Models and Tools for Dynamic Health-Relevant Diffusion over Complex Networks

Summary

Principal Investigator: PETER JOHN MUCHA
Abstract: DESCRIPTION (provided by applicant): Health and health behavior depend crucially on diffusion processes over social networks;both the spread of communicable diseases, such as HIV, and the diffusion of beliefs and practices that shape health behavior, such as dietary risk behavior, can be understood as generalized diffusion over (sometimes very complex and dynamic) social networks. However, despite the clear need, few of our formal analytic tools can be used to model diffusion over any but the simplest of these systems, as the mathematics for modeling diffusion over dynamic multi- relational networks are currently intractable except by direct simulation;which is often a weak foundation for generalizable knowledge;we provide a novel solution to modeling complex diffusion processes over dynamic networks by decomposing the networks into a set of tractable subsets and relation specific transmission rules. We will develop improved methods for network community detection that specifically targets understanding diffusion, and include such communities in our general framework;then test these new models against a bank of constructed and real social networks to assess model performance. Using simulation, novel new network clustering techniques and extensions of formal diffusion models, this project will develop the tools necessary to interpolate between the simplest direct diffusion cases and the most complex social behavior cases;advances will provide fundamental insights into health- relevant diffusion, yielding more robust modeling and highlighting directions for possible intervention.
Funding Period: 2013-09-01 - 2018-05-31
more information: NIH RePORT

Research Grants

  1. Hopkins Center for Eliminate Cardiovascular Health Disparities
    Lisa A Cooper; Fiscal Year: 2013
  2. DIFFUSION OF SUBSTANCES THROUGH THE BRAIN
    Charles Nicholson; Fiscal Year: 2013
  3. NUCLEAR STRUCTURE AND GENE EXPRESSION
    Janet L Stein; Fiscal Year: 2013
  4. INNOVATIVE APPROACHES FOR COCAINE PHARMACOTHERAPY
    KYLE MATTHEW KAMPMAN; Fiscal Year: 2013
  5. Early Phase Psychosis: Informing Treatment Decisions
    John M Kane; Fiscal Year: 2013
  6. Referral Center-Animal models of human genetic disease
    Mark E Haskins; Fiscal Year: 2013

Detail Information

Research Grants30

  1. Hopkins Center for Eliminate Cardiovascular Health Disparities
    Lisa A Cooper; Fiscal Year: 2013
    ..abstract_text> ..
  2. DIFFUSION OF SUBSTANCES THROUGH THE BRAIN
    Charles Nicholson; Fiscal Year: 2013
    ..Development of an imaging technique for fluorescent molecules will provide a relatively inexpensive method for measuring diffusion of drugs in brain tissue. ..
  3. NUCLEAR STRUCTURE AND GENE EXPRESSION
    Janet L Stein; Fiscal Year: 2013
    ..abstract_text> ..
  4. INNOVATIVE APPROACHES FOR COCAINE PHARMACOTHERAPY
    KYLE MATTHEW KAMPMAN; Fiscal Year: 2013
    ..By starting with a large number of candidate medications and sequentially testing as described, we hope to more rapidly identify effective medications that justify the next level of development: Multi-site trials. ..
  5. Early Phase Psychosis: Informing Treatment Decisions
    John M Kane; Fiscal Year: 2013
    ..Our ability to intervene appropriately, effectively and consistently in this population can have profound long-term public health consequences. ..
  6. Referral Center-Animal models of human genetic disease
    Mark E Haskins; Fiscal Year: 2013
    ..abstract_text> ..