FETAL SWALLOWING--ONTOGENY AND REGULATION

Summary

Principal Investigator: MICHAEL GLENN ROSS
Affiliation: University of California
Country: USA
Abstract: Thirst and swallowing represent a fundamental biologic system for the regulation of body water homeostasis. In-utero swallowing, modulated by fetal "thirst" and electrocortical state, results in the resorption of amniotic fluid water, electrolytes and endocrine factors. During the perinatal period, imprinting of hormonal and physiologic factors regulating thirst may permanently alter adult fluid balance. Therefore, the study of fetal "thirst" and swallowing can contribute to an understanding of the development of mechanisms for fluid regulation. In addition, analysis of patterns of esophageal fluid flow and fetal behavioral states may provide insight into the association of neonatal thirst, regurgitation and altered breathing patterns. Spontaneous and thirst-mediated swallowing behavior develop and mature in-utero in sheep and humans. Thus, a fetal model is necessary to investigate the ontogenesis of thirst regulation. We have developed a chronic ovine fetal model for the quantification of swallowing activity and volume and the simultaneous determination of fetal behavioral state. We have demonstrated that, similar to the adult, fetal swallowing both occurs spontaneously and can be stimulated by dipsogenic factors. However, fetal responses to known dipsogenic stimuli may differ from the adult. Furthermore, spontaneous fetal swallowing activity may be suppressed in accordance with behavioral state alterations. This project will characterize the ontogeny of spontaneous fetal swallowing, the presence of diurnal rhythms and the association with fetal behavioral state maturation. The ontogeny of fetal swallowing stimulation by primary systemic stimuli (hyperosmolality and angiotensin II; AII) and the modulation by arginine vasopressin (AVP) and atrial natriuretic factor (ANF) will be studied. The receptor mediation of AII and AVP stimulated swallowing will be probed with selective receptor antagonists. In addition, the central stimulation and suppression of swallowing by primary endocrine factors (AII, AVP, ANF) will be explored. The ovine model offers the opportunity to study, in a precocial species, the ontogeny of "thirst" physiology, an important but relatively unexplored area of perinatal physiology.
Funding Period: 1991-08-01 - 1995-09-29
more information: NIH RePORT

Top Publications

  1. ncbi Central angiotensin II AT1 receptors mediate fetal swallowing and pressor responses in the near-term ovine fetus
    Mostafa A El-Haddad
    David Geffen UCLA Medical School, Research and Educational Institute, Harbor UCLA Medical Center, 1124 W Carson St, RB 1, Torrance, CA 90502, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1014-20. 2005
  2. ncbi Gestational programming: population survival effects of drought and famine during pregnancy
    Michael G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, 1000 W Carson St, Box 3, Torrance, CA 90509, USA
    Am J Physiol Regul Integr Comp Physiol 288:R25-33. 2005
  3. ncbi N-methyl-D-aspartate glutamate receptor mediates spontaneous and angiotensin II-stimulated ovine fetal swallowing
    Mostafa A El-Haddad
    Perinatal Research Laboratories, Harbor UCLA Medical Center, School of Medicine, Los Angeles, California, USA
    J Soc Gynecol Investig 12:504-9. 2005
  4. ncbi Persistent sucrose stimulation of ovine fetal ingestion: lack of adaptation responses
    Mostafa A El-Haddad
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, Geffen School of Medicine at UCLA, Harbor UCLA Medical Center, Torrance, California, USA
    J Matern Fetal Neonatal Med 18:123-7. 2005
  5. ncbi Gender-specific orexigenic and anorexigenic mechanisms in rats
    Dave A Gayle
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA and Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance CA 90502, United States
    Life Sci 79:1531-6. 2006
  6. ncbi Gestational programming of offspring obesity: a potential contributor to Alzheimer's disease
    Michael G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Curr Alzheimer Res 4:213-7. 2007
  7. pmc Enhanced nephrogenesis in offspring of water-restricted rat dams
    Roy Mansano
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Am J Obstet Gynecol 196:480.e1-6. 2007
  8. pmc Adult sequelae of intrauterine growth restriction
    Michael G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Semin Perinatol 32:213-8. 2008
  9. doi Early undernutrition attenuates the inflammatory response in adult rat offspring
    Mina Desai
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles Medical Center, Torrance, 90502, USA
    J Matern Fetal Neonatal Med 22:571-5. 2009

Detail Information

Publications9

  1. ncbi Central angiotensin II AT1 receptors mediate fetal swallowing and pressor responses in the near-term ovine fetus
    Mostafa A El-Haddad
    David Geffen UCLA Medical School, Research and Educational Institute, Harbor UCLA Medical Center, 1124 W Carson St, RB 1, Torrance, CA 90502, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1014-20. 2005
    ..These data demonstrate that in the near-term ovine fetus, AT1 receptor but not AT2 receptors accessible via CSF contribute to dipsogenic and pressor responses...
  2. ncbi Gestational programming: population survival effects of drought and famine during pregnancy
    Michael G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, 1000 W Carson St, Box 3, Torrance, CA 90509, USA
    Am J Physiol Regul Integr Comp Physiol 288:R25-33. 2005
    ..Importantly, these results suggest that programming effects may be either potentiated or prevented by interventions during the neonatal period...
  3. ncbi N-methyl-D-aspartate glutamate receptor mediates spontaneous and angiotensin II-stimulated ovine fetal swallowing
    Mostafa A El-Haddad
    Perinatal Research Laboratories, Harbor UCLA Medical Center, School of Medicine, Los Angeles, California, USA
    J Soc Gynecol Investig 12:504-9. 2005
    ..The aim of present study was to determine the role of central NMDA receptors in the modulation of fetal swallowing activity...
  4. ncbi Persistent sucrose stimulation of ovine fetal ingestion: lack of adaptation responses
    Mostafa A El-Haddad
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, Geffen School of Medicine at UCLA, Harbor UCLA Medical Center, Torrance, California, USA
    J Matern Fetal Neonatal Med 18:123-7. 2005
    ..We sought to determine if prolonged oral sucrose infusion to the near term ovine fetus will evoke adaptation, as manifested by reduced swallowing stimulation...
  5. ncbi Gender-specific orexigenic and anorexigenic mechanisms in rats
    Dave A Gayle
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA and Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance CA 90502, United States
    Life Sci 79:1531-6. 2006
    ....
  6. ncbi Gestational programming of offspring obesity: a potential contributor to Alzheimer's disease
    Michael G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Curr Alzheimer Res 4:213-7. 2007
    ..These findings suggest that potential risk factors for the development of Alzheimer's disease may be present as early as newborn life...
  7. pmc Enhanced nephrogenesis in offspring of water-restricted rat dams
    Roy Mansano
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Am J Obstet Gynecol 196:480.e1-6. 2007
    ..Maternal water restriction (WR) may induce offspring plasma hypertonicity and enhanced vasopressin secretory responses. We determined effects of pregnancy WR on offspring body composition, renal morphology, and blood pressure...
  8. pmc Adult sequelae of intrauterine growth restriction
    Michael G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Semin Perinatol 32:213-8. 2008
    ..In some animal models, aspects of fetal programming can be reversed postnatally; however, at the present time, the best strategy for avoiding the adult consequences of fetal growth restriction is prevention...
  9. doi Early undernutrition attenuates the inflammatory response in adult rat offspring
    Mina Desai
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles Medical Center, Torrance, 90502, USA
    J Matern Fetal Neonatal Med 22:571-5. 2009
    ..We determined the impact of maternal food restriction during gestation and lactation or lactation alone on basal inflammation and lipopolysaccharide (LPS)-stimulated cytokine induction in adult female offspring...