Pulse wave velocity in chronic kidney disease

Summary

Principal Investigator: Raymond Townsend
Affiliation: University of Pennsylvania
Country: USA
Abstract: The National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) established the Chronic Renal Insufficiency Cohort Study in 2001. The principal goals of the CRIC Study are to examine risk factors for chronic kidney disease (CKD) progression (i.e. further loss of kidney function) and cardiovascular events among patients with varying severity of CKD, and develop predictive models that will identify high-risk subgroups with CKD. The latter results will target enrollment of high-risk subjects into future treatment trials and increase application of available preventive therapies. Hypertension treatment has been the most effective intervention altering the course of renal function loss in CKD. However, the drugs used in the treatment of hypertension differ in their benefits on renal function. This raises the possibility that blood pressure reduction by itself only partly explains their beneficial effect and beckons a broader understanding of vascular adaptation to diseases such as CKD. Determination of the pulse wave velocity (PWV) a reflection of large vessel stiffness has provided useful information in cardiovascular disease epidemiology.
Funding Period: 2005-05-01 - 2010-04-30
more information: NIH RePORT

Top Publications

  1. ncbi What's in a pulse? Part 2
    Radhika Katakam
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 8:288-90. 2006
  2. ncbi Analyzing the radial pulse waveform: narrowing the gap between blood pressure and outcomes
    Raymond R Townsend
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Nephrol Hypertens 16:261-6. 2007
  3. ncbi Chemotherapy agents and hypertension: a focus on angiogenesis blockade
    Manish Jain
    Department of Medicine, University of Pennsylvania, 3400 Spruce Street, 1 Gibson, Philadelphia, PA 19104, USA
    Curr Hypertens Rep 9:320-8. 2007
  4. ncbi Correlation between pulse wave velocity and other measures of arterial stiffness in chronic kidney disease
    N J Wimmer
    Department of Medicine, Renal Electrolyte and Hypertension Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Clin Nephrol 68:133-43. 2007
  5. ncbi Vascular compliance and arterial calcification: impact on blood pressure reduction
    Raymond R Townsend
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Nephrol Hypertens 17:93-8. 2008
  6. ncbi Vascular stiffness: its measurement and significance for epidemiologic and outcome studies
    Stephanie S DeLoach
    Renal Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Clin J Am Soc Nephrol 3:184-92. 2008
  7. ncbi Aortic calcification predicts cardiovascular events and all-cause mortality in renal transplantation
    Stephanie S DeLoach
    Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Nephrol Dial Transplant 24:1314-9. 2009
  8. ncbi Aortic pulse pressure is associated with carotid IMT in chronic kidney disease: report from Chronic Renal Insufficiency Cohort
    Stephanie S DeLoach
    Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Hypertens 22:1235-41. 2009

Scientific Experts

  • Raymond Townsend
  • Stephanie S DeLoach
  • Sylvia E Rosas
  • Marshall M Joffe
  • N J Wimmer
  • Manish Jain
  • Radhika Katakam
  • Jing Chen
  • Afshin Parsa
  • Valerie Teal
  • Emile R Mohler
  • Crystal A Gadegbeku
  • Lawrence J Appel
  • Simin Goral
  • Kalyani Perumal
  • Xingchen Mai
  • Susan P Steigerwalt
  • Mohammed A Rafey
  • M M Joffe
  • A S Go
  • J P Lash

Detail Information

Publications8

  1. ncbi What's in a pulse? Part 2
    Radhika Katakam
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 8:288-90. 2006
  2. ncbi Analyzing the radial pulse waveform: narrowing the gap between blood pressure and outcomes
    Raymond R Townsend
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Nephrol Hypertens 16:261-6. 2007
    ..This review will briefly recount the history behind this technology and discuss where it fits into the measurement of vascular properties that may predict outcomes such as death, heart attack, stroke or kidney disease progression...
  3. ncbi Chemotherapy agents and hypertension: a focus on angiogenesis blockade
    Manish Jain
    Department of Medicine, University of Pennsylvania, 3400 Spruce Street, 1 Gibson, Philadelphia, PA 19104, USA
    Curr Hypertens Rep 9:320-8. 2007
    ....
  4. ncbi Correlation between pulse wave velocity and other measures of arterial stiffness in chronic kidney disease
    N J Wimmer
    Department of Medicine, Renal Electrolyte and Hypertension Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Clin Nephrol 68:133-43. 2007
    ..Given the large burden of cardiovascular disease in individuals with chronic kidney disease (CKD), assessing the relationship between vascular stiffness parameters in this population is important...
  5. ncbi Vascular compliance and arterial calcification: impact on blood pressure reduction
    Raymond R Townsend
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Nephrol Hypertens 17:93-8. 2008
    ..The aim of this article is to review the relationship between vascular calcification and difficult to control hypertension. This does not address antihypertensive treatment of drug resistant hypertension per se...
  6. ncbi Vascular stiffness: its measurement and significance for epidemiologic and outcome studies
    Stephanie S DeLoach
    Renal Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Clin J Am Soc Nephrol 3:184-92. 2008
    ....
  7. ncbi Aortic calcification predicts cardiovascular events and all-cause mortality in renal transplantation
    Stephanie S DeLoach
    Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Nephrol Dial Transplant 24:1314-9. 2009
    ..Our objective was to prospectively examine the association of aortic calcification with cardiovascular events and all-cause mortality among asymptomatic incident renal transplant recipients...
  8. ncbi Aortic pulse pressure is associated with carotid IMT in chronic kidney disease: report from Chronic Renal Insufficiency Cohort
    Stephanie S DeLoach
    Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Hypertens 22:1235-41. 2009
    ....