Licit and Illicit Abused Stimulant Drugs

Summary

Principal Investigator: ROLAND GRIFFITHS
Affiliation: Johns Hopkins University
Country: USA
Abstract: Research in human subjects will characterize the reinforcing effects of nicotine and caffeine and will investigate interactions between these drugs and cocaine. A series of six studies will focus nicotine, caffeine and cocaine administered intravenously to stimulant drug abusers in a residential research laboratory. Using choice procedures to assess relative reinforcing effects, one study will evaluate a range of nicotine doses and another study will evaluate a range of caffeine doses. Using similar procedures, a third study will directly compare the reinforcing effects of nicotine and cocaine, and a fourth study will compare nicotine and caffeine. Two other studies will examine the effects of acute caffeine pretreatment on the effects of intravenous nicotine and cocaine, and the effects of acute nicotine pretreatment on the effects of intravenous caffeine and cocaine. Concurrent with the residential studies, a series of five nonresidential studies will also focus on the reinforcing effects of and drug interactions between nicotine and caffeine in normal volunteers. Two studies will use drug discrimination procedures to determine whether familiarity with subtle mood-altering drug effects enhances the reinforcing effects of nicotine in nicotine non-users and oral caffeine in caffeine consumers. A third study will extend research on nicotine-caffeine interactions by determining whether chronic caffeine exposure enhances the reinforcing effects of nicotine in nicotine non-users. Another study will determine whether individual differences in the reinforcing effects of caffeine predict the reinforcing effects of nicotine in nicotine non-users. A final study will carefully characterize a group of caffeine dependent individuals, and evaluate the efficacy of a brief treatment intervention for caffeine dependence. This project will be of clinical importance in identifying determinants of vulnerability to nicotine and caffeine dependence in the general population. The studies with nicotine, caffeine and cocaine should also advance our understanding about drug interactions among these compounds and about pharmacological and behavioral mechanisms underlying stimulant drug abuse. Ultimately, this project should have relevance to the development of prevention and treatment strategies for stimulant drug abuse.
Funding Period: 1984-07-01 - 2010-08-31
more information: NIH RePORT

Top Publications

  1. ncbi Caffeine dependence in combination with a family history of alcoholism as a predictor of continued use of caffeine during pregnancy
    Dace S Svikis
    Department of Psychology, Virginia Commonwealth University, 1101 East Marshall St, Sanger Hall, Room 11 028, Box 980343, Richmond, VA 23298 0343, USA
    Am J Psychiatry 162:2344-51. 2005
  2. ncbi Ramelteon: a novel hypnotic lacking abuse liability and sedative adverse effects
    Matthew W Johnson
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Arch Gen Psychiatry 63:1149-57. 2006
  3. ncbi Investigating the pharmacological and nonpharmacological factors that modulate drug reinforcement
    Stacey C Sigmon
    Department of Psychiatry, University of Vermont, VT, USA
    Exp Clin Psychopharmacol 15:1-20. 2007
  4. pmc Caffeinated energy drinks--a growing problem
    CHAD J REISSIG
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Drug Alcohol Depend 99:1-10. 2009
  5. pmc Caffeine withdrawal, acute effects, tolerance, and absence of net beneficial effects of chronic administration: cerebral blood flow velocity, quantitative EEG, and subjective effects
    Stacey C Sigmon
    Department of Psychiatry, University of Vermont College of Medicine, SATC UHC, Room 1415, Burlington, VT, 05401, USA
    Psychopharmacology (Berl) 204:573-85. 2009
  6. pmc Cognitive, psychomotor, and subjective effects of sodium oxybate and triazolam in healthy volunteers
    Lawrence P Carter
    Department of Psychiatry, Center for Addiction Research, University of Arkansas for Medical Sciences, 4301 W Markham Street 843, Little Rock, AR 72205, USA
    Psychopharmacology (Berl) 206:141-54. 2009

Scientific Experts

  • STACEY SIGMON
  • Dace S Svikis
  • Roland R Griffiths
  • CHAD J REISSIG
  • Lawrence P Carter
  • Matthew W Johnson
  • Eric C Strain
  • Miriam Z Mintzer
  • Patricia E Suess

Detail Information

Publications6

  1. ncbi Caffeine dependence in combination with a family history of alcoholism as a predictor of continued use of caffeine during pregnancy
    Dace S Svikis
    Department of Psychology, Virginia Commonwealth University, 1101 East Marshall St, Sanger Hall, Room 11 028, Box 980343, Richmond, VA 23298 0343, USA
    Am J Psychiatry 162:2344-51. 2005
    ..The purpose of the study was to examine whether caffeine dependence and a family history of alcoholism are associated with continued use of caffeine during pregnancy...
  2. ncbi Ramelteon: a novel hypnotic lacking abuse liability and sedative adverse effects
    Matthew W Johnson
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Arch Gen Psychiatry 63:1149-57. 2006
    ..Ramelteon is a novel MT1 and MT2 melatonin receptor selective agonist recently approved for insomnia treatment. Most approved insomnia medications have potential for abuse and cause motor and cognitive impairment...
  3. ncbi Investigating the pharmacological and nonpharmacological factors that modulate drug reinforcement
    Stacey C Sigmon
    Department of Psychiatry, University of Vermont, VT, USA
    Exp Clin Psychopharmacol 15:1-20. 2007
    ..In summary, understanding the interactions among the variables present in the context of drug use is critical to understanding risk factors for substance use disorders as well as developing efficacious treatments for drug dependence...
  4. pmc Caffeinated energy drinks--a growing problem
    CHAD J REISSIG
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Drug Alcohol Depend 99:1-10. 2009
    ..Several studies suggest that energy drinks may serve as a gateway to other forms of drug dependence. Regulatory implications concerning labeling and advertising, and the clinical implications for children and adolescents are discussed...
  5. pmc Caffeine withdrawal, acute effects, tolerance, and absence of net beneficial effects of chronic administration: cerebral blood flow velocity, quantitative EEG, and subjective effects
    Stacey C Sigmon
    Department of Psychiatry, University of Vermont College of Medicine, SATC UHC, Room 1415, Burlington, VT, 05401, USA
    Psychopharmacology (Berl) 204:573-85. 2009
    ..Although the subjective effects of caffeine abstinence, acute and chronic administration, and tolerance are well described, the corresponding neurophysiological effects are not...
  6. pmc Cognitive, psychomotor, and subjective effects of sodium oxybate and triazolam in healthy volunteers
    Lawrence P Carter
    Department of Psychiatry, Center for Addiction Research, University of Arkansas for Medical Sciences, 4301 W Markham Street 843, Little Rock, AR 72205, USA
    Psychopharmacology (Berl) 206:141-54. 2009
    ..Illicit gamma-hydroxybutyrate (GHB) has received attention as a "date rape drug" that produces robust amnesia; however, there is little experimental evidence in support of GHB's amnestic effects...