Licit and Illicit Abused Stimulant Drugs

Summary

Principal Investigator: ROLAND GRIFFITHS
Affiliation: Johns Hopkins University
Country: USA
Abstract: Research in human subjects will characterize the reinforcing effects of nicotine and caffeine and will investigate interactions between these drugs and cocaine. A series of six studies will focus nicotine, caffeine and cocaine administered intravenously to stimulant drug abusers in a residential research laboratory. Using choice procedures to assess relative reinforcing effects, one study will evaluate a range of nicotine doses and another study will evaluate a range of caffeine doses. Using similar procedures, a third study will directly compare the reinforcing effects of nicotine and cocaine, and a fourth study will compare nicotine and caffeine. Two other studies will examine the effects of acute caffeine pretreatment on the effects of intravenous nicotine and cocaine, and the effects of acute nicotine pretreatment on the effects of intravenous caffeine and cocaine. Concurrent with the residential studies, a series of five nonresidential studies will also focus on the reinforcing effects of and drug interactions between nicotine and caffeine in normal volunteers. Two studies will use drug discrimination procedures to determine whether familiarity with subtle mood-altering drug effects enhances the reinforcing effects of nicotine in nicotine non-users and oral caffeine in caffeine consumers. A third study will extend research on nicotine-caffeine interactions by determining whether chronic caffeine exposure enhances the reinforcing effects of nicotine in nicotine non-users. Another study will determine whether individual differences in the reinforcing effects of caffeine predict the reinforcing effects of nicotine in nicotine non-users. A final study will carefully characterize a group of caffeine dependent individuals, and evaluate the efficacy of a brief treatment intervention for caffeine dependence. This project will be of clinical importance in identifying determinants of vulnerability to nicotine and caffeine dependence in the general population. The studies with nicotine, caffeine and cocaine should also advance our understanding about drug interactions among these compounds and about pharmacological and behavioral mechanisms underlying stimulant drug abuse. Ultimately, this project should have relevance to the development of prevention and treatment strategies for stimulant drug abuse.
Funding Period: 1984-07-01 - 2010-08-31
more information: NIH RePORT

Top Publications

  1. pmc Characterization of individuals seeking treatment for caffeine dependence
    Laura M Juliano
    Department of Psychology, American University, Washington, DC 20016, USA
    Psychol Addict Behav 26:948-54. 2012
  2. pmc Increased alcohol consumption, nonmedical prescription drug use, and illicit drug use are associated with energy drink consumption among college students
    Amelia M Arria
    Center for Substance Abuse Research CESAR, University of Maryland, 4321 Hartwick Road, Suite 501, College Park, Maryland 20740, USA
    J Addict Med 4:74-80. 2010
  3. pmc Caffeine choice prospectively predicts positive subjective effects of caffeine and d-amphetamine
    Stacey C Sigmon
    Department of Psychiatry, University of Vermont College of Medicine, SATC UHC, Room 1415, Burlington, VT 05401, USA
    Drug Alcohol Depend 118:341-8. 2011
  4. pmc Energy drink consumption and increased risk for alcohol dependence
    Amelia M Arria
    Center on Young Adult Health and Development, Department of Family Science, University of Maryland School of Public Health, College Park, 20740, USA
    Alcohol Clin Exp Res 35:365-75. 2011
  5. pmc Effects of oral caffeine pretreatment on response to intravenous nicotine and cocaine
    Matthew W Johnson
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6823, USA
    Exp Clin Psychopharmacol 18:305-15. 2010
  6. pmc Principles of laboratory assessment of drug abuse liability and implications for clinical development
    Lawrence P Carter
    Department of Psychiatry, University of Arkansas for Medical Sciences, Psychiatric Research Institute Center for Addiction Research, Little Rock, AR 72205, United States
    Drug Alcohol Depend 105:S14-25. 2009
  7. pmc Cognitive, psychomotor, and subjective effects of sodium oxybate and triazolam in healthy volunteers
    Lawrence P Carter
    Department of Psychiatry, Center for Addiction Research, University of Arkansas for Medical Sciences, 4301 W Markham Street 843, Little Rock, AR 72205, USA
    Psychopharmacology (Berl) 206:141-54. 2009
  8. pmc Caffeine withdrawal, acute effects, tolerance, and absence of net beneficial effects of chronic administration: cerebral blood flow velocity, quantitative EEG, and subjective effects
    Stacey C Sigmon
    Department of Psychiatry, University of Vermont College of Medicine, SATC UHC, Room 1415, Burlington, VT, 05401, USA
    Psychopharmacology (Berl) 204:573-85. 2009
  9. pmc Caffeinated energy drinks--a growing problem
    CHAD J REISSIG
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Drug Alcohol Depend 99:1-10. 2009
  10. ncbi Investigating the pharmacological and nonpharmacological factors that modulate drug reinforcement
    Stacey C Sigmon
    Department of Psychiatry, University of Vermont, VT, USA
    Exp Clin Psychopharmacol 15:1-20. 2007

Scientific Experts

Detail Information

Publications12

  1. pmc Characterization of individuals seeking treatment for caffeine dependence
    Laura M Juliano
    Department of Psychology, American University, Washington, DC 20016, USA
    Psychol Addict Behav 26:948-54. 2012
    ..This investigation reveals that there are individuals with problematic caffeine use who are seeking treatment and suggests that there is a need for effective caffeine dependence treatments...
  2. pmc Increased alcohol consumption, nonmedical prescription drug use, and illicit drug use are associated with energy drink consumption among college students
    Amelia M Arria
    Center for Substance Abuse Research CESAR, University of Maryland, 4321 Hartwick Road, Suite 501, College Park, Maryland 20740, USA
    J Addict Med 4:74-80. 2010
    ..This longitudinal study examined the prevalence and correlates of energy drink use among college students, and investigated its possible prospective associations with subsequent drug use, including nonmedical prescription drug use...
  3. pmc Caffeine choice prospectively predicts positive subjective effects of caffeine and d-amphetamine
    Stacey C Sigmon
    Department of Psychiatry, University of Vermont College of Medicine, SATC UHC, Room 1415, Burlington, VT 05401, USA
    Drug Alcohol Depend 118:341-8. 2011
    ..The present study sought to determine whether individual differences in caffeine choice prospectively predict subjective response to acute doses of caffeine and d-amphetamine...
  4. pmc Energy drink consumption and increased risk for alcohol dependence
    Amelia M Arria
    Center on Young Adult Health and Development, Department of Family Science, University of Maryland School of Public Health, College Park, 20740, USA
    Alcohol Clin Exp Res 35:365-75. 2011
    ..This study investigated the extent to which energy drink use might pose additional risk for alcohol dependence over and above that from known risk factors...
  5. pmc Effects of oral caffeine pretreatment on response to intravenous nicotine and cocaine
    Matthew W Johnson
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6823, USA
    Exp Clin Psychopharmacol 18:305-15. 2010
    ..In contrast to the previous research using chronic caffeine maintenance, these data suggest that infrequent acute caffeine administration may attenuate nicotine effects...
  6. pmc Principles of laboratory assessment of drug abuse liability and implications for clinical development
    Lawrence P Carter
    Department of Psychiatry, University of Arkansas for Medical Sciences, Psychiatric Research Institute Center for Addiction Research, Little Rock, AR 72205, United States
    Drug Alcohol Depend 105:S14-25. 2009
    ..Well-designed patient and physician education, pharmacovigilance, and postmarketing surveillance can reduce the diversion and misuse of drugs with abuse liability and can effectively foster the protection and promotion of public health...
  7. pmc Cognitive, psychomotor, and subjective effects of sodium oxybate and triazolam in healthy volunteers
    Lawrence P Carter
    Department of Psychiatry, Center for Addiction Research, University of Arkansas for Medical Sciences, 4301 W Markham Street 843, Little Rock, AR 72205, USA
    Psychopharmacology (Berl) 206:141-54. 2009
    ..Illicit gamma-hydroxybutyrate (GHB) has received attention as a "date rape drug" that produces robust amnesia; however, there is little experimental evidence in support of GHB's amnestic effects...
  8. pmc Caffeine withdrawal, acute effects, tolerance, and absence of net beneficial effects of chronic administration: cerebral blood flow velocity, quantitative EEG, and subjective effects
    Stacey C Sigmon
    Department of Psychiatry, University of Vermont College of Medicine, SATC UHC, Room 1415, Burlington, VT, 05401, USA
    Psychopharmacology (Berl) 204:573-85. 2009
    ..Although the subjective effects of caffeine abstinence, acute and chronic administration, and tolerance are well described, the corresponding neurophysiological effects are not...
  9. pmc Caffeinated energy drinks--a growing problem
    CHAD J REISSIG
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Drug Alcohol Depend 99:1-10. 2009
    ..Several studies suggest that energy drinks may serve as a gateway to other forms of drug dependence. Regulatory implications concerning labeling and advertising, and the clinical implications for children and adolescents are discussed...
  10. ncbi Investigating the pharmacological and nonpharmacological factors that modulate drug reinforcement
    Stacey C Sigmon
    Department of Psychiatry, University of Vermont, VT, USA
    Exp Clin Psychopharmacol 15:1-20. 2007
    ..In summary, understanding the interactions among the variables present in the context of drug use is critical to understanding risk factors for substance use disorders as well as developing efficacious treatments for drug dependence...
  11. ncbi Ramelteon: a novel hypnotic lacking abuse liability and sedative adverse effects
    Matthew W Johnson
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Arch Gen Psychiatry 63:1149-57. 2006
    ..Ramelteon is a novel MT1 and MT2 melatonin receptor selective agonist recently approved for insomnia treatment. Most approved insomnia medications have potential for abuse and cause motor and cognitive impairment...
  12. ncbi Caffeine dependence in combination with a family history of alcoholism as a predictor of continued use of caffeine during pregnancy
    Dace S Svikis
    Department of Psychology, Virginia Commonwealth University, 1101 East Marshall St, Sanger Hall, Room 11 028, Box 980343, Richmond, VA 23298 0343, USA
    Am J Psychiatry 162:2344-51. 2005
    ..The purpose of the study was to examine whether caffeine dependence and a family history of alcoholism are associated with continued use of caffeine during pregnancy...