Physiology and genetics of food procurement in rodents

Summary

Principal Investigator: NEIL EDWARD ROWLAND
Abstract: [unreadable] DESCRIPTION (provided by applicant): Overeating and obesity are significant health problems for Americans of all ages. The proposed studies will examine, in mice of normal and obese genetic backgrounds, the effects of imposing economic costs (lever presses) on food intake and patterns of eating. Additionally, we will examine whether prospective appetite suppressant drugs become more effective under conditions of selectively imposed economic costs. Both human and animal models point to multiple causes of obesity, including genetic predispositions to gain weight, ready availability of highly caloric foods, and reduced everyday exercise. Animal models have been instrumental in understanding genetic abnormalities that produce obesity but these models have been tested almost exclusively in environments in which there is no cost associated with obtaining food. In contrast, the evolution of abilities to procure and utilize food in hard times has been critical. It is important to develop and test animal protocols in which the effect of effort on food procurement and consumption are measured, and also to assess the effect of potential treatments in these protocols. Specifically, the protocols that we will use are "closed economy" in which mice must obtain all of their food in that environment. The first aim is to examine in outbred ICR:CD1 mice whether several types of economic cost, simulated by lever pressing as a fixed price (ratio), as a premeal foraging or procurement cost, or as an incrementing cost during the meal (progressive ratio) affect meal patterns. The latter two types of cost are predicted to have opposite effects on meal parameters, so we will also test their combination and develop a brief or streamlined protocol for future testing. The second aim, using the streamlined closed economy protocol, is to test whether mice either heterozygous or homozygous for genetic deletion of melanocortin 4 receptor deletion exhibit altered meal patterns or elasticity of food demand compared with wild type controls. The third aim, again using the streamlined protocol and outbred CD1 mice, is to examine whether chronic treatment with putative anorectic agents affect economic food choices. The agents to be studied are serotonergic agonist dexfenfluramine and the cannabinoid receptor antagonist rimonabant. The proposed studies will be the first to address the issue of behavioral change induced by anorectics under such conditions of simulated economic costs. [unreadable] [unreadable] [unreadable]
Funding Period: 2006-08-15 - 2010-05-31
more information: NIH RePORT

Top Publications

  1. pmc Feeding behavior, obesity, and neuroeconomics
    Neil E Rowland
    Department of Psychology, University of Florida, Gainesville, FL 32611 2250, United States
    Physiol Behav 93:97-109. 2008
  2. pmc Order and disorder: temporal organization of eating
    Neil E Rowland
    Department of Psychology, University of Florida, PO Box 112250, Gainesville, FL 32611 2250, USA
    Behav Brain Res 231:272-8. 2012
  3. pmc Effects of meal frequency and snacking on food demand in mice
    Deniz Atalayer
    Department of Psychology, University of Florida, P O Box 112250, Gainesville, FL 32611 2250, USA
    Appetite 58:117-23. 2012
  4. pmc Structure of motivation using food demand in mice
    Deniz Atalayer
    University of Florida, Gainesville, United States
    Physiol Behav 104:15-9. 2011
  5. pmc Comparison of voluntary and foraging running wheel activity on food demand in mice
    Deniz Atalayer
    Department of Psychology, University of Florida, Gainesville, FL 32611 2250, USA
    Physiol Behav 102:22-9. 2011
  6. pmc Effect of MTII on food intake and brain c-Fos in melanocortin-3, melanocortin-4, and double MC3 and MC4 receptor knockout mice
    Neil E Rowland
    Department of Psychology, University of Florida, Gainesville, FL 32611 2250, United States
    Peptides 31:2314-7. 2010
  7. ncbi Effect of high-fat diet on stress responsiveness in borderline hypertensive rats
    A Mitra
    Department of Psychology, University of Florida, Gainesville, FL, 32611 2250, USA
    Stress 14:42-52. 2011
  8. pmc Food demand and meal size in mice with single or combined disruption of melanocortin type 3 and 4 receptors
    Deniz Atalayer
    Department of Psychology, University of Florida, Gainesville, Florida 32611 2250, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1667-74. 2010
  9. pmc Effect of serotonergic anorectics on food intake and induction of Fos in brain of mice with disruption of melanocortin 3 and/or 4 receptors
    Neil E Rowland
    Department of Psychology, University of Florida, Gainesville, FL, USA
    Pharmacol Biochem Behav 97:107-11. 2010
  10. pmc Comparison of C57BL/6 and DBA/2 mice in food motivation and satiety
    Deniz Atalayer
    Department of Psychology, University of Florida, Gainesville, FL 32611 2250, USA
    Physiol Behav 99:679-83. 2010

Detail Information

Publications16

  1. pmc Feeding behavior, obesity, and neuroeconomics
    Neil E Rowland
    Department of Psychology, University of Florida, Gainesville, FL 32611 2250, United States
    Physiol Behav 93:97-109. 2008
    ..The fact is that humans are eating more and gaining weight in favorable food environments in exactly the way predicted from some of these models, and this has implications for the appropriate way to treat obesity...
  2. pmc Order and disorder: temporal organization of eating
    Neil E Rowland
    Department of Psychology, University of Florida, PO Box 112250, Gainesville, FL 32611 2250, USA
    Behav Brain Res 231:272-8. 2012
    ..It is further argued that the modern human food environment is so immoderate that physiological manipulations designed to restrain eating have little hope of achieving this goal...
  3. pmc Effects of meal frequency and snacking on food demand in mice
    Deniz Atalayer
    Department of Psychology, University of Florida, P O Box 112250, Gainesville, FL 32611 2250, USA
    Appetite 58:117-23. 2012
    ..At FUP25, mice also decreased demand, but by less than the energy obtained from sugar. These data show that choice for pellets over a free palatable snack, and subsequent compensation of energy intake, is modified by effort and demand...
  4. pmc Structure of motivation using food demand in mice
    Deniz Atalayer
    University of Florida, Gainesville, United States
    Physiol Behav 104:15-9. 2011
    ..These data are discussed in terms of potential economic strategies that could address the human obesity epidemic, for example by maximally targeting meal size and/or snacking behavior...
  5. pmc Comparison of voluntary and foraging running wheel activity on food demand in mice
    Deniz Atalayer
    Department of Psychology, University of Florida, Gainesville, FL 32611 2250, USA
    Physiol Behav 102:22-9. 2011
    ..When running was voluntary (experiment 1), the day-night cycle for activity was more pronounced compared to when running was a foraging or approach activity (experiment 2)...
  6. pmc Effect of MTII on food intake and brain c-Fos in melanocortin-3, melanocortin-4, and double MC3 and MC4 receptor knockout mice
    Neil E Rowland
    Department of Psychology, University of Florida, Gainesville, FL 32611 2250, United States
    Peptides 31:2314-7. 2010
    ..These data suggest that both receptor subtypes are involved in the behavioral action of MTII, and that the critical receptors are in different brain regions...
  7. ncbi Effect of high-fat diet on stress responsiveness in borderline hypertensive rats
    A Mitra
    Department of Psychology, University of Florida, Gainesville, FL, 32611 2250, USA
    Stress 14:42-52. 2011
    ..Serum corticosterone level was also higher in rats fed with the junk-food diet post-weaning compared with those fed with chow only, but there were no significant effects of gestational or lactational dietary history...
  8. pmc Food demand and meal size in mice with single or combined disruption of melanocortin type 3 and 4 receptors
    Deniz Atalayer
    Department of Psychology, University of Florida, Gainesville, Florida 32611 2250, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1667-74. 2010
    ..These data are discussed in terms of demand functions for food intake, MC receptors involved in feeding, and their relation to actions of gut hormones, such as CCK, and to obesity...
  9. pmc Effect of serotonergic anorectics on food intake and induction of Fos in brain of mice with disruption of melanocortin 3 and/or 4 receptors
    Neil E Rowland
    Department of Psychology, University of Florida, Gainesville, FL, USA
    Pharmacol Biochem Behav 97:107-11. 2010
    ..These data suggest that MC3Rs may be involved in the response to serotonergic anorectic agents, and more generally in control of food intake...
  10. pmc Comparison of C57BL/6 and DBA/2 mice in food motivation and satiety
    Deniz Atalayer
    Department of Psychology, University of Florida, Gainesville, FL 32611 2250, USA
    Physiol Behav 99:679-83. 2010
    ....
  11. ncbi Selection of a palatable dietary option is not preferentially reduced by cannabinoid CB1 receptor antagonist AM251 in female C57Bl/6J mice
    Clare M Mathes
    Department of Psychology, University of Florida, PO Box 112250, Gainesville, FL 32611 2250, USA
    Pharmacol Biochem Behav 94:119-23. 2009
    ..This difference from results in rats suggests that the effect of AM251 on palatable food intake may only be evident in models that induce overconsumption and/or that rats and mice may react differently to CB1 receptor antagonists...
  12. pmc Meal patterns of mice under systematically varying approach and unit costs for food in a closed economy
    Deniz Atalayer
    Department of Psychology, University of Florida, Gainesville, FL 32611 2250, USA
    Physiol Behav 98:85-93. 2009
    ..Thus, meal patterns in mice are sensitive to approach cost while total amount consumed is more sensitive to unit price. These data are discussed in terms of the concept of foraging cost as either a unitary or a multidimensional variable...
  13. pmc Effect of high-fat diet during gestation, lactation, or postweaning on physiological and behavioral indexes in borderline hypertensive rats
    Anaya Mitra
    Psychology, Univ of Florida, Gainesville, FL 32611 2250, USA
    Am J Physiol Regul Integr Comp Physiol 296:R20-8. 2009
    ..The postweaning effects of junk food diet were evident on the majority of the parameters measured, including body weight, fat pad mass, serum leptin and insulin levels, and operant performance...
  14. pmc Food demand functions in mice
    Melissa A Chaney
    Department of Psychology, University of Florida, Gainesville, FL 32611 2250, USA
    Appetite 51:669-75. 2008
    ..These data show in mice that large changes in unit price or consummatory cost have relatively small effects on demand and meal patterns, but small amounts of foraging (procurement) cost have very large effects...
  15. pmc Cannabinoid-1 receptor antagonists reduce caloric intake by decreasing palatable diet selection in a novel dessert protocol in female rats
    Clare M Mathes
    Department of Psychology, University of Florida, Gainesville, Florida 32611 2250, USA
    Am J Physiol Regul Integr Comp Physiol 295:R67-75. 2008
    ..This supports the hypothesis that these CB1 receptor antagonists impact feeding by modulating the perception of palatability...
  16. ncbi Action of a serotonergic anorectic in meal-fed mice working for food
    Neil E Rowland
    Department of Psychology, University of Florida, Gainesville, Florida 32611 2250, USA
    Behav Pharmacol 23:560-6. 2012
    ..Within a meal, the effect of the drug was the greatest in the first half of the available time. Therefore, the anorectic effect of DNOR was modified by the concurrent cost of food...