Treatment adherence in minorities with rheumatic disease

Summary

Principal Investigator: M E Suarez-Almazor
Abstract: DESCRIPTION (provided by investigator): The outcome of patients with rheumatic disease, in particular rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is variable and often unpredictable, and important differences have been observed across racial groups. Patients often show poor adherence to therapy, but the determinants and outcomes of compliance-related behaviors have not been adequately documented. We hypothesize that some of the ethnic differences in the outcome of these diseases may be related to degree of compliance with physician recommendations. The overall objective of this study is to quantify adherence to medical recommendations in patients with RA and SLE from diverse ethnic backgrounds, and to determine which are its predictors and outcomes, with an emphasis on psychosocial factors and medical interaction issues. The study will: a) compare attitudes and behaviors toward adherence to treatment in patients with RA and SLE from diverse ethnic backgrounds; b) assess the role of patient beliefs, expectations and attitudes about their disease on their adherence to treatment; c) assess the role of selected elements of the medical interaction on patients' compliance; d) evaluate ethnic differences in compliance in the context of a modified Health Belief Model (HBM); and e) determine the impact of non-compliance on patient outcomes. Phase I will use focus groups (including White, Hispanic, and Black patients) to explore the views of patients with RA and SLE toward adherence to treatment, barriers and perceived benefits. The groups will also provide information to develop scales that measure barriers and expectations in the context of the HBM. Phase 2 will be a 2-year cohort study of patients with RA and SLE from diverse ethnic backgrounds which will evaluate the determinants of adherence to treatment on the basis of the HBM, and will also examine health outcomes at the end of the 2 years according to the degree of adherence.
Funding Period: 2002-04-01 - 2006-06-30
more information: NIH RePORT

Top Publications

  1. ncbi Measuring therapeutic adherence in systemic lupus erythematosus with electronic monitoring
    M F Marengo
    The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Lupus 21:1158-65. 2012
  2. pmc Electronic monitoring of oral therapies in ethnically diverse and economically disadvantaged patients with rheumatoid arthritis: consequences of low adherence
    Christian A Waimann
    University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Arthritis Rheum 65:1421-9. 2013
  3. ncbi Determinants of treatment adherence in ethnically diverse, economically disadvantaged patients with rheumatic disease
    Maria G Garcia Popa-Lisseanu
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    J Rheumatol 32:913-9. 2005
  4. ncbi Trust in physicians and elements of the medical interaction in patients with rheumatoid arthritis and systemic lupus erythematosus
    Javier P Berrios-Rivera
    Baylor College of Medicine and Michael E DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Arthritis Rheum 55:385-93. 2006
  5. ncbi Initiation of disease-modifying antirheumatic drug therapy in minority and disadvantaged patients with rheumatoid arthritis
    Maria E Suarez-Almazor
    Department of General Internal Medicine Rheumatology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Rheumatol 34:2400-7. 2007
  6. ncbi Treatment adherence in patients with rheumatoid arthritis and systemic lupus erythematosus
    Araceli Garcia-Gonzalez
    University of Texas M D Anderson Cancer Center, Anderson 1400 Holcombe Boulevard Unit 437, Houston, TX 77030, USA
    Clin Rheumatol 27:883-9. 2008
  7. ncbi Doctor-patient interactions in Mexican patients with rheumatic disease
    Araceli Garcia-Gonzalez
    Department of Symptom Research, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA
    J Clin Rheumatol 15:120-3. 2009

Scientific Experts

  • M E Suarez-Almazor
  • Araceli Garcia-Gonzalez
  • John D Reveille
  • Donald M Marcus
  • Christian A Waimann
  • Maria G Garcia Popa-Lisseanu
  • M F Marengo
  • Marsha N Richardson
  • Vanessa Cox
  • Michael A Kallen
  • Marsha Richardson
  • Javier P Berrios-Rivera
  • Namieta M Janssen
  • Sofia de Achaval
  • Vanessa L Cox
  • María F Marengo
  • H Zhang
  • M N Richardson
  • A Garcia-Gonzalez
  • J D Reveille
  • C A Waimann
  • S de Achaval
  • Brenda E Rodriguez-Arreola
  • Jorge Iván Gámez-Nava
  • Laura Gonzalez-Lopez
  • Namieta Janssen
  • Maria Garcia Popa-Lisseanu
  • Bernard Ng
  • Richard L Street
  • Noranna B Warner
  • Kimberly J O'Malley
  • Anthony Greisinger
  • Jasmeet Tagore

Detail Information

Publications9

  1. ncbi Measuring therapeutic adherence in systemic lupus erythematosus with electronic monitoring
    M F Marengo
    The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Lupus 21:1158-65. 2012
    ..We used an electronic monitoring system to quantify adherence to prescribed oral therapies by patients with systemic lupus erythematosus (SLE)...
  2. pmc Electronic monitoring of oral therapies in ethnically diverse and economically disadvantaged patients with rheumatoid arthritis: consequences of low adherence
    Christian A Waimann
    University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Arthritis Rheum 65:1421-9. 2013
    ..To quantify adherence to oral therapies in ethnically diverse and economically disadvantaged patients with rheumatoid arthritis (RA), using electronic medication monitoring, and to evaluate the clinical consequences of low adherence...
  3. ncbi Determinants of treatment adherence in ethnically diverse, economically disadvantaged patients with rheumatic disease
    Maria G Garcia Popa-Lisseanu
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    J Rheumatol 32:913-9. 2005
    ....
  4. ncbi Trust in physicians and elements of the medical interaction in patients with rheumatoid arthritis and systemic lupus erythematosus
    Javier P Berrios-Rivera
    Baylor College of Medicine and Michael E DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Arthritis Rheum 55:385-93. 2006
    ..To identify components of the patient-doctor relationship associated with trust in physicians...
  5. ncbi Initiation of disease-modifying antirheumatic drug therapy in minority and disadvantaged patients with rheumatoid arthritis
    Maria E Suarez-Almazor
    Department of General Internal Medicine Rheumatology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Rheumatol 34:2400-7. 2007
    ..To evaluate disparities in time to initiation of disease modifying antirheumatic drugs (DMARD) in patients with rheumatoid arthritis (RA) receiving care in public or private healthcare settings...
  6. ncbi Treatment adherence in patients with rheumatoid arthritis and systemic lupus erythematosus
    Araceli Garcia-Gonzalez
    University of Texas M D Anderson Cancer Center, Anderson 1400 Holcombe Boulevard Unit 437, Houston, TX 77030, USA
    Clin Rheumatol 27:883-9. 2008
    ..These appear to be more prevalent in African Americans and Hispanics than Whites; the impact of decreased adherence on outcomes could be significant and should be considered when treating patients with RA and SLE...
  7. ncbi Doctor-patient interactions in Mexican patients with rheumatic disease
    Araceli Garcia-Gonzalez
    Department of Symptom Research, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA
    J Clin Rheumatol 15:120-3. 2009
    ..To evaluate the characteristics of physician-patient communications in Mexican patients with rheumatic diseases...