INTL POPULATION STUDY ON MACRONUTRIENTS AND BP INTERMAP

Summary

Principal Investigator: Jeremiah Stamler
Affiliation: Northwestern University
Country: USA
Abstract: INTERMAP is basic epidemiologic investigation designed to help clarify unanswered questions on the role of dietary factors, particularly macronutrients, in the etiology of unfavorable blood pressure (BP) levels prevailing for a majority of middle-aged and older individuals in the U.S. population. A particular focus -- within the context of this overall objective -- is to help elucidate the role of these dietary factors in accounting for the even more adverse BP patterns of less educated population state, e.g., in the U.S. both less educated African-Americans and Whites. INTERMAP aims to achieve a major advance on these important issues, based on its design, patterned after the tested INTERSALT model: large sample size of 5,200 persons (2,600 men and 2,600 women), ages 40-59 from 20 diverse population samples of varied ethnicity, SES, and dietary habits in 4 countries (China, Japan, U.K., U.S.) (260 persons per sample). Cost effectiveness is assured by major cost-sharing by non-U.S. centers, so that costs for NHLBI are much less than for research of this scope done solely in the U.S. Specific aims involve elucidating influences on BP of amount and type of protein, lipids, carbohydrates, also amino acids, Ca, Mg, antioxidants, fiber, caffeine. Primary hypotheses to be tested, with control for BMI, intake of alcohol, Na, K, age, sex, other confounders are; dietary protein is inversely related to BP; inverse relations between education and BP are significantly accounted for by education-correlated differences in dietary protein intake; there is a direct relation to BP of dietary SFA, cholesterol, keys score, starch; there is an inverse relation of PFA and of P.S. Participants, randomly selected, are to provide 2 timed 24-hr urine collections for assessment of Na, K, creatinine, urea, and are to complete four 24-hr dietary recalls. BP is to be measured twice at each of 4 clinic visits. The study is to be coordinated by two Coordinating Centers -- Northwestern University, Chicago and london School of Hygiene and Tropical Medicine. Urinary determinations are to be made at a Central Laboratory in Leuven, Belgium. 24-hr dietary recalls are to be converted into nutrients with use in each country of an up-to-date, extensive, high- quality, well-maintained national data base on nutrient composition of foods and recipes, with international study-wide standardization, quality control, and support for this and related local and national tasks. Data analyses o test hypotheses and explore nutrient-BP relations are to be done at the london Coordinating Center. Findings on relations of multiple dietary factors to BP are to be used to estimate favorable impact on BP of multiple improvements in nutrition by populations. This, in turn, should aid in making dietary recommendations toward achieving the goal of primary prevention of hypertension, and shifting BP distributions downward to avoid excess risk associated with present levels generally above optimal.
Funding Period: 1995-07-01 - 2000-06-30
more information: NIH RePORT

Top Publications

  1. pmc Relation of raw and cooked vegetable consumption to blood pressure: the INTERMAP Study
    Q Chan
    Department of Epidemiology and Biostatistics, MRC HPA Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London, London, UK
    J Hum Hypertens 28:353-9. 2014
  2. pmc Nutrient and food intakes of middle-aged adults at low risk of cardiovascular disease: the international study of macro-/micronutrients and blood pressure (INTERMAP)
    Christina M Shay
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Eur J Nutr 51:917-26. 2012
  3. pmc Urinary metabolic phenotyping the slc26a6 (chloride-oxalate exchanger) null mouse model
    Isabel Garcia-Perez
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ London, UK
    J Proteome Res 11:4425-35. 2012
  4. pmc Food and nutrient intakes and their associations with lower BMI in middle-aged US adults: the International Study of Macro-/Micronutrients and Blood Pressure (INTERMAP)
    Christina M Shay
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Am J Clin Nutr 96:483-91. 2012
  5. pmc A nutrient-wide association study on blood pressure
    Ioanna Tzoulaki
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Circulation 126:2456-64. 2012
  6. doi Subset optimization by reference matching (STORM): an optimized statistical approach for recovery of metabolic biomarker structural information from 1H NMR spectra of biofluids
    Joram M Posma
    Section of Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London SW7 2AZ, United Kingdom
    Anal Chem 84:10694-701. 2012
  7. doi Serum leptin and total dietary energy intake: the INTERLIPID Study
    Yasuyuki Nakamura
    Cardiovascular Epidemiology, Kyoto Women s University, 35 Imakumano Kitahiyoshi cho, Higashiyama ku, Kyoto, Kyoto 605 8501, Japan
    Eur J Nutr 52:1641-8. 2013
  8. pmc Association of raw fruit and fruit juice consumption with blood pressure: the INTERMAP Study
    Linda M Oude Griep
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
    Am J Clin Nutr 97:1083-91. 2013
  9. pmc Relationship of dietary monounsaturated fatty acids to blood pressure: the International Study of Macro/Micronutrients and Blood Pressure
    Katsuyuki Miura
    Department of Health Science, Shiga University of Medical Science, Otsu, Japan
    J Hypertens 31:1144-50. 2013
  10. pmc Dietary and urinary metabonomic factors possibly accounting for higher blood pressure of black compared with white Americans: results of International Collaborative Study on macro-/micronutrients and blood pressure
    Jeremiah Stamler
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr, Suite 1400, Chicago, IL 60611
    Hypertension 62:1074-80. 2013

Scientific Experts

  • Yasuyuki Nakamura
  • P Elliott
  • J David Curb
  • Cheryl Am Anderson
  • Nagako Okuda
  • Katsuyuki Miura
  • Rie Naganuma
  • Nagako Chiba
  • Jeremiah Stamler
  • Marc Emmanuel Dumas
  • Hirotsugu Ueshima
  • Henrik Antti
  • Sujata L Archer
  • Martha Daviglus
  • Queenie Chan
  • Ian J Brown
  • Elaine Holmes
  • Liancheng Zhao
  • Linda Van Horn
  • Jeremy K Nicholson
  • Ruey Leng Loo
  • Alan R Dyer
  • Ioanna Tzoulaki
  • Magda Bictash
  • Maria De Iorio
  • Christina M Shay
  • Isabel Garcia-Perez
  • Hugo Kesteloot
  • Ivan K S Yap
  • Elaine Maibaum
  • Joram M Posma
  • Anisha Wijeyesekera
  • Akira Okayama
  • Claire E Robertson
  • Hideaki Nakagawa
  • Beatriz L Rodriguez
  • Chiang Ching Huang
  • Kiyomi Sakata
  • Marc Chadeau-Hyam
  • Ka He
  • Q Chan
  • Linda M Oude Griep
  • Arlene L Hankinson
  • Tomonori Okamura
  • Masaru Sakurai
  • Timothy M D Ebbels
  • Yasushi Suwazono
  • Li Qiang Qin
  • Silke S Heinzmann
  • Zhao Guo
  • John C Lindon
  • Timothy Ebbels
  • Hannelore Kaspar
  • Olivier Cloarec
  • S Yoneyama
  • Muireann Coen
  • Claire Robertson
  • Par Jonsson
  • I J Brown
  • L Van Horn
  • A R Dyer
  • L M Oude Griep
  • J K Nicholson
  • E Holmes
  • L Zhao
  • Lyn M Steffen
  • Ian Brown
  • Atul J Butte
  • Coral Barbas
  • Chirag J Patel
  • Zhirong Jiang
  • John P A Ioannidis
  • Jeremy Nicholson
  • Alma Villaseñor
  • Robert Unwin
  • PETER ARONSON
  • Pengcheng Xun
  • Robert J Unwin
  • Deborah Bujnowski
  • Mirei Uetani
  • Kazuhiro Nogawa
  • David J Curb
  • Timothy M Ebbels
  • Tanvir Chowdhury Turin
  • Katsushi Yoshita
  • Sohel R Choudhury
  • Sunil Kochhar
  • Takashi Kadowaki
  • Shigeyuki Saitoh
  • Atsushi Hozawa

Detail Information

Publications53

  1. pmc Relation of raw and cooked vegetable consumption to blood pressure: the INTERMAP Study
    Q Chan
    Department of Epidemiology and Biostatistics, MRC HPA Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London, London, UK
    J Hum Hypertens 28:353-9. 2014
    ..Among commonly eaten cooked vegetables, tomatoes, peas, celery, and scallions related significantly inversely to BP. ..
  2. pmc Nutrient and food intakes of middle-aged adults at low risk of cardiovascular disease: the international study of macro-/micronutrients and blood pressure (INTERMAP)
    Christina M Shay
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Eur J Nutr 51:917-26. 2012
    ..The purpose of the current study was to compare nutrient/food intakes of LR participants with participants not LR in the INTERMAP study...
  3. pmc Urinary metabolic phenotyping the slc26a6 (chloride-oxalate exchanger) null mouse model
    Isabel Garcia-Perez
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ London, UK
    J Proteome Res 11:4425-35. 2012
    ....
  4. pmc Food and nutrient intakes and their associations with lower BMI in middle-aged US adults: the International Study of Macro-/Micronutrients and Blood Pressure (INTERMAP)
    Christina M Shay
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Am J Clin Nutr 96:483-91. 2012
    ..Few studies have documented dietary patterns or nutrient intakes that favor leanness [BMI (in kg/m²) ≤25] in free-living populations...
  5. pmc A nutrient-wide association study on blood pressure
    Ioanna Tzoulaki
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Circulation 126:2456-64. 2012
    ..A nutrient-wide approach may be useful to comprehensively test and validate associations between nutrients (derived from foods and supplements) and blood pressure (BP) in an unbiased manner...
  6. doi Subset optimization by reference matching (STORM): an optimized statistical approach for recovery of metabolic biomarker structural information from 1H NMR spectra of biofluids
    Joram M Posma
    Section of Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London SW7 2AZ, United Kingdom
    Anal Chem 84:10694-701. 2012
    ..It can be applied to any type of data, provided that there is interpretable correlation among variables, and can also be applied to data with more than one dimension (e.g., 2D NMR spectra)...
  7. doi Serum leptin and total dietary energy intake: the INTERLIPID Study
    Yasuyuki Nakamura
    Cardiovascular Epidemiology, Kyoto Women s University, 35 Imakumano Kitahiyoshi cho, Higashiyama ku, Kyoto, Kyoto 605 8501, Japan
    Eur J Nutr 52:1641-8. 2013
    ..We investigated relations between serum leptin and total energy intake using INTERLIPID/INTERMAP data on Japanese-Americans in Hawaii and Japanese in Japan...
  8. pmc Association of raw fruit and fruit juice consumption with blood pressure: the INTERMAP Study
    Linda M Oude Griep
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
    Am J Clin Nutr 97:1083-91. 2013
    ..Epidemiologic evidence suggests that fruit consumption may lower the risk of cardiovascular diseases through blood pressure (BP)-lowering effects; little is known on the independent effect of raw fruit and fruit juice on BP...
  9. pmc Relationship of dietary monounsaturated fatty acids to blood pressure: the International Study of Macro/Micronutrients and Blood Pressure
    Katsuyuki Miura
    Department of Health Science, Shiga University of Medical Science, Otsu, Japan
    J Hypertens 31:1144-50. 2013
    ..We report associations of monounsaturated fatty acid intake of individuals with blood pressure in a cross-sectional study...
  10. pmc Dietary and urinary metabonomic factors possibly accounting for higher blood pressure of black compared with white Americans: results of International Collaborative Study on macro-/micronutrients and blood pressure
    Jeremiah Stamler
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr, Suite 1400, Chicago, IL 60611
    Hypertension 62:1074-80. 2013
    ..Improved dietary patterns can contribute to prevention/control of more adverse black blood pressure levels...
  11. pmc Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study
    Ivan K S Yap
    Department of Surgery and Cancer, Faculty of Medicine, School of Public Health, Imperial College London, United Kingdom
    J Proteome Res 9:6647-54. 2010
    ..These findings indicate the importance of environmental influences (e.g., diet), endogenous metabolism, and mammalian-gut microbial cometabolism, which may help explain north-south China differences in cardiovascular disease risk...
  12. pmc Dietary glycine and blood pressure: the International Study on Macro/Micronutrients and Blood Pressure
    Jeremiah Stamler
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Clin Nutr 98:136-45. 2013
    ..Available data have indicated independent direct relations of dietary animal protein and meat to the blood pressure (BP) of individuals...
  13. pmc Diet composition and activity level of at risk and metabolically healthy obese American adults
    Arlene L Hankinson
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Obesity (Silver Spring) 21:637-43. 2013
    ....
  14. pmc Relation of dietary and lifestyle traits to difference in serum leptin of Japanese in Japan and Hawaii: the INTERLIPID study
    Y Nakamura
    Cardiovascular Epidemiology, Kyoto Women s University, 35 Imakumano Kitahiyoshi cho, Higashiyama ku, Kyoto 605 8501, Japan
    Nutr Metab Cardiovasc Dis 22:14-22. 2012
    ..We investigated whether differences in dietary and other lifestyle factors explain higher serum leptin concentrations in Japanese living a Western lifestyle in Hawaii compared with Japanese in Japan...
  15. pmc Metabolic profiling and the metabolome-wide association study: significance level for biomarker identification
    Marc Chadeau-Hyam
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London W2 1PG, United Kingdom
    J Proteome Res 9:4620-7. 2010
    ..Our results show that the MWSL approach as estimated by the univariate t test is not outperformed by OPLS and offers a fast and simple method to detect disease-related discriminatory features in human NMR urinary metabolic profiles...
  16. pmc Application of hybrid approach for estimating the benchmark dose of urinary cadmium for adverse renal effects in the general population of Japan
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoku, Chiba 260 8670, Japan
    J Appl Toxicol 31:89-93. 2011
    ..6 µg g⁻¹ cre) was somewhat lower than average urinary cadmium in Japanese older population. These results suggest the importance of measures to decrease cadmium exposure in the general population of Japan...
  17. pmc Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption
    Silke S Heinzmann
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom
    Am J Clin Nutr 92:436-43. 2010
    ..New food biomarkers are needed to objectively evaluate the effect of diet on health and to check adherence to dietary recommendations and healthy eating patterns...
  18. pmc Higher branched-chain amino acid intake is associated with a lower prevalence of being overweight or obese in middle-aged East Asian and Western adults
    Li Qiang Qin
    Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Nutr 141:249-54. 2011
    ..03). In conclusion, higher dietary BCAA intake is associated with lower prevalence of overweight status/obesity among apparently healthy middle-aged adults from East Asian and Western countries...
  19. doi Differences in lipoprotein particle subclass distribution for Japanese Americans in Hawaii and Japanese in Japan: the INTERLIPID study
    J David Curb
    Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii, 347 N Kuakini St HPM9, Honolulu, HI 96817, USA
    J Clin Lipidol 5:30-6. 2011
    ..Rates of CHD appear to continue to be lower in Japan despite increasing cholesterol levels in Japan and decreasing CHD rates in the United States...
  20. pmc Sugar-sweetened beverage, sugar intake of individuals, and their blood pressure: international study of macro/micronutrients and blood pressure
    Ian J Brown
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom
    Hypertension 57:695-701. 2011
    ..These findings, plus adverse nutrient intakes among SSB consumers, and greater sugar-BP differences for persons with higher sodium excretion lend support to recommendations that intake of SSBs, sugars, and salt be substantially reduced...
  21. pmc Relation of urinary calcium and magnesium excretion to blood pressure: The International Study Of Macro- And Micro-nutrients And Blood Pressure and The International Cooperative Study On Salt, Other Factors, And Blood Pressure
    Hugo Kesteloot
    Central Laboratory, Akademisch Ziekenhuis St Rafael, Leuven, Belgium
    Am J Epidemiol 174:44-51. 2011
    ..The present data suggest that altered calcium homoeostasis, as exhibited by increased calcium excretion, is associated with higher BP levels...
  22. pmc A comparison of self-reported analgesic use and detection of urinary ibuprofen and acetaminophen metabolites by means of metabonomics: the INTERMAP Study
    Ruey Leng Loo
    Clinical and Professional Practice Division, Medway School of Pharmacy, Universities of Kent and Greenwich, Kent, United Kingdom
    Am J Epidemiol 175:348-58. 2012
    ..This approach has the potential to reduce recall bias and other biases in epidemiologic studies for a range of substances, including pharmaceuticals, dietary supplements, and foods...
  23. ncbi Dietary sources of sodium in China, Japan, the United Kingdom, and the United States, women and men aged 40 to 59 years: the INTERMAP study
    Cheryl A M Anderson
    Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    J Am Diet Assoc 110:736-45. 2010
    ..To avoid excess sodium intake in Japan, the United Kingdom, and the United States, salt must be reduced in commercially processed foods...
  24. ncbi Relationship of the polyunsaturated to saturated fatty acid ratio to cardiovascular risk factors and metabolic syndrome in Japanese: the INTERLIPID study
    Zhao Guo
    Department of Health Science, Shiga University of Medical Science, Otsu, Japan
    J Atheroscler Thromb 17:777-84. 2010
    ..There have been few studies on the relationships of the dietary polyunsaturated to saturated fatty acid ratio (P/S) to cardiovascular risk factors and metabolic syndrome. We hypothesized that there would be favorable relationships...
  25. pmc Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology
    Magda Bictash
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK
    J Clin Epidemiol 63:970-9. 2010
    ....
  26. pmc Relationship of dietary cholesterol to blood pressure: the INTERMAP study
    Masaru Sakurai
    Department of Epidemiology and Public Health, Kanazawa Medical University, Ishikawa, Japan
    J Hypertens 29:222-8. 2011
    ..Cross-sectional data from the International Study of Macro/Micro-nutrients and Blood Pressure (INTERMAP) were used to assess relations of dietary cholesterol intake to blood pressure in men and women from four countries...
  27. ncbi Dietary intake and urinary excretion of selenium in the Japanese adult population: the INTERMAP Study Japan
    S Yoneyama
    Department of Epidemiology and Public Health, Kanazawa Medical University, Ishikawa, Japan
    Eur J Clin Nutr 62:1187-93. 2008
    ..This study is to examine the relationship between dietary selenium intake and 24-h urinary selenium excretion in Japanese population samples participating in the INTERMAP Study...
  28. ncbi Food omega-3 fatty acid intake of individuals (total, linolenic acid, long-chain) and their blood pressure: INTERMAP study
    Hirotsugu Ueshima
    Department of Health Science, Shiga University of Medical Science, Tsukinowa cho Seta, Otsu, Shiga 520 2192, Japan
    Hypertension 50:313-9. 2007
    ..In summary, food omega-3 PFA intake related inversely to blood pressure, including in nonhypertensive persons, with small estimated effect size. Food omega-3 PFA may contribute to prevention and control of adverse blood pressure levels...
  29. ncbi Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy
    Elaine Holmes
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
    Anal Chem 79:2629-40. 2007
    ..This approach should be of value in considering interpopulation patterns of drug metabolism in epidemiological and pharmacogenetic studies...
  30. ncbi Dietary factors related to higher plasma fibrinogen levels of Japanese-americans in hawaii compared with Japanese in Japan
    Katsuyuki Miura
    Department of Epidemiology and Public Health, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, 920 0293, Japan
    Arterioscler Thromb Vasc Biol 26:1674-9. 2006
    ..We investigated whether dietary factors explain higher plasma fibrinogen levels in Japanese emigrants living a Western lifestyle in Hawaii compared with Japanese in Japan...
  31. ncbi Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics for large-scale epidemiological research: the INTERMAP Study
    Marc Emmanuel Dumas
    Biological Chemistry, Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London UK
    Anal Chem 78:2199-208. 2006
    ..These cross-population differences in urinary metabolites could be related to genetic, dietary, and gut microbial factors...
  32. ncbi Association between protein intake and blood pressure: the INTERMAP Study
    Paul Elliott
    Department of Epidemiology and Public Health, Faculty of Medicine, St Mary s Campus, Imperial College London, London, England
    Arch Intern Med 166:79-87. 2006
    ..Findings from epidemiological studies suggest an inverse relationship between individuals' protein intake and their blood pressure...
  33. ncbi Attainment of precision in implementation of 24 h dietary recalls: INTERMAP UK
    Claire Robertson
    Department of Nutrition and Dietetics, King s College London, 150 Stamford Street, London SE1 8WA, UK
    Br J Nutr 94:588-94. 2005
    ..1 % were below. Experiences from the INTERMAP Belfast centre indicate that difficulties in collection of dietary information can be anticipated and contained by the systematic use of methods to prevent, detect and correct errors...
  34. ncbi Association of dietary supplement use with specific micronutrient intakes among middle-aged American men and women: the INTERMAP Study
    Sujata L Archer
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Am Diet Assoc 105:1106-14. 2005
    ....
  35. ncbi Extraction, interpretation and validation of information for comparing samples in metabolic LC/MS data sets
    Par Jonsson
    Research Group for Chemometrics, Department of Chemistry, Umea University, SE 90187 Umea, Sweden
    Analyst 130:701-7. 2005
    ..The presented findings suggest that this is a general approach for data handling, analysis, and evaluation of large metabolic LC/MS data sets...
  36. ncbi Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: the INTERLIPID study
    Nagako Okuda
    Department of Health Science, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    Atherosclerosis 178:371-9. 2005
    ..011). This association was not observed in women. This positive association of dietary n-3 PUFA with serum HDL cholesterol may partially explain the low mortality from CHD among Japanese men...
  37. ncbi Dietary phosphorus and blood pressure: international study of macro- and micro-nutrients and blood pressure
    Paul Elliott
    Department of Epidemiology and Public Health, Faculty of Medicine, St Mary s Campus, Imperial College London, London, United Kingdom
    Hypertension 51:669-75. 2008
    ..These results indicate the potential for increased phosphorus/mineral intake to lower blood pressure as part of the recommendations for healthier eating patterns for the prevention and control of prehypertension and hypertension...
  38. doi Human metabolic phenotype diversity and its association with diet and blood pressure
    Elaine Holmes
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    Nature 453:396-400. 2008
    ..Metabolic phenotyping applied to high-quality epidemiological data offers the potential to develop an area of aetiopathogenetic knowledge involving discovery of novel biomarkers related to cardiovascular disease risk...
  39. pmc Association of monosodium glutamate intake with overweight in Chinese adults: the INTERMAP Study
    Ka He
    Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Obesity (Silver Spring) 16:1875-80. 2008
    ..03) and 2.75 (95% confidence interval, 1.28-5.95, P = 0.04). This research provides data that MSG intake may be associated with increased risk of overweight independent of physical activity and total energy intake in humans...
  40. doi Relation of serum leptin to blood pressure of Japanese in Japan and Japanese-Americans in Hawaii
    Yasuyuki Nakamura
    Cardiovascular Epidemiology, Kyoto Women s University, 35 Imakumano Kitahiyoshi cho, Higashiyama ku, Kyoto 605 8501, Japan
    Hypertension 54:1416-22. 2009
    ..01 to <0.05). These findings are consistent with the inference that leptin may be an independent mediator for obesity-related elevations in BP...
  41. pmc Glutamic acid, the main dietary amino acid, and blood pressure: the INTERMAP Study (International Collaborative Study of Macronutrients, Micronutrients and Blood Pressure)
    Jeremiah Stamler
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Circulation 120:221-8. 2009
    ....
  42. pmc Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies
    Ruey Leng Loo
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
    Anal Chem 81:5119-29. 2009
    ..The NMR-based metabolic screening strategy provides a new objective approach for evaluation of self-reported medication data and is extendable to other aspects of population xenometabolome profiling...
  43. pmc Urinary amino acid analysis: a comparison of iTRAQ-LC-MS/MS, GC-MS, and amino acid analyzer
    Hannelore Kaspar
    Institute of Functional Genomics, University of Regensburg, Josef Engert Strasse 9, 93053 Regensburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 877:1838-46. 2009
    ....
  44. ncbi Relation of long-term body weight change to change in lipoprotein particle size in Japanese men and women: the INTERMAP Toyama Study
    Rie Naganuma
    Department of Epidemiology and Public Health, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Atherosclerosis 206:282-6. 2009
    ..This study investigated the relationship between changes in lipoprotein particle size and body weight change over a 9-year period in Japanese adult men and women...
  45. pmc Dietary starch intake of individuals and their blood pressure: the International Study of Macronutrients and Micronutrients and Blood Pressure
    Ian J Brown
    Department of Epidemiology and Public Health, Imperial College London, St Mary s Campus, London, UK
    J Hypertens 27:231-6. 2009
    ..Cross-sectional data from the International Study of Macronutrients and Micronutrients and Blood Pressure (INTERMAP) were used to assess relations of dietary starch intake to blood pressure in men and women from four countries...
  46. ncbi Development of a food frequency and quantity method for assessing dietary habits of Japanese individuals--comparison with results from 24hr recall dietary survey
    Nagako Chiba
    Department of Health and Nutrition, Tsukuba International Junior College, Tsuchiura, Ibaraki, Japan
    J Atheroscler Thromb 15:324-33. 2008
    ..001) for cereals, r=0.261 (p=0.023) for meat, and r=0.333 (p=0.003) for fish and shellfish. This method was thought to be appropriate for quantitative assessment of the intake of major nutrients and food groups of individuals in Japan...
  47. ncbi Relation of dietary and other lifestyle traits to difference in serum adiponectin concentration of Japanese in Japan and Hawaii: the INTERLIPID Study
    Yasuyuki Nakamura
    Cardiovascular Epidemiology, Kyoto Women s University, Kyoto, Japan
    Am J Clin Nutr 88:424-30. 2008
    ..In initial analyses, we found significant differences between serum adiponectin in Japanese living in Japan and Hawaii...
  48. pmc Relation of iron and red meat intake to blood pressure: cross sectional epidemiological study
    Ioanna Tzoulaki
    Department of Epidemiology and Public Health, Imperial College London, St Mary s Campus, London W2 1PG
    BMJ 337:a258. 2008
    ..To investigate associations of dietary iron (total, haem, and non-haem), supplemental iron, and red meat with blood pressure...
  49. doi Relationship of dietary linoleic acid to blood pressure. The International Study of Macro-Micronutrients and Blood Pressure Study [corrected]
    Katsuyuki Miura
    Department of Health Science, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, Shiga 520 2192, Japan
    Hypertension 52:408-14. 2008
    ..42/-0.98 mm Hg (P<0.05 for both) with 2 SD higher intake (4.04% kcal). Dietary linoleic acid intake may contribute to prevention and control of adverse blood pressure levels in general populations...
  50. ncbi Relation of nutrient intake to microalbuminuria in nondiabetic middle-aged men and women: International Population Study on Macronutrients and Blood Pressure (INTERMAP)
    Martha L Daviglus
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Kidney Dis 45:256-66. 2005
    ..Microalbuminuria (MA) is a risk factor for cardiovascular and renal disease. However, little is known about the relation of nutritional factors to MA, especially in individuals without diabetes...