Biomed Eng 42:642-50. 2014
  3. pmc Reproducibility of intensity-based estimates of lung ventilation
    Kaifang Du
    Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa 52242, USA
    Med Phys 40:063504. 2013
  4. pmc Registration-based lung mechanical analysis of chronic obstructive pulmonary disease (COPD) using a supervised machine learning framework
    Sandeep Bodduluri
    Department of Biomedical Engineering, The University of Iowa, Iowa City, IA, USA
    Acad Radiol 20:527-36. 2013
  5. pmc Comparison of image registration based measures of regional lung ventilation from dynamic spiral CT with Xe-CT
    Kai Ding
    Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa 52242, USA
    Med Phys 39:5084-98. 2012
  6. pmc Respiratory effort correction strategies to improve the reproducibility of lung expansion measurements
    Kaifang Du
    Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa 52242
    Med Phys 40:123504. 2013
  7. pmc Registration-based estimates of local lung tissue expansion compared to xenon CT measures of specific ventilation
    Joseph M Reinhardt
    Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
    Med Image Anal 12:752-63. 2008
  8. pmc Analysis of regional mechanics in canine lung injury using forced oscillations and 3D image registration
    David W Kaczka
    Harvard Medical School, and Department of Anesthesiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Ann Biomed Eng 39:1112-24. 2011
  9. doi Anatomy-guided lung lobe segmentation in X-ray CT images
    Soumik Ukil
    Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242, USA
    IEEE Trans Med Imaging 28:202-14. 2009
  10. pmc Mass preserving nonrigid registration of CT lung images using cubic B-spline
    Youbing Yin
    Department of Mechanical and Industrial Engineering, and IIHR Hydroscience and Engineering, The University of Iowa, Iowa City, Iowa 52242, USA
    Med Phys 36:4213-22. 2009

Scientific Experts

  • Kai Ding
  • David W Kaczka
  • Joseph M Reinhardt
  • Gary E Christensen
  • Kaifang Du
  • Kunlin Cao
  • Eric A Hoffman
  • Youbing Yin
  • John E Bayouth
  • Ryan E Amelon
  • Sandeep Bodduluri
  • Madhavan L Raghavan
  • Luke M Gabe
  • Ryan Amelon
  • Ching Long Lin
  • Soumik Ukil
  • John D Newell
  • Gary W Hunninghake
  • Kimberly M Baker
  • Edwin J R van Beek
  • Shalmali V Bodas

Detail Information

Publications16

  1. ncbi Registration-derived estimates of local lung expansion as surrogates for regional ventilation
    Joseph M Reinhardt
    Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242, USA
    Inf Process Med Imaging 20:763-74. 2007
    ..We compare lung expansion estimated across five pressure changes to a xenon CT based measure of specific ventilation, and have shown good agreement (linear regression, r2 = 0.89 during gas wash-in) in one animal...
  2. pmc A measure for characterizing sliding on lung boundaries
    Ryan E Amelon
    Department of Biomedical Engineering, University of Iowa, 1136 Seamans Center, Iowa City, IA, 52242, USA
    Ann Biomed Eng 42:642-50. 2014
    ..Sliding is a key aspect of lung deformation during breathing. The proposed measure may help resolve artifacts introduced by sliding in deformation analysis techniques used for radiotherapy. ..
  3. pmc Reproducibility of intensity-based estimates of lung ventilation
    Kaifang Du
    Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa 52242, USA
    Med Phys 40:063504. 2013
    ..The intensity-based estimates are compared to the estimates of lung function derived from image registration deformation field...
  4. pmc Registration-based lung mechanical analysis of chronic obstructive pulmonary disease (COPD) using a supervised machine learning framework
    Sandeep Bodduluri
    Department of Biomedical Engineering, The University of Iowa, Iowa City, IA, USA
    Acad Radiol 20:527-36. 2013
    ..It performed well when compared to CT-derived density and textural features of lung function and the presence and severity of COPD...
  5. pmc Comparison of image registration based measures of regional lung ventilation from dynamic spiral CT with Xe-CT
    Kai Ding
    Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa 52242, USA
    Med Phys 39:5084-98. 2012
    ..The authors compare this new measure, along with two existing registration based measures of lung ventilation, to a regional ventilation measurement derived from xenon-CT (Xe-CT) imaging...
  6. pmc Respiratory effort correction strategies to improve the reproducibility of lung expansion measurements
    Kaifang Du
    Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa 52242
    Med Phys 40:123504. 2013
    ..In this study, the authors present normalization schemes that correct ventilation images for variations in respiratory effort and assess the reproducibility improvement after effort correction...
  7. pmc Registration-based estimates of local lung tissue expansion compared to xenon CT measures of specific ventilation
    Joseph M Reinhardt
    Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
    Med Image Anal 12:752-63. 2008
    ..Using 3D image registration to match images acquired at 10 cm H(2)O and 15 cm H(2)O airway pressures gave the best match between the average Jacobian and the xenon CT specific ventilation (linear regression, average r(2)=0.73)...
  8. pmc Analysis of regional mechanics in canine lung injury using forced oscillations and 3D image registration
    David W Kaczka
    Harvard Medical School, and Department of Anesthesiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Ann Biomed Eng 39:1112-24. 2011
    ....
  9. doi Anatomy-guided lung lobe segmentation in X-ray CT images
    Soumik Ukil
    Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242, USA
    IEEE Trans Med Imaging 28:202-14. 2009
    ..The detected incomplete fissure is used to extrapolate and smoothly complete the fissure. We evaluate the method by testing on data sets from normal subjects and subjects with mild to moderate emphysema...
  10. pmc Mass preserving nonrigid registration of CT lung images using cubic B-spline
    Youbing Yin
    Department of Mechanical and Industrial Engineering, and IIHR Hydroscience and Engineering, The University of Iowa, Iowa City, Iowa 52242, USA
    Med Phys 36:4213-22. 2009
    ..Over 100 annotated landmarks located at vessel bifurcations were generated using a semiautomatic system. The results show that the SSTVD method yields smaller average landmark errors than the SSD method across all six registration pairs...
  11. pmc 4DCT-based measurement of changes in pulmonary function following a course of radiation therapy
    Kai Ding
    Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa 52242, USA
    Med Phys 37:1261-72. 2010
    ..In this article, the authors propose a method that quantitatively measures the regional changes in lung tissue function following a course of radiation therapy by using 4DCT and image registration techniques...
  12. pmc Reproducibility of registration-based measures of lung tissue expansion
    Kaifang Du
    Department of Biomedical Engineering, The University of Iowa, Iowa City, IA, USA
    Med Phys 39:1595-608. 2012
    ..In this study, the authors examine the reproducibility of Jacobian-based measures of lung tissue expansion in two repeat 4DCT acquisitions of mechanically ventilated sheep and free-breathing humans...
  13. pmc Three-dimensional characterization of regional lung deformation
    Ryan Amelon
    Department of Biomedical Engineering, University of Iowa, IA 52242, United States
    J Biomech 44:2489-95. 2011
    ..The developed deformation indices lend themselves to exhaustive and physiologically intuitive interpretations of the displacement fields in the lung determined through image-registration techniques or finite element simulations...
  14. pmc Evaluation of lobar biomechanics during respiration using image registration
    Kai Ding
    Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242, USA
    Med Image Comput Comput Assist Interv 12:739-46. 2009
    ..The results show a superior-inferior gradient in the magnitude of lobar sliding. We compare whole-lung-based registration accuracy to lobe-by-lobe registration accuracy using vessel bifurcation landmarks...
  15. pmc A cubic B-spline-based hybrid registration of lung CT images for a dynamic airway geometric model with large deformation
    Youbing Yin
    Department of Mechanical and Industrial Engineering, University of Iowa, Iowa City, IA 52242, USA
    Phys Med Biol 56:203-18. 2011
    ..Statistical results also show that the proposed hybrid approach yields significantly improved results as compared with approaches using either landmarks or intensity alone...
  16. pmc Effect of segmental bronchoalveolar lavage on quantitative computed tomography of the lung
    Luke M Gabe
    Department of Radiology, University of Iowa, Iowa City, IA 52242, USA
    Acad Radiol 18:876-84. 2011
    ....