Chronic respiratory effects of early life PM exposure

Summary

Principal Investigator: Kirk R Smith
Abstract: DESCRIPTION (provided by applicant): Accumulating evidence suggests that chronic exposure to particulate matter (PM) negatively affects growth of lung function in children and can lead to COPD in adults, but there is a dearth of information on the long-term effects of early life exposure to PM. In the proposed research we address the effects of exposure during infancy to biomass smoke PM on respiratory health later in childhood. Our mechanistic hypothesis is that the combustion-generated organic compounds present on fine particles in biomass smoke induce oxidative stress, upregulation of inflammatory cytokine production, and subsequent airway inflammation. Variation in the genotypes of key antioxidant enzymes (e.g., GSTM1 and GSTP1) may help to identify which children are more susceptible to the effects of inhaled PM on respiratory health. We propose to conduct a longitudinal follow-up study of a birth cohort of infants currently enrolled in a NIH-funded, randomized stove intervention trial to reduce acute lower respiratory illness (ALRI) in rural Guatemala. The improved cookstove markedly reduces biomass smoke exposure. After the participating child is 18 months old all families are offered the improved stove. Our proposed longitudinal follow-up study is designed to a) determine whether exposure to higher levels of PM during the first 18 months of life is associated with increased respiratory symptoms, bronchodilator responsiveness, sensitization to aeroallergens, and decreased rate of growth of lung function and somatic growth;and b) determine whether the GSTM1 null genotype renders children more susceptible and the GSTP1val105 variant less susceptible to the development of PM-induced oxidative stress and chronic respiratory effects. The effects of biomass smoke exposure have never been studied in a longitudinal design with quantitative exposure assessment. The current randomized intervention trial provides a unique opportunity to study the long-term effects of high exposure to biomass smoke/PM during the critical time window of lung development if follow-up is extended until later in childhood.
Funding Period: 2001-06-01 - 2010-08-31
more information: NIH RePORT

Top Publications

  1. pmc Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women
    Michael J Guarnieri
    Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 9:e88455. 2014
  2. pmc Longitudinal relationship between personal CO and personal PM2.5 among women cooking with woodfired cookstoves in Guatemala
    John P McCracken
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS ONE 8:e55670. 2013
  3. pmc Household light makes global heat: high black carbon emissions from kerosene wick lamps
    Nicholas L Lam
    Environmental Health Sciences, University of California, Berkeley, California 94720, USA
    Environ Sci Technol 46:13531-8. 2012
  4. ncbi Unintended benefits: leadership skills and behavioral change among Guatemalan fieldworkers employed in a longitudinal household air pollution study
    Devina Kuo
    University of California, Berkeley, CA, USA
    Int Q Community Health Educ 31:311-30. 2010
  5. ncbi Effect of reduction in household air pollution on childhood pneumonia in Guatemala (RESPIRE): a randomised controlled trial
    Kirk R Smith
    Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Lancet 378:1717-26. 2011
  6. ncbi Non-invasive measurement of carbon monoxide burden in Guatemalan children and adults following wood-fired temazcal (sauna-bath) use
    Nick Lam
    Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA
    J Environ Monit 13:2172-81. 2011
  7. pmc Intervention to lower household wood smoke exposure in Guatemala reduces ST-segment depression on electrocardiograms
    John McCracken
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 119:1562-8. 2011
  8. pmc Impact of reduced maternal exposures to wood smoke from an introduced chimney stove on newborn birth weight in rural Guatemala
    Lisa M Thompson
    Family Health Care Nursing, School of Nursing, University of California, San Francisco, California, USA
    Environ Health Perspect 119:1489-94. 2011
  9. ncbi Exposures to high levels of carbon monoxide from wood-fired temazcal (steam bath) use in highland Guatemala
    Lisa M Thompson
    Department of Family Health Care Nursing, School of Nursing, University of California, San Francisco, USA
    Int J Occup Environ Health 17:103-12. 2011
  10. pmc When smoke gets in your lungs
    John R Balmes
    UCSF, Box 0843, San Francisco, CA 94143 0843, USA
    Proc Am Thorac Soc 7:98-101. 2010

Scientific Experts

  • John P McCracken
  • Kirk R Smith
  • John R Balmes
  • Lisa Thompson
  • Eduardo Canuz
  • Michael J Guarnieri
  • Nicholas L Lam
  • Nick Lam
  • Carolina Romero
  • Ilse Ruiz-Mercado
  • Amanda Northcross
  • Devina Kuo
  • Gian Allen-Piccolo
  • Michael Clark
  • Tone Smith-Sivertsen
  • Nigel Bruce
  • Colin Solomon
  • Daniel Pope
  • Anaite Diaz
  • Janet V Diaz
  • Chandreyi Basu
  • Pankaj Sadavarte
  • Joseph Arineitwe
  • Michael A Johnson
  • Justin E Ellis
  • Cheryl Weyant
  • Yanju Chen
  • Benjamin T Brem
  • Tami C Bond
  • Chandra Venkataraman
  • Mark Nicas
  • Amy Lee
  • Zohir Chowdhury
  • Kyra N Shields
  • Rufus Edwards
  • Michael C Clark
  • T Tracy Allen
  • Jamesine V Rogers
  • Christopher D Simpson
  • Michael Paulsen

Detail Information

Publications17

  1. pmc Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women
    Michael J Guarnieri
    Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 9:e88455. 2014
    ..More than two-fifths of the world's population uses solid fuels, mostly biomass, for cooking. The resulting biomass smoke exposure is a major cause of chronic obstructive pulmonary disease (COPD) among women in developing countries...
  2. pmc Longitudinal relationship between personal CO and personal PM2.5 among women cooking with woodfired cookstoves in Guatemala
    John P McCracken
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS ONE 8:e55670. 2013
    ..5 exposure. This finding has important implications for the feasibility of reliably estimating long-term (months to years) PM2.5 exposure in large-scale epidemiological and intervention studies of HAP...
  3. pmc Household light makes global heat: high black carbon emissions from kerosene wick lamps
    Nicholas L Lam
    Environmental Health Sciences, University of California, Berkeley, California 94720, USA
    Environ Sci Technol 46:13531-8. 2012
    ..Replacement of kerosene-fueled wick lamps deserves strong consideration for programs that target short-lived climate forcers...
  4. ncbi Unintended benefits: leadership skills and behavioral change among Guatemalan fieldworkers employed in a longitudinal household air pollution study
    Devina Kuo
    University of California, Berkeley, CA, USA
    Int Q Community Health Educ 31:311-30. 2010
    ..Recommendations for future researchers include inclusion of additional training courses and adoption of community participatory approaches...
  5. ncbi Effect of reduction in household air pollution on childhood pneumonia in Guatemala (RESPIRE): a randomised controlled trial
    Kirk R Smith
    Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Lancet 378:1717-26. 2011
    ..We investigated whether an intervention to lower indoor wood smoke emissions would reduce pneumonia in children...
  6. ncbi Non-invasive measurement of carbon monoxide burden in Guatemalan children and adults following wood-fired temazcal (sauna-bath) use
    Nick Lam
    Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA
    J Environ Monit 13:2172-81. 2011
    ....
  7. pmc Intervention to lower household wood smoke exposure in Guatemala reduces ST-segment depression on electrocardiograms
    John McCracken
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 119:1562-8. 2011
    ..RESPIRE (Randomized Exposure Study of Pollution Indoors and Respiratory Effects) was a randomized trial of a chimney woodstove that reduces wood smoke exposure...
  8. pmc Impact of reduced maternal exposures to wood smoke from an introduced chimney stove on newborn birth weight in rural Guatemala
    Lisa M Thompson
    Family Health Care Nursing, School of Nursing, University of California, San Francisco, California, USA
    Environ Health Perspect 119:1489-94. 2011
    ..A growing body of evidence indicates a relationship between household indoor air pollution from cooking fires and adverse neonatal outcomes, such as low birth weight (LBW), in resource-poor countries...
  9. ncbi Exposures to high levels of carbon monoxide from wood-fired temazcal (steam bath) use in highland Guatemala
    Lisa M Thompson
    Department of Family Health Care Nursing, School of Nursing, University of California, San Francisco, USA
    Int J Occup Environ Health 17:103-12. 2011
    ....
  10. pmc When smoke gets in your lungs
    John R Balmes
    UCSF, Box 0843, San Francisco, CA 94143 0843, USA
    Proc Am Thorac Soc 7:98-101. 2010
    ..Ongoing research in Guatemala is attempting to address these data gaps...
  11. ncbi Estimating personal PM2.5 exposures using CO measurements in Guatemalan households cooking with wood fuel
    Amanda Northcross
    Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    J Environ Monit 12:873-8. 2010
    ..27 +/- 0.02, 0.20 +/- 0.02, and 0.16 +/- 0.02 mg m(-3) respectively. In chimney-stove homes, mothers and children experienced PM2.5 personal concentrations of 0.22 +/- 0.03 and 0.14 +/- 0.03 mg m(-3), respectively...
  12. ncbi Personal child and mother carbon monoxide exposures and kitchen levels: methods and results from a randomized trial of woodfired chimney cookstoves in Guatemala (RESPIRE)
    Kirk R Smith
    Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720 7360, USA
    J Expo Sci Environ Epidemiol 20:406-16. 2010
    ....
  13. ncbi An ultrasound personal locator for time-activity assessment
    Gian Allen-Piccolo
    Received from EME Systems, Berkeley, CA, USA
    Int J Occup Environ Health 15:122-32. 2009
    ....
  14. ncbi Combining individual- and group-level exposure information: child carbon monoxide in the Guatemala woodstove randomized control trial
    John P McCracken
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 20:127-36. 2009
    ..Rather than choose between these error-prone estimates, we borrow strength from each by use of mixed-model prediction and we compare the predictive validity...
  15. pmc Chimney stove intervention to reduce long-term wood smoke exposure lowers blood pressure among Guatemalan women
    John P McCracken
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 115:996-1001. 2007
    ..Given the evidence that ambient particles increase blood pressure, we hypothesized that the intervention would lower blood pressure...
  16. pmc Nxwisen, ntzarrin or ntzo'lin? Mapping children's respiratory symptoms among indigenous populations in Guatemala
    Lisa Thompson
    University of California, Berkeley, CA, USA
    Soc Sci Med 65:1337-50. 2007
    ..It is important to use linguistically and culturally appropriate terminology to describe wheeze in prevalence studies of asthmatic symptoms among relatively isolated communities in lesser-developed countries...
  17. ncbi Urinary methoxyphenol biomarkers and woodsmoke exposure: comparisons in rural Guatemala with personal CO and kitchen CO, levoglucosan, and PM2.5
    Michael Clark
    Environmental Health Sciences, School of Public Health, University of California at Berkeley, 140 Warren Hall, Berkeley, California 94720, USA
    Environ Sci Technol 41:3481-7. 2007
    ..Although based on relatively few measurements, this study demonstrates that the urinary concentrations of specific methoxyphenols may be effective biomarkers of short-term exposures to inhaled woodsmoke in field conditions...