Tests of Models of Retinal/Optic Nerve Diseases&Adaption

Summary

Principal Investigator: Donald C Hood
Affiliation: Columbia University
Country: USA
Abstract: A major long-term objective is to develop techniques for localizing the sites, and identifying the mechanisms of diseases of the retina and optic nerve. The multifocal electroretinogram (mERG) and visual evoked potential (mVEP) techniques are relatively new ways for measuring the physiological activity of local retinal and cortical activity. By studying the mERGs from patients with a variety of retinal/optic nerve problems we aim to develop a conceptual framework for relating changes in the mERG to sites and mechanisms of damage (aim 1a). In addition, some retinal diseases affect retinal mechanisms of adaptation and studies are designed to understand these changes. The mVEP technique is less developed and studies are proposed to improve this technology. These include the development of a method for measuring and specifying the strength of the signal in the mVEP response (aim 1b). Specific studies are proposed to understand the contribution of cone pathways to the mVEP, to assess repeat reliability, to optimize recording techniques, and to develop norms. The second long-term objective is to improve our understanding of the sites and mechanisms of particular diseases of the retina/optic nerve through studies employing behavioral (e.g. visual fields), structural (e.g. nerve fiber layer analysis) and electrophysiological techniques (e.g. mERG and mVEP). As part of aim 2, the mERG and visual field measures will be employed to better understand retinal damage in patients with retinitis pigmentosa and diabetic retinopathy and to assess possible damage following retinal surgery for macular holes and macular pucker. In addition, the sites and mechanisms of glaucomatous damage will be studied. These studies include a comparison of structural and functional measures to better understand the mechanism(s) of damage, an attempt to detect early damage, an assessment of the effect of acute decreases in intraocular pressure, and an assessment of whether there are selective deficits in the cone pathways. Finally, patients with acute optic neuritis will be followed with behavioral and mVEP techniques. An attempt will be made to understand the recovery o vision following optic neuritis (ON).
Funding Period: 1977-08-01 - 2005-07-31
more information: NIH RePORT

Top Publications

  1. ncbi The multifocal visual evoked potential: an objective measure of visual fields?
    William Seiple
    Department of Ophthalmology, New York University School of Medicine, BEL 5N15, 550 First Avenue, New York, NY 10016, USA
    Vision Res 45:1155-63. 2005
  2. ncbi A framework for comparing structural and functional measures of glaucomatous damage
    Donald C Hood
    Department of Psychology, Columbia University, 116th and Broadway, New York, NY, 10027 7004, USA
    Prog Retin Eye Res 26:688-710. 2007
  3. ncbi A comparison of multifocal and conventional visual evoked potential techniques in patients with optic neuritis/multiple sclerosis
    Larissa K Grover
    Department of Psychology, Columbia University, Schermerhorn Hall, New York, NY 10027 7004, USA
    Doc Ophthalmol 117:121-8. 2008
  4. ncbi Effect of recording duration on the diagnostic performance of multifocal visual-evoked potentials in high-risk ocular hypertension and early glaucoma
    Brad Fortune
    Discoveries in Sight, Devers Eye Institute, Legacy Health System, Portland, OR 97232, USA
    J Glaucoma 17:175-82. 2008
  5. ncbi Preferred retinal locus in macular disease: characteristics and clinical implications
    Vivienne C Greenstein
    Department of Ophthalmology, Columbia University, 630 West 165th Street, New York, NY 10032, USA
    Retina 28:1234-40. 2008
  6. ncbi An analysis of normal variations in retinal nerve fiber layer thickness profiles measured with optical coherence tomography
    Quraish Ghadiali
    Department of Psychology, Columbia University, New York, NY 10027, USA
    J Glaucoma 17:333-40. 2008
  7. ncbi A method to detect progression of glaucoma using the multifocal visual evoked potential technique
    Boonchai Wangsupadilok
    Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Doc Ophthalmol 118:139-50. 2009
  8. ncbi A multiplicative model for spatial interaction in the human visual cortex
    Xian Zhang
    Department of Psychology, Columbia University, New York, NY, USA
    J Vis 8:4.1-9. 2008
  9. ncbi Blood vessel contributions to retinal nerve fiber layer thickness profiles measured with optical coherence tomography
    Donald C Hood
    Departments of Psychology and Ophthalmology, Columbia University, New York, NY 10027, USA
    J Glaucoma 17:519-28. 2008
  10. ncbi Comparison of contrast-response functions from multifocal visual-evoked potentials (mfVEPs) and functional MRI responses
    Jason C Park
    Department of Psychology, Columbia University, New York, NY, USA
    J Vis 8:8.1-12. 2008

Scientific Experts

  • Donald C Hood
  • Brad Fortune
  • V C Greenstein
  • Xian Zhang
  • K Holopigian
  • Jeffrey M Liebmann
  • Robert Ritch
  • Tomas M Grippo
  • Quraish Ghadiali
  • Boonchai Wangsupadilok
  • Wener Cella
  • Stephen H Tsang
  • Larissa K Grover
  • Fabio N Kanadani
  • Jeffrey G Odel
  • Luiz H Lima
  • Nuno L Gomes
  • R Theodore Smith
  • Min Wang
  • Jason C Park
  • Stanley Chang
  • Isaac Ezon
  • Myles M Behrens
  • E Bo Yang
  • Samir R Tari
  • R Ritch
  • C Rodarte
  • J M Liebmann
  • Phamornsak Thienprasiddhi
  • F N Kanadani
  • William Seiple
  • Gaetano Barile
  • Mihai Busuioc
  • Jana Zernant-Rajang
  • Gustavo V De Moraes
  • Carlos Gustavo De Moraes
  • Theodore R Smith
  • Nan Kai Wang
  • Joshua N Carlson
  • Rando Allikmets
  • Celso Tello
  • Jung Suk Cho
  • Ronald E Carr
  • Lawrence A Yannuzzi
  • Joy Hirsch
  • Jack Manns
  • Clara Lee
  • John Ferrera
  • Adam S Wenick
  • Alex Llinas
  • Chris Rodarte
  • Orit Vidne Hay
  • Gaetano R Barile
  • Orit Vidne-Hay
  • B Wangsupadilok
  • Li Xu
  • E B Yang
  • N Harizman
  • T Grippo
  • David H Chu
  • T M Grippo
  • Colleen Clemens

Detail Information

Publications35

  1. ncbi The multifocal visual evoked potential: an objective measure of visual fields?
    William Seiple
    Department of Ophthalmology, New York University School of Medicine, BEL 5N15, 550 First Avenue, New York, NY 10016, USA
    Vision Res 45:1155-63. 2005
    ..Therefore, the mfVEP provides an objective measure of visual field function that may be useful for some patients with unreliable automated static perimetry results...
  2. ncbi A framework for comparing structural and functional measures of glaucomatous damage
    Donald C Hood
    Department of Psychology, Columbia University, 116th and Broadway, New York, NY, 10027 7004, USA
    Prog Retin Eye Res 26:688-710. 2007
    ....
  3. ncbi A comparison of multifocal and conventional visual evoked potential techniques in patients with optic neuritis/multiple sclerosis
    Larissa K Grover
    Department of Psychology, Columbia University, Schermerhorn Hall, New York, NY 10027 7004, USA
    Doc Ophthalmol 117:121-8. 2008
    ..To compare conventional visual evoked potential (cVEP) and multifocal visual evoked potential (mfVEP) methods in patients with optic neuritis/multiple sclerosis (ON/MS)...
  4. ncbi Effect of recording duration on the diagnostic performance of multifocal visual-evoked potentials in high-risk ocular hypertension and early glaucoma
    Brad Fortune
    Discoveries in Sight, Devers Eye Institute, Legacy Health System, Portland, OR 97232, USA
    J Glaucoma 17:175-82. 2008
    ..To evaluate the effect on diagnostic performance of reducing multifocal visual-evoked potential (mfVEP) recording duration from 16 to 8 minutes per eye...
  5. ncbi Preferred retinal locus in macular disease: characteristics and clinical implications
    Vivienne C Greenstein
    Department of Ophthalmology, Columbia University, 630 West 165th Street, New York, NY 10032, USA
    Retina 28:1234-40. 2008
    ..To investigate the location and fixation stability of preferred retinal locations (PRLs) in patients with macular disease, and the relationship among areas of abnormal fundus autofluorescence, the PRL and visual sensitivity...
  6. ncbi An analysis of normal variations in retinal nerve fiber layer thickness profiles measured with optical coherence tomography
    Quraish Ghadiali
    Department of Psychology, Columbia University, New York, NY 10027, USA
    J Glaucoma 17:333-40. 2008
    ..To assess the normal variations in retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography (OCT)...
  7. ncbi A method to detect progression of glaucoma using the multifocal visual evoked potential technique
    Boonchai Wangsupadilok
    Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Doc Ophthalmol 118:139-50. 2009
    ..To describe a method for monitoring progression of glaucoma using the multifocal visual evoked potential (mfVEP) technique...
  8. ncbi A multiplicative model for spatial interaction in the human visual cortex
    Xian Zhang
    Department of Psychology, Columbia University, New York, NY, USA
    J Vis 8:4.1-9. 2008
    ..A modified multiplicative model that incorporates these elements describes the results...
  9. ncbi Blood vessel contributions to retinal nerve fiber layer thickness profiles measured with optical coherence tomography
    Donald C Hood
    Departments of Psychology and Ophthalmology, Columbia University, New York, NY 10027, USA
    J Glaucoma 17:519-28. 2008
    ..To understand better the influence of retinal blood vessels (BVs) on the interindividual variation in the retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography (OCT)...
  10. ncbi Comparison of contrast-response functions from multifocal visual-evoked potentials (mfVEPs) and functional MRI responses
    Jason C Park
    Department of Psychology, Columbia University, New York, NY, USA
    J Vis 8:8.1-12. 2008
    ..J. Heeger, A. C. Huk, W. S. Geisler, and D. G. Albrecht (2000) does not fit the results...
  11. ncbi The effects of optic disc drusen on the latency of the pattern-reversal checkerboard and multifocal visual evoked potentials
    Tomas M Grippo
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York 10003 4297, USA
    Invest Ophthalmol Vis Sci 50:4199-204. 2009
    ..To determine the effect of optic disc drusen on the latency of the pattern-reversal checkerboard visual evoked potentials (VEPs) and multifocal (mf)VEPs and to better understand the pathophysiology of the condition...
  12. ncbi G1961E mutant allele in the Stargardt disease gene ABCA4 causes bull's eye maculopathy
    Wener Cella
    Department of Ophthalmology, Bernard and Shirlee Brown Glaucoma Laboratory, Edward S Harkness Eye Institute, Columbia University, 160 Fort Washington Avenue, New York, NY 10032, USA
    Exp Eye Res 89:16-24. 2009
    ..In addition, genetic testing provides precise diagnosis of the underlying maculopathy, and current non-invasive imaging techniques could be used to detect photoreceptor damage at the earliest clinical onset of the disease...
  13. ncbi A comparison of retinal nerve fiber layer (RNFL) thickness obtained with frequency and time domain optical coherence tomography (OCT)
    Donald C Hood
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Opt Express 17:3997-4003. 2009
    ..The results were comparable. More importantly, we learned that the key factor determining whether results from different machines will be comparable is the algorithm used to segment RNFL thickness, not the type of OCT...
  14. ncbi A comparison of fundus autofluorescence and retinal structure in patients with Stargardt disease
    Nuno L Gomes
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Invest Ophthalmol Vis Sci 50:3953-9. 2009
    ..To improve the understanding of Stargardt disease by comparing structural changes seen on spectral domain optical coherence tomography (SD-OCT) to those visible on fundus autofluorescence (FAF)...
  15. ncbi A test of a linear model of glaucomatous structure-function loss reveals sources of variability in retinal nerve fiber and visual field measurements
    Donald C Hood
    Department of Psychology, Columbia University, New York, New York 10027, USA
    Invest Ophthalmol Vis Sci 50:4254-66. 2009
    ..Retinal nerve fiber (RNFL) thickness and visual field loss data from patients with glaucoma were analyzed in the context of a model, to better understand individual variation in structure versus function...
  16. ncbi Structural assessment of hyperautofluorescent ring in patients with retinitis pigmentosa
    Luiz H Lima
    Vitreous, Retina, Macula Consultants of New York, New York, USA
    Retina 29:1025-31. 2009
    ..To analyze the retinal structure underlying the hyperautofluorescent ring visible on fundus autofluorescence in patients with retinitis pigmentosa...
  17. ncbi Retinal nerve fiber structure versus visual field function in patients with ischemic optic neuropathy. A test of a linear model
    Donald C Hood
    Department of Psychology, Columbia University, New York, New York 10027 7004, USA
    Ophthalmology 115:904-10. 2008
    ..To test a linear model relating the regional loss in retinal nerve fiber (RNFL) thickness to the corresponding regional loss in sensitivity with data from patients with previous anterior ischemic optic neuropathy (AION)...
  18. ncbi Structure versus function in glaucoma: an application of a linear model
    Donald C Hood
    Department of Psychology, Columbia University, New York, New York 10027, USA
    Invest Ophthalmol Vis Sci 48:3662-8. 2007
    ..To evaluate a linear model that relates the glaucomatous loss in retinal nerve fiber (RNFL) thickness, measured with optical coherence tomography (OCT), to the loss in sensitivity, measured with standard automated perimetry (SAP)...
  19. ncbi Multifocal visual evoked potential and automated perimetry abnormalities in strabismic amblyopes
    Vivienne C Greenstein
    Department of Ophthalmology, Columbia University, New York, New York, USA
    J AAPOS 12:11-7. 2008
    ..To compare visual field abnormalities obtained with standard automated perimetry (SAP) to those obtained with the multifocal visual evoked potential (mfVEP) technique in strabismic amblyopes...
  20. ncbi The pattern electroretinogram in glaucoma patients with confirmed visual field deficits
    Donald C Hood
    Department of Psychology, Columbia University, New York, New York 10027, USA
    Invest Ophthalmol Vis Sci 46:2411-8. 2005
    ..To better understand the relationship between the amplitude of the pattern electroretinogram (PERG) and visual loss, measured with static automated perimetry...
  21. ncbi Multifocal visual evoked potentials to cone specific stimuli in patients with retinitis pigmentosa
    K Holopigian
    Department of Ophthalmology, New York University School of Medicine, BEL 5N15, 462 First Avenue, New York, NY 10016, USA
    Vision Res 45:3244-52. 2005
    ..4 degrees ). For the first ring, mfERG amplitudes were more impaired than were the mfVEPs or the visual field thresholds. For most of the patients, there was local response correspondence among our measures of visual function...
  22. ncbi Repeatability of normal multifocal VEP: implications for detecting progression
    Brad Fortune
    Discoveries in Sight, Devers Eye Institute, Legacy Health System, Portland, OR 97232, USA
    J Glaucoma 15:131-41. 2006
    ..Our second aim was to assess the repeatability of false alarm rates determined previously for the mfVEP using various cluster criteria...
  23. ncbi The effects of glaucoma on the latency of the multifocal visual evoked potential
    C Rodarte
    Department of Psychology, 405 Schermerhorn, Columbia University, New York, NY 10027, USA
    Br J Ophthalmol 90:1132-6. 2006
    ..These results differ markedly from those of a recent conventional VEP study, which reported 100% sensitivity, 100% specificity, and an average delay that exceeded 25 ms...
  24. ncbi Detecting early functional damage in glaucoma suspect and ocular hypertensive patients with the multifocal VEP technique
    Phamornsak Thienprasiddhi
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, NY, USA
    J Glaucoma 15:321-7. 2006
    ..CONCLUSIONS: The mfVEP technique can detect visual field deficits in a minority of eyes with glaucomatous optic disks and normal SAP results...
  25. ncbi Contrast-response functions for multifocal visual evoked potentials: a test of a model relating V1 activity to multifocal visual evoked potentials activity
    Donald C Hood
    Department of Psychology, Columbia University, New York, NY, USA
    J Vis 6:580-93. 2006
    ..This deviation suggests that one or more of the model's assumptions may be violated. Second, the latency of the mfVEP changed far less than expected based upon single-cell data...
  26. ncbi Structural and functional assessment of the macular region in patients with glaucoma
    F N Kanadani
    Department of Psychology, Columbia University, 405 Schermerhorn, New York, NY 10027, USA
    Br J Ophthalmol 90:1393-7. 2006
    ..CONCLUSIONS: Good agreement exists between macular thickness and functional defects in patients with glaucoma. Study of the macular region may provide a quantitative measure for disease staging and monitoring...
  27. ncbi A comparison between multifocal and conventional VEP latency changes secondary to glaucomatous damage
    Tomas M Grippo
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York, USA
    Invest Ophthalmol Vis Sci 47:5331-6. 2006
    ..Either a delayed VEP is not a good indicator of damaged, as opposed to dead, retinal ganglion cells, or there are relatively few patients who exhibit evidence of damaged ganglion cells...
  28. ncbi Improvement in conduction velocity after optic neuritis measured with the multifocal VEP
    E Bo Yang
    Department of Psychology, Columbia University, New York, New York 10027, USA
    Invest Ophthalmol Vis Sci 48:692-8. 2007
    ..To test the efficacy of the multifocal visual evoked potential (mfVEP) technique after long-term latency changes in optic neuritis (ON)/multiple sclerosis (MS), mfVEPs were recorded in 12 patients with ON/MS...
  29. ncbi Retinal nerve fibre thickness measured with optical coherence tomography accurately detects confirmed glaucomatous damage
    D C Hood
    Department of Psychology, 405 Schermerhorn, Columbia University, New York, NY 10027, USA
    Br J Ophthalmol 91:905-7. 2007
    ....
  30. ncbi Comparing multifocal VEP and standard automated perimetry in high-risk ocular hypertension and early glaucoma
    Brad Fortune
    Discoveries in Sight, Devers Eye Institute, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 48:1173-80. 2007
    ..To compare the diagnostic performance of multifocal visual evoked potential (mfVEP) and standard automated perimetry (SAP), in eyes with high-risk ocular hypertension or early glaucoma...
  31. ncbi Scotopic sensitivity and color vision with a blue-light-absorbing intraocular lens
    Vivienne C Greenstein
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    J Cataract Refract Surg 33:667-72. 2007
    ..To investigate possible adverse effects of a yellow-tinted intraocular lens (IOL) on scotopic sensitivity and hue discrimination...
  32. ncbi Relating retinal nerve fiber thickness to behavioral sensitivity in patients with glaucoma: application of a linear model
    Donald C Hood
    Department of Psychology, Columbia University, New York, NY 10027, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1426-30. 2007
    ..Second, previous work by others was shown to be consistent with this model...
  33. ncbi The role of the multifocal visual evoked potential (mfVEP) latency in understanding optic nerve and retinal diseases
    Donald C Hood
    Columbia University, New York, New York, USA
    Trans Am Ophthalmol Soc 104:71-7. 2006
    ..In general, this does not present a problem when using the mfVEP in the clinic. However, a retinal problem can be confused with ON/MS or, in fact, dismissed as functional, especially if the fundus appears normal...
  34. ncbi Functional and structural measurements for the assessment of internal limiting membrane peeling in idiopathic macular pucker
    Samir R Tari
    Department of Ophthalmology, Columbia University, 635 West 165th Street, New York, NY 10032, USA
    Retina 27:567-72. 2007
    ..To investigate the role of structural and functional measurements in the assessment of internal limiting membrane (ILM) peeling for the treatment of eyes with macular pucker...
  35. ncbi Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography
    Min Wang
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Arch Ophthalmol 127:875-81. 2009
    ....