GUSTATORY THALAMUS AND TASTE GUIDED BEHAVIOR

Summary

Principal Investigator: STEPHEN REILLY
Abstract: The long-term objective of the current proposal is to elucidate the role of the gustatory thalamus in taste-guided behavior. The proposed research is intended to investigate the hypothesis that the gustatory thalamus is primarily involved with sophisticated preparatory, but not the consummatory, aspects of taste-guided behavior. The preparatory phase consists of complex perceptual and cognitive strategies that guide the environmental search for potential food sources; the consummatory phase (served by the hindbrain), by comparison, involves eating and drinking responses once food makes contact with the mouth. Three series of experiment will be undertaken using rats with electrophysiologically guided ibotenic acid lesions of the gustatory thalamus. The experiments of Specific Aim number 1 are intended to determine the nature of the lesion-induced higher-order associative learning deficit by examining performance on complex taste information processing tasks which similarly involve the modulation of the strength of an acquired gustatory aversion. By examining performance on instrumental contrast procedures, the research proposed in Specific Aim number 2 will determine if the gustatory thalamus functions as a general reward comparison mechanism such that lesions disrupt all forms of contrast effects involving gustatory rewards. Finally, the experiments of Specific Aim number 3 will determine if the contrast deficits found in rats with lesions of the thalamic taste area result from an underlying dysfunction of gustatory memory. The results of the research proposed in this application will significantly enhance our understanding of the information processing role(s) of the thalamic taste area of the rat.
Funding Period: 2000-02-15 - 2006-01-31
more information: NIH RePORT

Top Publications

  1. pmc Taste neophobia and c-Fos expression in the rat brain
    Jian You Lin
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1448:82-8. 2012
  2. pmc Basolateral amygdala and morphine-induced taste avoidance in the rat
    Jamie Lovaglio
    University of Illinois at Chicago, Biologic Resources Laboratory, 1840 West Taylor St, Chicago, IL 60612, USA
    Physiol Behav 99:419-23. 2010
  3. pmc Taste-potentiated odor aversion learning in rats with lesions of the insular cortex
    Jian You Lin
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1297:135-42. 2009
  4. pmc Insular cortex and consummatory successive negative contrast in the rat
    Jian You Lin
    Department of Psychology, University of Illinois at Chicago, Chicago, IL 60607, USA
    Behav Neurosci 123:810-4. 2009
  5. pmc Morphine-induced suppression of conditioned stimulus intake: effects of stimulus type and insular cortex lesions
    Jian You Lin
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1292:52-60. 2009
  6. pmc Insular cortex lesions and morphine-induced suppression of conditioned stimulus intake in the rat
    Christopher Roman
    Department of Psychology, University of Illinois at Chicago, Chicago, IL 60607, USA
    Behav Neurosci 123:206-11. 2009
  7. pmc Conditioned taste aversion and latent inhibition following extensive taste preexposure in rats with insular cortex lesions
    Christopher Roman
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1259:68-73. 2009
  8. pmc Taste, olfactory and trigeminal neophobia in rats with forebrain lesions
    Jian You Lin
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1251:195-203. 2009
  9. pmc NMDA receptors in the basolateral amygdala and gustatory neophobia
    Yazmin Figueroa-Guzman
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1210:200-3. 2008
  10. ncbi Effects of insular cortex lesions on conditioned taste aversion and latent inhibition in the rat
    Christopher Roman
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Eur J Neurosci 26:2627-32. 2007

Scientific Experts

Detail Information

Publications17

  1. pmc Taste neophobia and c-Fos expression in the rat brain
    Jian You Lin
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1448:82-8. 2012
    ..The present results are discussed with respect to a forebrain taste neophobia system...
  2. pmc Basolateral amygdala and morphine-induced taste avoidance in the rat
    Jamie Lovaglio
    University of Illinois at Chicago, Biologic Resources Laboratory, 1840 West Taylor St, Chicago, IL 60612, USA
    Physiol Behav 99:419-23. 2010
    ..Potential interpretations of the results are discussed including a disruption of the mechanism that governs drug-induced taste avoidance in normal subjects and the more rapid development of tolerance in BLAX rats...
  3. pmc Taste-potentiated odor aversion learning in rats with lesions of the insular cortex
    Jian You Lin
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1297:135-42. 2009
    ..The finding that taste did not potentiate odor aversion learning in the IC-lesioned rats provides support for the "within-compound association" analysis but is inconsistent with the "sensory-and-gate" account of TPOA learning...
  4. pmc Insular cortex and consummatory successive negative contrast in the rat
    Jian You Lin
    Department of Psychology, University of Illinois at Chicago, Chicago, IL 60607, USA
    Behav Neurosci 123:810-4. 2009
    ..Potential interpretations are discussed including a lesion-induced impairment in the ability to accurately recognize the novelty of the postshift saccharin stimulus...
  5. pmc Morphine-induced suppression of conditioned stimulus intake: effects of stimulus type and insular cortex lesions
    Jian You Lin
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1292:52-60. 2009
    ..These results indicate that the perceived innate reward value of the CS is not a factor that governs drug-induced intake suppression...
  6. pmc Insular cortex lesions and morphine-induced suppression of conditioned stimulus intake in the rat
    Christopher Roman
    Department of Psychology, University of Illinois at Chicago, Chicago, IL 60607, USA
    Behav Neurosci 123:206-11. 2009
    ..The results are discussed in terms of a lesion-induced disruption of (i) a reward comparison mechanism and (ii) the perception of taste novelty...
  7. pmc Conditioned taste aversion and latent inhibition following extensive taste preexposure in rats with insular cortex lesions
    Christopher Roman
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1259:68-73. 2009
    ..The present experiment confirmed this hypothesis in a design that compared CTA acquisition in normal and ICX rats following either extensive taste familiarization or no taste familiarization prior to conditioning...
  8. pmc Taste, olfactory and trigeminal neophobia in rats with forebrain lesions
    Jian You Lin
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1251:195-203. 2009
    ..Each type of lesion, however, disrupted the initial occurrence of neophobia to the taste stimulus. The significance of these findings to conditioned taste aversion is discussed...
  9. pmc NMDA receptors in the basolateral amygdala and gustatory neophobia
    Yazmin Figueroa-Guzman
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1210:200-3. 2008
    ....
  10. ncbi Effects of insular cortex lesions on conditioned taste aversion and latent inhibition in the rat
    Christopher Roman
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Eur J Neurosci 26:2627-32. 2007
    ....
  11. ncbi Effects of central and basolateral amygdala lesions on conditioned taste aversion and latent inhibition
    Justin St Andre
    Department of Psychology, University of Illinois at Chicago, Chicago, IL 60607, USA
    Behav Neurosci 121:90-9. 2007
    ..The pattern of results suggests that the CTA deficit in rats with BLA lesions may be a secondary consequence of a disruption of perceived stimulus novelty...
  12. pmc C-fos expression in the rat brain following lithium chloride-induced illness
    Justin St Andre
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1135:122-8. 2007
    ..The results are discussed with respect to the neural substrates of conditioned taste aversion...
  13. ncbi Effects of lesions of the bed nucleus of the stria terminalis, lateral hypothalamus, or insular cortex on conditioned taste aversion and conditioned odor aversion
    Christopher Roman
    Department of Psychology, University of Illinois at Chicago, Chicago, IL 60607, USA
    Behav Neurosci 120:1257-67. 2006
    ..The implications of these findings are discussed with regard to the forebrain influence on parabrachial nucleus function during CTA acquisition...
  14. ncbi NMDA receptor antagonist MK-801 infused into the insular cortex prevents the attenuation of gustatory neophobia in rats
    Yazmin Figueroa-Guzman
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1114:183-6. 2006
    ..Results showed that acute microinfusion of MK-801 into the insular cortex prevented the attenuation of gustatory neophobia indicating that this process is an NMDA receptor-dependent phenomenon...
  15. ncbi Excitotoxic lesions of the gustatory thalamus eliminate consummatory but not instrumental successive negative contrast in rats
    Aristides Sastre
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Behav Brain Res 170:34-40. 2006
    ..0M sucrose to 0.15% sodium saccharin. The obtained pattern of results suggests that separate reward comparison mechanisms with different neural substrates underlie expression of cSNC and iSNC...
  16. ncbi Medial parabrachial nucleus neurons modulate d-fenfluramine-induced anorexia through 5HT2C receptors
    Radmila Trifunovic
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1067:170-6. 2006
    ..These results are consistent with the hypothesis that medial PBN neurons mediate anorexia through 5HT2C receptors...
  17. ncbi Conditioned taste aversion and amygdala lesions in the rat: a critical review
    Steve Reilly
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Neurosci Biobehav Rev 29:1067-88. 2005
    ..The key to understanding the functional significance of the basolateral amygdala in conditioned taste aversion reduces, we believe, to determining the role of this structure in gustatory neophobia...