Southern Community Cohort Study

Summary

Principal Investigator: Wei Zheng
Abstract: DESCRIPTION (provided by applicant): The second five-year renewal of the Southern Community Cohort Study (SCCS) is proposed in this grant application. Progress during the initial nine years of the study has been exceptional. We achieved a final cohort size of approximately 86,000 adults aged 40-79, two-thirds of whom are African American, with detailed baseline data assembled for all and biological specimens in frozen storage for nearly 90%. The cohort is now under follow-up for cancer mortality and incidence and other health outcomes. Historically, large-scale recruitment of African Americans, a group disproportionately burdened by cancer, into health research studies has been challenging. However, we uniquely overcame many known barriers to inclusion by developing partnerships with a network of southern Community Health Centers (CHCs), institutions that provide basic health services primarily to America's poor and uninsured. The SCCS thus differs from all other cohort studies in racial composition and socioeconomic disadvantage, and tracks a population possibly at higher cancer risk than any American population segment studied to date. Our specific aims for the renewal are (1) to continue passive follow-up of the cohort via linkages with various national and state registries to identify deaths, incident cancers and other health outcomes, (2) to continue active follow-up of the cohort via re-contact with participants to directly update exposure and health information, and (3) to conduct multiple new cohort and nested case-control analyses utilizing the baseline and follow-up data and stored DNA and blood specimens for evaluation of lifestyle, genetic and other risk or protective factors affecting the incidence of and disparities in the major cancers (lung, breast, prostate, and colon/rectum). We will evaluate hypotheses that the SCCS is uniquely or especially well positioned to address, many for the first time among African Americans, including the roles of obesity, vitamin D, specific infections (Chlamydia pneumoniae, Trichomonas vaginalis, Helicobacter pylori, and xenotropic murine leukemia virus-related virus), several nutrition-related pathways (one carbon metabolism, n-6 and n-3 polyunsaturated fatty acids and other dietary factors), cigarette mentholation, and use of the commonly prescribed glycemic control medication metformin, in relation to cancer risk and cancer disparities.
Funding Period: 2001-09-30 - 2016-06-30
more information: NIH RePORT

Top Publications

  1. pmc Mortality among low-income African Americans and whites with diabetes
    Baqiyyah N Conway
    Department of Medicine, Division of Epidemiology, Vanderbilt University, Nashville, TN, USA
    Diabetes Care 35:2293-9. 2012
  2. pmc Prevalence and correlates of complementary and alternative medicine services use in low-income African Americans and whites: a report from the Southern Community Cohort Study
    Yong Cui
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Altern Complement Med 18:844-9. 2012
  3. pmc Obesity and all-cause mortality among black adults and white adults
    Sarah S Cohen
    International Epidemiology Institute, Rockville, MD 20850, USA
    Am J Epidemiol 176:431-42. 2012
  4. pmc A multi-stage approach to maximizing geocoding success in a large population-based cohort study through automated and interactive processes
    Jennifer S Sonderman
    International Epidemiology Institute, Rockville, MD 20850, USA
    Geospat Health 6:273-84. 2012
  5. pmc Neighborhood socio-economic characteristics, African ancestry, and Helicobacter pylori sero-prevalence
    Meira Epplein
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, 2525 West End Avenue, 6th Floor, Nashville, TN 37203 1738, USA
    Cancer Causes Control 23:897-906. 2012
  6. ncbi A community-driven intervention for prostate cancer screening in African Americans
    Kushal Patel
    Meharry Medical College, Nashville, TN 37208 3599, USA
    Health Educ Behav 40:11-8. 2013
  7. pmc Differences in the association between serum leptin levels and body mass index in black and white women: a report from the Southern Community Cohort Study
    Sarah S Cohen
    International Epidemiology Institute, Rockville, MD, USA
    Ann Nutr Metab 60:90-7. 2012
  8. pmc Mortality experience of a low-income population with young-onset diabetes
    Baqiyyah N Conway
    Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes Care 35:542-8. 2012
  9. pmc Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African Americans
    Lisa B Signorello
    International Epidemiology Institute, Rockville, Maryland, United States of America
    PLoS ONE 6:e28623. 2011
  10. pmc HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes
    Todd L Edwards
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    Am J Epidemiol 175:11-21. 2012

Research Grants

  1. Comparative Mechanisms of Cancer Chemoprevention
    Roderick H Dashwood; Fiscal Year: 2013
  2. DIETARY AND HORMONAL DETERMINANTS OF CANCER IN WOMEN
    Meir Stampfer; Fiscal Year: 2013
  3. Penn TREC Survivor Center
    Kathryn H Schmitz; Fiscal Year: 2013
  4. Understanding and preventing breast cancer disparties in Latinas
    Beti Thompson; Fiscal Year: 2013
  5. DRUG DEPENDENCE CLINICAL RESEARCH PROGRAM
    Reese T Jones; Fiscal Year: 2013
  6. Hopkins Center for Eliminate Cardiovascular Health Disparities
    Lisa A Cooper; Fiscal Year: 2013
  7. NEW MODALITIES FOR TREATMENT OF PAIN AND DRUG ABUSE
    Victor J Hruby; Fiscal Year: 2013

Detail Information

Publications72

  1. pmc Mortality among low-income African Americans and whites with diabetes
    Baqiyyah N Conway
    Department of Medicine, Division of Epidemiology, Vanderbilt University, Nashville, TN, USA
    Diabetes Care 35:2293-9. 2012
    ..To estimate mortality rates and risk factors for mortality in a low-socioeconomic status (SES) population of African Americans and whites with diabetes...
  2. pmc Prevalence and correlates of complementary and alternative medicine services use in low-income African Americans and whites: a report from the Southern Community Cohort Study
    Yong Cui
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Altern Complement Med 18:844-9. 2012
    ..This study aimed to examine the prevalence, trends, and correlates of practitioner-based complementary and alternative medicine (CAM) services use according to race in a socioeconomically disadvantaged population...
  3. pmc Obesity and all-cause mortality among black adults and white adults
    Sarah S Cohen
    International Epidemiology Institute, Rockville, MD 20850, USA
    Am J Epidemiol 176:431-42. 2012
    ..males, 9,343 white males, 30,810 black females, and 14,447 white females, aged 40-79 years, from the Southern Community Cohort Study, an epidemiologic cohort of largely low-income participants in 12 southeastern US states...
  4. pmc A multi-stage approach to maximizing geocoding success in a large population-based cohort study through automated and interactive processes
    Jennifer S Sonderman
    International Epidemiology Institute, Rockville, MD 20850, USA
    Geospat Health 6:273-84. 2012
    ....
  5. pmc Neighborhood socio-economic characteristics, African ancestry, and Helicobacter pylori sero-prevalence
    Meira Epplein
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, 2525 West End Avenue, 6th Floor, Nashville, TN 37203 1738, USA
    Cancer Causes Control 23:897-906. 2012
    ..We sought to determine whether neighborhood-level socio-economic characteristics are associated with H. pylori prevalence and whether this helps explain the link between African ancestry and H. pylori...
  6. ncbi A community-driven intervention for prostate cancer screening in African Americans
    Kushal Patel
    Meharry Medical College, Nashville, TN 37208 3599, USA
    Health Educ Behav 40:11-8. 2013
    ....
  7. pmc Differences in the association between serum leptin levels and body mass index in black and white women: a report from the Southern Community Cohort Study
    Sarah S Cohen
    International Epidemiology Institute, Rockville, MD, USA
    Ann Nutr Metab 60:90-7. 2012
    ....
  8. pmc Mortality experience of a low-income population with young-onset diabetes
    Baqiyyah N Conway
    Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes Care 35:542-8. 2012
    ..We describe the mortality experience of a low-income, predominantly minority population with diabetes diagnosed before age 30 years, stratified by insulin therapy...
  9. pmc Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African Americans
    Lisa B Signorello
    International Epidemiology Institute, Rockville, Maryland, United States of America
    PLoS ONE 6:e28623. 2011
    ..Within the Southern Community Cohort Study, we investigated the association between 94 single nucleotide polymorphisms (SNPs) in five vitamin D ..
  10. pmc HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes
    Todd L Edwards
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    Am J Epidemiol 175:11-21. 2012
    ..SNPs) in African Americans (n = 1,173) and 897 SNPs in Caucasians (n = 1,165) were examined in the Southern Community Cohort Study (2002-2009) for associations with BMI and gene × environment interactions...
  11. pmc Individual and neighborhood-level socioeconomic characteristics in relation to smoking prevalence among black and white adults in the Southeastern United States: a cross-sectional study
    Sarah S Cohen
    International Epidemiology Institute, 1455 Research Blvd, Suite 550, Rockville, MD 20850, USA
    BMC Public Health 11:877. 2011
    ..Recent work has examined whether neighborhood-level SES may affect smoking behavior independently from individual-level measures. However, few comparisons of neighborhood-level effects on smoking by race and gender are available...
  12. pmc Relationship between smoking and obesity among women
    Kushal Patel
    Prevention Research Unit, Department of Internal Medicine, School of Medicine, Meharry Medical College, Nashville, TN, USA
    Am J Health Behav 35:627-36. 2011
    ..To examine the relationship between smoking and weight status in adult women and whether this association differed by race...
  13. pmc Obesity, physical activity and lower urinary tract symptoms: results from the Southern Community Cohort Study
    David F Penson
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37203 1738, USA
    J Urol 186:2316-22. 2011
    ..In this study we determined the independent associations of physical activity and obesity with lower urinary tract symptoms at followup among white and African-American men...
  14. pmc Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry
    Amidou N'Diaye
    Montreal Heart Institute, Montreal, Canada
    PLoS Genet 7:e1002298. 2011
    ..01). Our results highlight the utility of genetic studies in non-European populations to understand the etiology of complex human diseases and traits...
  15. pmc Evaluation of a questionnaire to assess sedentary and active behaviors in the Southern Community Cohort Study
    Maciej S Buchowski
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    J Phys Act Health 9:765-75. 2012
    ..This study evaluated the PA questionnaire (PAQ) used in the Southern Cohort Community Study, a prospective investigation of health disparities between African-American and white adults...
  16. pmc The landscape of recombination in African Americans
    Anjali G Hinch
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 476:170-5. 2011
    ..Sites of this motif are predicted to be risk loci for disease-causing genomic rearrangements in individuals carrying these alleles. More generally, this map provides a resource for research in human genetic variation and evolution...
  17. pmc Race-specific impact of atrial fibrillation risk factors in blacks and whites in the southern community cohort study
    Loren Lipworth
    Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am J Cardiol 110:1637-42. 2012
    ..Among white and black participants in the Southern Community Cohort Study (SCCS) aged ≥65 years receiving Medicare coverage from 1999 to 2008 (n = 8,836), diagnoses of AF (..
  18. pmc A genome-wide association study of breast cancer in women of African ancestry
    Fang Chen
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    Hum Genet 132:39-48. 2013
    ..Identification of novel risk variants for breast cancer in women of African ancestry will demand testing of a substantially larger set of markers from stage 1 in a larger replication sample...
  19. pmc Plasma selenium biomarkers in low income black and white americans from the southeastern United States
    Margaret K Hargreaves
    Department of Internal Medicine, Meharry Medical College, Nashville, Tennessee, United States of America
    PLoS ONE 9:e84972. 2014
    ..The findings suggest that SEPP1 may be an effective biomarker of selenium status and disease risk in adults and that low selenium status may disproportionately affect black and white cohort participants...
  20. pmc Factors associated with the prevalence of hypertension in the southeastern United States: insights from 69,211 blacks and whites in the Southern Community Cohort Study
    Uchechukwu K A Sampson
    Department of Medicine
    Circ Cardiovasc Qual Outcomes 7:33-54. 2014
    ..Lifestyle and socioeconomic status have been implicated in the prevalence of hypertension; thus, we evaluated factors associated with hypertension in a cohort of blacks and whites with similar socioeconomic status characteristics...
  21. pmc Helicobacter pylori protein-specific antibodies and risk of colorectal cancer
    Meira Epplein
    Authors Affiliations Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, and Division of Gastroenterology, Departments of Medicine and Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee International Epidemiology Institute, Rockville, Maryland and Division of Genome Modifications and Carcinogenesis, Infection and Cancer Program, German Cancer Research Center DFKZ, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 22:1964-74. 2013
    ..We assessed the association of H. pylori protein-specific infection and colorectal cancer risk in the prospective cohort, the Southern Community Cohort Study.
  22. pmc Intraindividual variation in one-carbon metabolism plasma biomarkers
    Elizabeth L Cope
    Authors Affiliations International Epidemiology Institute, Rockville, Maryland Division of Epidemiology, Department of Medicine Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee Section for Pharmacology, Institute of Medicine, University of Bergen Laboratory of Clinical Biochemistry, Haukeland University Hospital BEVITAL, Bergen, Norway Department of Epidemiology, Harvard School of Public Health and Dana Farber Harvard Cancer Center, Boston, Massachusetts
    Cancer Epidemiol Biomarkers Prev 22:1894-9. 2013
    ..19 OCM biomarkers in a sample of 147 African American and 68 non-Hispanic white participants from the Southern Community Cohort Study who donated blood samples and responded to questionnaires at two time points from 2005 to 2008...
  23. pmc Diabetes and prostate cancer screening in black and white men
    Maureen Sanderson
    Department of Family and Community Medicine, Meharry Medical College, 1005 Dr D B Todd Jr Blvd, Nashville, TN, 37208, USA
    Cancer Causes Control 24:1893-9. 2013
    ..The purpose of the present study was to investigate the association between diabetes and prostate cancer screening...
  24. pmc Fine-mapping of genome-wide association study-identified risk loci for colorectal cancer in African Americans
    Hansong Wang
    Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA
    Hum Mol Genet 22:5048-55. 2013
    ..07, P = 3.4 × 10(-10)). The contribution of the two new risk SNPs to CRC heritability was estimated to be 1.5% in African Americans. This study highlights the importance of fine-mapping in diverse populations. ..
  25. pmc Mortality by race among low-income adults with early-onset insulin-treated diabetes
    Baqiyyah Nilija Conway
    Corresponding author Baqiyyah Nilija Conway
    Diabetes Care 36:3107-12. 2013
    ..To determine if long-term mortality rates in early-onset insulin-treated diabetes differ by race among adults of similar socioeconomic status...
  26. pmc Evaluating genome-wide association study-identified breast cancer risk variants in African-American women
    Jirong Long
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 8:e58350. 2013
    ..study including up to 3,300 African-American women (1,231 cases and 2,069 controls), recruited in the Southern Community Cohort Study (SCCS) and the Nashville Breast Health Study (NBHS)...
  27. pmc A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
    Keri L Monda
    The Center for Observational Research, Amgen, Inc Thousand Oaks, California, USA
    Nat Genet 45:690-6. 2013
    ..7 × 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations...
  28. pmc Sedentary behavior, physical activity, and likelihood of breast cancer among Black and White women: a report from the Southern Community Cohort Study
    Sarah S Cohen
    International Epidemiology Institute, 1455 Research Blvd, Suite 550, Rockville, MD 20850, USA
    Cancer Prev Res (Phila) 6:566-76. 2013
    ..study within 546 cases (374 among Black women) and 2,184 matched controls enrolled in the Southern Community Cohort Study. Sedentary and physically active behaviors were assessed via self-report at study baseline (2002-2009)..
  29. pmc Sedentary and physically active behavior patterns among low-income African-American and white adults living in the southeastern United States
    Sarah S Cohen
    International Epidemiology Institute, Rockville, Maryland, United States of America
    PLoS ONE 8:e59975. 2013
    ..men, 9,899 white men, 32,214 black women, and 15,425 white women (age 40-79) at enrollment into the Southern Community Cohort Study. Descriptive statistics for sedentary time; light, moderate, and vigorous household/occupational ..
  30. pmc A small number of candidate gene SNPs reveal continental ancestry in African Americans
    Nuri Kodaman
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
    Ann Hum Genet 77:56-66. 2013
    ..Our results demonstrate that a small number of SNPs randomly selected from candidate genes can be used to estimate admixture proportions in African Americans reliably...
  31. pmc Evaluation of genome-wide association study-identified type 2 diabetes loci in African Americans
    Jirong Long
    Division of Epidemiology, Departmentof Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee 37203 1738, USA
    Am J Epidemiol 176:995-1001. 2012
    ..These results extend some of the recent GWAS findings to African Americans and may guide future efforts to identify causal variants for T2D...
  32. pmc A prospective study of serum 25-hydroxyvitamin d levels and mortality among African Americans and non-African Americans
    Lisa B Signorello
    International Epidemiology Institute, Rockville, Maryland, USA
    Am J Epidemiol 177:171-9. 2013
    ..The authors conducted a nested case-control study within the prospective Southern Community Cohort Study to relate baseline serum levels of 25-hydroxyvitamin D (25(OH)D) with subsequent mortality...
  33. pmc Incidence and predictors of end stage renal disease among low-income blacks and whites
    Loren Lipworth
    Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA
    PLoS ONE 7:e48407. 2012
    ..Incident diagnoses of ESRD among 79,943 black and white participants in the Southern Community Cohort Study (SCCS) were ascertained by linkage with the United States Renal Data System (USRDS) from 2002 through ..
  34. pmc Reproducibility of serum 25-hydroxyvitamin d and vitamin D-binding protein levels over time in a prospective cohort study of black and white adults
    Jennifer S Sonderman
    International Epidemiology Institute, 1455 Research Blvd, Suite 550, Rockville, MD 20850, USA
    Am J Epidemiol 176:615-21. 2012
    ..twice in samples collected between 2005 and 2008 from 225 participants (155 black, 70 white) in the Southern Community Cohort Study. Reproducibility for 25(OH)D was uniformly high, with adjusted intraclass correlation coefficients (..
  35. pmc Association between socioeconomic status (SES) and lower urinary tract symptom (LUTS) severity among black and white men
    Jay H Fowke
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    J Gen Intern Med 26:1305-10. 2011
    ..A higher prevalence of moderate or severe lower urinary tract symptoms (LUTS) has been reported among African Americans, but the separate effects of race and socioeconomic status (SES) on LUTS severity are unclear...
  36. pmc Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America
    PLoS Genet 7:e1001387. 2011
    ..Our findings with variants at 8q24 also reinforce the importance of this region as a major risk locus for prostate cancer in men of African ancestry...
  37. pmc Racial differences in the association between body mass index and serum IGF1, IGF2, and IGFBP3
    Jay H Fowke
    Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, Tennessee 37203 1738, USA
    Endocr Relat Cancer 17:51-60. 2010
    ..The effects of obesity throughout life on the IGF axis and racial differences in breast cancer risk require study...
  38. pmc Parity and breastfeeding in relation to obesity among black and white women in the southern community cohort study
    Sarah S Cohen
    International Epidemiology Institute, Rockville, Maryland 20850, USA
    J Womens Health (Larchmt) 18:1323-32. 2009
    ..This research sought to describe associations among parity, breastfeeding, and adult obesity in black and white women in the southeastern United States...
  39. pmc Estimating nutrient intake from a food frequency questionnaire: incorporating the elements of race and geographic region
    Lisa B Signorello
    International Epidemiology Institute, Rockville, Maryland 20850, USA
    Am J Epidemiol 170:104-11. 2009
    ..For the Southern Community Cohort Study, the authors developed and assessed results from a nutrient database system incorporating sex-, race-,..
  40. pmc Seasonal changes in amount and patterns of physical activity in women
    Maciej S Buchowski
    Energy Balance Laboratory, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Phys Act Health 6:252-61. 2009
    ..Environmental factors including seasonal changes are important to guide physical activity (PA) programs to achieve or sustain weight loss. The goal was to determine seasonal variability in the amount and patterns of free-living PA in women...
  41. pmc Race and socioeconomic status are independently associated with benign prostatic hyperplasia
    Jay H Fowke
    Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, Tennessee 37203 1738, USA
    J Urol 180:2091-6; discussion 2096. 2008
    ..We investigated racial differences in and surgical intervention for benign prostatic hyperplasia in a large and predominantly low income population...
  42. pmc Correlates of high serum C-reactive protein levels in a socioeconomically disadvantaged population
    Xianglan Zhang
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA
    Dis Markers 24:351-9. 2008
    ..with demographic and lifestyle factors in a sample of 792 participants aged 40-79 years from the Southern Community Cohort Study, which has an over-representation of socioeconomically disadvantaged individuals (over 60% with a ..
  43. pmc Papanicolaou testing among women in the southern United States
    Neeraja B Peterson
    Institute for Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8300, USA
    J Womens Health (Larchmt) 17:939-46. 2008
    ..We examined Pap testing among southern women, mostly of low income and educational status, to determine if rates were similar to those reported nationally and to examine which factors were related to receipt of Pap tests...
  44. pmc Colonoscopy screening in African Americans and Whites with affected first-degree relatives
    Harvey J Murff
    Vanderbilt Epidemiology Center, Nashville, TN 37203 1738, USA
    Arch Intern Med 168:625-31. 2008
    ..Racial differences in colon cancer mortality could be related to variations in screening of increased-risk individuals...
  45. ncbi Vitamin D insufficiency among African-Americans in the southeastern United States: implications for cancer disparities (United States)
    Kathleen M Egan
    Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA
    Cancer Causes Control 19:527-35. 2008
    ..To determine the prevalence and predictors of vitamin D insufficiency among black and white adult residents of the southern US...
  46. pmc Use of colonoscopy and flexible sigmoidoscopy among African Americans and whites in a low-income population
    Neeraja B Peterson
    Prev Chronic Dis 5:A28. 2008
  47. ncbi Mammography use in the Southern Community Cohort Study (United States)
    Yong Cui
    Department of Internal Medicine, Meharry Medical College, Nashville, TN 37208, USA
    J Health Care Poor Underserved 18:102-17. 2007
    ....
  48. pmc Comparing diabetes prevalence between African Americans and Whites of similar socioeconomic status
    Lisa B Signorello
    International Epidemiology Institute, Rockville, MD 20850, USA lisa
    Am J Public Health 97:2260-7. 2007
    ..We investigated whether racial disparities in the prevalence of type 2 diabetes exist beyond what may be attributable to differences in socioeconomic status (SES) and other modifiable risk factors...
  49. ncbi Association between prostate-specific antigen and leptin, adiponectin, HbA1c or C-peptide among African-American and Caucasian men
    J H Fowke
    Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37203 1738, USA
    Prostate Cancer Prostatic Dis 11:264-9. 2008
    ..84, 0.73, 0.77 and 0.45 ng ml(-1) across quartiles of HbA1c, respectively; P(trend)=0.005). This may suggest that metabolic disturbances related to metabolic syndrome or diabetes affect the ability to detect early-stage prostate cancer...
  50. ncbi Obesity and recent mammography use among black and white women in the Southern Community Cohort Study (United States)
    Sarah S Cohen
    International Epidemiology Institute, 1455 Research Blvd, Suite 550, Rockville, MD 20850, USA
    Cancer Causes Control 18:765-73. 2007
    ..To examine the relationship between obesity and mammography use in a large population of black and white women...
  51. ncbi Separate estimates of portion size were not essential for energy and nutrient estimation: results from the Southern Community Cohort food-frequency questionnaire pilot study
    David G Schlundt
    Department of Psychology, Vanderbilt University, Nashville, TN 37232, USA
    Public Health Nutr 10:245-51. 2007
    A food-frequency questionnaire (FFQ) was developed to assess habitual dietary intake in the Southern Community Cohort Study (SCCS), a prospective epidemiological study to analyse disparities in cancer and other chronic diseases between ..
  52. ncbi Effects of obesity and height on prostate-specific antigen (PSA) and percentage of free PSA levels among African-American and Caucasian men
    Jay H Fowke
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Cancer 107:2361-7. 2006
    ..The association between body mass index (BMI) and height on PSA and percentage of free PSA (%fPSA) was investigated within AA and CA men without a prior prostate cancer diagnosis...
  53. pmc Evaluation of 11 breast cancer susceptibility loci in African-American women
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 18:2761-4. 2009
    ..The results from this study extend some of the recent GWAS findings to African-Americans and may guide future efforts to identify the causal variants for breast cancer...
  54. pmc Adult weight gain and diabetes among African American and white adults in southeastern US communities
    Sarah S Cohen
    International Epidemiology Institute, Rockville, MD 20850, USA
    Prev Med 49:476-81. 2009
    ..To examine associations between adult weight gain and diabetes among African Americans and Whites...
  55. pmc Renal cancer paradox: higher incidence but not higher mortality among African-Americans
    Loren Lipworth
    International Epidemiology Institute, Rockville, Maryland 20850, USA
    Eur J Cancer Prev 20:331-3. 2011
    ..Further research into the enigmatic descriptive epidemiology and the biology and natural history of renal cell cancer may shed light on the etiology of this malignancy and its more frequent occurrence among black Americans...
  56. pmc Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California, USA
    Nat Genet 43:570-3. 2011
    ..Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations...
  57. pmc Renal cell cancer among African Americans: an epidemiologic review
    Loren Lipworth
    International Epidemiology Institute, 1455 Research Boulevard, Suite 550, Rockville, MD 20850, USA
    BMC Cancer 11:133. 2011
    ....
  58. pmc Helicobacter pylori prevalence and circulating micronutrient levels in a low-income United States population
    Meira Epplein
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Cancer Prev Res (Phila) 4:871-8. 2011
    ..The present study seeks to further our understanding of this potential connection in the Southern Community Cohort Study, representing a low-income population in the United States. Blood levels of antibodies to H...
  59. pmc Lung cancer risk among smokers of menthol cigarettes
    William J Blot
    International Epidemiology Institute, 1455 Research Blvd, Ste 550, Rockville, MD 20850, USA
    J Natl Cancer Inst 103:810-6. 2011
    ..The Food and Drug Administration is currently considering whether to ban the sale of menthol cigarettes in the United States...
  60. pmc Race, African ancestry, and Helicobacter pylori infection in a low-income United States population
    Meira Epplein
    Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 20:826-34. 2011
    ..Gastric cancer incidence in African Americans is twice that of whites, and differing prevalence of Helicobacter pylori strain-specific isolates may help explain the disparity...
  61. pmc Replication and functional genomic analyses of the breast cancer susceptibility locus at 6q25.1 generalize its importance in women of chinese, Japanese, and European ancestry
    Qiuyin Cai
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Cancer Res 71:1344-55. 2011
    ..This association may be explained in part by a putatively functional variant (rs6913578) identified in the region...
  62. pmc ADIPOQ, ADIPOR1, and ADIPOR2 polymorphisms in relation to serum adiponectin levels and BMI in black and white women
    Sarah S Cohen
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Obesity (Silver Spring) 19:2053-62. 2011
    ..interview data and blood samples collected from 990 black and 977 white women enrolled in the Southern Community Cohort Study (SCCS) from 2002 to 2006, we examined 25 SNPs in ADIPOQ, 19 in ADIPOR1, and 27 in ADIPOR2 in relation ..
  63. pmc Serum adiponectin in relation to body mass index and other correlates in black and white women
    Sarah S Cohen
    Department of Epidemiology, University of North Carolina, Chapel Hill, USA
    Ann Epidemiol 21:86-94. 2011
    ..Adiponectin is a promising biomarker linking obesity and disease risk; however, limited data are available regarding adiponectin in black women among whom obesity is highly prevalent...
  64. pmc Diabetes and co-morbid depression among racially diverse, low-income adults
    Chandra Y Osborn
    Department of Medicine, Division of General Internal Medicine, Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Ann Behav Med 41:300-9. 2011
    ..Research suggests individuals with diabetes are twice as likely as those without diabetes to be clinically depressed. Still unknown is the relationship between diabetes and depression in socioeconomically disadvantaged populations...
  65. pmc Blood vitamin d levels in relation to genetic estimation of African ancestry
    Lisa B Signorello
    1International Epidemiology Institute, Rockville, Maryland 20850, USA
    Cancer Epidemiol Biomarkers Prev 19:2325-31. 2010
    ..Little is known about the genetic determinants of 25(OH)D levels nor whether the degree of African ancestry associates with circulating 25(OH)D...
  66. pmc Physical activity and obesity gap between black and white women in the southeastern U.S
    Maciej S Buchowski
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Am J Prev Med 39:140-7. 2010
    ..Differences between black and white women in the associations of sedentary and active behaviors and obesity are mostly unknown...
  67. pmc Racial disparities in the treatment of depression in low-income persons with diabetes
    Chandra Y Osborn
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Diabetes Care 33:1050-4. 2010
    ..The goal of this study was to examine racial disparities in the treatment of depression with antidepressant medication in the southeastern U.S...
  68. pmc The Southern Community Cohort Study: investigating health disparities
    Lisa B Signorello
    Department of Medicine, Vanderbilt University Medical Center, Vanderbilt Ingram Cancer Center, Nashville, TN, USA
    J Health Care Poor Underserved 21:26-37. 2010
    ..The Southern Community Cohort Study is a unique national resource for assessing determinants of racial/ethnic differentials in diseases.
  69. pmc Biochemical validation of food frequency questionnaire-estimated carotenoid, alpha-tocopherol, and folate intakes among African Americans and non-Hispanic Whites in the Southern Community Cohort Study
    Lisa B Signorello
    International Epidemiology Institute, Rockville, MD20850, USA
    Am J Epidemiol 171:488-97. 2010
    ..The authors conducted a validation study within the Southern Community Cohort Study to evaluate FFQ-estimated intakes of alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein/..
  70. pmc Racial differences in serum cotinine levels of smokers
    Lisa B Signorello
    International Epidemiology Institute, Rockville, MD 20850, USA
    Dis Markers 27:187-92. 2009
    ..Sera from 255 current smokers sampled from Southern Community Cohort Study participants (65 black men, 65 black women, 63 white men, 62 white women) were analyzed for cotinine, ..
  71. ncbi Obesity and prostate cancer screening among African-American and Caucasian men
    Jay H Fowke
    Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA
    Prostate 66:1371-80. 2006
    ..We investigated the relationship between obesity and PSA testing, and evaluated the role of prior diagnoses and disease screening on PSA testing patterns...

Research Grants30

  1. Comparative Mechanisms of Cancer Chemoprevention
    Roderick H Dashwood; Fiscal Year: 2013
    ..This application is innovative and timely in bridging basic mechanisms, preclinical models, and human studies of epigenetics and diet. ..
  2. DIETARY AND HORMONAL DETERMINANTS OF CANCER IN WOMEN
    Meir Stampfer; Fiscal Year: 2013
    ..abstract_text> ..
  3. Penn TREC Survivor Center
    Kathryn H Schmitz; Fiscal Year: 2013
    ..abstract_text> ..
  4. Understanding and preventing breast cancer disparties in Latinas
    Beti Thompson; Fiscal Year: 2013
    ..Through its four projects and cores, the proposed Center will cover a myriad of aspects of breast cancer, from biological processes and genetic pathways to individual determinants and social determinants of breast cancer. ..
  5. DRUG DEPENDENCE CLINICAL RESEARCH PROGRAM
    Reese T Jones; Fiscal Year: 2013
    ..abstract_text> ..
  6. Hopkins Center for Eliminate Cardiovascular Health Disparities
    Lisa A Cooper; Fiscal Year: 2013
    ..abstract_text> ..
  7. NEW MODALITIES FOR TREATMENT OF PAIN AND DRUG ABUSE
    Victor J Hruby; Fiscal Year: 2013
    ....