Tests of Models of Retinal/Optic Nerve Diseases&Adaption

Summary

Principal Investigator: Donald C Hood
Affiliation: Columbia University
Country: USA
Abstract: A major long-term objective is to develop techniques for localizing the sites, and identifying the mechanisms of diseases of the retina and optic nerve. The multifocal electroretinogram (mERG) and visual evoked potential (mVEP) techniques are relatively new ways for measuring the physiological activity of local retinal and cortical activity. By studying the mERGs from patients with a variety of retinal/optic nerve problems we aim to develop a conceptual framework for relating changes in the mERG to sites and mechanisms of damage (aim 1a). In addition, some retinal diseases affect retinal mechanisms of adaptation and studies are designed to understand these changes. The mVEP technique is less developed and studies are proposed to improve this technology. These include the development of a method for measuring and specifying the strength of the signal in the mVEP response (aim 1b). Specific studies are proposed to understand the contribution of cone pathways to the mVEP, to assess repeat reliability, to optimize recording techniques, and to develop norms. The second long-term objective is to improve our understanding of the sites and mechanisms of particular diseases of the retina/optic nerve through studies employing behavioral (e.g. visual fields), structural (e.g. nerve fiber layer analysis) and electrophysiological techniques (e.g. mERG and mVEP). As part of aim 2, the mERG and visual field measures will be employed to better understand retinal damage in patients with retinitis pigmentosa and diabetic retinopathy and to assess possible damage following retinal surgery for macular holes and macular pucker. In addition, the sites and mechanisms of glaucomatous damage will be studied. These studies include a comparison of structural and functional measures to better understand the mechanism(s) of damage, an attempt to detect early damage, an assessment of the effect of acute decreases in intraocular pressure, and an assessment of whether there are selective deficits in the cone pathways. Finally, patients with acute optic neuritis will be followed with behavioral and mVEP techniques. An attempt will be made to understand the recovery o vision following optic neuritis (ON).
Funding Period: 1977-08-01 - 2005-07-31
more information: NIH RePORT

Top Publications

  1. ncbi Spectral-domain optical coherence tomography staging and autofluorescence imaging in achromatopsia
    Jonathan P Greenberg
    Department of Ophthalmology, Columbia University, New York, New York
    JAMA Ophthalmol 132:437-45. 2014
  2. pmc Relationship between retinal layer thickness and the visual field in early age-related macular degeneration
    Jennifer H Acton
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 53:7618-24. 2012
  3. pmc Glaucomatous damage of the macula
    Donald C Hood
    Department of Psychology, Columbia University, New York, NY 10027 7004, USA
    Prog Retin Eye Res 32:1-21. 2013
  4. pmc Comparison between MP-1 and Humphrey visual field defects in glaucoma and retinitis pigmentosa
    Jennifer H Acton
    Department of Ophthalmology, Columbia University, New York, New York, USA
    Optom Vis Sci 89:1050-8. 2012
  5. pmc Retinal ganglion cell and inner plexiform layer thickness measurements in regions of severe visual field sensitivity loss in patients with glaucoma
    A L de A Moura
    Department of Psychology, Columbia University, New York, NY, USA
    Eye (Lond) 26:1188-93. 2012
  6. pmc Clinical use of multifocal visual-evoked potentials in a glaucoma practice: a prospective study
    Carlos Gustavo De Moraes
    Department of Ophthalmology, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, USA
    Doc Ophthalmol 125:1-9. 2012
  7. doi Retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma
    Ali S Raza
    Department of Psychology, Columbia University, 1190 Amsterdam Ave, 405 Schermerhorn Hall, Room 301, New York, NY 10027 7004, USA
    Arch Ophthalmol 129:1529-36. 2011
  8. doi Beta-zone parapapillary atrophy and multifocal visual evoked potentials in eyes with glaucomatous optic neuropathy
    Carlos Gustavo De Moraes
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, USA
    Doc Ophthalmol 123:43-50. 2011
  9. pmc Automated layer segmentation of macular OCT images using dual-scale gradient information
    Qi Yang
    Topcon Advanced Biomedical Imaging Laboratory, Oakland, NJ 07436, USA
    Opt Express 18:21293-307. 2010
  10. pmc Evaluation of inner retinal layers in patients with multiple sclerosis or neuromyelitis optica using optical coherence tomography
    Danilo B Fernandes
    Department of Ophthalmology, University of Sao Paulo, Sao Paulo, Brazil
    Ophthalmology 120:387-94. 2013

Scientific Experts

  • Donald C Hood
  • Brad Fortune
  • Vivienne C Greenstein
  • K Holopigian
  • Xian Zhang
  • Jeffrey M Liebmann
  • Robert Ritch
  • Jennifer H Acton
  • Ali S Raza
  • Tomas M Grippo
  • R Theodore Smith
  • Carlos Gustavo De Moraes
  • Stephen H Tsang
  • Jonathan P Greenberg
  • Quraish Ghadiali
  • Jeffrey G Odel
  • Min Wang
  • Boonchai Wangsupadilok
  • Wener Cella
  • Fabio N Kanadani
  • Larissa K Grover
  • Ilana Traynis
  • Danilo B Fernandes
  • Kenzo Hokazono
  • Mário L R Monteiro
  • Carlos G V De Moraes
  • Charles A Reisman
  • A L de A Moura
  • Lawrence A Yannuzzi
  • Daiyan Xin
  • Oraorn Thonginnetra
  • Elizabeth A Dale
  • Qi Yang
  • Nuno L Gomes
  • Luiz H Lima
  • Stanley Chang
  • Jason C Park
  • Myles M Behrens
  • Isaac Ezon
  • Samir R Tari
  • E Bo Yang
  • Phamornsak Thienprasiddhi
  • F N Kanadani
  • R Ritch
  • J M Liebmann
  • C Rodarte
  • William Seiple
  • Britta Baumann
  • Susanne Kohl
  • Tobias Duncker
  • Bernd Wissinger
  • Sandrine A Zweifel
  • Royce W S Chen
  • Carlos G De Moraes
  • Jerome Sherman
  • Diane Wang
  • Marcela Marsiglia
  • Rafael G F Nogueira
  • Maria K Oyamada
  • Dagoberto Callegaro
  • Mirela Tabacaru
  • M A Lazow
  • C G de Moraes
  • A S Raza
  • Christopher C Teng
  • Carlos Gustavo V De Moraes
  • Nicholas S Bartlett
  • Randy H Kardon
  • Christine L Talamini
  • Scott Ketner
  • Joshua R Ehrlich
  • Jungsuk Cho
  • Makoto Araie
  • David Chu
  • Zhenguo Wang
  • Kinpui Chan
  • Yasufumi Fukuma
  • Atsuo Tomidokoro
  • Masanori Hangai
  • Nagahisa Yoshimura
  • Jung Suk Cho
  • Rando Allikmets
  • Mihai Busuioc
  • Jana Zernant-Rajang
  • Celso Tello
  • Ronald E Carr
  • Nan Kai Wang
  • Joshua N Carlson
  • Gaetano Barile
  • Theodore R Smith

Detail Information

Publications62

  1. ncbi Spectral-domain optical coherence tomography staging and autofluorescence imaging in achromatopsia
    Jonathan P Greenberg
    Department of Ophthalmology, Columbia University, New York, New York
    JAMA Ophthalmol 132:437-45. 2014
    ..The proposed staging system facilitates classification of the disease into different phases of progression and may have therapeutic implications. ..
  2. pmc Relationship between retinal layer thickness and the visual field in early age-related macular degeneration
    Jennifer H Acton
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 53:7618-24. 2012
    ..To quantify and compare the structural and functional changes in subjects with early age-related macular degeneration (AMD), using spectral-domain optical coherence tomography (SD-OCT) and microperimetry...
  3. pmc Glaucomatous damage of the macula
    Donald C Hood
    Department of Psychology, Columbia University, New York, NY 10027 7004, USA
    Prog Retin Eye Res 32:1-21. 2013
    ....
  4. pmc Comparison between MP-1 and Humphrey visual field defects in glaucoma and retinitis pigmentosa
    Jennifer H Acton
    Department of Ophthalmology, Columbia University, New York, New York, USA
    Optom Vis Sci 89:1050-8. 2012
    ....
  5. pmc Retinal ganglion cell and inner plexiform layer thickness measurements in regions of severe visual field sensitivity loss in patients with glaucoma
    A L de A Moura
    Department of Psychology, Columbia University, New York, NY, USA
    Eye (Lond) 26:1188-93. 2012
    ..To better understand the effects of severe glaucoma on the thickness of the retinal ganglion cell (RGC) and inner plexiform (IP) layers measured with frequency-domain optical coherence tomography...
  6. pmc Clinical use of multifocal visual-evoked potentials in a glaucoma practice: a prospective study
    Carlos Gustavo De Moraes
    Department of Ophthalmology, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, USA
    Doc Ophthalmol 125:1-9. 2012
    ..To test a framework that describes how the multifocal visual-evoked potential (mfVEP) technique is used in a particular glaucoma practice...
  7. doi Retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma
    Ali S Raza
    Department of Psychology, Columbia University, 1190 Amsterdam Ave, 405 Schermerhorn Hall, Room 301, New York, NY 10027 7004, USA
    Arch Ophthalmol 129:1529-36. 2011
    ..To compare loss in sensitivity measured using standard automated perimetry (SAP) with local retinal ganglion cell layer (RGC) thickness measured using frequency-domain optical coherence tomography in the macula of patients with glaucoma...
  8. doi Beta-zone parapapillary atrophy and multifocal visual evoked potentials in eyes with glaucomatous optic neuropathy
    Carlos Gustavo De Moraes
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, USA
    Doc Ophthalmol 123:43-50. 2011
    ..Thus, ßPPA does not appear to be an independent factor affecting mfVEP responses in eyes with GON...
  9. pmc Automated layer segmentation of macular OCT images using dual-scale gradient information
    Qi Yang
    Topcon Advanced Biomedical Imaging Laboratory, Oakland, NJ 07436, USA
    Opt Express 18:21293-307. 2010
    ..The execution time is about 16 seconds per volume (480x512x128 voxels). The algorithm shows potential for quantifying images from diseased retinas as well...
  10. pmc Evaluation of inner retinal layers in patients with multiple sclerosis or neuromyelitis optica using optical coherence tomography
    Danilo B Fernandes
    Department of Ophthalmology, University of Sao Paulo, Sao Paulo, Brazil
    Ophthalmology 120:387-94. 2013
    ..To evaluate the thickness of the inner retinal layers in the macula using frequency-domain optical coherence tomography (fd-OCT) in patients with demyelinating diseases...
  11. ncbi Prevalence and nature of early glaucomatous defects in the central 10° of the visual field
    Ilana Traynis
    Department of Psychology, Columbia University, New York, New York2Tufts University School of Medicine, Boston, Massachusetts
    JAMA Ophthalmol 132:291-7. 2014
    ..The macula is essential for visual functioning and is known to be affected even in early glaucoma. However, little is currently understood about the prevalence and nature of central vision loss in early glaucoma...
  12. pmc Early glaucoma involves both deep local, and shallow widespread, retinal nerve fiber damage of the macular region
    Donald C Hood
    Department of Psychology, Columbia University, New York, New York
    Invest Ophthalmol Vis Sci 55:632-49. 2014
    ..To better understand the nature of early glaucomatous damage of the macula by comparing the results from 10-2 visual fields, optical coherence tomography (OCT) macular cube scans, and OCT circumpapillary circle scans...
  13. pmc The locations of circumpapillary glaucomatous defects seen on frequency-domain OCT scans
    Donald C Hood
    Department of Psychology, Columbia University, New York, New York
    Invest Ophthalmol Vis Sci 54:7338-43. 2013
    ..To examine the locations of local glaucomatous damage around the optic disc as seen in the circumpapillary retinal nerve fiber layer (RNFL) on frequency domain optical coherence tomography (fdOCT)...
  14. pmc Fundus-driven perimetry (microperimetry) compared to conventional static automated perimetry: similarities, differences, and clinical applications
    Jennifer H Acton
    School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, Wales, CF24 4LU, United Kingdom Electronic address
    Can J Ophthalmol 48:358-63. 2013
    ..In addition, the advantages and limitations of the technique are summarized...
  15. doi Pattern electroretinogram in neuromyelitis optica and multiple sclerosis with or without optic neuritis and its correlation with FD-OCT and perimetry
    Kenzo Hokazono
    Division of Ophthalmology and Laboratory of Investigation in Ophthalmology LIM 33, University of Sao Paulo Medical School, Av Angélica 1757 conj 61, Sao Paulo, SP, 01227 200, Brazil
    Doc Ophthalmol 127:201-15. 2013
    ....
  16. pmc Evaluation of multimodal imaging in carriers of X-linked retinitis pigmentosa
    Jennifer H Acton
    Department of Ophthalmology, Columbia University, Edward S Harkness Eye Inst, 635 W 165th Street, 5th Floor, New York, NY 10032, USA
    Exp Eye Res 113:41-8. 2013
    ..Peripheral SD-OCT imaging and central retinal layer quantification revealed significant structural abnormalities...
  17. pmc Improving glaucoma detection using spatially correspondent clusters of damage and by combining standard automated perimetry and optical coherence tomography
    Ali S Raza
    Department of Psychology, Columbia University, New York, New York
    Invest Ophthalmol Vis Sci 55:612-24. 2014
    ..To improve the detection of glaucoma, techniques for assessing local patterns of damage and for combining structure and function were developed...
  18. pmc The location of the inferior and superior temporal blood vessels and interindividual variability of the retinal nerve fiber layer thickness
    Donald C Hood
    Department of Psychology, Columbia University, New York, NY 10027 7004, USA
    J Glaucoma 19:158-66. 2010
    ..To determine if adjusting for blood vessel (BV) location can decrease the intersubject variability of retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography (OCT)...
  19. pmc A comparison of multifocal ERG and frequency domain OCT changes in patients with abnormalities of the retina
    Elizabeth A Dale
    Department of Psychology, Columbia University, 405 Schermerhorn, New York, NY 10027, USA
    Doc Ophthalmol 120:175-86. 2010
    ..While improved imaging and analysis may show fdOCT abnormalities in some cases, in others early damage may not appear on structural tests...
  20. pmc Normal versus high tension glaucoma: a comparison of functional and structural defects
    Oraorn Thonginnetra
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY, USA
    J Glaucoma 19:151-7. 2010
    ....
  21. pmc Simultaneous recording of multifocal VEP responses to short-wavelength and achromatic stimuli
    Xian Zhang
    Radiology Department, Columbia University, Neurological Institute B41, 710 W 168th Street, New York, NY 10032, USA
    Doc Ophthalmol 121:93-102. 2010
    ..These results indicate that it is possible to simultaneously record an SWmfVEP with little LM cone contribution along with an achromatic mfVEP...
  22. pmc Initial arcuate defects within the central 10 degrees in glaucoma
    Donald C Hood
    Departments of Psychology, Columbia University, New York, NY 10027, USA
    Invest Ophthalmol Vis Sci 52:940-6. 2011
    ....
  23. pmc Reliability of a computer-aided manual procedure for segmenting optical coherence tomography scans
    Donald C Hood
    Department of Psychology, Columbia University, New York, New York 10027, USA
    Optom Vis Sci 88:113-23. 2011
    ..To assess the within- and between-operator agreement of a computer-aided manual segmentation procedure for frequency-domain optical coherence tomography scans...
  24. pmc Hypodense regions (holes) in the retinal nerve fiber layer in frequency-domain OCT scans of glaucoma patients and suspects
    Daiyan Xin
    Department of Psychology, Columbia University, New York, New York 10027, USA
    Invest Ophthalmol Vis Sci 52:7180-6. 2011
    ..To better understand hypodense regions (holes) that appear in the retinal nerve fiber layer (RNFL) of frequency-domain optical coherence tomography (fdOCT) scans of patients with glaucoma and glaucoma suspects...
  25. pmc Comparing the Nidek MP-1 and Humphrey field analyzer in normal subjects
    Jennifer H Acton
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Optom Vis Sci 88:1288-97. 2011
    ..A secondary aim was to establish MP-1 normative data to calculate the total deviation analyses and global indices analogous to those used by the HFA...
  26. pmc A method to detect progression of glaucoma using the multifocal visual evoked potential technique
    Boonchai Wangsupadilok
    Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Doc Ophthalmol 118:139-50. 2009
    ..To describe a method for monitoring progression of glaucoma using the multifocal visual evoked potential (mfVEP) technique...
  27. pmc Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography
    Min Wang
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Arch Ophthalmol 127:875-81. 2009
    ....
  28. pmc Structural assessment of hyperautofluorescent ring in patients with retinitis pigmentosa
    Luiz H Lima
    Vitreous, Retina, Macula Consultants of New York, New York, USA
    Retina 29:1025-31. 2009
    ..To analyze the retinal structure underlying the hyperautofluorescent ring visible on fundus autofluorescence in patients with retinitis pigmentosa...
  29. pmc Structural and functional assessment of the macular region in patients with glaucoma
    F N Kanadani
    Department of Psychology, Columbia University, 405 Schermerhorn, New York, NY 10027, USA
    Br J Ophthalmol 90:1393-7. 2006
    ....
  30. pmc A test of a linear model of glaucomatous structure-function loss reveals sources of variability in retinal nerve fiber and visual field measurements
    Donald C Hood
    Department of Psychology, Columbia University, New York, New York 10027, USA
    Invest Ophthalmol Vis Sci 50:4254-66. 2009
    ..Retinal nerve fiber (RNFL) thickness and visual field loss data from patients with glaucoma were analyzed in the context of a model, to better understand individual variation in structure versus function...
  31. pmc A comparison of fundus autofluorescence and retinal structure in patients with Stargardt disease
    Nuno L Gomes
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Invest Ophthalmol Vis Sci 50:3953-9. 2009
    ..To improve the understanding of Stargardt disease by comparing structural changes seen on spectral domain optical coherence tomography (SD-OCT) to those visible on fundus autofluorescence (FAF)...
  32. pmc A comparison of retinal nerve fiber layer (RNFL) thickness obtained with frequency and time domain optical coherence tomography (OCT)
    Donald C Hood
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Opt Express 17:3997-4003. 2009
    ..The results were comparable. More importantly, we learned that the key factor determining whether results from different machines will be comparable is the algorithm used to segment RNFL thickness, not the type of OCT...
  33. ncbi Relating retinal nerve fiber thickness to behavioral sensitivity in patients with glaucoma: application of a linear model
    Donald C Hood
    Department of Psychology, Columbia University, New York, NY 10027, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1426-30. 2007
    ..Second, previous work by others was shown to be consistent with this model...
  34. pmc Scotopic sensitivity and color vision with a blue-light-absorbing intraocular lens
    Vivienne C Greenstein
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    J Cataract Refract Surg 33:667-72. 2007
    ..To investigate possible adverse effects of a yellow-tinted intraocular lens (IOL) on scotopic sensitivity and hue discrimination...
  35. ncbi Comparing multifocal VEP and standard automated perimetry in high-risk ocular hypertension and early glaucoma
    Brad Fortune
    Discoveries in Sight, Devers Eye Institute, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 48:1173-80. 2007
    ..To compare the diagnostic performance of multifocal visual evoked potential (mfVEP) and standard automated perimetry (SAP), in eyes with high-risk ocular hypertension or early glaucoma...
  36. pmc Retinal nerve fibre thickness measured with optical coherence tomography accurately detects confirmed glaucomatous damage
    D C Hood
    Department of Psychology, 405 Schermerhorn, Columbia University, New York, NY 10027, USA
    Br J Ophthalmol 91:905-7. 2007
    ....
  37. ncbi Improvement in conduction velocity after optic neuritis measured with the multifocal VEP
    E Bo Yang
    Department of Psychology, Columbia University, New York, New York 10027, USA
    Invest Ophthalmol Vis Sci 48:692-8. 2007
    ..To test the efficacy of the multifocal visual evoked potential (mfVEP) technique after long-term latency changes in optic neuritis (ON)/multiple sclerosis (MS), mfVEPs were recorded in 12 patients with ON/MS...
  38. ncbi A comparison between multifocal and conventional VEP latency changes secondary to glaucomatous damage
    Tomas M Grippo
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York, USA
    Invest Ophthalmol Vis Sci 47:5331-6. 2006
    ..Previous reports of prolonged cVEP latency suggest a vehicle for detecting abnormal ganglion cells and for monitoring neuroprotection...
  39. ncbi Contrast-response functions for multifocal visual evoked potentials: a test of a model relating V1 activity to multifocal visual evoked potentials activity
    Donald C Hood
    Department of Psychology, Columbia University, New York, NY, USA
    J Vis 6:580-93. 2006
    ..This deviation suggests that one or more of the model's assumptions may be violated. Second, the latency of the mfVEP changed far less than expected based upon single-cell data...
  40. ncbi Detecting early functional damage in glaucoma suspect and ocular hypertensive patients with the multifocal VEP technique
    Phamornsak Thienprasiddhi
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, NY, USA
    J Glaucoma 15:321-7. 2006
    ....
  41. pmc The effects of glaucoma on the latency of the multifocal visual evoked potential
    C Rodarte
    Department of Psychology, 405 Schermerhorn, Columbia University, New York, NY 10027, USA
    Br J Ophthalmol 90:1132-6. 2006
    ..To determine the effect of glaucomatous damage on the latency of the multifocal visual evoked potential (mfVEP)...
  42. ncbi Repeatability of normal multifocal VEP: implications for detecting progression
    Brad Fortune
    Discoveries in Sight, Devers Eye Institute, Legacy Health System, Portland, OR 97232, USA
    J Glaucoma 15:131-41. 2006
    ..Our second aim was to assess the repeatability of false alarm rates determined previously for the mfVEP using various cluster criteria...
  43. ncbi Multifocal visual evoked potentials to cone specific stimuli in patients with retinitis pigmentosa
    K Holopigian
    Department of Ophthalmology, New York University School of Medicine, BEL 5N15, 462 First Avenue, New York, NY 10016, USA
    Vision Res 45:3244-52. 2005
    ..4 degrees ). For the first ring, mfERG amplitudes were more impaired than were the mfVEPs or the visual field thresholds. For most of the patients, there was local response correspondence among our measures of visual function...
  44. ncbi The pattern electroretinogram in glaucoma patients with confirmed visual field deficits
    Donald C Hood
    Department of Psychology, Columbia University, New York, New York 10027, USA
    Invest Ophthalmol Vis Sci 46:2411-8. 2005
    ..To better understand the relationship between the amplitude of the pattern electroretinogram (PERG) and visual loss, measured with static automated perimetry...
  45. pmc The role of the multifocal visual evoked potential (mfVEP) latency in understanding optic nerve and retinal diseases
    Donald C Hood
    Columbia University, New York, New York, USA
    Trans Am Ophthalmol Soc 104:71-7. 2006
    ..To examine the extent to which changes in the latency of the multifocal visual evoked potential (mfVEP) overlap in patients with glaucoma, recovered optic neuritis/multiple sclerosis (ON/MS), and retinal disease...
  46. ncbi Functional and structural measurements for the assessment of internal limiting membrane peeling in idiopathic macular pucker
    Samir R Tari
    Department of Ophthalmology, Columbia University, 635 West 165th Street, New York, NY 10032, USA
    Retina 27:567-72. 2007
    ..To investigate the role of structural and functional measurements in the assessment of internal limiting membrane (ILM) peeling for the treatment of eyes with macular pucker...
  47. pmc Multifocal visual evoked potential and automated perimetry abnormalities in strabismic amblyopes
    Vivienne C Greenstein
    Department of Ophthalmology, Columbia University, New York, New York, USA
    J AAPOS 12:11-7. 2008
    ..To compare visual field abnormalities obtained with standard automated perimetry (SAP) to those obtained with the multifocal visual evoked potential (mfVEP) technique in strabismic amblyopes...
  48. pmc G1961E mutant allele in the Stargardt disease gene ABCA4 causes bull's eye maculopathy
    Wener Cella
    Department of Ophthalmology, Bernard and Shirlee Brown Glaucoma Laboratory, Edward S Harkness Eye Institute, Columbia University, 160 Fort Washington Avenue, New York, NY 10032, USA
    Exp Eye Res 89:16-24. 2009
    ..In addition, genetic testing provides precise diagnosis of the underlying maculopathy, and current non-invasive imaging techniques could be used to detect photoreceptor damage at the earliest clinical onset of the disease...
  49. pmc The effects of optic disc drusen on the latency of the pattern-reversal checkerboard and multifocal visual evoked potentials
    Tomas M Grippo
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York 10003 4297, USA
    Invest Ophthalmol Vis Sci 50:4199-204. 2009
    ..To determine the effect of optic disc drusen on the latency of the pattern-reversal checkerboard visual evoked potentials (VEPs) and multifocal (mf)VEPs and to better understand the pathophysiology of the condition...
  50. pmc Comparison of contrast-response functions from multifocal visual-evoked potentials (mfVEPs) and functional MRI responses
    Jason C Park
    Department of Psychology, Columbia University, New York, NY, USA
    J Vis 8:8.1-12. 2008
    ..J. Heeger, A. C. Huk, W. S. Geisler, and D. G. Albrecht (2000) does not fit the results...
  51. pmc Blood vessel contributions to retinal nerve fiber layer thickness profiles measured with optical coherence tomography
    Donald C Hood
    Departments of Psychology and Ophthalmology, Columbia University, New York, NY 10027, USA
    J Glaucoma 17:519-28. 2008
    ..To understand better the influence of retinal blood vessels (BVs) on the interindividual variation in the retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography (OCT)...
  52. pmc A multiplicative model for spatial interaction in the human visual cortex
    Xian Zhang
    Department of Psychology, Columbia University, New York, NY, USA
    J Vis 8:4.1-9. 2008
    ..A modified multiplicative model that incorporates these elements describes the results...
  53. pmc An analysis of normal variations in retinal nerve fiber layer thickness profiles measured with optical coherence tomography
    Quraish Ghadiali
    Department of Psychology, Columbia University, New York, NY 10027, USA
    J Glaucoma 17:333-40. 2008
    ..To assess the normal variations in retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography (OCT)...
  54. pmc Preferred retinal locus in macular disease: characteristics and clinical implications
    Vivienne C Greenstein
    Department of Ophthalmology, Columbia University, 630 West 165th Street, New York, NY 10032, USA
    Retina 28:1234-40. 2008
    ..To investigate the location and fixation stability of preferred retinal locations (PRLs) in patients with macular disease, and the relationship among areas of abnormal fundus autofluorescence, the PRL and visual sensitivity...
  55. pmc Effect of recording duration on the diagnostic performance of multifocal visual-evoked potentials in high-risk ocular hypertension and early glaucoma
    Brad Fortune
    Discoveries in Sight, Devers Eye Institute, Legacy Health System, Portland, OR 97232, USA
    J Glaucoma 17:175-82. 2008
    ..To evaluate the effect on diagnostic performance of reducing multifocal visual-evoked potential (mfVEP) recording duration from 16 to 8 minutes per eye...
  56. pmc A comparison of multifocal and conventional visual evoked potential techniques in patients with optic neuritis/multiple sclerosis
    Larissa K Grover
    Department of Psychology, Columbia University, Schermerhorn Hall, New York, NY 10027 7004, USA
    Doc Ophthalmol 117:121-8. 2008
    ..To compare conventional visual evoked potential (cVEP) and multifocal visual evoked potential (mfVEP) methods in patients with optic neuritis/multiple sclerosis (ON/MS)...
  57. pmc A framework for comparing structural and functional measures of glaucomatous damage
    Donald C Hood
    Department of Psychology, Columbia University, 116th and Broadway, New York, NY, 10027 7004, USA
    Prog Retin Eye Res 26:688-710. 2007
    ....
  58. pmc Retinal nerve fiber structure versus visual field function in patients with ischemic optic neuropathy. A test of a linear model
    Donald C Hood
    Department of Psychology, Columbia University, New York, New York 10027 7004, USA
    Ophthalmology 115:904-10. 2008
    ..To test a linear model relating the regional loss in retinal nerve fiber (RNFL) thickness to the corresponding regional loss in sensitivity with data from patients with previous anterior ischemic optic neuropathy (AION)...
  59. ncbi Structure versus function in glaucoma: an application of a linear model
    Donald C Hood
    Department of Psychology, Columbia University, New York, New York 10027, USA
    Invest Ophthalmol Vis Sci 48:3662-8. 2007
    ..To evaluate a linear model that relates the glaucomatous loss in retinal nerve fiber (RNFL) thickness, measured with optical coherence tomography (OCT), to the loss in sensitivity, measured with standard automated perimetry (SAP)...
  60. ncbi The multifocal visual evoked potential: an objective measure of visual fields?
    William Seiple
    Department of Ophthalmology, New York University School of Medicine, BEL 5N15, 550 First Avenue, New York, NY 10016, USA
    Vision Res 45:1155-63. 2005
    ..Therefore, the mfVEP provides an objective measure of visual field function that may be useful for some patients with unreliable automated static perimetry results...