Genomes and Genes
RISK FACTORS FOR AGED RELATED BONE LOSS
Principal Investigator: Douglas Kiel
Affiliation: Harvard University
Abstract: DESCRIPTION: (Adapted from Investigator's Abstract) Osteoporosis and related fractures represent major public health problems that will only increase in importance as the population ages. Several studies have now convincingly demonstrated that aging-related bone loss continues, and may even accelerate, in extreme old age. A better understanding of the factors that may be unique to bone loss in old age may help to refine the types of interventions to preserve bone mass in old age. The present application is a competing continuation proposal from the Framingham osteoporosis study group to examine in detail several risk factors for bone loss in old age using three related cohorts, the original Framingham cohort, The Framingham Offspring cohort and a new Framingham minority cohort. The Original Framingham cohort has been the subject of two previous exams that included measurement of bone density. The Framingham Offspring Cohort was recruited from among the children, and their spouses, of members of the original cohort starting in 1971; 3570 are expected to participate in this osteoporosis study. The Minority cohort is currently being recruited and will consist of 300 subjects (34% black and 66% Hispanic). The proposed studies will extend and expand upon the research group s previous investigations of more traditional risk factors for bone loss by taking advantage of developments in nutritional assessment, as well as findings from cellular and molecular biology of bone, which offer an opportunity to examine risk factors for bone loss that have been less well studied. The primary aim (1) of the proposed studies is to examine the effect of dietary factors on bone health, in particular the effect on bone density and bone loss of consumption choices among common food groups, and the effect on bone loss of specific nutrients that have not been well-studied with regard to bone, including magnesium, potassium, vitamin C, sodium, and vitamin K. The dietary studies will be performed using longitudinal data on bone density from the original Framingham cohort, and using cross-sectional bone density data in the Offspring and Minority Cohorts. Dietary data, in the form of food frequency questionnaires in all three cohorts, and 3 day food records in the Offspring Cohort, have already been collected at previous examinations. For this aim, follow-up for bone loss in the Original Framingham Cohort will be extended from 4-5 years to 8 years by adding an assessment of bone density at a planned future Framingham biennial examination (Exam 24). A special call back visit will be required to obtain bone density in all of the approximately 3,600 members of the Offspring Cohort. Both dietary data and bone density are already being measured in an ongoing examination of the Minority Cohort. There are also several other Aims of the study, as follow: (2) to examine the cross-sectional association of IGF-1 and IGF-BP4 with bone density in a subset of 100 men and 100 women in the Framingham Offspring cohort using blood specimens obtained 5 years prior to the measurement of bone density; (3) to examine the cross-sectional association with bone density of two new measures of weight-bearing physical activity, a validated questionnaire and an automated weight-bearing activity monitor, in subsets of 200 men and 200 women in each of the Original and Offspring Cohorts; physical activity will also be examined in relation to a new measurement of QUS of the heel in this subset from the Original cohort; the physical activity measures will be obtained in a special callback or regular visit in the Offspring Cohort and at Exam 24 in the original cohort; and (4) to compare measures of quantitative ultrasound (QUS) of the calcaneus between members of the Original Cohort who attend Exam 24 and those who are unable to attend the exam to determine if bone loss may be underestimated by studying subjects who attend clinic examinations. QUS will be assessed with a new dry system device in all those in the original cohort who attend Exam 24 as well as those who receive the standard Framingham home visit.
Funding Period: 1991-09-30 - 2002-08-31
more information: NIH RePORT
- Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis StudyKatherine L Tucker
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
J Bone Miner Res 20:152-8. 2005..Men with plasma B12 < 148 pM had significantly lower BMD at the hip, and women at the spine, relative to those with higher B12, and trends were similar for both at all sites. Low vitamin B12 may be a risk factor for low BMD...
- Effects of beer, wine, and liquor intakes on bone mineral density in older men and womenKatherine L Tucker
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 89:1188-96. 2009..Moderate intake of alcohol has been reported to have beneficial effects on bone. However, different classes of alcoholic beverages have not been investigated...
- Bivariate genome-wide linkage analysis of femoral bone traits and leg lean mass: Framingham studyDavid Karasik
Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts, USA
J Bone Miner Res 24:710-8. 2009..Identification and subsequent characterization of these shared loci may further elucidate the genetic contributions to both osteoporosis and sarcopenia...
- High vitamin C intake is associated with lower 4-year bone loss in elderly menShivani Sahni
Dietary Assessment and Epidemiology Research Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 138:1931-8. 2008..Null associations were observed among women. These results suggest a possible protective role of vitamin C for bone health in older men...
- Thyroid function and the risk of Alzheimer disease: the Framingham StudyZaldy S Tan
Department of Medicine, Gerontology Division, Beth Israel Deaconess Medical Center, 110 Francis St, LMOB 1A, Boston, MA 02215, USA
Arch Intern Med 168:1514-20. 2008..Clinical hypothyroidism and hyperthyroidism are recognized causes of reversible dementia, but previous studies relating thyrotropin levels to cognitive performance in clinically euthyroid persons have yielded inconsistent results...
- Polymorphisms in the endothelial nitric oxide synthase gene and bone density/ultrasound and geometry in humansK Cho
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
Bone 42:53-60. 2008..Thus, NOS3 genetic variation does not appear to be a major contributor to adult bone density/ultrasound and geometry in our sample...
- Genome-wide association with bone mass and geometry in the Framingham Heart StudyDouglas P Kiel
Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA
BMC Med Genet 8:S14. 2007..There have been no genome-wide association and linkage studies for these traits using high-density genotyping platforms...
- Meniscal damage associated with increased local subchondral bone mineral density: a Framingham studyG H Lo
Tufts New England Medical Center, Boston, MA 02111, USA
Osteoarthritis Cartilage 16:261-7. 2008..We hypothesized that knees with higher M:L BMD, consistent with increased medial subchondral BMD, would be associated with medial meniscal damage, and lower ratios with lateral meniscal damage...
- Bivariate linkage study of proximal hip geometry and body size indices: the Framingham studyD Karasik
Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, 1200 Centre Street, Boston, MA 02131, USA
Calcif Tissue Int 81:162-73. 2007....
- Hip structural geometry in old and old-old age: similarities and differences between men and womenLaurel B Yates
Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
Bone 41:722-32. 2007....
- Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in menDouglas P Kiel
Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA 02131, USA
Bone 40:587-96. 2007..These observations suggest that Wnt-LRP5 may play a role in the adaptation of bone to mechanical load in humans, and may explain some gender-related differences in bone mass...
- Abdominal aortic calcification and exostoses at the hand and lumbar spine: the Framingham StudyD Karasik
Hebrew SeniorLife and Harvard Medical School, Boston, MA, USA
Calcif Tissue Int 78:1-8. 2006..In conclusion, in this cross-sectional study, anterior lumbar osteophytes and AAC occurred in the same individuals after adjustment for age and other covariates. In general, hand exostoses were not associated with aortic calcification...
- Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitusPeter W F Wilson
The NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
Circulation 112:3066-72. 2005..The objective was to investigate risk for CVD, CHD, and T2DM according to metabolic syndrome traits...
- Vertebral deformity, back symptoms, and functional limitations among older women: the Framingham StudySusan L Edmond
University of Medicine and Dentistry New Jersey, SHRP PT, 65 Bergen Street, Newark, NJ 07101 1709, USA
Osteoporos Int 16:1086-95. 2005..Efforts to prevent and treat back pain, independent of vertebral deformity status, might help to reduce functional limitations in older women...
- Bone mineral density and the risk of Alzheimer diseaseZaldy Sy Tan
Division on Aging, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA 02215, USA
Arch Neurol 62:107-11. 2005..Bone mineral density (BMD) is a potential surrogate marker for cumulative estrogen exposure and has been associated with cognitive performance and risk of cognitive deterioration...
- 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home servicesJ S Buell
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
Neurology 74:18-26. 2010..However, no studies have examined the association between vitamin D status, dementia, and cranial MRI indicators of cerebrovascular disease (CVD)...