Instruments for measuring physical activity

Summary

Principal Investigator: J A Levine
Affiliation: Mayo Clinic
Country: USA
Abstract: The energy expended in physical activity is an important component of energy balance and body weight. Because of the variety of physical activities that free-living humans undertake, it has been extremely challenging to obtain accurate measurements of either the amount or energy cost of human physical activity. The energy expended in physical activity consists of energy expended in purposeful exercise and the energy expended in non-exercise activity thermo genesis (NEAT). The latter is even more difficult to measure than the former. Since most Americans engage in relatively little purposeful physical activity, the majority of energy expended in physical activity will be through NEAT. The research proposed in this application focuses on improving measurement systems for amount and energy cost of physical activity, with specific techniques proposed for measuring non-exercise physical activity and NEAT. We propose to develop a new high-precision Physical Activity Measurement System (PAMS). PAMS will be developed using off-the-shelf components and macros written in an universally available software program. PAMS will allow physical activity to be accurately measured at low cost and will be easily available to investigators worldwide. In Specific Aim #1, we propose to develop PAMS and validate it using subjects who will be confined in a whole-room indirect calorimeter. In Specific Aim #2, we propose to validate PAMS in free-living subjects. We will then, in Specific Aim #3, utilize PAMS to develop normative data for lean and obese subjects. In this specific aim we will define the components of NEAT in the lean and obese. This will not only be essential information for users of PAMS but will enhance our understanding of how physical activity and its components impacts obesity. PAMS has the potential to empower researchers from a variety of disciplines to measure physical activity precisely and cost-effectively. This should allow us to better define the role of physical activity in health and disease.
Funding Period: 2004-03-01 - 2009-02-28
more information: NIH RePORT

Top Publications

  1. ncbi Interindividual variation in posture allocation: possible role in human obesity
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Science 307:584-6. 2005
  2. ncbi Nonexercise activity thermogenesis--liberating the life-force
    J A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 5590, USA
    J Intern Med 262:273-87. 2007
  3. ncbi Sensitivity of the hypothalamic paraventricular nucleus to the locomotor-activating effects of neuromedin U in obesity
    Colleen M Novak
    Mayo Clinic, Endocrine Research Unit, St Marys Hospital, Joseph 5 194, 200 1st St SW, Rochester, MN 55905, USA
    Brain Res 1169:57-68. 2007
  4. ncbi Feasibility of a walking workstation to increase daily walking
    W G Thompson
    Occupational and Aerospace Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Br J Sports Med 42:225-8; discussion 228. 2008
  5. ncbi Gait and balance of transfemoral amputees using passive mechanical and microprocessor-controlled prosthetic knees
    K R Kaufman
    Motion Analysis Laboratory, Mayo Clinic, Rochester, MN 55905, USA
    Gait Posture 26:489-93. 2007
  6. ncbi Measurement of daily activity in restrictive type anorexia nervosa
    Ann M Harris
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Int J Eat Disord 41:280-3. 2008
  7. ncbi Changing the school environment to increase physical activity in children
    Lorraine Lanningham-Foster
    Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Obesity (Silver Spring) 16:1849-53. 2008
  8. ncbi Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype
    Cheryl A Conover
    Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic, 200 First Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    J Endocrinol 198:599-605. 2008
  9. ncbi Energy expenditure and activity of transfemoral amputees using mechanical and microprocessor-controlled prosthetic knees
    Kenton R Kaufman
    Motion Analysis Laboratory, Mayo Clinic, Rochester, MN 55905, USA
    Arch Phys Med Rehabil 89:1380-5. 2008
  10. ncbi Pedometer accuracy for children: can we recommend them for our obese population?
    Naim Mitre
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Pediatrics 123:e127-31. 2009

Scientific Experts

  • J A Levine
  • Colleen M Novak
  • Kenton Kaufman
  • CATHERINE KOTZ
  • W G Thompson
  • Cheryl Conover
  • Lorraine Lanningham-Foster
  • Randal C Foster
  • Shelly K McCrady
  • Ann M Harris
  • Naim Mitre
  • Chinmay U Manohar
  • Teresa B Jensen
  • Chinmay Manohar
  • David A McAlpine
  • Ioannis T Pavlidis
  • Shelly McCrady
  • Randal Foster
  • James O Hill
  • Donald E McAlpine
  • Rashmi Shirbhate
  • Naim G Mitre
  • Donald Hensrud
  • Brian A Walker
  • Aoife B Redmond
  • Dieter Heinz
  • Michael D Jensen
  • Denny J Padgett
  • Lorraine M Lanningham-Foster
  • Lana J Nysse

Detail Information

Publications28

  1. ncbi Interindividual variation in posture allocation: possible role in human obesity
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Science 307:584-6. 2005
    ..If obese individuals adopted the NEAT-enhanced behaviors of their lean counterparts, they might expend an additional 350 calories (kcal) per day...
  2. ncbi Nonexercise activity thermogenesis--liberating the life-force
    J A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 5590, USA
    J Intern Med 262:273-87. 2007
    ..Data support the central hypothesis that NEAT is pivotal in the regulation of human energy expenditure and body weight regulation and that NEAT is important for understanding the cause and effective treatment for obesity...
  3. ncbi Sensitivity of the hypothalamic paraventricular nucleus to the locomotor-activating effects of neuromedin U in obesity
    Colleen M Novak
    Mayo Clinic, Endocrine Research Unit, St Marys Hospital, Joseph 5 194, 200 1st St SW, Rochester, MN 55905, USA
    Brain Res 1169:57-68. 2007
    ..Taken together with previous studies, these results suggest that obesity may represent a state associated with decreased central sensitivity to neuropeptides such as NMU that increase physical activity and therefore energy expenditure...
  4. ncbi Feasibility of a walking workstation to increase daily walking
    W G Thompson
    Occupational and Aerospace Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Br J Sports Med 42:225-8; discussion 228. 2008
    ..A walking workstation that allows workers to walk while they work has the potential to increase caloric expenditure. We evaluated whether employees can and will use walking workstations while performing their jobs...
  5. ncbi Gait and balance of transfemoral amputees using passive mechanical and microprocessor-controlled prosthetic knees
    K R Kaufman
    Motion Analysis Laboratory, Mayo Clinic, Rochester, MN 55905, USA
    Gait Posture 26:489-93. 2007
    ..These joints are more sophisticated and more expensive than mechanical ones. The literature is contradictory regarding changes in gait and balance when using these sophisticated devices...
  6. ncbi Measurement of daily activity in restrictive type anorexia nervosa
    Ann M Harris
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Int J Eat Disord 41:280-3. 2008
    ..We wanted to test a daily activity detecting device named, the physical activity monitoring system (PAMS)...
  7. ncbi Changing the school environment to increase physical activity in children
    Lorraine Lanningham-Foster
    Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Obesity (Silver Spring) 16:1849-53. 2008
    ..Children will move more in an activity-permissive environment. Strategies to increase the activity of school children may involve re-designing the school itself...
  8. ncbi Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype
    Cheryl A Conover
    Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic, 200 First Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    J Endocrinol 198:599-605. 2008
    ..These findings are discussed in the context of those from other long-lived mouse models...
  9. ncbi Energy expenditure and activity of transfemoral amputees using mechanical and microprocessor-controlled prosthetic knees
    Kenton R Kaufman
    Motion Analysis Laboratory, Mayo Clinic, Rochester, MN 55905, USA
    Arch Phys Med Rehabil 89:1380-5. 2008
    ..To quantify the energy efficiency of locomotion and free-living physical activity energy expenditure of transfemoral amputees using a mechanical and microprocessor-controlled prosthetic knee...
  10. ncbi Pedometer accuracy for children: can we recommend them for our obese population?
    Naim Mitre
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Pediatrics 123:e127-31. 2009
    ..Our secondary hypothesis was that the accelerometer-based step-counter provides an accurate measure of walking steps in normal and overweight children...
  11. ncbi Activity-promoting video games and increased energy expenditure
    Lorraine Lanningham-Foster
    Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA
    J Pediatr 154:819-23. 2009
    ..To test the hypothesis that both children and adults would expend more calories and move more while playing activity-promoting video games compared with sedentary video games...
  12. ncbi Daily intraparaventricular orexin-A treatment induces weight loss in rats
    Colleen M Novak
    Endocrine Research Unit, Mayo Clinic, St Marys Hospital, Rochester, Minnesota, USA
    Obesity (Silver Spring) 17:1493-8. 2009
    ..These results support the concept that orexinergic agents have the potential to produce negative energy balance through increasing physical activity. This presents a promising, untapped potential resource for weight loss...
  13. ncbi Endurance capacity, not body size, determines physical activity levels: role of skeletal muscle PEPCK
    Colleen M Novak
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 4:e5869. 2009
    ..Therefore, the lean phenotype is characterized by high endurance capacity and high activity and may stem from altered skeletal muscle energetics...
  14. ncbi Exercise: a walk in the park?
    James A Levine
    Mayo Clin Proc 82:797-8. 2007
  15. ncbi An office-place stepping device to promote workplace physical activity
    David A McAlpine
    Mayo Clinic, 200 First St SW, Rochester 55905, USA
    Br J Sports Med 41:903-7. 2007
    ..The objective was to assess the effect of using an office-place stepping device on the energy expenditure of lean and obese office workers...
  16. ncbi Caloric restriction and physical activity in zebrafish (Danio rerio)
    Colleen M Novak
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, St Mary s Hospital, Rochester, MN 55905, USA
    Neurosci Lett 383:99-104. 2005
    ..Thus, the association between negative energy balance and reductions in PA occurs across genera in biology and is associated with predictable neurological changes in brain gene expression...
  17. ncbi NEAT--non-exercise activity thermogenesis--egocentric & geocentric environmental factors vs. biological regulation
    J A Levine
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN, USA
    Acta Physiol Scand 184:309-18. 2005
    ..Deciphering the role of NEAT may lead to a better understanding of the pathogenesis, prevention and treatment of obesity...
  18. ncbi Precision and accuracy of an ankle-worn accelerometer-based pedometer in step counting and energy expenditure
    Randal C Foster
    Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Prev Med 41:778-83. 2005
    ..8). CONCLUSION: The counts from the Stepwatch were virtually identical to the manual counts from a trained investigator and provided a reliable predictor of walking energy expenditure...
  19. ncbi Central orexin sensitivity, physical activity, and obesity in diet-induced obese and diet-resistant rats
    Colleen M Novak
    Endocrine Research Unit, Mayo Clinic, 200 1st St. SW, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 290:E396-403. 2006
    ..A putative mechanism for changes in NEAT that accompany obesity is a decreased sensitivity to the NEAT-activating effects of neuropeptides such as orexin...
  20. ncbi Measurement of energy expenditure
    James A Levine
    Mayo Clinic, Endocrine Research Unit, Rochester, MN 55902, USA
    Public Health Nutr 8:1123-32. 2005
    ..The factorial method for combining activity logs and data on the energy costs of activities can also provide detailed information on free-living subjects...
  21. ncbi Non-exercise activity thermogenesis: the crouching tiger hidden dragon of societal weight gain
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 26:729-36. 2006
    ..To reverse obesity, we need to develop individual strategies to promote standing and ambulating time by 2.5 hours per day and also re-engineer our work, school, and home environments to render active living the option of choice...
  22. ncbi Weekly changes in basal metabolic rate with eight weeks of overfeeding
    Ann M Harris
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Obesity (Silver Spring) 14:690-5. 2006
    ..There seems to be a short-term increase in BMR in the first 2 weeks of overfeeding that is not representative of longer-term changes...
  23. ncbi Orexin A mediation of time spent moving in rats: neural mechanisms
    C M Kotz
    Veterans Affairs Medical Center, Geriatric Research, Education and Clinical Care 11G, One Veterans Drive, Minneapolis, MN 55417, USA
    Neuroscience 142:29-36. 2006
    ..This potential for conferring physical activity stimulation may be useful for inducing shifts in time spent moving, which has important implications for obesity...
  24. ncbi Neuromedin U in the paraventricular and arcuate hypothalamic nuclei increases non-exercise activity thermogenesis
    C M Novak
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Neuroendocrinol 18:594-601. 2006
    ..In co-ordination with its suppressive effects on feeding, the NEAT-activating effects of NMU make it a potential candidate in the combat of obesity...
  25. ncbi Energy expenditure of sedentary screen time compared with active screen time for children
    Lorraine Lanningham-Foster
    Endocrine Research Unit, Mayo Clinic, 200 First St, SW, Rochester, MN 55905, USA
    Pediatrics 118:e1831-5. 2006
    ..CONCLUSIONS: Energy expenditure more than doubles when sedentary screen time is converted to active screen time. Such interventions might be considered for obesity prevention and treatment...
  26. ncbi The energy expenditure of using a "walk-and-work" desk for office workers with obesity
    James A Levine
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Br J Sports Med 41:558-61. 2007
    ..Our hypothesis was that a vertical workstation that allows an obese individual to work while walking would be associated with significant and substantial increases in energy expenditure over seated work...
  27. ncbi An accelerometer-based earpiece to monitor and quantify physical activity
    Chinmay Manohar
    Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA
    J Phys Act Health 6:781-9. 2009
    ..Here we examined whether the PASE could accurately and precisely detect physical activity and measure its intensity and thence predict energy expenditure...