RETINOPATHY OF PREMATURITY--UNDERSTAND ITS PATHOGENESIS
Principal Investigator: John Penn
Affiliation: Vanderbilt University
Abstract: The increased survival of premature infants in modem neonatal intensive care units has caused a resurgence of retinopathy of prematurity (ROP). It is reasoned that as more and smaller premature babies survive, the incidence of visual loss from ROP will continue to increase unless effective treatments are found. Advanced ROP is characterized by a period of unregulated growth of retinal blood vessels. This growth occurs by a process known as angiogenesis, indicating that the new vessels form by an abnormal sprouting of existing vessels. The loss of vision from angiogenesis is not unique to ROP; collectively, ocular disorders with this feature constitute the leading cause of blindness in the U.S. The significance of research aimed at understanding retinal angiogenesis in an animal model of one of these diseases is amplified by the potential of applying the new knowledge to other ocular conditions in which angiogenesis plays a role. The ultimate goal of this project is to develop methods to prevent retinal angiogenesis based upon understanding gained from studies of a rat model of ROP. To this end, four interrelated research projects are proposed: 1) identification of components of the endothelial cell signal pathways by which angiogenesis is initiated, 2) examination of the digestion of extracellular matrix by angiogenic endothelial cells, 3) investigation of the cell attachment mechanisms by which angiogenic endothelial cells migrate, and 4) determination of the precise mechanism through which fluctuating oxygen exposures encourage retinal angiogenesis.
Funding Period: 1988-04-01 - 2001-06-30
more information: NIH RePORT
- The role of the NFAT signaling pathway in retinal neovascularizationColin A Bretz
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee
Invest Ophthalmol Vis Sci 54:7020-7. 2013....
- Imaging of endothelial progenitor cell subpopulations in angiogenesis using quantum dot nanocrystalsJoshua M Barnett
Vanderbilt Eye Institute, Vanderbilt University, Nashville, TN, USA
Methods Mol Biol 1026:45-56. 2013....
- Peroxisome proliferator-activated receptor-β/δ regulates angiogenic cell behaviors and oxygen-induced retinopathyMegan E Capozzi
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
Invest Ophthalmol Vis Sci 54:4197-207. 2013....
- Ketorolac inhibits choroidal neovascularization by suppression of retinal VEGFStephen J Kim
Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
Exp Eye Res 91:537-43. 2010..05) and 29% at 7 days (P<0.001) and retinal VEGF by 31% at 3 days (P=0.10) and 19% at 7 days (P<0.001). Topical ketorolac inhibited CNV and suppressed retinal PGE(2) and VEGF production...
- Genetic deletion of COX-2 diminishes VEGF production in mouse retinal Müller cellsSusan E Yanni
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 8808, USA
Exp Eye Res 91:34-41. 2010..Our study suggests that PGE(2), signaling through the EP(2) and/or EP(4) receptor and PKA, mediates the VEGF response of Müller cells...
- The effects of nepafenac and amfenac on retinal angiogenesisSusan E Yanni
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 8000 Medical Center East, Nashville, TN 37232 8808, USA
Brain Res Bull 81:310-9. 2010..The purpose of the present study was to investigate the capacity of amfenac to inhibit discrete aspects of the angiogenic cascade in vitro, and to test the efficacy of amfenac and nepafenac in vivo, using the rat OIR model...
- The development of the rat model of retinopathy of prematurityJoshua M Barnett
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
Doc Ophthalmol 120:3-12. 2010..This article provides historical perspective on the development and use of the rat model of ROP. Key findings generated through the use of this model are also summarized...
- Reduced choroidal neovascular membrane formation in cyclooxygenase-2 null miceKasra A Rezaei
Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Invest Ophthalmol Vis Sci 52:701-7. 2011....
- Proteomic analysis of the retina: removal of RPE alters outer segment assembly and retinal protein expressionXiaofei Wang
Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
Glia 57:380-92. 2009....
- Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIRJoshua M Barnett
Vanderbilt Eye Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Invest Ophthalmol Vis Sci 48:907-15. 2007..The susceptibilities of MMP-2(-/-) and -9(-/-) mice to preretinal neovascularization were investigated in a mouse model of oxygen-induced retinopathy...