INTL POPULATION STUDY ON MACRONUTRIENTS AND BP INTERMAP

Summary

Principal Investigator: Jeremiah Stamler
Affiliation: Northwestern University
Country: USA
Abstract: INTERMAP is basic epidemiologic investigation designed to help clarify unanswered questions on the role of dietary factors, particularly macronutrients, in the etiology of unfavorable blood pressure (BP) levels prevailing for a majority of middle-aged and older individuals in the U.S. population. A particular focus -- within the context of this overall objective -- is to help elucidate the role of these dietary factors in accounting for the even more adverse BP patterns of less educated population state, e.g., in the U.S. both less educated African-Americans and Whites. INTERMAP aims to achieve a major advance on these important issues, based on its design, patterned after the tested INTERSALT model: large sample size of 5,200 persons (2,600 men and 2,600 women), ages 40-59 from 20 diverse population samples of varied ethnicity, SES, and dietary habits in 4 countries (China, Japan, U.K., U.S.) (260 persons per sample). Cost effectiveness is assured by major cost-sharing by non-U.S. centers, so that costs for NHLBI are much less than for research of this scope done solely in the U.S. Specific aims involve elucidating influences on BP of amount and type of protein, lipids, carbohydrates, also amino acids, Ca, Mg, antioxidants, fiber, caffeine. Primary hypotheses to be tested, with control for BMI, intake of alcohol, Na, K, age, sex, other confounders are; dietary protein is inversely related to BP; inverse relations between education and BP are significantly accounted for by education-correlated differences in dietary protein intake; there is a direct relation to BP of dietary SFA, cholesterol, keys score, starch; there is an inverse relation of PFA and of P.S. Participants, randomly selected, are to provide 2 timed 24-hr urine collections for assessment of Na, K, creatinine, urea, and are to complete four 24-hr dietary recalls. BP is to be measured twice at each of 4 clinic visits. The study is to be coordinated by two Coordinating Centers -- Northwestern University, Chicago and london School of Hygiene and Tropical Medicine. Urinary determinations are to be made at a Central Laboratory in Leuven, Belgium. 24-hr dietary recalls are to be converted into nutrients with use in each country of an up-to-date, extensive, high- quality, well-maintained national data base on nutrient composition of foods and recipes, with international study-wide standardization, quality control, and support for this and related local and national tasks. Data analyses o test hypotheses and explore nutrient-BP relations are to be done at the london Coordinating Center. Findings on relations of multiple dietary factors to BP are to be used to estimate favorable impact on BP of multiple improvements in nutrition by populations. This, in turn, should aid in making dietary recommendations toward achieving the goal of primary prevention of hypertension, and shifting BP distributions downward to avoid excess risk associated with present levels generally above optimal.
Funding Period: 1995-07-01 - 2000-06-30
more information: NIH RePORT

Top Publications

  1. ncbi Relation of nutrient intake to microalbuminuria in nondiabetic middle-aged men and women: International Population Study on Macronutrients and Blood Pressure (INTERMAP)
    Martha L Daviglus
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Kidney Dis 45:256-66. 2005
  2. ncbi Association of monosodium glutamate intake with overweight in Chinese adults: the INTERMAP Study
    Ka He
    Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Obesity (Silver Spring) 16:1875-80. 2008
  3. ncbi Relationship of dietary linoleic acid to blood pressure. The International Study of Macro-Micronutrients and Blood Pressure Study [corrected]
    Katsuyuki Miura
    Department of Health Science, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, Shiga 520 2192, Japan
    Hypertension 52:408-14. 2008
  4. ncbi Relation of iron and red meat intake to blood pressure: cross sectional epidemiological study
    Ioanna Tzoulaki
    Department of Epidemiology and Public Health, Imperial College London, St Mary s Campus, London W2 1PG
    BMJ 337:a258. 2008
  5. ncbi Relation of dietary and other lifestyle traits to difference in serum adiponectin concentration of Japanese in Japan and Hawaii: the INTERLIPID Study
    Yasuyuki Nakamura
    Cardiovascular Epidemiology, Kyoto Women s University, Kyoto, Japan
    Am J Clin Nutr 88:424-30. 2008
  6. ncbi Development of a food frequency and quantity method for assessing dietary habits of Japanese individuals--comparison with results from 24hr recall dietary survey
    Nagako Chiba
    Department of Health and Nutrition, Tsukuba International Junior College, Tsuchiura, Ibaraki, Japan
    J Atheroscler Thromb 15:324-33. 2008
  7. ncbi Dietary starch intake of individuals and their blood pressure: the International Study of Macronutrients and Micronutrients and Blood Pressure
    Ian J Brown
    Department of Epidemiology and Public Health, Imperial College London, St Mary s Campus, London, UK
    J Hypertens 27:231-6. 2009
  8. ncbi Relation of long-term body weight change to change in lipoprotein particle size in Japanese men and women: the INTERMAP Toyama Study
    Rie Naganuma
    Department of Epidemiology and Public Health, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Atherosclerosis 206:282-6. 2009
  9. ncbi Urinary amino acid analysis: a comparison of iTRAQ-LC-MS/MS, GC-MS, and amino acid analyzer
    Hannelore Kaspar
    Institute of Functional Genomics, University of Regensburg, Josef Engert Strasse 9, 93053 Regensburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 877:1838-46. 2009
  10. ncbi Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies
    Ruey Leng Loo
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
    Anal Chem 81:5119-29. 2009

Scientific Experts

  • Yasuyuki Nakamura
  • P Elliott
  • Martha Daviglus
  • Nagako Chiba
  • Katsuyuki Miura
  • Jeremiah Stamler
  • Marc Emmanuel Dumas
  • Henrik Antti
  • Sujata L Archer
  • Hirotsugu Ueshima
  • Nagako Okuda
  • Rie Naganuma
  • Elaine Holmes
  • Queenie Chan
  • Ian J Brown
  • Liancheng Zhao
  • Ruey Leng Loo
  • Jeremy K Nicholson
  • Linda Van Horn
  • Elaine Maibaum
  • Hannelore Kaspar
  • Alan R Dyer
  • Magda Bictash
  • Ioanna Tzoulaki
  • S Yoneyama
  • Muireann Coen
  • Olivier Cloarec
  • Ka He
  • Par Jonsson
  • Claire Robertson
  • Claire E Robertson
  • Timothy Ebbels
  • Ivan Yap
  • Chiang Ching Huang
  • Beatriz L Rodriguez
  • Kiyomi Sakata
  • Subodh Nimkar
  • Peter J Oefner
  • Katja Dettmer
  • Scott Daniels
  • Dongshuang Guo
  • Yangfeng Wu
  • S Saitoh
  • Liguang Zhu
  • A Okayama
  • Maria De Iorio
  • Tim Ebbels
  • K Yoshita
  • Hugo Kesteloot
  • Daniel Garside
  • K Itai
  • Kirill A Veselkov
  • K Sakata
  • T Shimmura
  • H Nakagawa
  • Ivan K S Yap
  • Beifan Zhou
  • Huiru Tang
  • Ian D Wilson
  • Stephen Bruce
  • John C Lindon
  • Rana Conway
  • Thomas Moritz
  • Robert Plumb
  • Michael Sjostrom
  • Jennifer Granger
  • Stephen J Bruce
  • Johan Trygg
  • John Yarnell
  • Barbara Dennis

Detail Information

Publications24

  1. ncbi Relation of nutrient intake to microalbuminuria in nondiabetic middle-aged men and women: International Population Study on Macronutrients and Blood Pressure (INTERMAP)
    Martha L Daviglus
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Kidney Dis 45:256-66. 2005
    ..Microalbuminuria (MA) is a risk factor for cardiovascular and renal disease. However, little is known about the relation of nutritional factors to MA, especially in individuals without diabetes...
  2. ncbi Association of monosodium glutamate intake with overweight in Chinese adults: the INTERMAP Study
    Ka He
    Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Obesity (Silver Spring) 16:1875-80. 2008
    ..03) and 2.75 (95% confidence interval, 1.28-5.95, P = 0.04). This research provides data that MSG intake may be associated with increased risk of overweight independent of physical activity and total energy intake in humans...
  3. ncbi Relationship of dietary linoleic acid to blood pressure. The International Study of Macro-Micronutrients and Blood Pressure Study [corrected]
    Katsuyuki Miura
    Department of Health Science, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, Shiga 520 2192, Japan
    Hypertension 52:408-14. 2008
    ..42/-0.98 mm Hg (P<0.05 for both) with 2 SD higher intake (4.04% kcal). Dietary linoleic acid intake may contribute to prevention and control of adverse blood pressure levels in general populations...
  4. ncbi Relation of iron and red meat intake to blood pressure: cross sectional epidemiological study
    Ioanna Tzoulaki
    Department of Epidemiology and Public Health, Imperial College London, St Mary s Campus, London W2 1PG
    BMJ 337:a258. 2008
    ..To investigate associations of dietary iron (total, haem, and non-haem), supplemental iron, and red meat with blood pressure...
  5. ncbi Relation of dietary and other lifestyle traits to difference in serum adiponectin concentration of Japanese in Japan and Hawaii: the INTERLIPID Study
    Yasuyuki Nakamura
    Cardiovascular Epidemiology, Kyoto Women s University, Kyoto, Japan
    Am J Clin Nutr 88:424-30. 2008
    ..In initial analyses, we found significant differences between serum adiponectin in Japanese living in Japan and Hawaii...
  6. ncbi Development of a food frequency and quantity method for assessing dietary habits of Japanese individuals--comparison with results from 24hr recall dietary survey
    Nagako Chiba
    Department of Health and Nutrition, Tsukuba International Junior College, Tsuchiura, Ibaraki, Japan
    J Atheroscler Thromb 15:324-33. 2008
    ..001) for cereals, r=0.261 (p=0.023) for meat, and r=0.333 (p=0.003) for fish and shellfish. This method was thought to be appropriate for quantitative assessment of the intake of major nutrients and food groups of individuals in Japan...
  7. ncbi Dietary starch intake of individuals and their blood pressure: the International Study of Macronutrients and Micronutrients and Blood Pressure
    Ian J Brown
    Department of Epidemiology and Public Health, Imperial College London, St Mary s Campus, London, UK
    J Hypertens 27:231-6. 2009
    ..Cross-sectional data from the International Study of Macronutrients and Micronutrients and Blood Pressure (INTERMAP) were used to assess relations of dietary starch intake to blood pressure in men and women from four countries...
  8. ncbi Relation of long-term body weight change to change in lipoprotein particle size in Japanese men and women: the INTERMAP Toyama Study
    Rie Naganuma
    Department of Epidemiology and Public Health, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Atherosclerosis 206:282-6. 2009
    ..This study investigated the relationship between changes in lipoprotein particle size and body weight change over a 9-year period in Japanese adult men and women...
  9. ncbi Urinary amino acid analysis: a comparison of iTRAQ-LC-MS/MS, GC-MS, and amino acid analyzer
    Hannelore Kaspar
    Institute of Functional Genomics, University of Regensburg, Josef Engert Strasse 9, 93053 Regensburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 877:1838-46. 2009
    ....
  10. ncbi Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies
    Ruey Leng Loo
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
    Anal Chem 81:5119-29. 2009
    ..The NMR-based metabolic screening strategy provides a new objective approach for evaluation of self-reported medication data and is extendable to other aspects of population xenometabolome profiling...
  11. ncbi Glutamic acid, the main dietary amino acid, and blood pressure: the INTERMAP Study (International Collaborative Study of Macronutrients, Micronutrients and Blood Pressure)
    Jeremiah Stamler
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Circulation 120:221-8. 2009
    ....
  12. ncbi Human metabolic phenotype diversity and its association with diet and blood pressure
    Elaine Holmes
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    Nature 453:396-400. 2008
    ..Metabolic phenotyping applied to high-quality epidemiological data offers the potential to develop an area of aetiopathogenetic knowledge involving discovery of novel biomarkers related to cardiovascular disease risk...
  13. ncbi Dietary phosphorus and blood pressure: international study of macro- and micro-nutrients and blood pressure
    Paul Elliott
    Department of Epidemiology and Public Health, Faculty of Medicine, St Mary s Campus, Imperial College London, London, United Kingdom
    Hypertension 51:669-75. 2008
    ..These results indicate the potential for increased phosphorus/mineral intake to lower blood pressure as part of the recommendations for healthier eating patterns for the prevention and control of prehypertension and hypertension...
  14. ncbi Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: the INTERLIPID study
    Nagako Okuda
    Department of Health Science, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    Atherosclerosis 178:371-9. 2005
    ..011). This association was not observed in women. This positive association of dietary n-3 PUFA with serum HDL cholesterol may partially explain the low mortality from CHD among Japanese men...
  15. ncbi Extraction, interpretation and validation of information for comparing samples in metabolic LC/MS data sets
    Par Jonsson
    Research Group for Chemometrics, Department of Chemistry, Umea University, SE 90187 Umea, Sweden
    Analyst 130:701-7. 2005
    ..The presented findings suggest that this is a general approach for data handling, analysis, and evaluation of large metabolic LC/MS data sets...
  16. ncbi Association of dietary supplement use with specific micronutrient intakes among middle-aged American men and women: the INTERMAP Study
    Sujata L Archer
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Am Diet Assoc 105:1106-14. 2005
    ....
  17. ncbi Attainment of precision in implementation of 24 h dietary recalls: INTERMAP UK
    Claire Robertson
    Department of Nutrition and Dietetics, King s College London, 150 Stamford Street, London SE1 8WA, UK
    Br J Nutr 94:588-94. 2005
    ..1 % were below. Experiences from the INTERMAP Belfast centre indicate that difficulties in collection of dietary information can be anticipated and contained by the systematic use of methods to prevent, detect and correct errors...
  18. ncbi Association between protein intake and blood pressure: the INTERMAP Study
    Paul Elliott
    Department of Epidemiology and Public Health, Faculty of Medicine, St Mary s Campus, Imperial College London, London, England
    Arch Intern Med 166:79-87. 2006
    ..Findings from epidemiological studies suggest an inverse relationship between individuals' protein intake and their blood pressure...
  19. ncbi Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics for large-scale epidemiological research: the INTERMAP Study
    Marc Emmanuel Dumas
    Biological Chemistry, Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London UK
    Anal Chem 78:2199-208. 2006
    ..These cross-population differences in urinary metabolites could be related to genetic, dietary, and gut microbial factors...
  20. ncbi Dietary factors related to higher plasma fibrinogen levels of Japanese-americans in hawaii compared with Japanese in Japan
    Katsuyuki Miura
    Department of Epidemiology and Public Health, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, 920 0293, Japan
    Arterioscler Thromb Vasc Biol 26:1674-9. 2006
    ..We investigated whether dietary factors explain higher plasma fibrinogen levels in Japanese emigrants living a Western lifestyle in Hawaii compared with Japanese in Japan...
  21. ncbi Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy
    Elaine Holmes
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
    Anal Chem 79:2629-40. 2007
    ..This approach should be of value in considering interpopulation patterns of drug metabolism in epidemiological and pharmacogenetic studies...
  22. ncbi Food omega-3 fatty acid intake of individuals (total, linolenic acid, long-chain) and their blood pressure: INTERMAP study
    Hirotsugu Ueshima
    Department of Health Science, Shiga University of Medical Science, Tsukinowa cho Seta, Otsu, Shiga 520 2192, Japan
    Hypertension 50:313-9. 2007
    ..In summary, food omega-3 PFA intake related inversely to blood pressure, including in nonhypertensive persons, with small estimated effect size. Food omega-3 PFA may contribute to prevention and control of adverse blood pressure levels...
  23. ncbi Dietary intake and urinary excretion of selenium in the Japanese adult population: the INTERMAP Study Japan
    S Yoneyama
    Department of Epidemiology and Public Health, Kanazawa Medical University, Ishikawa, Japan
    Eur J Clin Nutr 62:1187-93. 2008
    ..This study is to examine the relationship between dietary selenium intake and 24-h urinary selenium excretion in Japanese population samples participating in the INTERMAP Study...
  24. ncbi Relation of serum leptin to blood pressure of Japanese in Japan and Japanese-Americans in Hawaii
    Yasuyuki Nakamura
    Cardiovascular Epidemiology, Kyoto Women s University, 35 Imakumano Kitahiyoshi cho, Higashiyama ku, Kyoto 605 8501, Japan
    Hypertension 54:1416-22. 2009
    ..01 to <0.05). These findings are consistent with the inference that leptin may be an independent mediator for obesity-related elevations in BP...