SACCADE TARGET SELECTION-FRONTAL CORTEX

Summary

Principal Investigator: JEFFREY SCHALL
Affiliation: Vanderbilt University
Country: USA
Abstract: The long-term goal of our research is to understand how the visual system decides where to look. The activity of multiple neurons will be monitored simultaneously in monkeys performing visual search tasks designed to dissociate visual processing from saccade preparation. The frontal eye field will be studied because it is situated anatomically to sample the outcome of visual processing to orient attention and produce motor commands to orient gaze. Patterns of neural activity will be analyzed to evaluate specific hypotheses about how visual information is encoded for target selection among pools of neurons (Aim 1), to describe how sensory-motor mapping occurs between visual and saccade neurons (Aim 2) and to determine how short-term and long-term experience influences saccade target selection (Aim 3). Understanding how the brain selects visual stimuli for action is necessary to understand the causes of impaired visual behavior.
Funding Period: 1991-01-01 - 2010-05-31
more information: NIH RePORT

Top Publications

  1. pmc Neural chronometry and coherency across speed-accuracy demands reveal lack of homomorphism between computational and neural mechanisms of evidence accumulation
    Richard P Heitz
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, PMB 407817, 2301 Vanderbilt Place, Nashville, TN 37240 781, USA
    Philos Trans R Soc Lond B Biol Sci 368:20130071. 2013
  2. pmc Visual and motor connectivity and the distribution of calcium-binding proteins in macaque frontal eye field: implications for saccade target selection
    Pierre Pouget
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University Nashville, TN, USA
    Front Neuroanat 3:2. 2009
  3. pmc Homologous mechanisms of visuospatial working memory maintenance in macaque and human: properties and sources
    Robert M G Reinhart
    Department of Psychology, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, TN 37240, USA
    J Neurosci 32:7711-22. 2012
  4. pmc Supplementary eye field during visual search: salience, cognitive control, and performance monitoring
    Braden A Purcell
    Department of Psychology, Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, Tennessee 37240 7817, USA
    J Neurosci 32:10273-85. 2012
  5. pmc Response variability of frontal eye field neurons modulates with sensory input and saccade preparation but not visual search salience
    Braden A Purcell
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240 7817, USA
    J Neurophysiol 108:2737-50. 2012
  6. pmc On the origin of event-related potentials indexing covert attentional selection during visual search: timing of selection by macaque frontal eye field and event-related potentials during pop-out search
    Braden A Purcell
    Department of Psychology, Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Vanderbilt University, Nashville, Tennessee 37240 7817, USA
    J Neurophysiol 109:557-69. 2013
  7. pmc Neural mechanisms of speed-accuracy tradeoff
    Richard P Heitz
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Neuron 76:616-28. 2012
  8. pmc Macrocircuits: decision networks
    Jeffrey D Schall
    Department of Psychology, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, TN 37240, USA
    Curr Opin Neurobiol 23:269-74. 2013
  9. pmc Neurally constrained modeling of perceptual decision making
    Braden A Purcell
    Department of Psychology, Vanderbilt University, 2301 Vanderbilt Place, Nashville, TN 37240 7817, USA
    Psychol Rev 117:1113-43. 2010
  10. pmc Nonindependent and nonstationary response times in stopping and stepping saccade tasks
    Matthew J Nelson
    California Institute of Technology, Pasadena, California, USA
    Atten Percept Psychophys 72:1913-29. 2010

Scientific Experts

  • Geoffrey F Woodman
  • JEFFREY SCHALL
  • Motonori Yamaguchi
  • Kirk G Thompson
  • Matthew J Nelson
  • Aditya Murthy
  • Richard P Heitz
  • Jeremiah Y Cohen
  • Braden A Purcell
  • Robert M G Reinhart
  • Pierre Pouget
  • Pauline K Weigand
  • Gordon D Logan
  • Thomas J Palmeri
  • Erin A Crowder
  • Chenchal R Subraveti
  • C R Camalier
  • D W Royal
  • Octavio Ruiz
  • Nancy B Carlisle
  • Min Suk Kang
  • MELANIE W LESLIE
  • Erik E Emeric
  • Iwona Stepniewska
  • G D Logan
  • A Gotler
  • T J Palmeri
  • Andrew F Rossi
  • Gyula Sary
  • Xin Chen
  • David Royal
  • Vivien A Casagrande
  • V A Casagrande
  • Gy S├íry

Detail Information

Publications30

  1. pmc Neural chronometry and coherency across speed-accuracy demands reveal lack of homomorphism between computational and neural mechanisms of evidence accumulation
    Richard P Heitz
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, PMB 407817, 2301 Vanderbilt Place, Nashville, TN 37240 781, USA
    Philos Trans R Soc Lond B Biol Sci 368:20130071. 2013
    ..Second, we report a new analysis demonstrating selective influence of SAT on frequency coupling between FEF neurons and local field potentials. None of these observations correspond to the mechanics of current accumulator models. ..
  2. pmc Visual and motor connectivity and the distribution of calcium-binding proteins in macaque frontal eye field: implications for saccade target selection
    Pierre Pouget
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University Nashville, TN, USA
    Front Neuroanat 3:2. 2009
    ..This finding also suggests that FEF neurons projecting to visual cortex and SC are embedded in different patterns of intracortical circuitry...
  3. pmc Homologous mechanisms of visuospatial working memory maintenance in macaque and human: properties and sources
    Robert M G Reinhart
    Department of Psychology, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, TN 37240, USA
    J Neurosci 32:7711-22. 2012
    ....
  4. pmc Supplementary eye field during visual search: salience, cognitive control, and performance monitoring
    Braden A Purcell
    Department of Psychology, Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, Tennessee 37240 7817, USA
    J Neurosci 32:10273-85. 2012
    ..Altogether, these results suggest that SEF plays a limited role in controlling ongoing visual search behavior, but may play a larger role in monitoring search performance...
  5. pmc Response variability of frontal eye field neurons modulates with sensory input and saccade preparation but not visual search salience
    Braden A Purcell
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240 7817, USA
    J Neurophysiol 108:2737-50. 2012
    ..These results indicate that the trial-by-trial response variability of FEF neurons reflects saccade preparation and the strength of sensory input, but not visual search salience or attentional allocation...
  6. pmc On the origin of event-related potentials indexing covert attentional selection during visual search: timing of selection by macaque frontal eye field and event-related potentials during pop-out search
    Braden A Purcell
    Department of Psychology, Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Vanderbilt University, Nashville, Tennessee 37240 7817, USA
    J Neurophysiol 109:557-69. 2013
    ..These observations are consistent with the hypothesis that feedback from FEF modulates neural activity in posterior regions that appear to generate the m-N2pc even when competition for attention among items in a visual scene is minimal...
  7. pmc Neural mechanisms of speed-accuracy tradeoff
    Richard P Heitz
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Neuron 76:616-28. 2012
    ..The diversity of neural mechanisms was reconciled with the accumulator framework through an integrated accumulator model constrained by requirements of the motor system...
  8. pmc Macrocircuits: decision networks
    Jeffrey D Schall
    Department of Psychology, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, TN 37240, USA
    Curr Opin Neurobiol 23:269-74. 2013
    ..This review will survey recent empirical and theoretical developments very selectively with an emphasis on neurophysiological data from nonhuman primates that provide the clearest information about neural mechanisms...
  9. pmc Neurally constrained modeling of perceptual decision making
    Braden A Purcell
    Department of Psychology, Vanderbilt University, 2301 Vanderbilt Place, Nashville, TN 37240 7817, USA
    Psychol Rev 117:1113-43. 2010
    ..The results also illustrate the use of neurophysiological data as a model selection tool and establish a novel framework to bridge computational and neural levels of explanation...
  10. pmc Nonindependent and nonstationary response times in stopping and stepping saccade tasks
    Matthew J Nelson
    California Institute of Technology, Pasadena, California, USA
    Atten Percept Psychophys 72:1913-29. 2010
    ..These results demonstrate the robustness of the race model to some aspects of nonindependence and nonstationarity and point to useful extensions of the model...
  11. ncbi Stopping while going! Response inhibition does not suffer dual-task interference
    Motonori Yamaguchi
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    J Exp Psychol Hum Percept Perform 38:123-34. 2012
    ..Therefore, the present study supports the claim that response inhibition does not suffer dual-task interference...
  12. pmc Neural mechanisms of saccade target selection: gated accumulator model of the visual-motor cascade
    Jeffrey D Schall
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, PMB 407817, 2301 Vanderbilt Place, Nashville, TN 37240 7817, USA
    Eur J Neurosci 33:1991-2002. 2011
    ..This union of cognitive modeling and neurophysiology indicates how the visual-motor transformation can occur, and provides a concrete mapping between neuron function and specific cognitive processes...
  13. pmc Event-related potentials elicited by errors during the stop-signal task. II: human effector-specific error responses
    Robert M G Reinhart
    Department of Psychology, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA
    J Neurophysiol 107:2794-807. 2012
    ..2011), we demonstrate a cross-species homology of error event-related potentials (ERPs) and lay the groundwork for definitively localizing the neural sources of performance-monitoring ERPs...
  14. pmc From salience to saccades: multiple-alternative gated stochastic accumulator model of visual search
    Braden A Purcell
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Despartment of Psychology, Vanderbilt University, Nashville, Tennessee 37240, USA
    J Neurosci 32:3433-46. 2012
    ..Adjustments in the level of gating inhibition can control trade-offs in speed and accuracy that optimize visual search performance...
  15. pmc Neural correlates of correct and errant attentional selection revealed through N2pc and frontal eye field activity
    Richard P Heitz
    Department of Psychology, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, USA
    J Neurophysiol 104:2433-41. 2010
    ..Our analyses also revealed distinct neural correlates of false alarms and guesses. These results demonstrate that errant gaze shifts during visual search arise from errant attentional processing...
  16. pmc Cooperation and competition among frontal eye field neurons during visual target selection
    Jeremiah Y Cohen
    Department of Psychology, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37240, USA
    J Neurosci 30:3227-38. 2010
    ..Thus, we provide evidence for dynamic and task-dependent cooperation and competition among frontal eye field neurons during visual target selection...
  17. pmc On the origin of event-related potentials indexing covert attentional selection during visual search
    Jeremiah Y Cohen
    Department of Psychology, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37240, USA
    J Neurophysiol 102:2375-86. 2009
    ..This neurochronometric comparison provides an empirical bridge connecting macaque and human experiments and a step toward localizing the neural generator of this important attention-related ERP component...
  18. ncbi Correlates of motor planning and postsaccadic fixation in the macaque monkey lateral geniculate nucleus
    D W Royal
    Center for Molecular Neuroscience, Vanderbilt University, Nashville, TN 37232 2175, USA
    Exp Brain Res 168:62-75. 2006
    ....
  19. ncbi Low-threshold Ca2+-associated bursts are rare events in the LGN of the awake behaving monkey
    Octavio Ruiz
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee 37232 8240, USA
    J Neurophysiol 95:3401-13. 2006
    ....
  20. ncbi Frontal eye field contributions to rapid corrective saccades
    Aditya Murthy
    National Brain Research Centre, Near NSG Campus, NH 8, Nainwal Mode, Manesar, Gurgaon 122050, Haryana, India
    J Neurophysiol 97:1457-69. 2007
    ..Thus movement-related activity leading to rapid corrective saccades can be guided by an internal representation of the environment updated with a forward model of the error...
  21. pmc Dynamics of saccade target selection: race model analysis of double step and search step saccade production in human and macaque
    C R Camalier
    Department of Psychology, Wilson Hall, Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Vanderbilt University, 111 21st Avenue South, Nashville, TN 37203, USA
    Vision Res 47:2187-211. 2007
    ..This model provides a computational account of saccade production when the image changes unexpectedly...
  22. pmc The role of working memory representations in the control of attention
    Geoffrey F Woodman
    Department of Psychology, Vanderbilt University, Nashville, TN 37240 1103, USA
    Cereb Cortex 17:i118-24. 2007
    ....
  23. pmc Nonhuman primate event-related potentials indexing covert shifts of attention
    Geoffrey F Woodman
    Department of Psychology, Vanderbilt Vision Research Center, Vanderbilt Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, TN 37203, USA
    Proc Natl Acad Sci U S A 104:15111-6. 2007
    ..These findings begin to bridge the gap between the disparate literatures by using electrophysiological measurements to study the deployment of visual attention in the brains of humans and nonhuman primates...
  24. ncbi Difficulty of visual search modulates neuronal interactions and response variability in the frontal eye field
    Jeremiah Y Cohen
    Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, USA
    J Neurophysiol 98:2580-7. 2007
    ..These findings show that a multivariate analysis can provide a measure of neuronal interactions and characterize the spiking activity of FEF neurons in the context of a population of neurons...
  25. pmc Review of signal distortion through metal microelectrode recording circuits and filters
    Matthew J Nelson
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, TN, USA
    J Neurosci Methods 169:141-57. 2008
    ..These distortions can be corrected, but must be accounted for when interpreting field potential and spike shape data...
  26. pmc The effect of visual search efficiency on response preparation: neurophysiological evidence for discrete flow
    Geoffrey F Woodman
    Department of Psychology, Center for Integrative and Cognitive Neuroscience, and Vanderbilt Vision Research Center, Vanderbilt University, Nashville, TN 37240 1103, USA
    Psychol Sci 19:128-36. 2008
    ..These findings provide neurophysiological support for the hypothesis that information is transmitted discretely between perceptual and response stages of processing during visual search...
  27. pmc Biophysical support for functionally distinct cell types in the frontal eye field
    Jeremiah Y Cohen
    Department of Pathology, Vanderbilt Brain Institute, Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Center, Vanderbilt University, 111 21st Ave South, Nashville, TN 37203, USA
    J Neurophysiol 101:912-6. 2009
    ..These results show how structure and function of FEF can be linked to guide inferences about neuronal architecture...
  28. pmc Neural basis of the set-size effect in frontal eye field: timing of attention during visual search
    Jeremiah Y Cohen
    Vanderbilt University, Wilson Hall, 111 21st Ave S, Nashville, TN 37240, USA
    J Neurophysiol 101:1699-704. 2009
    ..These findings indicate that the time taken by FEF neurons to select the target contributes to the variation in visual search efficiency...
  29. pmc Neural control of visual search by frontal eye field: effects of unexpected target displacement on visual selection and saccade preparation
    Aditya Murthy
    National Brain Research Centre, Manesar, Haryana, India
    J Neurophysiol 101:2485-506. 2009
    ..These findings indicate that visual activity in the frontal eye field signals the location of targets for orienting, whereas movement-related activity instantiates saccade preparation...
  30. pmc Frontal eye field activity before visual search errors reveals the integration of bottom-up and top-down salience
    Kirk G Thompson
    Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bldg 49, Rm 2A50, Bethesda, MD 20892, USA
    J Neurophysiol 93:337-51. 2005
    ..This map in FEF may correspond to the theoretical salience map of many models of attention and saccade target selection...