EXPERIENCE DEPENDENT VISUAL CORTICAL DEVELOPMENT

Summary

Principal Investigator: MARK BEAR
Affiliation: Massachusetts Institute of Technology
Country: USA
Abstract: The long-term goal of this project is to elucidate the molecular mechanisms of experience-dependent cortical plasticity, which must occur normally for the proper development of vision in mammals. The first aim is to assess the contribution of synaptic mobilization of glutamate receptors to deprivation-induced response depression in visual cortex and amblyopia. The second aim is to characterize the recently discovered phenomenon of stimulus-specific response potentiation (SRP), and test the hypothesis that SRP utilizes mechanisms that are revealed by the study of long-term synaptic potentiation (LTP). The proposed research promises to reveal the detailed molecular basis for experience-dependent bidirectional synaptic plasticity in the visual cortex. Besides the obvious relevance of this neural plasticity to the development of visual capabilities in humans and animals, it seems likely that similar processes form the basis for some forms of learning and memory, and also contribute to recovery of brain function after injury. Knowledge of the mechanisms of plasticity can be (and are being) applied to devise strategies to protect juvenile synapses from deleterious effects of environmental deprivation during development, and to promote synaptic strengthening and recovery of function.
Funding Period: 1998-08-01 - 2011-07-31
more information: NIH RePORT

Top Publications

  1. pmc A cholinergic mechanism for reward timing within primary visual cortex
    Alexander A Chubykin
    Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 77:723-35. 2013
  2. pmc Visual experience induces long-term potentiation in the primary visual cortex
    Sam F Cooke
    The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 30:16304-13. 2010
  3. pmc Bidirectional ocular dominance plasticity of inhibitory networks: recent advances and unresolved questions
    Gordon B Smith
    Department of Brain and Cognitive Sciences, Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology Cambridge, MA, USA
    Front Cell Neurosci 4:21. 2010
  4. pmc Essential role for a long-term depression mechanism in ocular dominance plasticity
    Bong June Yoon
    The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:9860-5. 2009
  5. pmc Learning reward timing in cortex through reward dependent expression of synaptic plasticity
    Jeffrey P Gavornik
    Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:6826-31. 2009
  6. pmc The ratio of NR2A/B NMDA receptor subunits determines the qualities of ocular dominance plasticity in visual cortex
    Kathleen K A Cho
    Picower Institute for Learning and Memory, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:5377-82. 2009
  7. pmc Bidirectional synaptic mechanisms of ocular dominance plasticity in visual cortex
    Gordon B Smith
    Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Philos Trans R Soc Lond B Biol Sci 364:357-67. 2009
  8. pmc Anatomical origins of ocular dominance in mouse primary visual cortex
    J E Coleman
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Howard Hughes Medical Institute, Massachusetts Institute of Technology 46 3301, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Neuroscience 161:561-71. 2009
  9. pmc Relative contribution of feedforward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex
    Lena A Khibnik
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
    Neuron 66:493-500. 2010
  10. pmc Rapid structural remodeling of thalamocortical synapses parallels experience-dependent functional plasticity in mouse primary visual cortex
    Jason E Coleman
    Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    J Neurosci 30:9670-82. 2010

Scientific Experts

  • MARK BEAR
  • Gordon B Smith
  • Arnold J Heynen
  • Kathleen K A Cho
  • Jeffrey P Gavornik
  • Benjamin D Philpot
  • Alexander A Chubykin
  • Marshall G Hussain Shuler
  • Jason E Coleman
  • Sam F Cooke
  • Lena A Khibnik
  • MONICA L LINDEN
  • J E Coleman
  • Bong June Yoon
  • Emma B Roach
  • Robert Haslinger
  • Marc Nahmani
  • Alev Erisir
  • Harel Z Shouval
  • Yonatan Loewenstein
  • Lena Khibnik
  • K Law
  • Rachael L Neve
  • Robert H Haslinger

Detail Information

Publications13

  1. pmc A cholinergic mechanism for reward timing within primary visual cortex
    Alexander A Chubykin
    Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 77:723-35. 2013
    ....
  2. pmc Visual experience induces long-term potentiation in the primary visual cortex
    Sam F Cooke
    The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 30:16304-13. 2010
    ..SRP therefore provides a simple assay to assess the integrity of LTP in the intact nervous system. Moreover, the results suggest that LTP of visual cortex, like SRP, can potentially be exploited to improve vision...
  3. pmc Bidirectional ocular dominance plasticity of inhibitory networks: recent advances and unresolved questions
    Gordon B Smith
    Department of Brain and Cognitive Sciences, Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology Cambridge, MA, USA
    Front Cell Neurosci 4:21. 2010
    ..A recent study by Yazaki-Sugiyama et al. (2009) in mouse visual cortex appears to re-open the debate. Here we take a critical look at these intriguing new data in the context of other recent findings in rodent visual cortex...
  4. pmc Essential role for a long-term depression mechanism in ocular dominance plasticity
    Bong June Yoon
    The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:9860-5. 2009
    ..These data suggest that AMPAR internalization is essential for the loss of synaptic strength caused by sensory deprivation in visual cortex...
  5. pmc Learning reward timing in cortex through reward dependent expression of synaptic plasticity
    Jeffrey P Gavornik
    Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:6826-31. 2009
    ..We implement our model numerically to explain reward-time learning in the primary visual cortex (V1), demonstrate experimental support, and suggest additional experimentally verifiable predictions...
  6. pmc The ratio of NR2A/B NMDA receptor subunits determines the qualities of ocular dominance plasticity in visual cortex
    Kathleen K A Cho
    Picower Institute for Learning and Memory, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:5377-82. 2009
    ..These data support the hypothesis that a reduction in the NR2A/B ratio during monocular deprivation is permissive for the compensatory potentiation of non-deprived inputs...
  7. pmc Bidirectional synaptic mechanisms of ocular dominance plasticity in visual cortex
    Gordon B Smith
    Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Philos Trans R Soc Lond B Biol Sci 364:357-67. 2009
    ..This review will discuss evidence supporting this three-stage model, along with outstanding issues in the field...
  8. pmc Anatomical origins of ocular dominance in mouse primary visual cortex
    J E Coleman
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Howard Hughes Medical Institute, Massachusetts Institute of Technology 46 3301, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Neuroscience 161:561-71. 2009
    ..Together, our findings establish that the relative density of feed-forward dLGN inputs determines the C/I response ratio of mouse binocular V1...
  9. pmc Relative contribution of feedforward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex
    Lena A Khibnik
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
    Neuron 66:493-500. 2010
    ..The results show that the rapid OD shift following MD is strongly expressed at the level of thalamocortical synaptic transmission...
  10. pmc Rapid structural remodeling of thalamocortical synapses parallels experience-dependent functional plasticity in mouse primary visual cortex
    Jason E Coleman
    Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    J Neurosci 30:9670-82. 2010
    ..Our results support the hypothesis that the rapid plasticity of TC synapses is a key step in the sequence of events that shift OD in visual cortex...
  11. pmc Thalamic activity that drives visual cortical plasticity
    MONICA L LINDEN
    Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Cambridge, Massachusetts, USA
    Nat Neurosci 12:390-2. 2009
    ..Our findings substantially alter the interpretation of previous studies and define the afferent activity patterns that trigger cortical plasticity...
  12. pmc Obligatory role of NR2A for metaplasticity in visual cortex
    Benjamin D Philpot
    Curriculum in Neurobiology, Neuroscience Center, and Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, 105 Mason Farm Road, Chapel Hill, NC 27599, USA
    Neuron 53:495-502. 2007
    ..These data support the hypothesis that experience-dependent changes in NR2A/B are functionally significant and yield a mechanism for an adjustable synaptic modification threshold in visual cortex...