SACCADE TARGET SELECTION-FRONTAL CORTEX

Summary

Principal Investigator: JEFFREY SCHALL
Affiliation: Vanderbilt University
Country: USA
Abstract: The long-term goal of our research is to understand how the visual system decides where to look. The activity of multiple neurons will be monitored simultaneously in monkeys performing visual search tasks designed to dissociate visual processing from saccade preparation. The frontal eye field will be studied because it is situated anatomically to sample the outcome of visual processing to orient attention and produce motor commands to orient gaze. Patterns of neural activity will be analyzed to evaluate specific hypotheses about how visual information is encoded for target selection among pools of neurons (Aim 1), to describe how sensory-motor mapping occurs between visual and saccade neurons (Aim 2) and to determine how short-term and long-term experience influences saccade target selection (Aim 3). Understanding how the brain selects visual stimuli for action is necessary to understand the causes of impaired visual behavior.
Funding Period: 1991-01-01 - 2010-05-31
more information: NIH RePORT

Top Publications

  1. pmc Frontal eye field activity before visual search errors reveals the integration of bottom-up and top-down salience
    Kirk G Thompson
    Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bldg 49, Rm 2A50, Bethesda, MD 20892, USA
    J Neurophysiol 93:337-51. 2005
  2. pmc Neural control of visual search by frontal eye field: effects of unexpected target displacement on visual selection and saccade preparation
    Aditya Murthy
    National Brain Research Centre, Manesar, Haryana, India
    J Neurophysiol 101:2485-506. 2009
  3. pmc Neural basis of the set-size effect in frontal eye field: timing of attention during visual search
    Jeremiah Y Cohen
    Vanderbilt University, Wilson Hall, 111 21st Ave S, Nashville, TN 37240, USA
    J Neurophysiol 101:1699-704. 2009
  4. pmc Biophysical support for functionally distinct cell types in the frontal eye field
    Jeremiah Y Cohen
    Department of Pathology, Vanderbilt Brain Institute, Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Center, Vanderbilt University, 111 21st Ave South, Nashville, TN 37203, USA
    J Neurophysiol 101:912-6. 2009
  5. doi The effect of visual search efficiency on response preparation: neurophysiological evidence for discrete flow
    Geoffrey F Woodman
    Department of Psychology, Center for Integrative and Cognitive Neuroscience, and Vanderbilt Vision Research Center, Vanderbilt University, Nashville, TN 37240 1103, USA
    Psychol Sci 19:128-36. 2008
  6. pmc Review of signal distortion through metal microelectrode recording circuits and filters
    Matthew J Nelson
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, TN, USA
    J Neurosci Methods 169:141-57. 2008
  7. ncbi Difficulty of visual search modulates neuronal interactions and response variability in the frontal eye field
    Jeremiah Y Cohen
    Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, USA
    J Neurophysiol 98:2580-7. 2007
  8. pmc Nonhuman primate event-related potentials indexing covert shifts of attention
    Geoffrey F Woodman
    Department of Psychology, Vanderbilt Vision Research Center, Vanderbilt Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, TN 37203, USA
    Proc Natl Acad Sci U S A 104:15111-6. 2007
  9. pmc The role of working memory representations in the control of attention
    Geoffrey F Woodman
    Department of Psychology, Vanderbilt University, Nashville, TN 37240 1103, USA
    Cereb Cortex 17:i118-24. 2007
  10. pmc Dynamics of saccade target selection: race model analysis of double step and search step saccade production in human and macaque
    C R Camalier
    Department of Psychology, Wilson Hall, Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Vanderbilt University, 111 21st Avenue South, Nashville, TN 37203, USA
    Vision Res 47:2187-211. 2007

Scientific Experts

Detail Information

Publications14

  1. pmc Frontal eye field activity before visual search errors reveals the integration of bottom-up and top-down salience
    Kirk G Thompson
    Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bldg 49, Rm 2A50, Bethesda, MD 20892, USA
    J Neurophysiol 93:337-51. 2005
    ..This map in FEF may correspond to the theoretical salience map of many models of attention and saccade target selection...
  2. pmc Neural control of visual search by frontal eye field: effects of unexpected target displacement on visual selection and saccade preparation
    Aditya Murthy
    National Brain Research Centre, Manesar, Haryana, India
    J Neurophysiol 101:2485-506. 2009
    ..These findings indicate that visual activity in the frontal eye field signals the location of targets for orienting, whereas movement-related activity instantiates saccade preparation...
  3. pmc Neural basis of the set-size effect in frontal eye field: timing of attention during visual search
    Jeremiah Y Cohen
    Vanderbilt University, Wilson Hall, 111 21st Ave S, Nashville, TN 37240, USA
    J Neurophysiol 101:1699-704. 2009
    ..These findings indicate that the time taken by FEF neurons to select the target contributes to the variation in visual search efficiency...
  4. pmc Biophysical support for functionally distinct cell types in the frontal eye field
    Jeremiah Y Cohen
    Department of Pathology, Vanderbilt Brain Institute, Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Center, Vanderbilt University, 111 21st Ave South, Nashville, TN 37203, USA
    J Neurophysiol 101:912-6. 2009
    ..These results show how structure and function of FEF can be linked to guide inferences about neuronal architecture...
  5. doi The effect of visual search efficiency on response preparation: neurophysiological evidence for discrete flow
    Geoffrey F Woodman
    Department of Psychology, Center for Integrative and Cognitive Neuroscience, and Vanderbilt Vision Research Center, Vanderbilt University, Nashville, TN 37240 1103, USA
    Psychol Sci 19:128-36. 2008
    ..These findings provide neurophysiological support for the hypothesis that information is transmitted discretely between perceptual and response stages of processing during visual search...
  6. pmc Review of signal distortion through metal microelectrode recording circuits and filters
    Matthew J Nelson
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, TN, USA
    J Neurosci Methods 169:141-57. 2008
    ..These distortions can be corrected, but must be accounted for when interpreting field potential and spike shape data...
  7. ncbi Difficulty of visual search modulates neuronal interactions and response variability in the frontal eye field
    Jeremiah Y Cohen
    Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, USA
    J Neurophysiol 98:2580-7. 2007
    ..These findings show that a multivariate analysis can provide a measure of neuronal interactions and characterize the spiking activity of FEF neurons in the context of a population of neurons...
  8. pmc Nonhuman primate event-related potentials indexing covert shifts of attention
    Geoffrey F Woodman
    Department of Psychology, Vanderbilt Vision Research Center, Vanderbilt Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, TN 37203, USA
    Proc Natl Acad Sci U S A 104:15111-6. 2007
    ..These findings begin to bridge the gap between the disparate literatures by using electrophysiological measurements to study the deployment of visual attention in the brains of humans and nonhuman primates...
  9. pmc The role of working memory representations in the control of attention
    Geoffrey F Woodman
    Department of Psychology, Vanderbilt University, Nashville, TN 37240 1103, USA
    Cereb Cortex 17:i118-24. 2007
    ....
  10. pmc Dynamics of saccade target selection: race model analysis of double step and search step saccade production in human and macaque
    C R Camalier
    Department of Psychology, Wilson Hall, Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Vanderbilt University, 111 21st Avenue South, Nashville, TN 37203, USA
    Vision Res 47:2187-211. 2007
    ..This model provides a computational account of saccade production when the image changes unexpectedly...
  11. ncbi Frontal eye field contributions to rapid corrective saccades
    Aditya Murthy
    National Brain Research Centre, Near NSG Campus, NH 8, Nainwal Mode, Manesar, Gurgaon 122050, Haryana, India
    J Neurophysiol 97:1457-69. 2007
    ..Thus movement-related activity leading to rapid corrective saccades can be guided by an internal representation of the environment updated with a forward model of the error...
  12. ncbi Low-threshold Ca2+-associated bursts are rare events in the LGN of the awake behaving monkey
    Octavio Ruiz
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee 37232 8240, USA
    J Neurophysiol 95:3401-13. 2006
    ....
  13. ncbi Correlates of motor planning and postsaccadic fixation in the macaque monkey lateral geniculate nucleus
    D W Royal
    Center for Molecular Neuroscience, Vanderbilt University, Nashville, TN 37232 2175, USA
    Exp Brain Res 168:62-75. 2006
    ....
  14. pmc On the origin of event-related potentials indexing covert attentional selection during visual search
    Jeremiah Y Cohen
    Department of Psychology, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37240, USA
    J Neurophysiol 102:2375-86. 2009
    ..This neurochronometric comparison provides an empirical bridge connecting macaque and human experiments and a step toward localizing the neural generator of this important attention-related ERP component...