EPIDEMIOLOGY: OXIDATIVE STRESS AND EARLY ATHEROSCLEROSIS

Summary

Principal Investigator: David R Jacobs
Abstract: DESCRIPTION (provided by applicant): Oxidative stress relates to inflammation and endothelial dysfunction, interacting with conditions such as adiposity, glycemia and smoking. Such oxidative stress, even in young adulthood, may contribute to long term disease risk long before clinical disease. To address these issues, we propose continuation of R01 HL053560, locally called Young Adult Longitudinal Trends in Antioxidants (YALTA). YALTA has been continuously funded since 1995, ancillary to Coronary Artery Risk Development in Young Adults (CARDIA), thus utilizing its infrastructure for cost efficiency and minimal participant burden. CARDIA (n=5115 black and white men and women aged 18-30 in 1985-86) retained 72% of participants at its 7th examination at year 20 and begins year 25 followup in 2010. YALTA's central purpose is to determine oxidative damage and its consequences by seamlessly obtaining additional samples and biochemistries, integrating with the full CARDIA database. YALTA studies oxidation and disease risk (metabolic syndrome, hypertension, dyslipidemia, diabetes, kidney and lung disease, coronary artery calcification, carotid artery wall thickness, and echocardiographic measures). YALTA has assayed over 20 oxidation-related indicators during CARDIA years 0 and 20 and can therefore define the timeframe when these variables become important in disease risk. Our previous measurements have provided a profile of indicators that are associated with elevated oxidative stress and disease risk. We propose to repeat measurement of several informative markers including oxidized LDL, intercellular adhesion molecule-1 (ICAM1), F2-isoprostanes, and HbA1C. In addition, circulating carotenoids and adiponectin will be repeated. Recent technological advances allow introduction of novel indicators, including fluorescent oxidation products, the RNA expression of several oxidant and antioxidant enzymes and a urinary metabolic profile, which will provide information on dietary intakes and flavonoid metabolism. These indicators will provide new information that is critical for our understanding of the evolution of oxidative stress and its interaction with obesity, inflammation, sources of oxidants and dietary intakes in disease risk. We hypothesize that indicators of oxidative damage and poor antioxidant status will be related to low intakes of nutrient-rich diets, physical inactivity, smoking and adiposity. Measurements of oxidant and antioxidant enzyme gene expression will be associated with oxidative stress and its consequences. The measurements of oxidative stress, singly and in combination, will be related to disease risk. The urinary metabolic profile will be related to dietary intakes of nutrient-rich foods and the risk of disease. Several oxidation-related activities are influenced by obesity and these relationships will be identified by the study. YALTA will ultimately be able to relate oxidation-related factors to clinical disease. These studies will aid in the identification of factors which can alter oxidation status and the identification of young adults with a critical need to favorably alter their oxidation status so that they can benefit in the long term from a reduction in oxidative stress.
Funding Period: 2000-04-01 - 2015-05-31
more information: NIH RePORT

Top Publications

  1. pmc The vitamin E isoforms α-tocopherol and γ-tocopherol have opposite associations with spirometric parameters: the CARDIA study
    Michelle E Marchese
    Division of Allergy and Immunology, Feinberg School of Medicine, Northwestern University, McGaw M304, 240 E, Huron, Chicago, IL, 60611, USA
    Respir Res 15:31. 2014
  2. pmc Longitudinal trends in diet and effects of sex, race, and education on dietary quality score change: the Coronary Artery Risk Development in Young Adults study
    Femke P C Sijtsma
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
    Am J Clin Nutr 95:580-6. 2012
  3. pmc Circulating soluble intercellular adhesion molecule 1 and subclinical atherosclerosis: the Coronary Artery Risk Development in Young Adults Study
    Myron D Gross
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Chem 58:411-20. 2012
  4. pmc Serum carotenoid concentrations predict lung function evolution in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    Bharat Thyagarajan
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, 55454, USA
    Am J Clin Nutr 94:1211-8. 2011
  5. pmc Polymorphisms in the ICAM1 gene predict circulating soluble intercellular adhesion molecule-1(sICAM-1)
    Suzette J Bielinski
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Harwick Building 6 56, 200 1st Street SW, Rochester, MN 55905, United States
    Atherosclerosis 216:390-4. 2011
  6. pmc Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes
    Duk Hee Lee
    Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    PLoS ONE 6:e15977. 2011
  7. pmc Serum adiponectin is positively associated with lung function in young adults, independent of obesity: the CARDIA study
    Bharat Thyagarajan
    Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota Minneapolis, MN 55455, USA
    Respir Res 11:176. 2010
  8. pmc Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes
    Dae Jung Kim
    Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Diabetes Care 33:2604-10. 2010
  9. pmc Low dose of some persistent organic pollutants predicts type 2 diabetes: a nested case-control study
    Duk Hee Lee
    Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    Environ Health Perspect 118:1235-42. 2010
  10. ncbi Variants in the adiponectin gene and serum adiponectin: the Coronary Artery Development in Young Adults (CARDIA) Study
    Christina L Wassel
    Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California, USA
    Obesity (Silver Spring) 18:2333-8. 2010

Research Grants

  1. Boston Puerto Rican Health Study - CVD Risk Factors
    Katherine L Tucker; Fiscal Year: 2013
  2. EARLY EVENTS IN ALZHEIMER PATHOGENESIS
    SUE TILTON GRIFFIN; Fiscal Year: 2013
  3. Pre- and peri-natal predictors of childhood obesity
    Matthew W Gillman; Fiscal Year: 2013
  4. Inflammatory responses of vascular cells
    Paul L Fox; Fiscal Year: 2013
  5. Neurohumoral control of veins in hypertension
    Gregory D Fink; Fiscal Year: 2013
  6. Hopkins Center for Eliminate Cardiovascular Health Disparities
    Lisa A Cooper; Fiscal Year: 2013
  7. Rush Center for Urban Health Equity
    Lynda H Powell; Fiscal Year: 2013
  8. Mechanisms of Microvascular Control and Coordination in Health and Disease
    Gerald A Meininger; Fiscal Year: 2013
  9. Comparative Mechanisms of Cancer Chemoprevention
    Roderick H Dashwood; Fiscal Year: 2013
  10. DIETARY ETIOLOGIES OF HEART DISEASE AND CANCER
    Eric B Rimm; Fiscal Year: 2013

Detail Information

Publications45

  1. pmc The vitamin E isoforms α-tocopherol and γ-tocopherol have opposite associations with spirometric parameters: the CARDIA study
    Michelle E Marchese
    Division of Allergy and Immunology, Feinberg School of Medicine, Northwestern University, McGaw M304, 240 E, Huron, Chicago, IL, 60611, USA
    Respir Res 15:31. 2014
    ..We previously demonstrated, in vitro and in animal studies, that the vitamin E isoform α-tocopherol protects, but the isoform γ-tocopherol promotes lung inflammation and airway hyperresponsiveness...
  2. pmc Longitudinal trends in diet and effects of sex, race, and education on dietary quality score change: the Coronary Artery Risk Development in Young Adults study
    Femke P C Sijtsma
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
    Am J Clin Nutr 95:580-6. 2012
    ..The food supply and dietary preferences have changed in recent decades...
  3. pmc Circulating soluble intercellular adhesion molecule 1 and subclinical atherosclerosis: the Coronary Artery Risk Development in Young Adults Study
    Myron D Gross
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Chem 58:411-20. 2012
    ..Soluble intercellular adhesion molecule 1 (sICAM-1) is associated with endothelial dysfunction and clinical cardiovascular disease. We investigated the relationship of subclinical atherosclerosis with sICAM-1 concentration...
  4. pmc Serum carotenoid concentrations predict lung function evolution in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    Bharat Thyagarajan
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, 55454, USA
    Am J Clin Nutr 94:1211-8. 2011
    ....
  5. pmc Polymorphisms in the ICAM1 gene predict circulating soluble intercellular adhesion molecule-1(sICAM-1)
    Suzette J Bielinski
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Harwick Building 6 56, 200 1st Street SW, Rochester, MN 55905, United States
    Atherosclerosis 216:390-4. 2011
    ..We sought to determine whether ICAM1 SNPs are associated with circulating sICAM-1 concentration, coronary artery calcium (CAC), and common and internal carotid intima medial thickness (IMT)...
  6. pmc Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes
    Duk Hee Lee
    Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    PLoS ONE 6:e15977. 2011
    ..The current study examined if low dose POPs predicted future adiposity, dyslipidemia, and insulin resistance among controls without diabetes in that study...
  7. pmc Serum adiponectin is positively associated with lung function in young adults, independent of obesity: the CARDIA study
    Bharat Thyagarajan
    Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota Minneapolis, MN 55455, USA
    Respir Res 11:176. 2010
    ..Adipose tissue produces adiponectin, an anti-inflammatory protein. Adiponectin deficiency in mice is associated with abnormal post-natal alveolar development...
  8. pmc Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes
    Dae Jung Kim
    Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Diabetes Care 33:2604-10. 2010
    ..To investigate the long-term associations of magnesium intake with incidence of diabetes, systemic inflammation, and insulin resistance among young American adults...
  9. pmc Low dose of some persistent organic pollutants predicts type 2 diabetes: a nested case-control study
    Duk Hee Lee
    Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    Environ Health Perspect 118:1235-42. 2010
    ..Low doses of some persistent organic pollutants (POPs) associate cross-sectionally with type 2 diabetes, whereas associations with high POP exposures are inconsistent...
  10. ncbi Variants in the adiponectin gene and serum adiponectin: the Coronary Artery Development in Young Adults (CARDIA) Study
    Christina L Wassel
    Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California, USA
    Obesity (Silver Spring) 18:2333-8. 2010
    ..0029) and between rs9882505 and smoking (P = 0.001) in whites. Many ADIPOQ SNPs have not yet been examined, and additional studies are needed to determine whether these may be functional variants...
  11. pmc Potassium intake and risk of incident type 2 diabetes mellitus: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
    R Chatterjee
    Duke University School of Medicine, Sutton Station Internal Medicine, 5832 Fayetteville Road, Suite 113, Durham, NC 27713, USA
    Diabetologia 55:1295-303. 2012
    ..We sought to determine if dietary potassium is associated with risk of incident type 2 diabetes in young adults...
  12. pmc Low serum adiponectin predicts future risk for asthma in women
    Akshay Sood
    Division of Pulmonary and Critical Care Medicine, University of New Mexico Health Sciences Center, School of Medicine, Department of Medicine, University of New Mexico, Albuquerque, NM 87131, USA
    Am J Respir Crit Care Med 186:41-7. 2012
    ..However, it is not known if serum adiponectin predicts future development of asthma or if asthma affects subsequent serum adiponectin concentrations among women...
  13. pmc Diet quality and markers of endothelial function: the CARDIA study
    F P C Sijtsma
    the Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA The Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands Electronic address
    Nutr Metab Cardiovasc Dis 24:632-8. 2014
    ..Dietary patterns are associated cross-sectionally with cellular adhesion molecules (CAMs). We studied prospective associations of three dietary patterns with CAMs...
  14. ncbi Chlorinated persistent organic pollutants, obesity, and type 2 diabetes
    Duk Hee Lee
    Department of Preventive Medicine D H L, School of Medicine, Kyungpook National University, Daegu 700 422, Korea BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science D H L, Kyungpook National University, Korea Hospital del Mar Institute of Medical Research M P, School of Medicine, Universitat Autonoma de Barcelona, and Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Barcelona 08193, Spain Division of Epidemiology D R J, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455 Department of Nutrition D R J, University of Oslo, 0313 Oslo, Norway and University of Massachusetts Amherst L N V, School of Public Health, Division of Environmental Health Sciences, Amherst, Massachusetts 01003
    Endocr Rev 35:557-601. 2014
    ..Also needed are laboratory experiments that more closely mimic real-world POP doses, mixtures, and exposure duration in humans. ..
  15. pmc Longitudinal association between serum urate and subclinical atherosclerosis: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    H Wang
    Division of Epidemiology and Community Health, University of Minnesota Twin Cities, Minneapolis, MN, USA Nutritional Epidemiology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Intern Med 274:594-609. 2013
    ..The aim of the present study was to determine whether serum urate (sUA) concentration is positively associated with subclinical atherosclerosis, independent of body mass index (BMI), amongst generally healthy adults...
  16. ncbi Body mass index is a stronger predictor than the metabolic syndrome for future asthma in women. The longitudinal CARDIA study
    Nour Assad
    Department of Medicine, University of New Mexico Health Sciences Center School of Medicine, Albuquerque, NM 87131, USA
    Am J Respir Crit Care Med 188:319-26. 2013
    ..It is hypothesized that the metabolic syndrome explains the association between body mass index (BMI) and asthma in adults...
  17. pmc Adult-onset asthma becomes the dominant phenotype among women by age 40 years. the longitudinal CARDIA study
    Akshay Sood
    University of New Mexico Health Sciences Center School of Medicine, Department of Medicine, Albuquerque, NM 87131, USA
    Ann Am Thorac Soc 10:188-97. 2013
    ..Although asthma is usually considered to originate in childhood, adult-onset disease is being increasingly reported...
  18. pmc Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts
    E C Oelsner
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Biomarkers 18:196-203. 2013
    ..Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown...
  19. pmc Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology
    Laura N Vandenberg
    Center for Regenerative and Developmental Biology, and Department of Biology, Tufts University, Medford, MA, United States
    Reprod Toxicol 38:1-15. 2013
    ..This discussion should result in a better understanding of these issues, and allow for additional dialog on their impact on risk assessment...
  20. pmc Dietary patterns are associated with plasma F₂-isoprostanes in an observational cohort study of adults
    Katie A Meyer
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    Free Radic Biol Med 57:201-9. 2013
    ..001). These associations remained statistically significant in prospective analysis. Our findings suggest that long-term adherence to a diet rich in fruits and vegetables and low in red meat may decrease lipid peroxidation...
  21. pmc Short sleep duration is associated with carotid intima-media thickness among men in the Coronary Artery Risk Development in Young Adults (CARDIA) Study
    Megan R Sands
    University of Pennsylvania, Perelman School of Medicine, Center for Sleep and Circadian Neurobiology, MPH, 3624 Market Street, Suite 205, Philadelphia, PA 19104, USA
    Stroke 43:2858-64. 2012
    ..The aim of this study is to determine whether sleep duration is associated with CIMT...
  22. pmc Neurochemical alterations in spinocerebellar ataxia type 1 and their correlations with clinical status
    GULIN OZ
    Center for MR Research, Department of Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Mov Disord 25:1253-61. 2010
    ..These data demonstrate that (1)H MRS biomarkers can be utilized to noninvasively assess neuronal and glial status in individual ataxia patients...
  23. pmc Passive smoke exposure and circulating carotenoids in the CARDIA study
    Rachel Widome
    Center for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, USA
    Ann Nutr Metab 56:113-8. 2010
    ..Our objective was to assess associations between passive smoke exposure in various venues and serum carotenoid concentrations...
  24. pmc Common coding variants of the HNF1A gene are associated with multiple cardiovascular risk phenotypes in community-based samples of younger and older European-American adults: the Coronary Artery Risk Development in Young Adults Study and The Cardiovascula
    Alexander P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
    Circ Cardiovasc Genet 2:244-54. 2009
    ..Common polymorphisms of the HNF-1 alpha gene (HNF1A) were recently associated with plasma C-reactive protein and gamma-glutamyl transferase concentration in middle-aged to older European Americans (EA)...
  25. ncbi Factors associated with paraoxonase genotypes and activity in a diverse, young, healthy population: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    Bharat Thyagarajan
    Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota Minneapolis, MN 55454, USA
    Clin Chem 54:738-46. 2008
    ..Paraoxonase may mitigate oxidative damage and thus lower risk of macrovascular disease...
  26. ncbi Effects of long-term exercise and diet intervention on plasma adipokine concentrations
    Merethe H Rokling-Andersen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Am J Clin Nutr 86:1293-301. 2007
    ..Alterations in leptin and plasminogen activator inhibitor-1 concentrations were previously reported from this study...
  27. ncbi Longitudinal association of serum carotenoids and tocopherols with hostility: the CARDIA Study
    Tetsuya Ohira
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
    Am J Epidemiol 167:42-50. 2008
    ..High hostility predicted future low levels of some serum carotenoids, which may help to explain the association of hostility and cardiovascular risk observed in other epidemiologic studies...
  28. pmc Does harboring hostility hurt? Associations between hostility and pulmonary function in the Coronary Artery Risk Development in (Young) Adults (CARDIA) study
    Benita Jackson
    Department of Psychology, Clark Science Center, Smith College, Northampton, MA 01063, and Brigham and Women s Hospital, Boston, USA
    Health Psychol 26:333-40. 2007
    ..To examine the cross-sectional association between hostility and pulmonary function (PF) and its consistency across race/ethnicity-gender groups...
  29. pmc Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: the Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALT
    Atsushi Hozawa
    Division of Epidemiology and Community Health, School of Public Health, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55454, USA
    Clin Chem 53:447-55. 2007
    ..To clarify the effect of carotenoids on atherosclerotic risk factors, we examined the association of circulating carotenoids with inflammation, oxidative stress, endothelial dysfunction, and smoking...
  30. ncbi Serum gamma-glutamyltransferase predicts non-fatal myocardial infarction and fatal coronary heart disease among 28,838 middle-aged men and women
    Duk Hee Lee
    Department of Preventive Medicine, School of Medicine, Kyungpook National University, Jung Gu, Daegu, South Korea 700 422
    Eur Heart J 27:2170-6. 2006
    ..This study examined if serum GGT predicted coronary heart disease (CHD), especially differentiating non-fatal myocardial infarction (MI) and fatal CHD event, among the general population or participants with type-2 diabetes...
  31. ncbi Associations of serum carotenoid concentrations with the development of diabetes and with insulin concentration: interaction with smoking: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
    Atsushi Hozawa
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, 55454, USA
    Am J Epidemiol 163:929-37. 2006
    ..46 (p = 0.03); per SD increase in insulin resistance, slope = -0.14 (p = 0.01)). In CARDIA, higher serum carotenoid concentrations are associated with lower risk of diabetes and insulin resistance in nonsmokers but not in smokers...
  32. ncbi Plasma fibrinogen and lung function: the CARDIA Study
    Bharat Thyagarajan
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, 55454, USA
    Int J Epidemiol 35:1001-8. 2006
    ..We hypothesized that fibrinogen, as a marker of chronic inflammation, is inversely associated with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV(1)) in healthy persons...
  33. pmc Graded associations of blood lead and urinary cadmium concentrations with oxidative-stress-related markers in the U.S. population: results from the third National Health and Nutrition Examination Survey
    Duk Hee Lee
    Department of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, Daegu, South Korea
    Environ Health Perspect 114:350-4. 2006
    ....
  34. pmc Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome
    Paul Holvoet
    Atherosclerosis and Metabolism Unit, Katholieke Universiteit Leuven, Belgium
    JAMA 299:2287-93. 2008
    ..Experimental data support the hypothesis that oxidized low-density lipoprotein (LDL) is associated with the metabolic syndrome. However, this hypothesis has not been tested in humans...
  35. ncbi Soluble P-selectin, SELP polymorphisms, and atherosclerotic risk in European-American and African-African young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
    Alexander P Reiner
    Departments of Epidemiology, University of Washington, Seattle, WA 98195, USA
    Arterioscler Thromb Vasc Biol 28:1549-55. 2008
    ..To characterize the genetic and clinical correlates of soluble P-selectin, and the relationship of P-selectin to atherosclerotic risk, in young European-American (EA) and African-American (AA) adults...
  36. ncbi Association of inflammation with worsening HOMA-insulin resistance
    K Park
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454, USA
    Diabetologia 52:2337-44. 2009
    ..We examined the cross-sectional and longitudinal relationships between C-reactive protein (CRP), a marker of low-grade inflammation, and insulin resistance and whether the association was independent of obesity and oxidative stress...
  37. ncbi Association of long-term change in waist circumference with insulin resistance
    Kyong Park
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    Obesity (Silver Spring) 18:370-6. 2010
    ..0001). We conclude that year 0 WC and long-term increment in WC are associated with worsening insulin resistance. However, the association of HOMA(IR) with slope of WC change may vary across the range of initial WC...
  38. pmc Obesity-asthma association: is it explained by systemic oxidant stress?
    Akshay Sood
    Department of Medicine, Akshay University of New Mexico Health Sciences Center School of Medicine, MSC 10 5550, Albuquerque, NM 87131, USA
    Chest 136:1055-62. 2009
    ..The mechanism for the obesity-asthma association is unknown. This study evaluated the hypothesis that systemic oxidant stress explains this association...
  39. pmc Oxidative stress and insulin resistance: the coronary artery risk development in young adults study
    Kyong Park
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes Care 32:1302-7. 2009
    ..This study examined the longitudinal relationships of oxidative stress biomarkers with the development of insulin resistance and whether these relationships were independent of obesity in nondiabetic young adults...
  40. pmc Association between Endothelial Biomarkers and Arterial Elasticity in Young Adults - The CARDIA Study
    Narayanan I Valappil
    Health Resources and Services Administration, 5600 Fishers Lane, Room 7A 42, Rockville, MD 20857
    J Am Soc Hypertens 2:70-9. 2008
    ..Pulse waveform analysis estimates large (LAE) and small (SAE) artery elasticity noninvasively. We assessed the associations between LAE and SAE and markers of endothelial dysfunction and CV risk factors...
  41. pmc Food synergy: an operational concept for understanding nutrition
    David R Jacobs
    School of Public Health, University of Minnesota, Minneapolis, MN, USA
    Am J Clin Nutr 89:1543S-1548S. 2009
    ..The more we understand about our own biology and that of plants and animals, the better we will be able to discern the combinations of foods, rather than supplements, which best promote health...
  42. pmc Circulating carotenoid concentrations and incident hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    Atsushi Hozawa
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    J Hypertens 27:237-42. 2009
    ..Thus, we examined the association of circulating carotenoids with hypertension, a major macrovascular disease risk factor...
  43. pmc Homogeneity in the relationship of serum cholesterol to coronary deaths across different cultures: 40-year follow-up of the Seven Countries Study
    Alessandro Menotti
    Association for Cardiac Research, Rome, Italy
    Eur J Cardiovasc Prev Rehabil 15:719-25. 2008
    ..The aim was to investigate whether multivariate coefficients of serum cholesterol in the prediction of coronary heart disease (CHD) deaths were similar across different cultures in a long-term follow-up...
  44. ncbi Longitudinal associations between body mass index and serum carotenoids: the CARDIA study
    Lene Frost Andersen
    Department of Nutrition, University of Oslo, Norway
    Br J Nutr 95:358-65. 2006
    ..The results for lycopene were, however, discordant from those of the other carotenoids...

Research Grants30

  1. Boston Puerto Rican Health Study - CVD Risk Factors
    Katherine L Tucker; Fiscal Year: 2013
    ..abstract_text> ..
  2. EARLY EVENTS IN ALZHEIMER PATHOGENESIS
    SUE TILTON GRIFFIN; Fiscal Year: 2013
    ..The synergy between our aims, approaches, and measures will enable us to meet our goal of defining early cellular interactions toward development of rational interventions in AD. ..
  3. Pre- and peri-natal predictors of childhood obesity
    Matthew W Gillman; Fiscal Year: 2013
    ..The results of this research will lead to new scientific knowledge about the drivers of growth and adiposity in childhood and may very well lead to new avenues for prevention of obesity, diabetes, and cardiovascular disease. ..
  4. Inflammatory responses of vascular cells
    Paul L Fox; Fiscal Year: 2013
    ..abstract_text> ..
  5. Neurohumoral control of veins in hypertension
    Gregory D Fink; Fiscal Year: 2013
    ..This project tests the idea that altered structure or function of veins also may cause hypertension, and that it may be possible to treat hypertension using drugs that affect veins. ..
  6. Hopkins Center for Eliminate Cardiovascular Health Disparities
    Lisa A Cooper; Fiscal Year: 2013
    ..abstract_text> ..
  7. Rush Center for Urban Health Equity
    Lynda H Powell; Fiscal Year: 2013
    ..Funding is now sought to bring these resources together to establish a unique center of excellence in health disparities interventions. ..
  8. Mechanisms of Microvascular Control and Coordination in Health and Disease
    Gerald A Meininger; Fiscal Year: 2013
    ..End of Abstract) ..
  9. Comparative Mechanisms of Cancer Chemoprevention
    Roderick H Dashwood; Fiscal Year: 2013
    ..This application is innovative and timely in bridging basic mechanisms, preclinical models, and human studies of epigenetics and diet. ..
  10. DIETARY ETIOLOGIES OF HEART DISEASE AND CANCER
    Eric B Rimm; Fiscal Year: 2013
    ....